CA2110058A1 - Hepatitis c virus (hcv) polypeptides - Google Patents
Hepatitis c virus (hcv) polypeptidesInfo
- Publication number
- CA2110058A1 CA2110058A1 CA002110058A CA2110058A CA2110058A1 CA 2110058 A1 CA2110058 A1 CA 2110058A1 CA 002110058 A CA002110058 A CA 002110058A CA 2110058 A CA2110058 A CA 2110058A CA 2110058 A1 CA2110058 A1 CA 2110058A1
- Authority
- CA
- Canada
- Prior art keywords
- hcv
- hepatitis
- polypeptides
- virus
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000711549 Hepacivirus C Species 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
HCV epitopes useful as immunogenic reagents, and corresponding antibodies and methods of use are disclosed.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72248991A | 1991-06-24 | 1991-06-24 | |
US722,489 | 1991-06-24 | ||
PCT/US1992/005388 WO1993000365A2 (en) | 1991-06-24 | 1992-06-24 | Hepatitis c virus (hcv) polypeptides |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2110058A1 true CA2110058A1 (en) | 1993-01-07 |
CA2110058C CA2110058C (en) | 2001-09-25 |
Family
ID=24902063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002110058A Expired - Lifetime CA2110058C (en) | 1991-06-24 | 1992-06-24 | Hepatitis c virus (hcv) polypeptides |
Country Status (16)
Country | Link |
---|---|
US (2) | US6346375B1 (en) |
EP (1) | EP0591431B1 (en) |
JP (9) | JP3516681B2 (en) |
KR (1) | KR0185426B1 (en) |
AT (1) | ATE229543T1 (en) |
BG (1) | BG61843B1 (en) |
CA (1) | CA2110058C (en) |
DE (1) | DE69232871T2 (en) |
ES (1) | ES2188583T3 (en) |
FI (2) | FI110099B (en) |
HU (1) | HU227547B1 (en) |
NO (1) | NO309528B1 (en) |
RO (1) | RO117329B1 (en) |
RU (1) | RU2148587C1 (en) |
UA (1) | UA40572C2 (en) |
WO (1) | WO1993000365A2 (en) |
Families Citing this family (85)
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---|---|---|---|---|
US5698390A (en) * | 1987-11-18 | 1997-12-16 | Chiron Corporation | Hepatitis C immunoassays |
US5714596A (en) * | 1987-11-18 | 1998-02-03 | Chiron Corporation | NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus |
US6171782B1 (en) | 1987-11-18 | 2001-01-09 | Chiron Corporation | Antibody compositions to HCV and uses thereof |
US6861212B1 (en) | 1987-11-18 | 2005-03-01 | Chiron Corporation | NANBV diagnostics and vaccines |
US5712088A (en) * | 1987-11-18 | 1998-01-27 | Chiron Corporation | Methods for detecting Hepatitis C virus using polynucleotides specific for same |
US6027729A (en) * | 1989-04-20 | 2000-02-22 | Chiron Corporation | NANBV Diagnostics and vaccines |
US5639594A (en) * | 1990-02-16 | 1997-06-17 | United Biomedical, Inc. | Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis |
US5582968A (en) * | 1990-02-16 | 1996-12-10 | United Biomedical, Inc. | Branched hybrid and cluster peptides effective in diagnosing and detecting non-A, non-B hepatitis |
GB9204274D0 (en) * | 1992-02-28 | 1992-04-08 | Wellcome Found | Novel peptides |
US6667387B1 (en) | 1996-09-30 | 2003-12-23 | N.V. Innogenetics S.A. | HCV core peptides |
US6709828B1 (en) | 1992-03-06 | 2004-03-23 | N.V. Innogenetics S.A. | Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them |
DE4240980A1 (en) * | 1992-08-07 | 1994-02-10 | Boehringer Mannheim Gmbh | HCV peptide antigens and method for the determination of HCV |
US7255997B1 (en) | 1993-04-27 | 2007-08-14 | N.V. Innogenetics S.A. | Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents |
US6762024B2 (en) | 1993-04-27 | 2004-07-13 | Innogenetics, S.A. | Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents |
ES2232815T5 (en) | 1993-05-10 | 2009-06-15 | Novartis Vaccines And Diagnostics, Inc. | TYPICAL METHODS OF HEPATITIS C VIRUS AND REAGENTS FOR USE THEREOF. |
EP0697888B1 (en) | 1993-05-12 | 2003-09-17 | Chiron Corporation | Conserved motif of hepatitis c virus e2/ns1 region |
US5514539A (en) * | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
US5639856A (en) | 1993-09-13 | 1997-06-17 | The Regents Of The University Of California | Semaphorin gene family |
US5885771A (en) * | 1993-10-29 | 1999-03-23 | Srl, Inc. | Antigenic peptide compound and immunoassay |
DK0725824T3 (en) * | 1993-11-04 | 2003-08-11 | Innogenetics Nv | Immunodominant human T cell epitopes of hepatitis C virus |
US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
EP1076092A3 (en) * | 1994-10-21 | 2001-03-28 | Innogenetics N.V. | Sequences of hepatitis C virus type10 and their use as prophylactic, therapeutic and diagnostic agents |
GB2294690B (en) * | 1994-11-01 | 1998-10-28 | United Biomedical Inc | Peptides effective for diagnosis and detection of hepatitis C infection |
JPH08333390A (en) * | 1995-04-07 | 1996-12-17 | Hoechst Japan Ltd | Peptide and autoimmune disease-treating medicine comprising the same |
US6034064A (en) * | 1995-04-07 | 2000-03-07 | Hoechst Pharmaceuticals & Chemicals K.K. | Peptides and therapeutic agent for autoimmune diseases containing the same |
KR19990008122A (en) * | 1995-04-28 | 1999-01-25 | 곤도도시유키 | Antigen Peptide Compounds and Immunological Assays |
GB9513261D0 (en) * | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
US6127116A (en) * | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
US6514731B1 (en) | 1996-05-24 | 2003-02-04 | Chiron Corporation | Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens |
ATE311463T1 (en) * | 1996-05-24 | 2005-12-15 | Chiron Corp | FUSION PROTEIN WITH MULTIPLE EPITOPES |
US7049428B1 (en) | 1998-03-04 | 2006-05-23 | Washington University | HCV variants |
US7338759B1 (en) | 1997-03-04 | 2008-03-04 | Washington University | HCV variants |
CA2303165C (en) | 1997-09-22 | 2006-07-11 | Chiron Corporation | Buffers for stabilizing antigens |
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US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
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JP3244284B2 (en) | 1991-02-14 | 2002-01-07 | 武田薬品工業株式会社 | Method for measuring hepatitis C virus-related antibodies and antigens |
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TW360711B (en) | 1991-06-10 | 1999-06-11 | Lucky Ltd | CDNAs of Korean hepatitis C virus and polypeptides encoded thereby |
CA2070952A1 (en) | 1991-06-11 | 1992-12-12 | Makoto Seki | Gene of hepatitis c virus or fragment thereof, polypeptide encoded by the same |
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1992
- 1992-06-24 JP JP50167193A patent/JP3516681B2/en not_active Expired - Lifetime
- 1992-06-24 HU HU9303703A patent/HU227547B1/en unknown
- 1992-06-24 KR KR1019930704022A patent/KR0185426B1/en not_active IP Right Cessation
- 1992-06-24 EP EP92914835A patent/EP0591431B1/en not_active Expired - Lifetime
- 1992-06-24 RU RU93058563A patent/RU2148587C1/en active
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- 1992-06-24 DE DE69232871T patent/DE69232871T2/en not_active Expired - Lifetime
- 1992-06-24 AT AT92914835T patent/ATE229543T1/en active
- 1992-06-24 RO RO93-01778A patent/RO117329B1/en unknown
- 1992-06-24 UA UA93004481A patent/UA40572C2/en unknown
- 1992-06-24 WO PCT/US1992/005388 patent/WO1993000365A2/en active IP Right Grant
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1993
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- 1993-12-22 FI FI935808A patent/FI110099B/en not_active IP Right Cessation
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1995
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- 1995-05-18 US US08/444,818 patent/US6150087A/en not_active Expired - Lifetime
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1999
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2002
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2003
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2004
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2006
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2007
- 2007-08-21 JP JP2007215324A patent/JP2008001716A/en not_active Withdrawn
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2008
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