CA2107118A1 - Isolated Osteogenic Factor - Google Patents

Isolated Osteogenic Factor

Info

Publication number
CA2107118A1
CA2107118A1 CA2107118A CA2107118A CA2107118A1 CA 2107118 A1 CA2107118 A1 CA 2107118A1 CA 2107118 A CA2107118 A CA 2107118A CA 2107118 A CA2107118 A CA 2107118A CA 2107118 A1 CA2107118 A1 CA 2107118A1
Authority
CA
Canada
Prior art keywords
bone
factor
purified
osteogenic factor
osteogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2107118A
Other languages
French (fr)
Other versions
CA2107118C (en
Inventor
Alain E. Lagarde
Abdulwahid Abdulwajid
Donna Bueschkens
Deanna Byrne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire NPS Pharmaceuticals Inc
Original Assignee
Alain E. Lagarde
Abdulwahid Abdulwajid
Donna Bueschkens
Deanna Byrne
Glaxo Canada Inc.
Allelix Biopharmaceuticals Inc.
Nps Allelix Corp.
Nps Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alain E. Lagarde, Abdulwahid Abdulwajid, Donna Bueschkens, Deanna Byrne, Glaxo Canada Inc., Allelix Biopharmaceuticals Inc., Nps Allelix Corp., Nps Pharmaceuticals, Inc. filed Critical Alain E. Lagarde
Publication of CA2107118A1 publication Critical patent/CA2107118A1/en
Application granted granted Critical
Publication of CA2107118C publication Critical patent/CA2107118C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/84—Bones; tendons; teeth; cartilage

Abstract

Described is a purified osteogenic factor that when delivered to bone in association with a physiologically acceptable delivery vehicle is capable of inducing new bone growth at the bone surface. The osteogenic factor is water soluble, and is characterized physically by a molecular weight of about 2.5 kD when measured by gel filtration under dissociating conditions and an isoelectric point in the pH range from about 4.6 to 7.2. Use of the purified factor in treating bone defects is described. Also described is a method for obtaining the purified factor from mammalian bone.
CA002107118A 1991-03-28 1992-03-25 Isolated osteogenic factor Expired - Fee Related CA2107118C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/676,179 US5169837A (en) 1991-03-28 1991-03-28 Isolated osteogenic factor
US676,179 1991-03-28
PCT/CA1992/000130 WO1992017501A1 (en) 1991-03-28 1992-03-25 Isolated osteogenic factor

Publications (2)

Publication Number Publication Date
CA2107118A1 true CA2107118A1 (en) 1992-09-29
CA2107118C CA2107118C (en) 2000-01-11

Family

ID=24713538

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002107118A Expired - Fee Related CA2107118C (en) 1991-03-28 1992-03-25 Isolated osteogenic factor

Country Status (10)

Country Link
US (2) US5169837A (en)
EP (1) EP0577649B1 (en)
AT (1) ATE170866T1 (en)
AU (1) AU1421792A (en)
CA (1) CA2107118C (en)
DE (1) DE69226949T2 (en)
DK (1) DK0577649T3 (en)
IE (1) IE920990A1 (en)
PT (1) PT100313B (en)
WO (1) WO1992017501A1 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169837A (en) * 1991-03-28 1992-12-08 Allelix Biopharmaceuticals Inc. Isolated osteogenic factor
US5290763A (en) * 1991-04-22 1994-03-01 Intermedics Orthopedics/Denver, Inc. Osteoinductive protein mixtures and purification processes
IL101943A0 (en) * 1991-05-24 1992-12-30 Genentech Inc Structure,production and use of heregulin
US5834229A (en) 1991-05-24 1998-11-10 Genentech, Inc. Nucleic acids vectors and host cells encoding and expressing heregulin 2-α
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
MX9204303A (en) * 1991-07-23 1993-11-01 Rhone Poulenc Rorer Int REGULATORY FACTOR OF OSTEOCLAST GROWTH.
US5719058A (en) * 1995-04-10 1998-02-17 Merck & Co., Inc. Method for producing a highly enriched population of osteoclast cells
WO1997000317A1 (en) * 1995-06-07 1997-01-03 Osteosa Inc. Osteoclast growth regulatory factor
AU6090896A (en) * 1995-06-07 1997-01-15 Osteosa Inc. Osteoclast growth regulatory factor
US5788976A (en) * 1996-02-12 1998-08-04 Wbk, Inc. Method for effecting bone repair
EP0946180A4 (en) * 1996-10-07 2003-07-23 Smithkline Beecham Corp Method for stimulating bone formation
DE69839265D1 (en) * 1997-05-29 2008-04-30 Curis Inc MODULATORS OF THE EXPORATION OF MORPHOGENS AND THEIR IDENTIFICATION METHOD
CA2291514C (en) * 1997-05-30 2011-07-12 Creative Biomolecules, Inc. Methods for evaluating tissue morphogenesis and activity
EP1007673B1 (en) 1997-07-30 2008-12-17 Emory University Novel bone mineralization proteins, dna, vectors, expression systems
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
US7819861B2 (en) * 2001-05-26 2010-10-26 Nuortho Surgical, Inc. Methods for electrosurgical electrolysis
US6902564B2 (en) 2001-08-15 2005-06-07 Roy E. Morgan Methods and devices for electrosurgery
US7445619B2 (en) * 2000-08-18 2008-11-04 Map Technologies Llc Devices for electrosurgery
US7771422B2 (en) * 2002-06-06 2010-08-10 Nuortho Surgical, Inc. Methods and devices for electrosurgery
US20040167244A1 (en) * 2000-08-18 2004-08-26 Auge Wayne K. Methods and compositions for fusing bone during endoscopy procedures
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US7066932B1 (en) 2001-05-26 2006-06-27 Map Technologies Llc Biologically enhanced irrigants
US8235979B2 (en) 2001-08-15 2012-08-07 Nuortho Surgical, Inc. Interfacing media manipulation with non-ablation radiofrequency energy system and method
US8734441B2 (en) * 2001-08-15 2014-05-27 Nuortho Surgical, Inc. Interfacing media manipulation with non-ablation radiofrequency energy system and method
US8591508B2 (en) * 2001-08-15 2013-11-26 Nuortho Surgical, Inc. Electrosurgical plenum
US7491691B2 (en) 2002-05-03 2009-02-17 Sindrey Dennis R Connective tissue stimulating peptides
US7622562B2 (en) * 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US7241874B2 (en) * 2002-06-26 2007-07-10 Zimmer Ortho Biologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US20040023322A1 (en) * 2002-08-01 2004-02-05 Goodheart Clyde R. Method of producing non-recombinant BMP-2 and use thereof
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US9532827B2 (en) 2009-06-17 2017-01-03 Nuortho Surgical Inc. Connection of a bipolar electrosurgical hand piece to a monopolar output of an electrosurgical generator
US8746719B2 (en) * 2010-08-03 2014-06-10 Polaris Industries Inc. Side-by-side vehicle
CA2817584C (en) 2010-11-15 2018-01-02 Zimmer Orthobiologics, Inc. Bone void fillers
US9408658B2 (en) 2011-02-24 2016-08-09 Nuortho Surgical, Inc. System and method for a physiochemical scalpel to eliminate biologic tissue over-resection and induce tissue healing
US9579142B1 (en) 2012-12-13 2017-02-28 Nuortho Surgical Inc. Multi-function RF-probe with dual electrode positioning

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458397A (en) * 1966-12-08 1969-07-29 Squibb & Sons Inc Process for producing osteogenic material
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
DE3588058T3 (en) * 1984-07-16 2005-04-07 Celtrix Pharmaceuticals, Inc., Palo Alto Cartilage-inducing polypeptide factors from bone
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US5169837A (en) * 1991-03-28 1992-12-08 Allelix Biopharmaceuticals Inc. Isolated osteogenic factor

Also Published As

Publication number Publication date
EP0577649B1 (en) 1998-09-09
PT100313B (en) 1999-06-30
CA2107118C (en) 2000-01-11
PT100313A (en) 1993-06-30
US5169837A (en) 1992-12-08
DE69226949D1 (en) 1998-10-15
ATE170866T1 (en) 1998-09-15
DE69226949T2 (en) 1999-05-20
WO1992017501A1 (en) 1992-10-15
US5403825A (en) 1995-04-04
IE920990A1 (en) 1992-10-07
AU1421792A (en) 1992-11-02
DK0577649T3 (en) 1999-06-07
EP0577649A1 (en) 1994-01-12

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Legal Events

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