CA2102431A1 - Microelectrospray Method and Apparatus - Google Patents

Microelectrospray Method and Apparatus

Info

Publication number
CA2102431A1
CA2102431A1 CA2102431A CA2102431A CA2102431A1 CA 2102431 A1 CA2102431 A1 CA 2102431A1 CA 2102431 A CA2102431 A CA 2102431A CA 2102431 A CA2102431 A CA 2102431A CA 2102431 A1 CA2102431 A1 CA 2102431A1
Authority
CA
Canada
Prior art keywords
solution
terminal portion
capillary tube
electrospraying
electrospray
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2102431A
Other languages
French (fr)
Other versions
CA2102431C (en
Inventor
James W. Jorgenson
Daniel M. Dohmeier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Original Assignee
James W. Jorgenson
Daniel M. Dohmeier
University Of North Carolina At Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by James W. Jorgenson, Daniel M. Dohmeier, University Of North Carolina At Chapel Hill filed Critical James W. Jorgenson
Publication of CA2102431A1 publication Critical patent/CA2102431A1/en
Application granted granted Critical
Publication of CA2102431C publication Critical patent/CA2102431C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers

Abstract

A method of generating an electrospray from a solution is disclosed which is useful for electrospraying at low flow rates, for electrospraying directly into a vacuum, or both. The method comprises the steps of causing the solution to flow through a capillary tube to an outlet opening formed in the terminal portion thereof.
The capillary tube terminal portion has an inner diameter of not more than 50 micrometers and an outer diameter of not more than 150 micrometers. An electrical potential difference is provided between the capillary tube terminal portion and a conductor spaced from said terminal portion, with the potential sufficient to cause the solution to electrospray from the capillary outlet.
The method is particularly useful for detecting analytes in the solution being electrosprayed by mass spectral analysis.
CA002102431A 1991-05-15 1992-05-14 Microelectrospray method and apparatus Expired - Fee Related CA2102431C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US700,572 1976-06-28
US07/700,572 US5115131A (en) 1991-05-15 1991-05-15 Microelectrospray method and apparatus
PCT/US1992/004015 WO1992020437A1 (en) 1991-05-15 1992-05-14 Microelectrospray method and apparatus

Publications (2)

Publication Number Publication Date
CA2102431A1 true CA2102431A1 (en) 1992-11-16
CA2102431C CA2102431C (en) 2000-04-25

Family

ID=24814024

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002102431A Expired - Fee Related CA2102431C (en) 1991-05-15 1992-05-14 Microelectrospray method and apparatus

Country Status (7)

Country Link
US (1) US5115131A (en)
EP (1) EP0586543B1 (en)
JP (1) JP3350547B2 (en)
AT (1) ATE170332T1 (en)
CA (1) CA2102431C (en)
DE (1) DE69226773T2 (en)
WO (1) WO1992020437A1 (en)

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US7047171B1 (en) 1995-12-08 2006-05-16 Sproch Norman K Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling
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US5495108A (en) * 1994-07-11 1996-02-27 Hewlett-Packard Company Orthogonal ion sampling for electrospray LC/MS
US5750988A (en) * 1994-07-11 1998-05-12 Hewlett-Packard Company Orthogonal ion sampling for APCI mass spectrometry
US5572023A (en) * 1995-05-30 1996-11-05 Board Of Regents, The University Of Texas System Electrospray methods and apparatus for trace analysis
US6278111B1 (en) 1995-08-21 2001-08-21 Waters Investments Limited Electrospray for chemical analysis
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US5828062A (en) * 1997-03-03 1998-10-27 Waters Investments Limited Ionization electrospray apparatus for mass spectrometry
US6127680A (en) * 1997-03-15 2000-10-03 Analytica Of Branford, Inc. Disposable microtip probe for low flow electrospray
GB2366663B (en) * 1997-03-15 2002-04-24 Analytica Of Branford Inc Disposable microchip probe for low flow electrospray
US6207955B1 (en) * 1998-09-28 2001-03-27 Varian, Inc. Pneumatically assisted electrospray device with alternating pressure gradients for mass spectrometry
CA2305071C (en) 1999-04-12 2009-03-24 Mds Inc. High intensity ion source
US6407382B1 (en) 1999-06-04 2002-06-18 Technispan Llc Discharge ionization source
ATE328670T1 (en) 1999-11-11 2006-06-15 Trinity College Dublin DEVICE AND METHOD FOR ADMINISTRATION OF DROPS
US6670607B2 (en) * 2000-01-05 2003-12-30 The Research Foundation Of State University Of New York Conductive polymer coated nano-electrospray emitter
US6768119B2 (en) * 2000-04-06 2004-07-27 De La Mora Juan F. Method and apparatus to produce ions and nanodrops from Taylor cones at reduced pressure
SE0004233D0 (en) * 2000-06-08 2000-11-17 Jonas Bergquist Jonas Electrospray emitter
US6525313B1 (en) * 2000-08-16 2003-02-25 Brucker Daltonics Inc. Method and apparatus for an electrospray needle for use in mass spectrometry
US20040099310A1 (en) * 2001-01-05 2004-05-27 Per Andersson Microfluidic device
US6653625B2 (en) * 2001-03-19 2003-11-25 Gyros Ab Microfluidic system (MS)
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
US6812456B2 (en) 2001-03-19 2004-11-02 Gyros Ab Microfluidic system (EDI)
WO2002075312A1 (en) 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
US20020168297A1 (en) * 2001-05-11 2002-11-14 Igor Shvets Method and device for dispensing of droplets
DE02744176T1 (en) 2001-05-24 2005-01-13 New Objective, Inc., Woburn METHOD AND DEVICE FOR ELECTROSPRAY WITH FEEDBACK CONTROL
US6803568B2 (en) 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
EP1433194A4 (en) * 2001-10-05 2006-09-20 Univ Yale Method and apparatus to produce ions and nanodrops from taylor cones of volatile liquids at reduced pressures
AU2003301073A1 (en) * 2002-12-18 2004-07-14 Brigham Young University Method and apparatus for aerodynamic ion focusing
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US7007710B2 (en) * 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US6870154B1 (en) 2004-02-27 2005-03-22 The University Of Western Ontario Capillary mixer with adjustable reaction chamber volume for mass spectrometry
US20060022130A1 (en) * 2004-07-29 2006-02-02 Predicant Biosciences, Inc., A Delaware Corporation Microfluidic devices and methods with integrated electrical contact
US20060060769A1 (en) * 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US20090084979A1 (en) * 2004-10-07 2009-04-02 Dewalch Norman Binz High-speed molecular analyzer system and method
US20090218481A1 (en) * 2004-10-07 2009-09-03 Dewalch Norman Binz High-Speed Molecular Analyzer System and Method
US7798420B2 (en) * 2005-02-11 2010-09-21 Battelle Memorial Institute Aerosol dispensing device and method
US20060208186A1 (en) * 2005-03-15 2006-09-21 Goodley Paul C Nanospray ion source with multiple spray emitters
GB0524979D0 (en) * 2005-12-07 2006-01-18 Queen Mary & Westfield College An electrospray device and a method of electrospraying
US7880140B2 (en) * 2007-05-02 2011-02-01 Dh Technologies Development Pte. Ltd Multipole mass filter having improved mass resolution
GB0709517D0 (en) * 2007-05-17 2007-06-27 Queen Mary & Westfield College An electrostatic spraying device and a method of electrostatic spraying
US8205558B2 (en) * 2007-07-09 2012-06-26 Middlesex General Industries, Inc. System and method of improving throughput and vehicle utilization of monorail factory transport systems
US7671344B2 (en) * 2007-08-31 2010-03-02 Battelle Memorial Institute Low pressure electrospray ionization system and process for effective transmission of ions
US8173960B2 (en) * 2007-08-31 2012-05-08 Battelle Memorial Institute Low pressure electrospray ionization system and process for effective transmission of ions
GB2471520B (en) 2009-07-03 2013-08-21 Microsaic Systems Plc An electrospray pneumatic nebuliser ionisation source
CN102221576B (en) 2010-04-15 2015-09-16 岛津分析技术研发（上海）有限公司 The method and apparatus of a kind of generation, analysis ion
WO2015031820A1 (en) * 2013-08-29 2015-03-05 University Of Notre Dame Du Lac High sensitivity electrospray interface
US9711341B2 (en) * 2014-06-10 2017-07-18 The University Of North Carolina At Chapel Hill Mass spectrometry systems with convective flow of buffer gas for enhanced signals and related methods
US9406492B1 (en) 2015-05-12 2016-08-02 The University Of North Carolina At Chapel Hill Electrospray ionization interface to high pressure mass spectrometry and related methods
WO2016182563A1 (en) * 2015-05-12 2016-11-17 The University Of North Carolina At Chapel Hill Electrospray ionization interface to high pressure mass spectrometry and related methods
CN108369889B (en) * 2015-12-18 2021-03-05 Dh科技发展私人贸易有限公司 System for minimizing electrical discharge during ESI operations
CN105575752B (en) * 2016-03-04 2017-09-22 北京工业大学 A kind of difunctional uniform internal diameter skin liquid spectrum nozzle needle and preparation method
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US5015845A (en) * 1990-06-01 1991-05-14 Vestec Corporation Electrospray method for mass spectrometry

Also Published As

Publication number Publication date
EP0586543A1 (en) 1994-03-16
JPH06507997A (en) 1994-09-08
DE69226773D1 (en) 1998-10-01
US5115131A (en) 1992-05-19
JP3350547B2 (en) 2002-11-25
CA2102431C (en) 2000-04-25
WO1992020437A1 (en) 1992-11-26
EP0586543B1 (en) 1998-08-26
ATE170332T1 (en) 1998-09-15
DE69226773T2 (en) 1999-04-29
EP0586543A4 (en) 1995-12-20

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