CA2111269A1 - Barrier coating - Google Patents

Barrier coating

Info

Publication number
CA2111269A1
CA2111269A1 CA002111269A CA2111269A CA2111269A1 CA 2111269 A1 CA2111269 A1 CA 2111269A1 CA 002111269 A CA002111269 A CA 002111269A CA 2111269 A CA2111269 A CA 2111269A CA 2111269 A1 CA2111269 A1 CA 2111269A1
Authority
CA
Canada
Prior art keywords
layer
assembly
barrier coating
polymer
parylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002111269A
Other languages
French (fr)
Inventor
Yelena G. Tropsha
Richard P. Clarke
Mitchell K. Antoon, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Yelena G. Tropsha
Richard P. Clarke
Mitchell K. Antoon, Jr.
Becton, Dickinson And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yelena G. Tropsha, Richard P. Clarke, Mitchell K. Antoon, Jr., Becton, Dickinson And Company filed Critical Yelena G. Tropsha
Publication of CA2111269A1 publication Critical patent/CA2111269A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154—Devices using pre-evacuated means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D23/00—Details of bottles or jars not otherwise provided for
    • B65D23/08—Coverings or external coatings
    • B65D23/0807—Coatings
    • B65D23/0814—Coatings characterised by the composition of the material
    • B65D23/0821—Coatings characterised by the composition of the material consisting mainly of polymeric materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/042—Coating with two or more layers, where at least one layer of a composition contains a polymer binder
    • C08J7/0423—Coating with two or more layers, where at least one layer of a composition contains a polymer binder with at least one layer of inorganic material and at least one layer of a composition containing a polymer binder
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/046—Forming abrasion-resistant coatings; Forming surface-hardening coatings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/048—Forming gas barrier coatings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/10—Homopolymers or copolymers of propene
    • C08J2323/12—Polypropene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2483/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
    • C08J2483/04—Polysiloxanes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/131—Glass, ceramic, or sintered, fused, fired, or calcined metal oxide or metal carbide containing [e.g., porcelain, brick, cement, etc.]
    • Y10T428/1317—Multilayer [continuous layer]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
    • Y10T428/1379—Contains vapor or gas barrier, polymer derived from vinyl chloride or vinylidene chloride, or polymer containing a vinyl alcohol unit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
    • Y10T428/1379—Contains vapor or gas barrier, polymer derived from vinyl chloride or vinylidene chloride, or polymer containing a vinyl alcohol unit
    • Y10T428/1383—Vapor or gas barrier, polymer derived from vinyl chloride or vinylidene chloride, or polymer containing a vinyl alcohol unit is sandwiched between layers [continuous layer]

Abstract

BARRIER COATING

ABSTRACT OF THE DISCLOSURE

The present invention is a plastic container coated with a barrier coating. The barrier coating is useful for providing an effective barrier against gas permeability in containers and for extending shelf-life of containers, especially plastic evacuated blood collection devices.

Description

EXPI~'SS MI~ BET~ R13822403824US
DATE OF DE~E'05IT: 12--18-92 UNITED STATES PATEN~ APPLICATION
OF: Yelena G. Tropsha, Richard P. Clarke, Mitchell K. Antoon, Jr.

FOR: BA~RIER COATING

BACKGROUND OF THE INVENTION
1. Field of the Invention This invention relates to a barrier coating for providing an effective barrier against gas and water permeability for containers, especiall.y plastic evacuated blood collection tubes.
2. Descri~ion of the Related Art With the increased emphasis on the use of plastic medical products, a special need exists for improving the barrier properties of articles made of polymers.
Such medical products that would derive a considerable benefit from improving their barrier properties include, but are not limited to, collection tubes and particularly those used for blood collection.
Blood collection tubes require certain performance standards to be acceptable for use in medical applications. Such performance standards include the ability to maintain greater than about 90% original draw volume over a one year period, to be radiation sterilizable and to be noninterfering in tests and analysis.
Therefore, a need exists to improve the barrier properties of articles made of polymers and in particular plastic evacuated blood collection tubes wherein certain performance standards would be able to be met and the article would be effective and usab].e in medical applications ' :

-" P-2468 21~126~ :;

SUIIMARY OF THE INV~T ION

The present invention is a plastic composite container coated with a barrier coating comprising at least two barrier materials. Desirably, the barrier coating comprises a first layer of an inorganic material and a second layer of a polymer material.
The first layer of the barrier coating may preferably be an aluminum oxide based composition, such as AlOX wherein x is from 0.3 to about 0.9; a silicon oxide based composition; or a diamond based composition. Most preferably, the first layer is an aluminum oxide based composition.
The second layer may preferably be vinylidene chloride-acrylonitrile-methyl methacrylate-methyl acry-late-acrylic acid copolymers, thermosetting epoxy coatings, parylene polymers, or polyesters. The barrier coating may be formed either on an interior surface portion, on an exterior surface portion, or both of the container.
Preferably, the second layer is a parylene -polymer. Parylene is the generic name for members of a polymer series developed by Union Carbide Corporation.
The base member of the series, called parylene N, is poly-p-xylylene, a linear, crystalline material:

~CUL~ C~L~

~:

P-246~ 2111269 ~

Parylene C, a second member of the parylene series is produced from the same monomer as parylene N and modified by the substitution of a chlorine atom for one of the aromatic hydrogens:

~ C~ ~ CI~L\~

Parylene D, the third member of the parylene series is produced from the same monomer as parylene N
and modified by the substitution of the chlorine atom for two of the aromatic hydrogens:
lS

~ C~IL~ CH~

2~
Most preferably, the polymer layer is a vinylidene chloride-methyl methacrylate-methacrylate acrylic acid polymer. This polymer is available as DARAN~ 8600-C
25 (trademark of W.R. Grace and Co.) sold by GRACE, Organic Chemicals Division, Lexington, Mass.
Plastic tubes coated with the barrier coating are able to maintain substantially far better vacuum retention and draw volume retention than previous tubes comprised of polymer compositions and blends thereof without a coating of barrier materials.
Printing may be placed on the barrier coating applied to the container of interest. For example, a product identification, bar code, brand name, company logo, lot number, expiration date and other data and information may all be included on the barrier coating.
Moreover, a matte finish or a corona discharged surface may be developed on the barrier coating so as to make the surface appropriate for writing additional information on the label. Furthermore, a pressure sensitive adhesive label may be placed over the barrier coating so as to accommodate various hospital over-labels, for example.

DESCRIPTION OF THE DRAWINGS
FIG. 1 is a perspective view of a typical blood collection tube with a stopper.
FIG. 2 is a longitudinal sectional view of the tube of FIG. 1 taken along line 2-2.
FIG. 3 is a longitudinal sectional view of a tube-shaped container, similar to the tube of FIG.
without a stopper, comprising a barrier coating.
FIG. 4 is a longitudinal sectional view of a tube-shaped container, similar to the tube of FIG.
with a stopper, comprising a barrier coating.
, "- ~''~
DETAILED DESCRIPTION

Referring to the drawings in which like reference -characters refer to like parts throughout the several views thereof, FIGS. 1 and 2 show a typical blood collection tube 10, having a sidewall 11 extending from an open end 16 to a closed end 18 and stopper 14 which includes a lower annular portion or ~skirt 15 which extends into and presses against the inner surface 12 of the sidewall for maintaining stopper 14 in place.
FIG. 3 shows the preferred embodiment of the invention, a plastic tube coated with at least two layers of barrier materials. The preferred embodiment :' ' ,, 2111~69 includes many components which are s-lbstantially identical to the components of FIGS. 1 and 2.
Accordingly, similar components performing similar functions will be numbered identically to those S components of FIGS. 1 and 2, except that a suffix "a"
will be used to identify those components in FIG. 3.
Referring now to FIG. 3, the preferred embodiment of the invention, collection tube assembly 20 comprises a plastic tube lOa, having a sidewall lla extending from an open end 16a to a closed end 18a.
A barrier coating 25 extends over a substantial portion of the length of the tube which is upon the outer surface of the tube with the exception of open end 16a. Barrier coating 25 comprises a first layer 26 of an inorganic material and a second layer 27 of a polymer material.
FIG. 4 illustrates an alternate embodiment of the invention, wherein collection tube assembly 40 comprises stopper 48 in place for closing open end 41 of tube 42. As can be seen, sidewall 43 extends from open end 41 to closed end 44 and stopper 48 includes an annular upper portion 50 which extends over the top edge of tube 42. Stopper 48 includes a lower annular portion or skirt 49 which extends into and presses against the inside inner surface 46 of sidewall 43 for maintaining stopper 48 in place and a well 52.
Covering a substantial portion of the length of the tube is a barrier coating 45. Barrier coating 45 covers substantially most of the tube with the exception of open end 41 thereof. Barrier coating 45 comprises a first layer 54 of an inorganic material and a second layer 56 of a polymer material.
FIG. 4 differs from the embodiment in FIG. 3 in that the tube may be evacuated with the simultaneous placement of stopper 48 therein after the application , P-2468 211126~

of barrier coating 45 over the tube. Alternatïvely, the barrier coating may be applied to the tube before it has been evacuated.
An alternate embodiment of the invention also includes a barrier coating incorporating both the upper portion of the stopper, as well as the entire container tube. Such an embodiment may be utilized, for example, for sealing the container with the stopper in place.
Once a sample has been placed in the tube, the sample cannot be tampered with by removal of the stopper.
Additionally, serrations could be included at the tube, stopper interface. The serrations may be registered so that it can be determined if the sealed container has been tampered with.
It will be understood by practitioners-in-the-art that such tubes may also contain reagents in the form of additives or coatings on the inner wall of the tube.
The barrier coating forms a substantially clear or translucent barrier. Therefore, the contents of a plastic tube layered with a barrier coating comprising at least two layers of barrier materials are substantially visible to the observer at the same time identifying information may be displayed over the barri.er coating after it is applied to the plastic tube.
The inorganic material of the barrier coating may be formed on a substrate as a first layer by radio frequency discharge, direct or dual ion beam deposition, sputtering or plasma chemical vapor deposition, as described in U.S. Patent Nos. 4,698,256, 4,809,876, 4,992,298 and 5,055,318, the disclosures of which are herein incorporated by reference.
The second layer of the barrier coating, a polymer material, may be a parylene polymer applied to the first layer by a process similar to vacuum metallizing, as described in U.S. Patent Nos. 3,342,754 and 3,300,332, the disclosures of which are herein incorporated by ~ .
", 211126~
` P-2468 reference. Alternatively, the second layer may be vinylidene chloride-acrylonitrile-methyl methacrylate-methyl acrylate-acid acrylic polymer, applied to the first layer by dip-coating, roll-coating or spraying an aqueous emulsion of the polymer, followed by air drying of the coating, as described in U.S. Patent Nos.
S,093,194 and 4,497,859, the disclosure of which are herein incorporated by reference.
The barrier coating of the present invention is preferably a first layer material comprising aluminum oxide, and a second layer of vinylidene chloride-acrylonitrile-methyl methacrylate-methyl acrylate-acrylic acid polymer applied to the first layer.
A plastic blood collection tube coated with the barrier coating will not interfere with testing and analysis that is typically performed on blood in a tube. Such tests include but are not limited to, routine chemical analysis, biological inertness, hematology, blood chemistry, blood typing, toxicology analysis or therapeutic drug monitoring and other clinical tests involving body fluids. Furthermore, a plastic blood collection tube coated with the barrier coating is capable of being subjected to automated machinery such as centrifuges and may be exposed to certain levels of radiation in the sterilization process with substantially no change in optical or mechanical and functional properties.
A plastic blood collection tube coated with the barrier coating is able to maintain 90~ original draw volume over a period of one year. Draw volume retention depends on the existence of a partial vacuum, or reduced pressure, inside the tube. The draw volume changes in direct proportion to the change in vacuum (reduced pressure). Therefore, draw volume retention is dependent on good vacuum retention. A plastic tube coated with a barrier coating substantially prevents gas - : : .~ ,~. .::. .

2~12S~I

permeation through the tube material so as to maintain and enhance the vacuum retention and draw volume retention of the tube.
If the barrier coating is also coated or applied on the innee surface of the plastic blood collection tube, the barrier coating may be hemorepellent and/or have characteristics of a clot activator if the first layer of the barrier coating is a diamond composition.
It will be understood that it makes no difference whether the plastic composite container is evacuated or not evacuated in accordance with this invention. The presence of a barrier coating on the outer surface of the container has the effect of maintaining the general integrity of the container holding a sample so that it may be properly disposed of without any contamination to the user. Notable is the clarity of the barrier coating as coated or applied on the container and its abrasion and scratch resistance. -The barrier coating used in accordance with this disclosure, may contain conventional additives and ingredients which do not adversely affect the properties of articles made therefrom.

-;~ -~ '

Claims (28)

1. A sample assembly comprising:
a plastic container having an open end, a closed end, an inner surface and an outer surface; and a barrier coating associated over the outer surface of said container and extending over a major portion of said outer surface of said container, said coating having a first layer including an inorganic material and a second layer on said first layer including a polymer.
2. The assembly of Claim 1 further comprising a closure in said open end of said container whereby a container and closure interface is formed.
3. The assembly of Claim 2 wherein said plastic container is a tube and said closure is an elastomeric stopper.
4. The assembly of Claim 1 wherein said barrier coating extends substantially from said open end of said container to and over said closed end of said container.
5. The assembly of Claim 3 wherein said barrier coating extends from a portion of said elastomer stopper to a point adjacent said closed end of said container.
6. The assembly of Claim 3 wherein said barrier coating covers said entire outer surface of said container and extends over a portion of said elastomer stopper.
7. The assembly of Claim 2 wherein said tube is evacuated.
8. The assembly of Claim 2 wherein said barrier coating includes registered tamper serrations adjacent said container and said closure interface.
9. The assembly of Claim 1 wherein said first layer is deposited by radio-frequency discharge, direct ion beam deposition, dual ion beam deposition, sputtering or plasma chemical vapor deposition.
10. The assembly of Claim 1 wherein said first layer is aluminum oxide, silicon oxide or a diamond based composition.
11. The assembly of Claim 10 wherein said second layer is thermosetting epoxy, parylene polymer, vinylidene chloride-acrylonitrile-methyl methacrylate-methyl acrylate-acrylic acid polymer, or polyesters.
12. The assembly of Claim 11 wherein said first layer comprises aluminum oxide and said second layer comprises vinylidene chloride-acrylonitrile-methyl methacrylate-methyl acrylate-acrylic acid polymer, or polyesters.
13. The assembly of Claim 11 wherein said first layer comprises silicon oxide and said second layer comprises vinylidene chloride-acrylonitrile-methyl methacrylate-methyl acrylate-acrylic acid polymer, or polyesters.
14. The assembly of Claim 11 wherein said second layer is a parylene polymer.
15. The assembly of Claim 14 wherein said parylene polymer is parylene N, parylene C or parylene D.
16. The assembly of Claim 1 further comprising a barrier coating over the inner surface of said container, said coating having a first layer including an inorganic material and a second layer on said first layer including a polymer.
17. The assembly of Claim 16 wherein said first layer is aluminum oxide, silicon oxide or a diamond-based composition.
18. The assembly of Claim 17 wherein said second layer is thermosetting epoxy, parylene polymer, vinylidene chloride-acrylonitrile-methyl methacrylate-methyl acrylate-acrylic acid polymer, or polyesters.
19. A barrier coating comprising:
a first layer comprising an inorganic material; and a second layer on said first layer comprising a polymer.
20. The barrier coating of Claim 19 wherein said first layer is aluminum oxide, silicon oxide or a diamond based composition.
21. The barrier coating of Claim 20 wherein said second layer is thermosetting epoxy, parylene polymer, vinylidene chloride-acrylonitrile-methyl methacrylate-methyl acrylate-acrylic acid polymer, or polyesters.
22. The barrier coating of Claim 21 wherein said first layer is aluminum oxide and said second layer is vinylidene chloride-acrylonitrile-methyl methacrylate-methyl acrylate-acrylic acid polymer.
23. The barrier coating of Claim 22 wherein said second layer is a parylene polymer.
24. The barrier coating of Claim 23 wherein said parylene polymer is parylene N, parylene C or parylene D.
25. A sample assembly comprising:
a plastic tube having an open end, a closed end, an inner surface and an outer surface; and a barrier coating associated over the inner surface of said tube, said coating having a first layer including an inorganic material and a second layer on said first layer including a polymer.
26. The assembly of Claim 25 wherein said first layer is aluminum oxide, silicon oxide or a diamond-based composition.
27. The assembly of Claim 26 wherein said second layer is thermosetting epoxy, parylene polymer, vinylidene chloride-acrylonitrile-methyl methacrylate-methyl acrylate-acrylic acid polymer, or polyesters.
28. A sample assembly comprising:
a plastic tube having an open end, a closed end, an inner surface and an outer surface; and a barrier coating associated over the outer surface of said tube, said coating having a first layer including aluminum oxide, silicon oxide or a diamond-based composition and a second layer on said first layer including thermosetting epoxy, parylene polymer, vinylidene chloride-acrylonitrile-methyl methacrylate-methyl acrylate-acrylic acid polymer, or polyesters.
CA002111269A 1992-12-18 1993-12-13 Barrier coating Abandoned CA2111269A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99327592A 1992-12-18 1992-12-18
US07/993,275 1992-12-18

Publications (1)

Publication Number Publication Date
CA2111269A1 true CA2111269A1 (en) 1994-06-19

Family

ID=25539326

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002111269A Abandoned CA2111269A1 (en) 1992-12-18 1993-12-13 Barrier coating

Country Status (12)

Country Link
US (1) US5654054A (en)
EP (1) EP0607573B1 (en)
JP (1) JP2589942B2 (en)
KR (1) KR960016297B1 (en)
AU (1) AU669754B2 (en)
BR (1) BR9305111A (en)
CA (1) CA2111269A1 (en)
DE (1) DE69314458T2 (en)
ES (1) ES2107604T3 (en)
MX (1) MX9307801A (en)
SG (1) SG49313A1 (en)
TW (1) TW351700B (en)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0698398A1 (en) * 1994-08-23 1996-02-28 Becton, Dickinson and Company Blood collection device
DE4438359C2 (en) * 1994-10-27 2001-10-04 Schott Glas Plastic container with a barrier coating
DE4445427C2 (en) * 1994-12-20 1997-04-30 Schott Glaswerke Plasma CVD method for producing a gradient layer
US5686157A (en) * 1996-01-30 1997-11-11 Becton, Dickinson And Company Blood collection tube assembly
US5702770A (en) * 1996-01-30 1997-12-30 Becton, Dickinson And Company Method for plasma processing
US5955161A (en) * 1996-01-30 1999-09-21 Becton Dickinson And Company Blood collection tube assembly
US5683771A (en) * 1996-01-30 1997-11-04 Becton, Dickinson And Company Blood collection tube assembly
US5738920A (en) * 1996-01-30 1998-04-14 Becton, Dickinson And Company Blood collection tube assembly
TW434301B (en) * 1996-01-30 2001-05-16 Becton Dickinson Co Non-ideal barrier coating composition comprising organic and inorganic materials
EP0814114A1 (en) * 1996-06-18 1997-12-29 Becton, Dickinson and Company Barrier coating
JP3770970B2 (en) * 1996-08-28 2006-04-26 昭和ゴム株式会社 Surface treatment method of medical article by argon gas cluster ion beam
US6001087A (en) * 1996-09-30 1999-12-14 Becton Dickinson And Company Collection assembly with a reservoir
JP3014334B2 (en) * 1996-11-29 2000-02-28 キヤノン販売株式会社 Method for manufacturing semiconductor device
NL1007781C2 (en) * 1997-12-12 1999-06-15 Packard Instr Bv Microtiter plate.
DE19811655A1 (en) * 1998-03-18 1999-09-23 Schaeffler Waelzlager Ohg Aluminum-coated plastic component useful as a sliding seal especially in a vehicle hydraulic clutch disengaging system
US6083342A (en) 1998-03-18 2000-07-04 Owens-Brockway Plastic Products Inc. Container labeling system
CA2348417A1 (en) * 1998-10-29 2000-05-11 Closure Medical Corporation Polymeric containers for 1,1-disubstituted monomer compositions
US6498835B1 (en) * 2000-02-29 2002-12-24 Ameritech Corporation Method and system for providing visual notification in a unified messaging system
DE10106362B4 (en) * 2001-02-12 2005-03-17 Licht, Michael, Dipl.-Ing. (FH) Apparatus and method for collecting aqueous fluid samples
JP4759831B2 (en) * 2001-04-16 2011-08-31 大日本印刷株式会社 Barrier film
US7469558B2 (en) 2001-07-10 2008-12-30 Springworks, Llc As-deposited planar optical waveguides with low scattering loss and methods for their manufacture
CN1607968A (en) * 2001-11-02 2005-04-20 梅里迪安医学技术公司 Medicament container, a medicament dispensing kit for administering medication and a method for packaging the same
US7404877B2 (en) 2001-11-09 2008-07-29 Springworks, Llc Low temperature zirconia based thermal barrier layer by PVD
US6884327B2 (en) 2002-03-16 2005-04-26 Tao Pan Mode size converter for a planar waveguide
US7378356B2 (en) 2002-03-16 2008-05-27 Springworks, Llc Biased pulse DC reactive sputtering of oxide films
US8404376B2 (en) 2002-08-09 2013-03-26 Infinite Power Solutions, Inc. Metal film encapsulation
US9793523B2 (en) 2002-08-09 2017-10-17 Sapurast Research Llc Electrochemical apparatus with barrier layer protected substrate
US8236443B2 (en) 2002-08-09 2012-08-07 Infinite Power Solutions, Inc. Metal film encapsulation
US8021778B2 (en) 2002-08-09 2011-09-20 Infinite Power Solutions, Inc. Electrochemical apparatus with barrier layer protected substrate
US8445130B2 (en) 2002-08-09 2013-05-21 Infinite Power Solutions, Inc. Hybrid thin-film battery
US20070264564A1 (en) 2006-03-16 2007-11-15 Infinite Power Solutions, Inc. Thin film battery on an integrated circuit or circuit board and method thereof
US8431264B2 (en) 2002-08-09 2013-04-30 Infinite Power Solutions, Inc. Hybrid thin-film battery
US8394522B2 (en) 2002-08-09 2013-03-12 Infinite Power Solutions, Inc. Robust metal film encapsulation
AU2003261463A1 (en) 2002-08-27 2004-03-19 Symmorphix, Inc. Optically coupling into highly uniform waveguides
US10966421B2 (en) 2002-10-16 2021-04-06 Streck, Inc. Method and device for collecting and preserving cells for analysis
KR100691168B1 (en) 2003-02-27 2007-03-09 섬모픽스, 인코포레이티드 Dielectric barrier layer films
US8728285B2 (en) 2003-05-23 2014-05-20 Demaray, Llc Transparent conductive oxides
US7238628B2 (en) 2003-05-23 2007-07-03 Symmorphix, Inc. Energy conversion and storage films and devices by physical vapor deposition of titanium and titanium oxides and sub-oxides
US8016816B2 (en) * 2003-09-09 2011-09-13 Convatec Technologies Inc. Fecal management appliance and method and apparatus for introducing same
US6997179B1 (en) 2004-01-13 2006-02-14 Essex Pb&R Corporation Protective hood
US20060091158A1 (en) * 2004-10-29 2006-05-04 Sonoco Development, Inc. High-barrier plastic caulk cartridge and method of making same
US7959769B2 (en) 2004-12-08 2011-06-14 Infinite Power Solutions, Inc. Deposition of LiCoO2
DE602005017512D1 (en) 2004-12-08 2009-12-17 Symmorphix Inc DEPOSIT OF LICOO2
JP4716773B2 (en) * 2005-04-06 2011-07-06 富士フイルム株式会社 Gas barrier film and organic device using the same
US7838133B2 (en) 2005-09-02 2010-11-23 Springworks, Llc Deposition of perovskite and other compound ceramic films for dielectric applications
US20070084556A1 (en) * 2005-10-14 2007-04-19 Langseder Neal E Method of applying a label to a squeeze tube
WO2008039471A2 (en) 2006-09-29 2008-04-03 Infinite Power Solutions, Inc. Masking of and material constraint for depositing battery layers on flexible substrates
US8323254B2 (en) * 2006-10-26 2012-12-04 Convatec Technologies, Inc. Silicone based tube for transporting malodoriforous matter from the human body
US8197781B2 (en) 2006-11-07 2012-06-12 Infinite Power Solutions, Inc. Sputtering target of Li3PO4 and method for producing same
EP2033986A1 (en) * 2007-09-03 2009-03-11 Alcan Technology & Management Ltd. Packaging part and method for its production
US8268488B2 (en) 2007-12-21 2012-09-18 Infinite Power Solutions, Inc. Thin film electrolyte for thin film batteries
TWI441937B (en) 2007-12-21 2014-06-21 Infinite Power Solutions Inc Method for sputter targets for electrolyte films
KR101606183B1 (en) 2008-01-11 2016-03-25 사푸라스트 리써치 엘엘씨 Thin film encapsulation for thin film batteries and other devices
KR101672254B1 (en) 2008-04-02 2016-11-08 사푸라스트 리써치 엘엘씨 Passive over/under voltage control and protection for energy storage devices associated with energy harvesting
CN102119454B (en) 2008-08-11 2014-07-30 无穷动力解决方案股份有限公司 Energy device with integral collector surface for electromagnetic energy harvesting and method thereof
KR101613671B1 (en) 2008-09-12 2016-04-19 사푸라스트 리써치 엘엘씨 Energy device with integral conductive surface for data communication via electromagnetic energy and method thereof
US8508193B2 (en) 2008-10-08 2013-08-13 Infinite Power Solutions, Inc. Environmentally-powered wireless sensor module
US11634747B2 (en) * 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
NO2398912T3 (en) 2009-02-18 2018-02-10
DK2251453T3 (en) 2009-05-13 2014-07-07 Sio2 Medical Products Inc container Holder
US7985188B2 (en) 2009-05-13 2011-07-26 Cv Holdings Llc Vessel, coating, inspection and processing apparatus
US9458536B2 (en) 2009-07-02 2016-10-04 Sio2 Medical Products, Inc. PECVD coating methods for capped syringes, cartridges and other articles
US8599572B2 (en) 2009-09-01 2013-12-03 Infinite Power Solutions, Inc. Printed circuit board with integrated thin film battery
US11624115B2 (en) 2010-05-12 2023-04-11 Sio2 Medical Products, Inc. Syringe with PECVD lubrication
US20110300432A1 (en) 2010-06-07 2011-12-08 Snyder Shawn W Rechargeable, High-Density Electrochemical Device
US9878101B2 (en) 2010-11-12 2018-01-30 Sio2 Medical Products, Inc. Cyclic olefin polymer vessels and vessel coating methods
US9272095B2 (en) 2011-04-01 2016-03-01 Sio2 Medical Products, Inc. Vessels, contact surfaces, and coating and inspection apparatus and methods
US11116695B2 (en) 2011-11-11 2021-09-14 Sio2 Medical Products, Inc. Blood sample collection tube
AU2012318242A1 (en) 2011-11-11 2013-05-30 Sio2 Medical Products, Inc. Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus
EP2846755A1 (en) 2012-05-09 2015-03-18 SiO2 Medical Products, Inc. Saccharide protective coating for pharmaceutical package
JP6509734B2 (en) 2012-11-01 2019-05-08 エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド Film inspection method
EP2920567B1 (en) 2012-11-16 2020-08-19 SiO2 Medical Products, Inc. Method and apparatus for detecting rapid barrier coating integrity characteristics
US9764093B2 (en) 2012-11-30 2017-09-19 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition
WO2014085346A1 (en) 2012-11-30 2014-06-05 Sio2 Medical Products, Inc. Hollow body with inside coating
US20160015898A1 (en) 2013-03-01 2016-01-21 Sio2 Medical Products, Inc. Plasma or cvd pre-treatment for lubricated pharmaceutical package, coating process and apparatus
US9937099B2 (en) 2013-03-11 2018-04-10 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging with low oxygen transmission rate
CN110074968B (en) 2013-03-11 2021-12-21 Sio2医药产品公司 Coated packaging material
EP2971227B1 (en) 2013-03-15 2017-11-15 Si02 Medical Products, Inc. Coating method.
US10091984B2 (en) 2013-07-24 2018-10-09 Streck, Inc. Compositions and methods for stabilizing circulating tumor cells
EP3693493A1 (en) 2014-03-28 2020-08-12 SiO2 Medical Products, Inc. Antistatic coatings for plastic vessels
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
DE102015207228A1 (en) * 2015-04-21 2016-10-27 Vetter Pharma-Fertigung GmbH & Co. KG Primary packaging and method of making a primary packaging
JP2018523538A (en) 2015-08-18 2018-08-23 エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド Drug packaging and other packaging with low oxygen transmission rate
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
EP3491381A1 (en) 2016-07-29 2019-06-05 Streck, Inc. Suspension composition for hematology analysis control
CN110603204A (en) * 2017-05-08 2019-12-20 生物医学再生Gf有限责任公司 Device for protecting inner container
JP6577068B2 (en) * 2018-01-30 2019-09-18 ダイセルバリューコーティング株式会社 Gas barrier film and method for producing the same
CN113302334A (en) * 2019-01-25 2021-08-24 应用材料公司 Method of forming a moisture and oxygen barrier coating
EP3913110A1 (en) * 2020-05-20 2021-11-24 Eppendorf AG Laboratory consumable and method for manufacturing same

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4131200A (en) * 1976-07-06 1978-12-26 Union Carbide Corporation Thermoplastic blood bag
US4698256A (en) * 1984-04-02 1987-10-06 American Cyanamid Company Articles coated with adherent diamondlike carbon films
DE3584188D1 (en) * 1984-05-11 1991-10-31 Terumo Corp METHOD FOR PRODUCING A SYNTETIC RESIN CONTAINER.
US4756964A (en) * 1986-09-29 1988-07-12 The Dow Chemical Company Barrier films having an amorphous carbon coating and methods of making
US4809876A (en) * 1987-08-27 1989-03-07 Aluminum Company Of America Container body having improved gas barrier properties
JPH01130310U (en) * 1988-02-25 1989-09-05
JPH0245895A (en) * 1988-08-06 1990-02-15 Fujitsu Ltd Paper money receiving machine
JP2600329B2 (en) * 1988-09-19 1997-04-16 凸版印刷株式会社 Gas barrier laminate film and method for producing the same
JPH0281621A (en) * 1988-09-20 1990-03-22 Terumo Corp Synthetic resin container and manufacture thereof
US5055318A (en) 1988-10-11 1991-10-08 Beamalloy Corporation Dual ion beam ballistic alloying process
US5297561A (en) * 1989-06-15 1994-03-29 Hulon Walter C Blood collection tube assembly
US5093194A (en) * 1989-11-01 1992-03-03 Mobil Oil Corporation Oriented multilayer heat sealable packaging film
US5067491A (en) * 1989-12-08 1991-11-26 Becton, Dickinson And Company Barrier coating on blood contacting devices
CA2038488A1 (en) * 1990-03-19 1991-09-20 Roger A. Olson Process for optimizing corrosion protection of coated substrates

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AU669754B2 (en) 1996-06-20
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AU5208393A (en) 1994-06-30
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JP2589942B2 (en) 1997-03-12
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US5654054A (en) 1997-08-05
ES2107604T3 (en) 1997-12-01

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