CA2121230A1 - 1,3-dihydro-2h-imidazo(4,5-b) quinolin-2-one derivatives - Google Patents
1,3-dihydro-2h-imidazo(4,5-b) quinolin-2-one derivativesInfo
- Publication number
- CA2121230A1 CA2121230A1 CA002121230A CA2121230A CA2121230A1 CA 2121230 A1 CA2121230 A1 CA 2121230A1 CA 002121230 A CA002121230 A CA 002121230A CA 2121230 A CA2121230 A CA 2121230A CA 2121230 A1 CA2121230 A1 CA 2121230A1
- Authority
- CA
- Canada
- Prior art keywords
- 6alkyl
- compounds
- quinolin
- imidazo
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Novel 1,3-dihydro-2H-imidazo(4,5-b)quinolin-2-one derivatives of formu-la (I) wherein R is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl optionally sub-stituted with from 1 to 3 substituents each independently selected from halo, hydroxy, C1-6alkyloxy, C5-6cycloalkyloxy, C1-6alkyl or trifluoromethyl; pyr-idinyl; thienyl optionally substituted with halo or C1-6alkyl; and (.alpha.) is a radi-cal of formula (a), (b), or (c); the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, said compounds being potent inhibitors of both phosphodiesterase III and IV, which are useful in the treatment of aller-gic disorders, atopic diseases and related afflictions. Intermediates in the prepar-ation thereof. Pharmaceutical compositions containing said compounds as an active ingredient. Methods of preparing said compounds and pharmaceutical compositions.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78495591A | 1991-10-30 | 1991-10-30 | |
US07/784,955 | 1991-10-30 | ||
PCT/EP1992/002496 WO1993009118A1 (en) | 1991-10-30 | 1992-10-27 | 1,3-dihydro-2h-imidazo(4,5-b)quinolin-2-one derivatives as phosphodiesterase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2121230A1 true CA2121230A1 (en) | 1993-05-13 |
CA2121230C CA2121230C (en) | 2003-03-11 |
Family
ID=25134048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002121230A Expired - Lifetime CA2121230C (en) | 1991-10-30 | 1992-10-27 | 1,3-dihydro-2h-imidazo(4,5-b) quinolin-2-one derivatives |
Country Status (24)
Country | Link |
---|---|
US (3) | US5521187A (en) |
EP (2) | EP0610372B1 (en) |
JP (1) | JP3488922B2 (en) |
KR (1) | KR100251895B1 (en) |
CN (1) | CN1041726C (en) |
AT (1) | ATE131479T1 (en) |
AU (1) | AU660337B2 (en) |
CA (1) | CA2121230C (en) |
DE (1) | DE69206820T2 (en) |
DK (1) | DK0610372T3 (en) |
ES (1) | ES2083773T3 (en) |
FI (1) | FI105548B (en) |
GR (1) | GR3018909T3 (en) |
HU (1) | HU220608B1 (en) |
IL (1) | IL103570A (en) |
MX (1) | MX9206258A (en) |
NO (1) | NO300976B1 (en) |
NZ (1) | NZ244779A (en) |
PH (1) | PH31245A (en) |
PL (1) | PL170749B1 (en) |
RU (1) | RU2127273C1 (en) |
TW (1) | TW249234B (en) |
WO (1) | WO1993009118A1 (en) |
ZA (1) | ZA928373B (en) |
Families Citing this family (58)
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PH31245A (en) * | 1991-10-30 | 1998-06-18 | Janssen Pharmaceutica Nv | 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives. |
US5502177A (en) * | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
US5703827A (en) * | 1996-02-29 | 1997-12-30 | Monolithic System Technology, Inc. | Method and structure for generating a boosted word line voltage and a back bias voltage for a memory array |
US6028183A (en) | 1997-11-07 | 2000-02-22 | Gilead Sciences, Inc. | Pyrimidine derivatives and oligonucleotides containing same |
US6007992A (en) * | 1997-11-10 | 1999-12-28 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
BR0114253A (en) * | 2000-10-02 | 2003-07-01 | Janssen Pharmaceutica Nv | Metabotropic Glutamate Receptor Antagonists |
SE0100903D0 (en) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0100902D0 (en) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
CN1537018A (en) | 2001-05-23 | 2004-10-13 | 田边制药株式会社 | Therapeutic compositions for repairing chondropathy |
KR20040007596A (en) | 2001-05-23 | 2004-01-24 | 다나베 세이야꾸 가부시키가이샤 | Compositions for promoting healing of bone fracture |
SE0103710D0 (en) * | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
AU2003226737B2 (en) * | 2002-03-29 | 2008-09-04 | Janssen Pharmaceutica N.V. | Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands |
SE0202539D0 (en) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
GB0221246D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
JP2007502288A (en) | 2003-08-12 | 2007-02-08 | スリーエム イノベイティブ プロパティズ カンパニー | Oxime-substituted imidazo-containing compounds |
EP1658076B1 (en) | 2003-08-27 | 2013-03-06 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted imidazoquinolines |
AU2004270201A1 (en) | 2003-09-05 | 2005-03-17 | 3M Innovative Properties Company | Treatment for CD5+ B cell lymphoma |
US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
BRPI0414856A (en) | 2003-10-03 | 2006-11-21 | 3M Innovative Properties Co | alkoxy-substituted imidazoquinolines |
CA2545774A1 (en) | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | Oxime substituted imidazo ring compounds |
WO2005048945A2 (en) | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | Hydroxylamine substituted imidazo ring compounds |
US8691837B2 (en) | 2003-11-25 | 2014-04-08 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
WO2005066170A1 (en) | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Arylalkenyl and arylalkynyl substituted imidazoquinolines |
US8735421B2 (en) | 2003-12-30 | 2014-05-27 | 3M Innovative Properties Company | Imidazoquinolinyl sulfonamides |
US20050203156A1 (en) * | 2004-03-12 | 2005-09-15 | Wyeth | Hydantoins having RNase modulatory activity |
WO2005094531A2 (en) | 2004-03-24 | 2005-10-13 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
WO2005123080A2 (en) | 2004-06-15 | 2005-12-29 | 3M Innovative Properties Company | Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
WO2006009826A1 (en) | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
WO2006065280A2 (en) | 2004-06-18 | 2006-06-22 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods |
WO2006038923A2 (en) | 2004-06-18 | 2006-04-13 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
SE0401762D0 (en) * | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
SE0403086D0 (en) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
SE0403085D0 (en) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
WO2006074003A2 (en) | 2004-12-30 | 2006-07-13 | 3M Innovative Properties Company | CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS |
CA2594674C (en) | 2004-12-30 | 2016-05-17 | 3M Innovative Properties Company | Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds |
US9248127B2 (en) | 2005-02-04 | 2016-02-02 | 3M Innovative Properties Company | Aqueous gel formulations containing immune response modifiers |
US7968563B2 (en) | 2005-02-11 | 2011-06-28 | 3M Innovative Properties Company | Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods |
EP1869043A2 (en) | 2005-04-01 | 2007-12-26 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridine-1,4-diamines and analogs thereof |
AU2006232375A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
EP1942879A1 (en) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
JP2009536669A (en) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | Neurogenesis by angiotensin regulation |
JP2009536667A (en) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | 5HT receptor-mediated neurogenesis |
US7906506B2 (en) | 2006-07-12 | 2011-03-15 | 3M Innovative Properties Company | Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
TW200831488A (en) * | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
EP1969929A1 (en) | 2007-03-12 | 2008-09-17 | Bayer CropScience AG | Substituted phenylamidines and their use as fungicides |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
WO2014055586A1 (en) | 2012-10-02 | 2014-04-10 | California Institute Of Technology | Transition-metal free reductive cleavage of aromatic c-o, c-n, and c-s bonds by activated silanes |
WO2014055587A1 (en) | 2012-10-02 | 2014-04-10 | California Institute Of Techonolgy | Transition-metal-free silylation of aromatic compounds |
US9809607B2 (en) | 2014-08-06 | 2017-11-07 | California Institute Of Technology | Silylation of aromatic heterocycles by earth abundant transition-metal-free catalysts |
CN106661059B (en) | 2014-09-02 | 2019-08-06 | 加州理工学院 | The base catalysis of terminal alkyne c h bond it is silylated |
WO2016100606A1 (en) | 2014-12-19 | 2016-06-23 | California Institute Of Technology | Silylation of aromatic heterocycles by disilanes using potassium alkoxide catalysts |
CN110441434A (en) * | 2019-08-29 | 2019-11-12 | 重庆华邦胜凯制药有限公司 | The method of related impurities in GC-MS separation determination PAS |
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GB1602188A (en) * | 1977-12-01 | 1981-11-11 | Wellcome Found | Hydantoin derivatives |
JPS6021941B2 (en) * | 1981-01-28 | 1985-05-30 | 株式会社村田製作所 | Piezoelectric porcelain composition |
US4668686A (en) * | 1985-04-25 | 1987-05-26 | Bristol-Myers Company | Imidazoquinoline antithrombrogenic cardiotonic agents |
US4775674A (en) * | 1986-05-23 | 1988-10-04 | Bristol-Myers Company | Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors |
US4701459A (en) * | 1986-07-08 | 1987-10-20 | Bristol-Myers Company | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation |
US5306822A (en) * | 1988-05-25 | 1994-04-26 | Warner-Lambert Company | Arylmethylenyl derivatives of oxazolidinone |
NZ234186A (en) * | 1989-07-07 | 1991-10-25 | Janssen Pharmaceutica Nv | Imidazo quinazolin-one derivatives and pharmaceutical compositions |
CN1030196C (en) * | 1989-07-07 | 1995-11-01 | 詹森药业有限公司 | Positive inotropic and lusitropic 3,5-dihydro-imidazo [2,1-6] quinazolin-2(1H)-one derivatives |
US5043327A (en) * | 1989-07-18 | 1991-08-27 | Janssen Pharmaceutica N.V. | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use |
US4943573A (en) * | 1989-11-01 | 1990-07-24 | Bristol-Myers Squibb Company | Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility |
WO1991007177A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders |
PH31245A (en) * | 1991-10-30 | 1998-06-18 | Janssen Pharmaceutica Nv | 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives. |
-
1992
- 1992-10-13 PH PH45100A patent/PH31245A/en unknown
- 1992-10-16 NZ NZ244779A patent/NZ244779A/en unknown
- 1992-10-22 TW TW081108413A patent/TW249234B/zh active
- 1992-10-27 US US08/204,412 patent/US5521187A/en not_active Expired - Lifetime
- 1992-10-27 DK DK92923030.8T patent/DK0610372T3/en active
- 1992-10-27 ES ES92923030T patent/ES2083773T3/en not_active Expired - Lifetime
- 1992-10-27 AU AU29083/92A patent/AU660337B2/en not_active Expired
- 1992-10-27 JP JP50815493A patent/JP3488922B2/en not_active Expired - Lifetime
- 1992-10-27 DE DE69206820T patent/DE69206820T2/en not_active Expired - Lifetime
- 1992-10-27 EP EP92923030A patent/EP0610372B1/en not_active Expired - Lifetime
- 1992-10-27 HU HU9401245A patent/HU220608B1/en not_active IP Right Cessation
- 1992-10-27 EP EP92203295A patent/EP0541153A1/en active Pending
- 1992-10-27 AT AT92923030T patent/ATE131479T1/en not_active IP Right Cessation
- 1992-10-27 KR KR1019940701365A patent/KR100251895B1/en not_active IP Right Cessation
- 1992-10-27 WO PCT/EP1992/002496 patent/WO1993009118A1/en active IP Right Grant
- 1992-10-27 RU RU94019971/04A patent/RU2127273C1/en not_active IP Right Cessation
- 1992-10-27 PL PL92303446A patent/PL170749B1/en unknown
- 1992-10-27 CA CA002121230A patent/CA2121230C/en not_active Expired - Lifetime
- 1992-10-28 IL IL10357092A patent/IL103570A/en not_active IP Right Cessation
- 1992-10-29 MX MX9206258A patent/MX9206258A/en unknown
- 1992-10-29 ZA ZA928373A patent/ZA928373B/en unknown
- 1992-10-30 CN CN92112391A patent/CN1041726C/en not_active Expired - Fee Related
-
1994
- 1994-04-25 NO NO941497A patent/NO300976B1/en not_active IP Right Cessation
- 1994-04-29 FI FI942010A patent/FI105548B/en not_active IP Right Cessation
-
1995
- 1995-04-18 US US08/423,116 patent/US5516908A/en not_active Expired - Lifetime
- 1995-04-18 US US08/423,920 patent/US5541325A/en not_active Expired - Lifetime
-
1996
- 1996-02-07 GR GR960400315T patent/GR3018909T3/en unknown
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