CA2109698A1 - Long-term delivery device including hydrophobic loading dose - Google Patents
Long-term delivery device including hydrophobic loading doseInfo
- Publication number
- CA2109698A1 CA2109698A1 CA2109698A CA2109698A CA2109698A1 CA 2109698 A1 CA2109698 A1 CA 2109698A1 CA 2109698 A CA2109698 A CA 2109698A CA 2109698 A CA2109698 A CA 2109698A CA 2109698 A1 CA2109698 A1 CA 2109698A1
- Authority
- CA
- Canada
- Prior art keywords
- agent
- delivery
- long
- lumen
- term
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
Abstract
The invention provides a dispensing device (20) comprising a loading dose (first agent delivery means) (32) for short-term and continuous delivery of an agent having a high potency, retained together with a long-term dispensing device (second agent delivery means) (12) capable of long-term and continuous delivery of agent. The combination of first and second agent delivery means provides a device in which a substantially constant dose of beneficial agent may be delivered to the environment of use over time. A rapid initial delivery of beneficial agent is followed by continuous and prolonged delivery of agent. In a preferred embodiment, the device includes (1) a loading dose chamber (30) and retaining means (16) retaining a loading dose (32) for rapid and continuous delivery of agent having a high potency to the environment of use; and (2) a long-term dispensing device (12) comprising a semipermeable wall (14) which surrounds and defines an internal lumen (20), a driving source (expansion means) (22) in the lumen for expanding and occupying an increased volume of the lumen, a beneficial agent (24) in the lumen that pro-vides a dispensable formulation to the environment of use, and an exit (28) in the device for delivery of the beneficial agent to the environment of use over time. A densifier (24) and/or a moveable barrier means (34) may also be included in the lumen of the long-term dispensing device.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71454491A | 1991-06-11 | 1991-06-11 | |
US07/714,544 | 1991-06-11 | ||
US07/842,939 US5227167A (en) | 1991-06-11 | 1992-02-27 | Long-term delivery device including hydrophobic loading dose |
US07/842,939 | 1992-02-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2109698A1 true CA2109698A1 (en) | 1992-12-23 |
CA2109698C CA2109698C (en) | 1996-10-22 |
Family
ID=27109175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002109698A Expired - Lifetime CA2109698C (en) | 1991-06-11 | 1992-06-11 | Long-term delivery device including hydrophobic loading dose |
Country Status (14)
Country | Link |
---|---|
US (1) | US5227167A (en) |
EP (1) | EP0588947B1 (en) |
JP (1) | JP3399527B2 (en) |
KR (1) | KR0137261B1 (en) |
AT (1) | ATE141525T1 (en) |
AU (1) | AU653425B2 (en) |
CA (1) | CA2109698C (en) |
DE (1) | DE69213009T2 (en) |
ES (1) | ES2092122T3 (en) |
IE (1) | IE69377B1 (en) |
MX (1) | MX9202800A (en) |
NZ (1) | NZ243105A (en) |
PT (1) | PT100586B (en) |
WO (1) | WO1992022346A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5456679A (en) * | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
US5308348A (en) * | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
US5540926A (en) * | 1992-09-04 | 1996-07-30 | Bristol-Myers Squibb Company | Soluble and its use in B cell stimulation |
US5672357A (en) * | 1994-07-01 | 1997-09-30 | Monsanto Company | Method and device for implantation of large diameter objects in bovines |
US5595752A (en) * | 1994-07-01 | 1997-01-21 | Monsanto Company | Increasing dressing percentage and carcass weight in finishing beef cattle |
US5906833A (en) * | 1995-05-22 | 1999-05-25 | Klatz; Ronald M. | Chronological food bar |
US20020131988A1 (en) * | 1999-12-16 | 2002-09-19 | Foster Todd P. | Pharmaceutical implant containing immediate-release and sustained-release components and method of administration |
DE102004042578A1 (en) * | 2004-09-02 | 2006-03-23 | Roche Diagnostics Gmbh | Micropump for pumping liquids with low flow rates in pressure / suction operation |
US20070190137A1 (en) * | 2005-10-07 | 2007-08-16 | Reyes Iran | Osmotic dosage form with controlled release and fast release aspects |
US20110251568A1 (en) * | 2010-04-08 | 2011-10-13 | Beeley Nathan R F | Punctal plugs for controlled release of therapeutic agents |
US11529310B2 (en) | 2020-12-08 | 2022-12-20 | Ruminant Biotech Corp Limited | Devices and methods for delivery of substances to animals |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US3995632A (en) * | 1973-05-04 | 1976-12-07 | Alza Corporation | Osmotic dispenser |
US4381780A (en) * | 1981-01-19 | 1983-05-03 | Research Corporation | Sustained release delivery system |
CH652025A5 (en) * | 1981-09-14 | 1985-10-31 | Hoffmann La Roche | Pharmaceutical preparation. |
US4564363A (en) * | 1983-07-13 | 1986-01-14 | Smithkline Beckman Corporation | Delayed action assembly |
GB8328916D0 (en) * | 1983-10-28 | 1983-11-30 | Castex Prod | Pharmaceutical pellet |
US4595583A (en) * | 1984-03-19 | 1986-06-17 | Alza Corporation | Delivery system controlled administration of beneficial agent to ruminants |
US4844984A (en) * | 1984-03-19 | 1989-07-04 | Alza Corporation | Dispensing system with means for increasing delivery of beneficial agent from the system |
US5000957A (en) * | 1984-03-19 | 1991-03-19 | Alza Corporation | Dispenser comprising hydrophilic osmopolymer |
US4772474A (en) * | 1985-08-09 | 1988-09-20 | Alza Corporation | Dispenser with internal arrangement of lamina means for dispensing beneficial agent |
US4729793A (en) * | 1985-08-09 | 1988-03-08 | Alza Corporation | Composition for manufacturing wall of dispensing device |
US4612186A (en) * | 1984-03-19 | 1986-09-16 | Alza Corporation | Method for establishing blood levels of biocide in animals |
GB8417202D0 (en) * | 1984-07-05 | 1984-08-08 | Norbrook Lab Ltd | Drug intermittent release device |
US4693886A (en) * | 1985-04-22 | 1987-09-15 | Alza Corporation | Osmotic device with inert core |
US4704118A (en) * | 1985-08-16 | 1987-11-03 | Alza Corporation | Ruminant dispensing device with thermo-activated memory |
US4643731A (en) * | 1985-08-16 | 1987-02-17 | Alza Corporation | Means for providing instant agent from agent dispensing system |
US5023088A (en) * | 1987-06-25 | 1991-06-11 | Alza Corporation | Multi-unit delivery system |
US4814181A (en) * | 1987-09-03 | 1989-03-21 | Alza Corporation | Dosage form comprising fast agent delivery followed by slow agent delivery |
US4872873A (en) * | 1987-12-14 | 1989-10-10 | Merck & Co., Inc. | Controlled release bolus device |
US5045082A (en) * | 1990-01-10 | 1991-09-03 | Alza Corporation | Long-term delivery device including loading dose |
-
1992
- 1992-02-27 US US07/842,939 patent/US5227167A/en not_active Expired - Lifetime
- 1992-06-11 PT PT100586A patent/PT100586B/en not_active IP Right Cessation
- 1992-06-11 EP EP92913865A patent/EP0588947B1/en not_active Expired - Lifetime
- 1992-06-11 NZ NZ24310592A patent/NZ243105A/en not_active IP Right Cessation
- 1992-06-11 WO PCT/US1992/005011 patent/WO1992022346A1/en active IP Right Grant
- 1992-06-11 CA CA002109698A patent/CA2109698C/en not_active Expired - Lifetime
- 1992-06-11 AT AT92913865T patent/ATE141525T1/en not_active IP Right Cessation
- 1992-06-11 DE DE69213009T patent/DE69213009T2/en not_active Expired - Lifetime
- 1992-06-11 KR KR1019930703814A patent/KR0137261B1/en not_active IP Right Cessation
- 1992-06-11 MX MX9202800A patent/MX9202800A/en unknown
- 1992-06-11 ES ES92913865T patent/ES2092122T3/en not_active Expired - Lifetime
- 1992-06-11 JP JP50105393A patent/JP3399527B2/en not_active Expired - Lifetime
- 1992-06-11 AU AU21933/92A patent/AU653425B2/en not_active Expired
- 1992-07-01 IE IE921885A patent/IE69377B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0588947B1 (en) | 1996-08-21 |
ATE141525T1 (en) | 1996-09-15 |
EP0588947A1 (en) | 1994-03-30 |
IE921885A1 (en) | 1992-12-16 |
DE69213009D1 (en) | 1996-09-26 |
US5227167A (en) | 1993-07-13 |
PT100586A (en) | 1994-05-31 |
ES2092122T3 (en) | 1996-11-16 |
DE69213009T2 (en) | 1996-12-19 |
IE69377B1 (en) | 1996-09-04 |
KR0137261B1 (en) | 1998-04-25 |
WO1992022346A1 (en) | 1992-12-23 |
NZ243105A (en) | 1994-07-26 |
AU2193392A (en) | 1993-01-12 |
JP3399527B2 (en) | 2003-04-21 |
KR940701285A (en) | 1994-05-28 |
PT100586B (en) | 1999-06-30 |
MX9202800A (en) | 1992-12-01 |
AU653425B2 (en) | 1994-09-29 |
JPH06507912A (en) | 1994-09-08 |
CA2109698C (en) | 1996-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |