CA2110058A1 - Hepatitis c virus (hcv) polypeptides - Google Patents

Hepatitis c virus (hcv) polypeptides

Info

Publication number
CA2110058A1
CA2110058A1 CA002110058A CA2110058A CA2110058A1 CA 2110058 A1 CA2110058 A1 CA 2110058A1 CA 002110058 A CA002110058 A CA 002110058A CA 2110058 A CA2110058 A CA 2110058A CA 2110058 A1 CA2110058 A1 CA 2110058A1
Authority
CA
Canada
Prior art keywords
hcv
hepatitis
polypeptides
virus
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002110058A
Other languages
French (fr)
Other versions
CA2110058C (en
Inventor
David Y. Chien
William Rutter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2110058A1 publication Critical patent/CA2110058A1/en
Application granted granted Critical
Publication of CA2110058C publication Critical patent/CA2110058C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

HCV epitopes useful as immunogenic reagents, and corresponding antibodies and methods of use are disclosed.
CA002110058A 1991-06-24 1992-06-24 Hepatitis c virus (hcv) polypeptides Expired - Lifetime CA2110058C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72248991A 1991-06-24 1991-06-24
US722,489 1991-06-24
PCT/US1992/005388 WO1993000365A2 (en) 1991-06-24 1992-06-24 Hepatitis c virus (hcv) polypeptides

Publications (2)

Publication Number Publication Date
CA2110058A1 true CA2110058A1 (en) 1993-01-07
CA2110058C CA2110058C (en) 2001-09-25

Family

ID=24902063

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002110058A Expired - Lifetime CA2110058C (en) 1991-06-24 1992-06-24 Hepatitis c virus (hcv) polypeptides

Country Status (16)

Country Link
US (2) US6346375B1 (en)
EP (1) EP0591431B1 (en)
JP (9) JP3516681B2 (en)
KR (1) KR0185426B1 (en)
AT (1) ATE229543T1 (en)
BG (1) BG61843B1 (en)
CA (1) CA2110058C (en)
DE (1) DE69232871T2 (en)
ES (1) ES2188583T3 (en)
FI (2) FI110099B (en)
HU (1) HU227547B1 (en)
NO (1) NO309528B1 (en)
RO (1) RO117329B1 (en)
RU (1) RU2148587C1 (en)
UA (1) UA40572C2 (en)
WO (1) WO1993000365A2 (en)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698390A (en) * 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US6861212B1 (en) 1987-11-18 2005-03-01 Chiron Corporation NANBV diagnostics and vaccines
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
US5639594A (en) * 1990-02-16 1997-06-17 United Biomedical, Inc. Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis
US5582968A (en) * 1990-02-16 1996-12-10 United Biomedical, Inc. Branched hybrid and cluster peptides effective in diagnosing and detecting non-A, non-B hepatitis
GB9204274D0 (en) * 1992-02-28 1992-04-08 Wellcome Found Novel peptides
US6667387B1 (en) 1996-09-30 2003-12-23 N.V. Innogenetics S.A. HCV core peptides
US6709828B1 (en) 1992-03-06 2004-03-23 N.V. Innogenetics S.A. Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them
DE4240980A1 (en) * 1992-08-07 1994-02-10 Boehringer Mannheim Gmbh HCV peptide antigens and method for the determination of HCV
US7255997B1 (en) 1993-04-27 2007-08-14 N.V. Innogenetics S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
US6762024B2 (en) 1993-04-27 2004-07-13 Innogenetics, S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
ES2232815T5 (en) 1993-05-10 2009-06-15 Novartis Vaccines And Diagnostics, Inc. TYPICAL METHODS OF HEPATITIS C VIRUS AND REAGENTS FOR USE THEREOF.
EP0697888B1 (en) 1993-05-12 2003-09-17 Chiron Corporation Conserved motif of hepatitis c virus e2/ns1 region
US5514539A (en) * 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
US5639856A (en) 1993-09-13 1997-06-17 The Regents Of The University Of California Semaphorin gene family
US5885771A (en) * 1993-10-29 1999-03-23 Srl, Inc. Antigenic peptide compound and immunoassay
DK0725824T3 (en) * 1993-11-04 2003-08-11 Innogenetics Nv Immunodominant human T cell epitopes of hepatitis C virus
US5709995A (en) 1994-03-17 1998-01-20 The Scripps Research Institute Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses
EP1076092A3 (en) * 1994-10-21 2001-03-28 Innogenetics N.V. Sequences of hepatitis C virus type10 and their use as prophylactic, therapeutic and diagnostic agents
GB2294690B (en) * 1994-11-01 1998-10-28 United Biomedical Inc Peptides effective for diagnosis and detection of hepatitis C infection
JPH08333390A (en) * 1995-04-07 1996-12-17 Hoechst Japan Ltd Peptide and autoimmune disease-treating medicine comprising the same
US6034064A (en) * 1995-04-07 2000-03-07 Hoechst Pharmaceuticals & Chemicals K.K. Peptides and therapeutic agent for autoimmune diseases containing the same
KR19990008122A (en) * 1995-04-28 1999-01-25 곤도도시유키 Antigen Peptide Compounds and Immunological Assays
GB9513261D0 (en) * 1995-06-29 1995-09-06 Smithkline Beecham Biolog Vaccines
US6127116A (en) * 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
US6514731B1 (en) 1996-05-24 2003-02-04 Chiron Corporation Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
ATE311463T1 (en) * 1996-05-24 2005-12-15 Chiron Corp FUSION PROTEIN WITH MULTIPLE EPITOPES
US7049428B1 (en) 1998-03-04 2006-05-23 Washington University HCV variants
US7338759B1 (en) 1997-03-04 2008-03-04 Washington University HCV variants
CA2303165C (en) 1997-09-22 2006-07-11 Chiron Corporation Buffers for stabilizing antigens
CA2658218C (en) 1998-04-17 2014-10-28 Innogenetics N.V. Improved immunodiagnostic assays using reducing agents
US7052830B1 (en) 1998-06-09 2006-05-30 Branch Andrea D Hepatitis C virus peptides and uses thereof
US7052696B2 (en) * 1998-07-10 2006-05-30 The United States Of America As Represented By The Department Of Health And Human Services Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
US6191256B1 (en) * 1998-11-20 2001-02-20 Bayer Corporation Recombinant factor VIII binding peptides
AU6226100A (en) * 1999-07-19 2001-04-24 Epimmune, Inc. Inducing cellular immune responses to hepatitis c virus using peptide and nucleic acid compositions
SI1354204T2 (en) 2000-06-15 2010-09-30 Novartis Vaccines & Diagnostic Hcv antigen/antibody combination assay
US6858590B2 (en) * 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
CA2419418A1 (en) 2000-08-17 2002-02-21 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6680059B2 (en) * 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
EP1195381A1 (en) * 2000-09-28 2002-04-10 Immusystems GmbH Hepatitis c virus epitopes specific for cd4+ t-cell lymphocytes
NZ529324A (en) 2001-04-24 2005-08-26 Innogenetics N Core-glycosylated HCV envelope proteins made in yeast cells
AU2002311897A1 (en) * 2001-05-09 2002-11-18 Third Wave Technologies, Inc. Nucleic acid detection in pooled samples
US7196183B2 (en) 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US20030100467A1 (en) * 2001-09-12 2003-05-29 Wolfgang Aehle Binding phenol oxidizing enzyme-peptide complexes
AR045702A1 (en) * 2001-10-03 2005-11-09 Chiron Corp COMPOSITIONS OF ASSISTANTS.
US7332269B2 (en) * 2001-11-11 2008-02-19 Ortho-Clinical Diagnostics, Inc. HCV core protein sequences
CN1659436A (en) * 2002-02-28 2005-08-24 英特塞尔股份公司 Method for isolating ligands
PT2014671E (en) * 2002-03-11 2010-06-16 Lab 21 Ltd Methods and compositions for identifying and characterizing hepatitis c
US7201904B2 (en) * 2002-05-16 2007-04-10 The General Hospital Corporation Epitopes of hepatitis C virus
FR2839722A1 (en) 2002-05-17 2003-11-21 Bio Merieux Combination of peptides, useful for treatment, prevention or diagnosis of hepatitis C infection
WO2004011650A2 (en) * 2002-07-24 2004-02-05 Intercell Ag Antigens encoded by alternative reading frame from pathogenic viruses
EP1546414B1 (en) 2002-09-09 2008-10-08 Novartis Vaccines and Diagnostics, Inc. Hcv assay
JP2006504687A (en) * 2002-09-13 2006-02-09 インターツェル・アクチェンゲゼルシャフト Method for isolating hepatitis C virus peptide
EP2287313A1 (en) * 2003-03-04 2011-02-23 Intercell AG Streptococcus pyogenes antigens
CN100355453C (en) * 2003-03-24 2007-12-19 英特塞尔股份公司 Improved vaccines
CA2517673C (en) 2003-03-24 2013-08-13 Intercell Ag Improved vaccines for preventing viral infection
AU2004230244B2 (en) 2003-04-15 2011-09-22 Intercell Ag S. pneumoniae antigens
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
CN1822856B (en) * 2003-07-11 2010-04-28 英特塞尔股份公司 HCV vaccines
US20050202036A1 (en) * 2003-07-22 2005-09-15 Branch Andrea D. Alternate reading frame polypeptides drived from hepatitis C and methods of their use
US8124747B2 (en) 2003-08-29 2012-02-28 Innogenetics HCV clade and prototype sequences thereof
FR2859909B1 (en) 2003-09-22 2007-09-07 Biomerieux Sa PROCESS FOR THE PREPARATION OF BIORESORBABLE MICROPARTICLES, MICROPARTICLES OBTAINED AND USE
EP1735336A2 (en) * 2004-04-16 2006-12-27 Genentech, Inc. Omi pdz modulators
ES2377978T3 (en) * 2004-08-27 2012-04-03 Novartis Vaccines And Diagnostics, Inc. HCV non-structural protein mutants and uses thereof
DE602006014126D1 (en) 2005-04-20 2010-06-17 Viromed Co Ltd COMPOSITIONS AND METHOD FOR SEPARATING FUSION PROTEINS
WO2007031867A2 (en) * 2005-05-25 2007-03-22 Tripep Ab A hepatitis c virus non-stru tural ns3/4a fusion gene
CA2661492A1 (en) 2006-08-25 2008-02-28 Novartis Ag Hcv fusion polypeptides
JP4975600B2 (en) * 2007-03-16 2012-07-11 シスメックス株式会社 Reagent kit for HCV antibody measurement and HCV antibody measurement method
US8071561B2 (en) 2007-08-16 2011-12-06 Chrontech Pharma Ab Immunogen platform
WO2009076158A1 (en) 2007-12-07 2009-06-18 Novartis Ag Compositions for inducing immune responses
WO2009130588A2 (en) * 2008-04-22 2009-10-29 Tripep Ab Immunogen platform
US20100104555A1 (en) * 2008-10-24 2010-04-29 The Scripps Research Institute HCV neutralizing epitopes
JP6120839B2 (en) 2011-07-06 2017-04-26 ノバルティス アーゲー Cationic oil-in-water emulsion
EP3424495A1 (en) 2011-07-06 2019-01-09 GlaxoSmithKline Biologicals S.A. Oil-in-water emulsions that contain nucleic acids
FR2984328B1 (en) 2011-12-20 2016-12-30 Bio-Rad Innovations METHOD FOR DETECTING HEPATITIS C VIRUS INFECTION
WO2013150450A1 (en) * 2012-04-02 2013-10-10 Universidade Do Porto Hcv homolog fragments, cell-lines and applications thereof
US9790478B2 (en) 2013-03-14 2017-10-17 Abbott Laboratories HCV NS3 recombinant antigens and mutants thereof for improved antibody detection
EP3564384A1 (en) 2013-03-14 2019-11-06 Abbott Laboratories Hcv core lipid binding domain monoclonal antibodies
CN105228649B (en) 2013-03-14 2019-01-18 雅培制药有限公司 HCV Ag-Ab combination measurement is with method and used in composition therein
DK3274478T3 (en) 2015-03-27 2020-11-23 Ortho Clinical Diagnostics K K HCV-NS4A / MODIFIED NS3 POLYPEPTIDES AND USES THEREOF
CN111153963B (en) * 2020-01-19 2021-08-10 华南理工大学 Anti-inflammatory pentapeptide, extraction and separation method thereof and application of anti-inflammatory pentapeptide in memory improvement

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861588A (en) * 1985-02-05 1989-08-29 New York Blood Center, Inc. Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers
CN1074422C (en) * 1987-11-18 2001-11-07 希龙股份有限公司 Nanbv diagnostics and vaccines
GB2212511B (en) 1987-11-18 1992-01-22 Chiron Corp Hepatitis c virus
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US5312737A (en) 1988-03-11 1994-05-17 Abbott Laboratories CKS method of HCV protein synthesis
AU650038B2 (en) 1988-03-11 1994-06-09 Abbott Laboratories CKS method of protein synthesis
HU225068B1 (en) * 1989-03-17 2006-05-29 Chiron Corp Process for producing diagnostics and vaccine of nanbh
EP0416725A3 (en) 1989-07-14 1991-03-20 Chugai Seiyaku Kabushiki Kaisha Blood-borne non-a, non-b hepatitis specific protein, dna encoding it, and process for its production
JP2818761B2 (en) 1989-09-14 1998-10-30 財団法人化学及血清療法研究所 Nucleic acid fragment encoding non-A non-B hepatitis virus antigen and use thereof
US5372928A (en) 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
CA2065287C (en) * 1989-09-15 1999-12-21 Tatsuo Miyamura New hcv isolates
ES2029171A6 (en) * 1989-12-18 1992-07-16 Wellcome Found PT-NANB hepatitis polypeptides
JPH03190898A (en) 1989-12-21 1991-08-20 Shima Kenkyusho:Kk Synthetic polypeptide and reagent for hcv antibody analysis using same polypeptide
AU638304B2 (en) * 1989-12-22 1993-06-24 Abbott Laboratories Hepatitis c assay
EP0435229A1 (en) 1989-12-27 1991-07-03 Sanwa Kagaku Kenkyusho Co., Ltd. DNA of non-A, non-B hepatitis virus gene, its clone and use thereof
US5106726A (en) * 1990-02-16 1992-04-21 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV
KR940000755B1 (en) * 1990-02-16 1994-01-29 유나이티드 바이오메디칼 인코오포레이티드 Synthetic peptides specific for the detection of antibodies to hcv
US5371017A (en) 1990-04-04 1994-12-06 Chiron Corporation Hepatitis C virus protease
EP1018558A3 (en) * 1990-04-06 2002-06-05 Genelabs Technologies, Inc. Hepatitis C Virus Epitopes
JPH044880A (en) 1990-04-20 1992-01-09 Terumasa Arima Dna coding hepatitis non-a and non-b antigen and polypeptide
JP3268502B2 (en) 1990-06-12 2002-03-25 徹雄 中村 Non-A non-B hepatitis virus-related polynucleotide, polypeptide
JPH0446196A (en) 1990-06-13 1992-02-17 Kuraray Co Ltd Antigen protein and dna fragment to code the same protein
FI913068A (en) 1990-06-25 1991-12-26 Univ Osaka Res Found NON-A-, NON-B-HEPATITISVIRUS PARTICLAR.
EP0464287A1 (en) 1990-06-25 1992-01-08 The Research Foundation for Microbial Diseases of Osaka University Non-A, non-B hepatitis virus genomic cDNA and antigen polypeptide
KR0181517B1 (en) 1990-07-09 1999-04-01 나까하라 노부유끼 Non-a, non-b hepatitis-specific antigen and its use in hepatitis diagnosis
JPH04126086A (en) 1990-07-12 1992-04-27 Yamanouchi Pharmaceut Co Ltd Antigen polypeptide against non-a and non-b type hepatitis virus, polynucleotide coding same polypeptide and diagnosis of non-a and non-b type hepatitis using them
CA2047792C (en) 1990-07-26 2002-07-02 Chang Y. Wang Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines
CZ282573B6 (en) 1990-08-10 1997-08-13 Chiron Corporation Method of detecting selected target region of hcv polynucleotide in an analyte chain, set and a reaction agent for making the method and in vitro detection method of blood polluted with infectious matters
CA2049679C (en) 1990-08-24 2005-06-21 Sushil G. Devare Hepatitis c assay utilizing recombinant antigens
WO1992003458A1 (en) 1990-08-25 1992-03-05 New York Blood Center Non-a, non-b hepatitis virus antigen, diagnostic methods and vaccines
JP3055793B2 (en) 1990-09-07 2000-06-26 財団法人化学及血清療法研究所 Non-A non-B hepatitis virus fusion peptide and method for producing the same
JPH04144686A (en) 1990-10-04 1992-05-19 Kunitada Shimotoono Structural protein gene, recombinant vector, escherichia coli transformed therewith, polypeptide and its production
JPH04159298A (en) 1990-10-19 1992-06-02 Olympus Optical Co Ltd Hcv peptide
DE59109221D1 (en) 1990-11-03 2001-11-15 Dade Behring Marburg Gmbh HCV-specific peptides, agents therefor and their use
CA2055149A1 (en) 1990-11-08 1992-05-09 Hiroaki Okamoto Non-a, non-b hepatitis virus related antigen, antibody, detection systems, polynucleotides and polypeptides
JPH04179482A (en) 1990-11-11 1992-06-26 Kunitada Shimotoono Gene derived from hepatitis c virus
JPH04187090A (en) 1990-11-22 1992-07-03 Toshio Shikata Dna encoding hepatitis antigen of non-a non-b type and polypeptide
WO1992009634A1 (en) 1990-11-29 1992-06-11 Toray Industries, Incorporated Non-a non-b hepatitis virus antigen protein
DE69029092T2 (en) * 1990-12-14 1997-04-17 Innogenetics Nv Synthetic antigens for the detection of antibodies against the hepatitis C virus
DE69225960T2 (en) 1991-01-31 1999-01-21 Abbott Lab MONOCLONAL ANTIBODIES AGAINST POSSIBLE HCV ENVELOPE REGIONS AND METHODS TO USE THEM
JP3244284B2 (en) 1991-02-14 2002-01-07 武田薬品工業株式会社 Method for measuring hepatitis C virus-related antibodies and antigens
US5574132A (en) 1991-04-05 1996-11-12 Biochem Immunosystems Inc. Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV)
JPH0568562A (en) 1991-05-30 1993-03-23 Sanwa Kagaku Kenkyusho Co Ltd Cdna of human hepatitis c virus, its clone and their use
JP3055964B2 (en) 1991-05-31 2000-06-26 株式会社トクヤマ HCV antigen-active polypeptide, method for producing polypeptide, transformed Escherichia coli, and method for detecting anti-HCV antibody
FR2677372B1 (en) 1991-06-06 1994-11-10 Pasteur Institut NUCLEOTIDE AND PEPTIDE SEQUENCES OF A HEPATITIS C VIRUS ISOLATE, DIAGNOSTIC AND THERAPEUTIC APPLICATIONS.
TW360711B (en) 1991-06-10 1999-06-11 Lucky Ltd CDNAs of Korean hepatitis C virus and polypeptides encoded thereby
CA2070952A1 (en) 1991-06-11 1992-12-12 Makoto Seki Gene of hepatitis c virus or fragment thereof, polypeptide encoded by the same
WO1992022571A1 (en) 1991-06-13 1992-12-23 Baxter Diagnostics Inc. Immunoassay for non-a non-b hepatitis
JP3103180B2 (en) 1992-01-30 2000-10-23 昭和電工株式会社 Soft synthetic resin sheet
JP3190898B2 (en) 1998-11-09 2001-07-23 米沢日本電気株式会社 Notebook personal computer

Also Published As

Publication number Publication date
JP2007131629A (en) 2007-05-31
WO1993000365A3 (en) 1993-04-29
JP2003277396A (en) 2003-10-02
NO309528B1 (en) 2001-02-12
JP3619827B2 (en) 2005-02-16
EP0591431A1 (en) 1994-04-13
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