CA2120481A1 - Assay system - Google Patents
Assay systemInfo
- Publication number
- CA2120481A1 CA2120481A1 CA002120481A CA2120481A CA2120481A1 CA 2120481 A1 CA2120481 A1 CA 2120481A1 CA 002120481 A CA002120481 A CA 002120481A CA 2120481 A CA2120481 A CA 2120481A CA 2120481 A1 CA2120481 A1 CA 2120481A1
- Authority
- CA
- Canada
- Prior art keywords
- beads
- excitation
- lens
- focal region
- fluorescent radiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/808—Optical sensing apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
Abstract
A system (30) for assaying a fluid sample. The system (30) comprising a lens (33) capable of focussing both excitation and fluorescent radiation, a fluid-flow conducting conduit (42) being provided in the lens (33) extending transversely of the optical axis of and through the focal region of the latter. At least one mechanical screen (38A, 38B) is disposed adjacent the focal region in the conduit (42) to arrest passage of beads (40) as a function of bead diameter. The beads (40) are precoated with at least a moiety of a ligand/conjugated complex and preferably transparent to both the excitation and fluorescent radiation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002518356A CA2518356C (en) | 1992-08-03 | 1993-07-23 | Assay system |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/924,720 | 1992-08-03 | ||
US07/924,720 US5372783A (en) | 1992-08-03 | 1992-08-03 | Assay system |
PCT/US1993/006967 WO1994003104A1 (en) | 1992-08-03 | 1993-07-23 | Assay system |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002518356A Division CA2518356C (en) | 1992-08-03 | 1993-07-23 | Assay system |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2120481A1 true CA2120481A1 (en) | 1994-02-17 |
CA2120481C CA2120481C (en) | 2005-12-20 |
Family
ID=25450611
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002518356A Expired - Lifetime CA2518356C (en) | 1992-08-03 | 1993-07-23 | Assay system |
CA002120481A Expired - Lifetime CA2120481C (en) | 1992-08-03 | 1993-07-23 | Assay system |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002518356A Expired - Lifetime CA2518356C (en) | 1992-08-03 | 1993-07-23 | Assay system |
Country Status (8)
Country | Link |
---|---|
US (3) | US5372783A (en) |
EP (1) | EP0606460B1 (en) |
JP (4) | JP3534756B2 (en) |
AT (1) | ATE242996T1 (en) |
CA (2) | CA2518356C (en) |
DE (1) | DE69333050T2 (en) |
DK (1) | DK0606460T3 (en) |
WO (1) | WO1994003104A1 (en) |
Families Citing this family (80)
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US5372783A (en) * | 1992-08-03 | 1994-12-13 | Sapidyne, Inc. | Assay system |
US6664114B1 (en) | 1992-08-03 | 2003-12-16 | Sapidyne Instruments, Inc. | Solid phase assay for detection of ligands |
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US5660798A (en) * | 1993-04-20 | 1997-08-26 | Actimed Laboratories, Inc. | Apparatus for red blood cell separation |
US5485270A (en) * | 1994-07-25 | 1996-01-16 | General Signal Corporation | Dynamic light scattering microvolume cell assembly for continuous flow dialysis |
CA2199868C (en) * | 1994-09-14 | 2000-05-16 | David R. Bowden | Compact spectrophotometer |
EP0781401B1 (en) * | 1994-09-14 | 2004-11-24 | X-Rite, Inc. | Scanning colorimeter |
USRE43097E1 (en) | 1994-10-13 | 2012-01-10 | Illumina, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
WO1998053300A2 (en) | 1997-05-23 | 1998-11-26 | Lynx Therapeutics, Inc. | System and apparaus for sequential processing of analytes |
GB2324603B (en) * | 1996-02-09 | 1999-08-04 | Kalibrant Limited | Assay apparatus |
US6159426A (en) * | 1996-02-09 | 2000-12-12 | Kalibrant Limited | Apparatus for fluid assay |
US5670375A (en) * | 1996-02-21 | 1997-09-23 | Biomerieux Vitek, Inc. | Sample card transport method for biological sample testing machine |
US6025189A (en) * | 1997-05-14 | 2000-02-15 | 3M Innovative Properties Company | Apparatus for reading a plurality of biological indicators |
GB9717020D0 (en) * | 1997-08-12 | 1997-10-15 | Kalibrant Limited | An assay apparatus with multiple detectors |
US7115884B1 (en) * | 1997-10-06 | 2006-10-03 | Trustees Of Tufts College | Self-encoding fiber optic sensor |
US7348181B2 (en) | 1997-10-06 | 2008-03-25 | Trustees Of Tufts College | Self-encoding sensor with microspheres |
US6100541A (en) | 1998-02-24 | 2000-08-08 | Caliper Technologies Corporation | Microfluidic devices and systems incorporating integrated optical elements |
US7220596B2 (en) * | 1998-04-15 | 2007-05-22 | Utah State University | Real time detection of antigens |
US6290912B1 (en) * | 1998-07-14 | 2001-09-18 | Bayer Corporation | Read head for luminometer |
US6623971B2 (en) * | 1999-01-11 | 2003-09-23 | Bayer Corporation | Method and apparatus for conducting a stat immunoassay analysis in a capsule chemistry analysis system |
JP2001004628A (en) * | 1999-06-18 | 2001-01-12 | Kanagawa Acad Of Sci & Technol | Immunoassay and its method |
US6867859B1 (en) | 1999-08-03 | 2005-03-15 | Lightwind Corporation | Inductively coupled plasma spectrometer for process diagnostics and control |
US6239871B1 (en) * | 1999-08-24 | 2001-05-29 | Waters Investments Limited | Laser induced fluorescence capillary interface |
US20020004246A1 (en) * | 2000-02-07 | 2002-01-10 | Daniels Robert H. | Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels |
US6690467B1 (en) * | 2000-05-05 | 2004-02-10 | Pe Corporation | Optical system and method for optically analyzing light from a sample |
US8173441B2 (en) | 2000-09-27 | 2012-05-08 | Universiteit Leiden | Method for applying NMR for ligand discovery or as a drug screening tool |
WO2002032567A1 (en) * | 2000-10-17 | 2002-04-25 | Febit Ag | Method and device for the integrated synthesis and analysis of analytes on a support |
US6538734B2 (en) * | 2000-11-29 | 2003-03-25 | Lightwind Corporation | Method and device utilizing real-time gas sampling |
US7691645B2 (en) * | 2001-01-09 | 2010-04-06 | Agilent Technologies, Inc. | Immunosubtraction method |
JP3844738B2 (en) | 2001-03-02 | 2006-11-15 | ウォーターズ・インヴェストメンツ・リミテッド | Fluorescence detector structure |
US6774995B2 (en) | 2001-08-03 | 2004-08-10 | Pointsource Technologies, Llc | Identification of particles in fluid |
US6519033B1 (en) | 2001-11-19 | 2003-02-11 | Point Source Technologies, Llc | Identification of particles in fluid |
US6590652B2 (en) | 2001-11-02 | 2003-07-08 | Pointsource Technologies, Inc. | Flow through light scattering device |
US6573992B1 (en) | 2001-11-13 | 2003-06-03 | Pointsource Technologies, Llc | Plano convex fluid carrier for scattering correction |
US6628386B2 (en) | 2001-12-12 | 2003-09-30 | Pointsource Technologies, Llc | Particle detection beam |
US6930769B1 (en) | 2002-03-21 | 2005-08-16 | Pointsource Technologies, Llc | Optical sensor module tester |
US7057724B1 (en) | 2002-03-21 | 2006-06-06 | Institute Of Critical Care Medicine | Particulate info to field units |
US6972424B1 (en) | 2002-04-16 | 2005-12-06 | Pointsource Technologies, Llc | High detection rate particle identifier |
JP2004069397A (en) * | 2002-08-02 | 2004-03-04 | Nec Corp | Analysis chip and analytical apparatus |
US7164533B2 (en) | 2003-01-22 | 2007-01-16 | Cyvera Corporation | Hybrid random bead/chip based microarray |
US7900836B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Optical reader system for substrates having an optically readable code |
US7508608B2 (en) | 2004-11-17 | 2009-03-24 | Illumina, Inc. | Lithographically fabricated holographic optical identification element |
US7441703B2 (en) | 2002-08-20 | 2008-10-28 | Illumina, Inc. | Optical reader for diffraction grating-based encoded optical identification elements |
US7872804B2 (en) | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
US7923260B2 (en) | 2002-08-20 | 2011-04-12 | Illumina, Inc. | Method of reading encoded particles |
US7901630B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Diffraction grating-based encoded microparticle assay stick |
CA2499046A1 (en) | 2002-09-12 | 2004-03-25 | Cyvera Corporation | Diffraction grating-based encoded micro-particles for multiplexed experiments |
US7092160B2 (en) | 2002-09-12 | 2006-08-15 | Illumina, Inc. | Method of manufacturing of diffraction grating-based optical identification element |
AU2003267192A1 (en) | 2002-09-12 | 2004-04-30 | Cyvera Corporation | Method and apparatus for aligning elongated microbeads in order to interrogate the same |
US20100255603A9 (en) | 2002-09-12 | 2010-10-07 | Putnam Martin A | Method and apparatus for aligning microbeads in order to interrogate the same |
SE0203548D0 (en) * | 2002-12-02 | 2002-12-02 | Biacore Ab | Method of determining site-specificity and kit therefor |
US20040175821A1 (en) * | 2003-03-07 | 2004-09-09 | Ehman Michael F. | Integrated photodetector for heavy metals and biological activity analysis |
US6819421B1 (en) | 2003-04-11 | 2004-11-16 | Point Source Technologies, Llc | Detection of new species of particles |
KR101581040B1 (en) | 2003-06-27 | 2015-12-30 | 암젠 프레몬트 인코포레이티드 | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
US7433123B2 (en) | 2004-02-19 | 2008-10-07 | Illumina, Inc. | Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein |
JP4579593B2 (en) * | 2004-03-05 | 2010-11-10 | キヤノン株式会社 | Target substance recognition element, detection method and apparatus |
US7177023B2 (en) * | 2004-03-19 | 2007-02-13 | Applera Corporation | Fluorescent light detection |
WO2006020363A2 (en) | 2004-07-21 | 2006-02-23 | Illumina, Inc. | Method and apparatus for drug product tracking using encoded optical identification elements |
DE602005022196D1 (en) * | 2004-07-23 | 2010-08-19 | Biosystem Dev Llc | DEVICE FOR AN IMMUNOASSAY AND METHOD FOR THEIR USE |
EP1901067A3 (en) * | 2004-08-03 | 2009-05-13 | On-Chip Cellomics Consortium | Cellomics system |
WO2006055735A2 (en) | 2004-11-16 | 2006-05-26 | Illumina, Inc | Scanner having spatial light modulator |
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US7604173B2 (en) | 2004-11-16 | 2009-10-20 | Illumina, Inc. | Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same |
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US7830575B2 (en) | 2006-04-10 | 2010-11-09 | Illumina, Inc. | Optical scanner with improved scan time |
US20080018894A1 (en) * | 2006-05-07 | 2008-01-24 | Zu Jianping Lily | Optical ball lens light scattering apparatus and method for use thereof |
US8012349B2 (en) * | 2006-11-20 | 2011-09-06 | Orbital Biosciences, Llc | Small volume unitary molded filters and supports for adsorbent beds |
DE102007020610A1 (en) * | 2007-04-30 | 2008-11-20 | Thomas Dr. Ruckstuhl | Container and method for detecting fluorescence |
DE102007033124B4 (en) * | 2007-07-16 | 2012-12-06 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device for the optical detection of substances in a liquid or gaseous medium |
US8405048B2 (en) * | 2008-02-07 | 2013-03-26 | Mitsui Engineering & Shipbuilding Co., Ltd. | Fluorescence detection device and fluorescence detection method |
EP2361375B1 (en) * | 2008-11-19 | 2018-10-10 | Postnova Analytics GmbH | Cell construction for scattered light detectors having self-focusing properties |
US7957002B2 (en) * | 2009-03-13 | 2011-06-07 | The Furukawa Electric Co., Ltd. | Method for optical measurement and optical measurement apparatus |
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CA2815951A1 (en) | 2010-11-03 | 2012-05-10 | Reametrix Inc. | Measurement system for fluorescent detection, and method therefor |
BR112014011912A2 (en) | 2011-11-16 | 2017-05-16 | Amgen Inc | method for treating a mammal that has a tumor |
WO2013136891A1 (en) * | 2012-03-12 | 2013-09-19 | オリンパス株式会社 | Spectroscopic device, spectroscopic lens and spectroscopic container |
DE102016113042A1 (en) * | 2016-07-15 | 2018-01-18 | B. Braun Melsungen Ag | Flow cell device for measuring fluid parameters |
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---|---|---|---|---|
US1716321A (en) * | 1927-05-26 | 1929-06-04 | Robert D Pearson | Lens |
US2798718A (en) * | 1951-10-26 | 1957-07-09 | William E Gross | Canister spring |
US3002092A (en) * | 1954-09-30 | 1961-09-26 | Donald S Cary | Optical system for infrared target tracking apparatus |
US2978718A (en) * | 1957-08-27 | 1961-04-11 | Service Metal Fabricators Inc | Vehicle wheel washing device |
US3025142A (en) * | 1959-10-30 | 1962-03-13 | Dale D Williams | Method and means of detecting ammonia and amine vapor |
US3492396A (en) * | 1967-03-13 | 1970-01-27 | Becton Dickinson Co | Agglutinate separation method and apparatus |
US3600063A (en) * | 1969-04-28 | 1971-08-17 | Thomas R Bowen | Varifocal beam spreader |
US3896217A (en) * | 1973-03-19 | 1975-07-22 | Summa Corp | Method and apparatus for radioimmunoassay with regeneration of immunoadsorbent |
US4036946A (en) * | 1975-10-20 | 1977-07-19 | Marcos Kleinerman | Immunofluorometric method for measuring minute quantities of antigens, antibodies and other substances |
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DE3424108A1 (en) * | 1984-06-29 | 1986-01-09 | Bernhard Prof. Dr.-Ing. 4300 Essen Schrader | SPECTROMETRY SAMPLE ARRANGEMENT, METHOD FOR MEASURING LUMINESCENCE AND SCATTERING AND USE OF THE SAMPLE ARRANGEMENT |
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US5372783A (en) * | 1992-08-03 | 1994-12-13 | Sapidyne, Inc. | Assay system |
-
1992
- 1992-08-03 US US07/924,720 patent/US5372783A/en not_active Expired - Lifetime
-
1993
- 1993-07-23 AT AT93918363T patent/ATE242996T1/en active
- 1993-07-23 DE DE69333050T patent/DE69333050T2/en not_active Expired - Lifetime
- 1993-07-23 WO PCT/US1993/006967 patent/WO1994003104A1/en active IP Right Grant
- 1993-07-23 JP JP50537394A patent/JP3534756B2/en not_active Expired - Lifetime
- 1993-07-23 EP EP93918363A patent/EP0606460B1/en not_active Expired - Lifetime
- 1993-07-23 CA CA002518356A patent/CA2518356C/en not_active Expired - Lifetime
- 1993-07-23 CA CA002120481A patent/CA2120481C/en not_active Expired - Lifetime
- 1993-07-23 DK DK93918363T patent/DK0606460T3/en active
-
1994
- 1994-06-24 US US08/265,648 patent/US6120734A/en not_active Expired - Lifetime
-
1995
- 1995-10-23 US US08/546,657 patent/US5554340A/en not_active Expired - Lifetime
-
2003
- 2003-09-29 JP JP2003337774A patent/JP2004069716A/en not_active Withdrawn
-
2005
- 2005-08-05 JP JP2005227435A patent/JP2005321416A/en not_active Withdrawn
-
2006
- 2006-05-23 JP JP2006143443A patent/JP4102837B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK0606460T3 (en) | 2003-10-13 |
DE69333050D1 (en) | 2003-07-24 |
WO1994003104A1 (en) | 1994-02-17 |
US5554340A (en) | 1996-09-10 |
JP2006258824A (en) | 2006-09-28 |
US5372783A (en) | 1994-12-13 |
EP0606460A4 (en) | 1994-12-07 |
CA2518356A1 (en) | 1994-02-17 |
ATE242996T1 (en) | 2003-07-15 |
EP0606460A1 (en) | 1994-07-20 |
JP3534756B2 (en) | 2004-06-07 |
JP2004069716A (en) | 2004-03-04 |
JP2005321416A (en) | 2005-11-17 |
CA2120481C (en) | 2005-12-20 |
JPH07500191A (en) | 1995-01-05 |
CA2518356C (en) | 2009-11-24 |
US6120734A (en) | 2000-09-19 |
DE69333050T2 (en) | 2004-05-27 |
EP0606460B1 (en) | 2003-06-18 |
JP4102837B2 (en) | 2008-06-18 |
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