CA2121696A1 - Fingerprinting bacterial strains using repetitive dna sequence amplification - Google Patents

Fingerprinting bacterial strains using repetitive dna sequence amplification

Info

Publication number
CA2121696A1
CA2121696A1 CA002121696A CA2121696A CA2121696A1 CA 2121696 A1 CA2121696 A1 CA 2121696A1 CA 002121696 A CA002121696 A CA 002121696A CA 2121696 A CA2121696 A CA 2121696A CA 2121696 A1 CA2121696 A1 CA 2121696A1
Authority
CA
Canada
Prior art keywords
bacteria
fingerprinting
primers
dna sequence
variety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002121696A
Other languages
French (fr)
Other versions
CA2121696C (en
Inventor
James R. Lupski
Thearith Koeuth
James Versalovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
James R. Lupski
Thearith Koeuth
James Versalovic
Baylor College Of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by James R. Lupski, Thearith Koeuth, James Versalovic, Baylor College Of Medicine filed Critical James R. Lupski
Publication of CA2121696A1 publication Critical patent/CA2121696A1/en
Application granted granted Critical
Publication of CA2121696C publication Critical patent/CA2121696C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Abstract

Oligonucleotide primers and methods for indentifying strains of bacteria by genomic fingerprinting are described. The methods are applicable to a variety of samples. The tasting procedure includes amplifying the bacterial DNA in the sample to be tested by adding a pair of outwardly-directed primers to the sample. The primers are capable of hybridizing to repetitive DNA
sequences in the bacterial DNA and extending outwardly from one hybridizable repetitive sequence to another hybridizable re-petitive sequence. After amplification the extension products are separated by size and the specific strain of bacteria is deter-mined by measuring the pattern of sized extension products. The procedure to identify strains of bacteria by fingerprinting has a variety of uses including: identifying bacteria in infections, agriculture and horticulture plots, bioremediation, food monitoring, production monitoring, quality assurance and quality control.
CA002121696A 1991-10-23 1992-10-21 Fingerprinting bacterial strains using repetitive dna sequence amplification Expired - Lifetime CA2121696C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78142491A 1991-10-23 1991-10-23
US781,424 1991-10-23
PCT/US1992/009230 WO1993008297A1 (en) 1991-10-23 1992-10-21 Fingerprinting bacterial strains using repetitive dna sequence amplification

Publications (2)

Publication Number Publication Date
CA2121696A1 true CA2121696A1 (en) 1993-04-29
CA2121696C CA2121696C (en) 2003-07-08

Family

ID=25122697

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002121696A Expired - Lifetime CA2121696C (en) 1991-10-23 1992-10-21 Fingerprinting bacterial strains using repetitive dna sequence amplification

Country Status (9)

Country Link
US (2) US5691136A (en)
EP (1) EP0610396B1 (en)
AT (1) ATE198773T1 (en)
AU (1) AU2931692A (en)
CA (1) CA2121696C (en)
DE (1) DE69231646T2 (en)
DK (1) DK0610396T3 (en)
ES (1) ES2152933T3 (en)
WO (1) WO1993008297A1 (en)

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Also Published As

Publication number Publication date
EP0610396B1 (en) 2001-01-17
EP0610396A4 (en) 1997-01-08
ATE198773T1 (en) 2001-02-15
ES2152933T3 (en) 2001-02-16
EP0610396A1 (en) 1994-08-17
US5523217A (en) 1996-06-04
DE69231646T2 (en) 2001-06-13
CA2121696C (en) 2003-07-08
WO1993008297A1 (en) 1993-04-29
AU2931692A (en) 1993-05-21
US5691136A (en) 1997-11-25
DE69231646D1 (en) 2001-02-22
DK0610396T3 (en) 2001-01-29

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