CA2120481A1 - Assay system - Google Patents

Assay system

Info

Publication number
CA2120481A1
CA2120481A1 CA002120481A CA2120481A CA2120481A1 CA 2120481 A1 CA2120481 A1 CA 2120481A1 CA 002120481 A CA002120481 A CA 002120481A CA 2120481 A CA2120481 A CA 2120481A CA 2120481 A1 CA2120481 A1 CA 2120481A1
Authority
CA
Canada
Prior art keywords
beads
excitation
lens
focal region
fluorescent radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002120481A
Other languages
French (fr)
Other versions
CA2120481C (en
Inventor
Steve J. Lackie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sapidyne Instruments Inc
Original Assignee
Steve J. Lackie
Sapidyne, Inc.
Sapidyne Instruments Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25450611&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2120481(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Steve J. Lackie, Sapidyne, Inc., Sapidyne Instruments Inc. filed Critical Steve J. Lackie
Priority to CA002518356A priority Critical patent/CA2518356C/en
Publication of CA2120481A1 publication Critical patent/CA2120481A1/en
Application granted granted Critical
Publication of CA2120481C publication Critical patent/CA2120481C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/0303Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/808Optical sensing apparatus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property

Abstract

A system (30) for assaying a fluid sample. The system (30) comprising a lens (33) capable of focussing both excitation and fluorescent radiation, a fluid-flow conducting conduit (42) being provided in the lens (33) extending transversely of the optical axis of and through the focal region of the latter. At least one mechanical screen (38A, 38B) is disposed adjacent the focal region in the conduit (42) to arrest passage of beads (40) as a function of bead diameter. The beads (40) are precoated with at least a moiety of a ligand/conjugated complex and preferably transparent to both the excitation and fluorescent radiation.
CA002120481A 1992-08-03 1993-07-23 Assay system Expired - Lifetime CA2120481C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002518356A CA2518356C (en) 1992-08-03 1993-07-23 Assay system

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/924,720 1992-08-03
US07/924,720 US5372783A (en) 1992-08-03 1992-08-03 Assay system
PCT/US1993/006967 WO1994003104A1 (en) 1992-08-03 1993-07-23 Assay system

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002518356A Division CA2518356C (en) 1992-08-03 1993-07-23 Assay system

Publications (2)

Publication Number Publication Date
CA2120481A1 true CA2120481A1 (en) 1994-02-17
CA2120481C CA2120481C (en) 2005-12-20

Family

ID=25450611

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002518356A Expired - Lifetime CA2518356C (en) 1992-08-03 1993-07-23 Assay system
CA002120481A Expired - Lifetime CA2120481C (en) 1992-08-03 1993-07-23 Assay system

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002518356A Expired - Lifetime CA2518356C (en) 1992-08-03 1993-07-23 Assay system

Country Status (8)

Country Link
US (3) US5372783A (en)
EP (1) EP0606460B1 (en)
JP (4) JP3534756B2 (en)
AT (1) ATE242996T1 (en)
CA (2) CA2518356C (en)
DE (1) DE69333050T2 (en)
DK (1) DK0606460T3 (en)
WO (1) WO1994003104A1 (en)

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Also Published As

Publication number Publication date
DK0606460T3 (en) 2003-10-13
DE69333050D1 (en) 2003-07-24
WO1994003104A1 (en) 1994-02-17
US5554340A (en) 1996-09-10
JP2006258824A (en) 2006-09-28
US5372783A (en) 1994-12-13
EP0606460A4 (en) 1994-12-07
CA2518356A1 (en) 1994-02-17
ATE242996T1 (en) 2003-07-15
EP0606460A1 (en) 1994-07-20
JP3534756B2 (en) 2004-06-07
JP2004069716A (en) 2004-03-04
JP2005321416A (en) 2005-11-17
CA2120481C (en) 2005-12-20
JPH07500191A (en) 1995-01-05
CA2518356C (en) 2009-11-24
US6120734A (en) 2000-09-19
DE69333050T2 (en) 2004-05-27
EP0606460B1 (en) 2003-06-18
JP4102837B2 (en) 2008-06-18

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