CA2123133A1 - Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system - Google Patents

Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system

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Publication number
CA2123133A1
CA2123133A1 CA002123133A CA2123133A CA2123133A1 CA 2123133 A1 CA2123133 A1 CA 2123133A1 CA 002123133 A CA002123133 A CA 002123133A CA 2123133 A CA2123133 A CA 2123133A CA 2123133 A1 CA2123133 A1 CA 2123133A1
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Prior art keywords
donor
chromophores
fluorophores
hybridization
energy transfer
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CA002123133A
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French (fr)
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CA2123133C (en
Inventor
Michael J. Heller
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Nanogen Inc
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Individual
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    • Y10T436/13—Tracers or tags

Abstract

The present invention contemplates chromophore-containing polynucleotides having at least two donor chromophores operatively linked to the polynucleotide by linker arms, such that the chromophores are positioned by linkage along the length of the polynucleotide at a donor-donor transfer distance, and at least one, fluorescing acceptor chromophore operatively linked to the polynucleotide by a linker arm, such that the fluorescing acceptor chromophore is positioned by linkage at a donor-acceptor transfer distance from at least one of the donor chromophores, to form a photonic structure for collecting photonic energy and transferring the energy to an acceptor chromophore, and methods using the photonic structures.
CA002123133A 1991-11-07 1992-11-06 Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system Expired - Fee Related CA2123133C (en)

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US79026291A 1991-11-07 1991-11-07
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Families Citing this family (382)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395492B1 (en) * 1990-01-11 2002-05-28 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US7273749B1 (en) * 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US6197508B1 (en) 1990-09-12 2001-03-06 Affymetrix, Inc. Electrochemical denaturation and annealing of nucleic acid
DE69233391D1 (en) 1991-11-07 2004-09-02 Nanotronics Inc Hybridization of polynucleotides conjugated with chromophores and fluorophores to create a donor-donor energy transfer system
US6652808B1 (en) 1991-11-07 2003-11-25 Nanotronics, Inc. Methods for the electronic assembly and fabrication of devices
US6569382B1 (en) 1991-11-07 2003-05-27 Nanogen, Inc. Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US6048690A (en) * 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US5787032A (en) * 1991-11-07 1998-07-28 Nanogen Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group
US7314708B1 (en) * 1998-08-04 2008-01-01 Nanogen, Inc. Method and apparatus for electronic synthesis of molecular structures
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US7101661B1 (en) 1993-11-01 2006-09-05 Nanogen, Inc. Apparatus for active programmable matrix devices
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5654419A (en) * 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
DE69507289T2 (en) 1994-03-15 1999-07-08 Scient Generics Ltd ELECTROCHEMICAL DENATUSING OF DOUBLE-STRANDED NUCLEIC ACID
US20070269799A9 (en) * 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
WO1996025518A1 (en) * 1995-02-17 1996-08-22 The Society For Techno-Innovation Of Agriculture, Foresty And Fisheries Probe for use in nucleic acid analysis and detecting method
US6008373A (en) 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
US6127127A (en) * 1995-06-27 2000-10-03 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6132971A (en) * 1995-06-27 2000-10-17 The University Of North Carolina At Chapel Hill Microelectronic device
US5968745A (en) * 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
US6387625B1 (en) 1995-06-27 2002-05-14 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6180346B1 (en) 1995-06-27 2001-01-30 The Universtiy Of North Carolina At Chapel Hill Electropolymerizable film, and method of making and use thereof
US6361951B1 (en) * 1995-06-27 2002-03-26 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
US6346387B1 (en) * 1995-06-27 2002-02-12 Xanthon, Inc. Detection of binding reactions using labels detected by mediated catalytic electrochemistry
US5876830A (en) * 1995-09-08 1999-03-02 Board Of Regents Of The University Of Colorado Method of assembly of molecular-sized nets and scaffolding
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US5728528A (en) * 1995-09-20 1998-03-17 The Regents Of The University Of California Universal spacer/energy transfer dyes
US20040086917A1 (en) * 1995-09-27 2004-05-06 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US10640425B2 (en) 1996-01-19 2020-05-05 Romeo Ilarian Ciuperca Method for predetermined temperature profile controlled concrete curing container and apparatus for same
DE69738687D1 (en) * 1996-04-12 2008-06-26 Phri Properties Inc PROBES, KITS AND ASSAYS
AU2735797A (en) * 1996-04-12 1998-03-26 Public Health Research Institute Of The City Of New York, Inc., The Detection probes, kits and assays
US7825237B2 (en) * 1996-05-03 2010-11-02 Applied Biosystems, Llc Oligonucleotides and analogs labeled with energy transfer dyes
US5945526A (en) 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US7388092B2 (en) 1996-05-03 2008-06-17 Applera Corporation Oligonucleotides and analogs labeled with energy transfer dyes
US6355436B1 (en) 1996-05-17 2002-03-12 L'ecole Centrale De Lyon Method for analyzing biological substances in a conductive liquid medium
ATE318327T1 (en) * 1996-06-04 2006-03-15 Univ Utah Res Found FLUORESCENCE-DONOR-ACCEPTOR PAIR
JP3400650B2 (en) * 1996-06-28 2003-04-28 株式会社日立製作所 Electrophoretic separation detection method and apparatus
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5910410A (en) * 1996-09-06 1999-06-08 Hewlett-Packard Company Dual tag binding assay
WO1998013524A1 (en) * 1996-09-27 1998-04-02 Laboratory Of Molecular Biophotonics Probes for detecting polynucleotides and detection method
AT405103B (en) * 1996-10-16 1999-05-25 Avl Verbrennungskraft Messtech SENSOR LAYER FOR QUANTITATIVE DETERMINATION OF AT LEAST ONE CHEMICAL COMPONENT OF A GASEOUS OR LIQUID SAMPLE
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US6706473B1 (en) 1996-12-06 2004-03-16 Nanogen, Inc. Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
CA2276462C (en) * 1996-12-31 2007-06-12 Genometrix Incorporated Multiplexed molecular analysis system apparatus and method
EP1666609B1 (en) * 1997-02-28 2012-09-26 Quest Diagnostics Investments Incorporated Fluorescence energy transfer by competitive hybridization
US7803528B1 (en) 1997-02-28 2010-09-28 Quest Diagnostics Incorporated Fluorescence energy transfer by competitive hybridization
US6391558B1 (en) 1997-03-18 2002-05-21 Andcare, Inc. Electrochemical detection of nucleic acid sequences
GB9707996D0 (en) * 1997-04-21 1997-06-11 Univ Cambridge Tech Screening
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
JPH1189598A (en) * 1997-09-18 1999-04-06 Hitachi Software Eng Co Ltd Fluorescence labeled probe and hybridization detection method
US20030219803A1 (en) * 1997-12-15 2003-11-27 Somalogic, Incorporated Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
AU3909199A (en) 1997-12-15 1999-07-05 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
US20030039967A1 (en) * 1997-12-19 2003-02-27 Kris Richard M. High throughput assay system using mass spectrometry
US20100105572A1 (en) * 1997-12-19 2010-04-29 Kris Richard M High throughput assay system
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6365346B1 (en) * 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
US6582962B1 (en) * 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6230306B1 (en) 1998-04-17 2001-05-08 Lsi Logic Corporation Method and apparatus for minimization of process defects while routing
US7875440B2 (en) * 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) * 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US8198096B2 (en) * 1998-05-05 2012-06-12 Massachusetts Institute Of Technology Emissive polymers and devices incorporating these polymers
WO1999057222A1 (en) * 1998-05-05 1999-11-11 Massachusetts Institute Of Technology Emissive polymers and devices incorporating these polymers
US20050147534A1 (en) * 1998-05-05 2005-07-07 Massachusetts Institute Of Technology Emissive sensors and devices incorporating these sensors
US6331633B1 (en) 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
US6624197B1 (en) 1998-05-08 2003-09-23 Calyx Therapeutics, Inc. Diphenylethylene compounds
US7105552B2 (en) 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6245814B1 (en) 1998-05-08 2001-06-12 Calyx Therapeutics, Inc. Diphenylethylene compounds
US6768000B1 (en) * 1998-06-12 2004-07-27 Intergen Company Multi-fluorescent hairpin energy transfer oligonucleotides
GB9812768D0 (en) * 1998-06-13 1998-08-12 Zeneca Ltd Methods
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6037130A (en) * 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
DE19840531C2 (en) * 1998-08-28 2003-05-15 Roboscreen Ges Fuer Molekulare Reaction spaces coated with nucleic acids, processes for their preparation and their use
GB9819418D0 (en) * 1998-09-07 1998-10-28 Secr Defence Amplification method
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
US7160869B2 (en) * 1998-12-16 2007-01-09 University Of Saskatchewan Biologically active metal-containing nucleic acids
US7468250B2 (en) * 1998-12-23 2008-12-23 Rutgers, The State University Of New Jersey Methods and kits for screening nucleic acid duplex stability
US6815163B1 (en) * 1998-12-23 2004-11-09 Rutgers, The State University Methods and kits for screening nucleic acid duplex stability
US6833267B1 (en) * 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US20050026209A1 (en) * 1999-01-08 2005-02-03 Vann Charles S. Optical fiber bundle for detecting binding of chemical species
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
US6635470B1 (en) 1999-01-08 2003-10-21 Applera Corporation Fiber array and methods for using and making same
WO2000047600A1 (en) * 1999-02-10 2000-08-17 University Of Maryland Photo-induced nucleic acid hybridization
US6294063B1 (en) * 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US6238909B1 (en) * 1999-05-04 2001-05-29 Motorola, Inc. Method and apparatus for obtaining electric field-enhanced bioconjugation
WO2000079009A2 (en) * 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US7501245B2 (en) * 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
AU6105200A (en) * 1999-07-15 2001-02-05 Trid Store Ip, L.L.C. Multilayer fluorescent optical disc with photosensitive fluorescent material
ES2319380T3 (en) 1999-07-26 2009-05-07 Clinical Micro Sensors, Inc. DETERMINATION OF NUCLEIC ACID SEQUENCES USING ELECTRONIC DETECTION.
US6506887B1 (en) * 1999-07-29 2003-01-14 Somalogic, Incorporated Conditional-selex
US6358684B1 (en) * 1999-08-27 2002-03-19 Pe Corporation UV excitable fluorescent energy transfer dyes
US20080108825A1 (en) * 1999-11-08 2008-05-08 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US6525093B1 (en) * 1999-11-08 2003-02-25 Calyx Therapeutics Inc. Compounds to treat diabetes and associated conditions
US20020002200A1 (en) * 2000-02-04 2002-01-03 Bishwagit Nag Novel diphenylethylene compounds
US7323496B2 (en) * 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US6727356B1 (en) * 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US20040081959A9 (en) * 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
CN1250741C (en) * 2000-02-03 2006-04-12 研究发展基金会 Signaling aptamers that transducer molecular recognition to a differential signal
US20080103302A1 (en) * 2000-02-04 2008-05-01 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
AU4345401A (en) * 2000-03-06 2001-09-17 Ribozyme Pharmaceuticals, Inc. Nucleic acid sensor molecules
US7455975B2 (en) * 2000-04-14 2008-11-25 Esa Biosciences, Inc. Electrochemical detection of nucleic acid sequences
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
DE60138196D1 (en) * 2000-08-21 2009-05-14 Massachusetts Inst Technology COMPOSITION INCLUDING IPTYCEN POLYMERS WITH LARGE FREE INTERNAL VOLUME
WO2002018660A2 (en) 2000-08-31 2002-03-07 Mayo Foundation For Medical Education And Research Detection of varicella-zoster virus
US20040185464A1 (en) * 2000-09-15 2004-09-23 Kris Richard M. High throughput assay system
US6815164B2 (en) 2000-10-06 2004-11-09 Nugen Technologies, Inc. Methods and probes for detection and/or quantification of nucleic acid sequences
WO2002047266A2 (en) * 2000-10-20 2002-06-13 The Board Of Trustees Of The Leland Stanford Junior University Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample
DE60142709D1 (en) 2000-12-13 2010-09-09 Nugen Technologies Inc METHODS AND COMPOSITIONS FOR GENERATING A VARIETY OF COPIES OF NUCLEIC ACID SEQUENCES AND METHODS OF DETECTING THE SAME
NZ527128A (en) * 2000-12-27 2005-11-25 Invitrogen Corp Primers and methods for the detection and discrimination of nucleic acids
DE60236068D1 (en) * 2001-01-31 2010-06-02 Mayo Foundation PROOF OF HERPEX SIMPLEX VIRUS
US20030165866A1 (en) * 2001-01-31 2003-09-04 Cockerill Franklin R. Detection of bordetella
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US20040067511A1 (en) * 2001-02-27 2004-04-08 Thomas David C. Circular probe amplification (cpa) using energy-transfer primers
ZA200210369B (en) 2001-03-09 2004-07-08 Nugen Technologies Inc Methods and compositions for amplification or RNA sequences.
US7270786B2 (en) 2001-03-28 2007-09-18 Handylab, Inc. Methods and systems for processing microfluidic samples of particle containing fluids
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7192557B2 (en) 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
ATE408710T1 (en) * 2001-05-07 2008-10-15 Mayo Foundation DETECTION OF LEGIONELLA BY A METHOD USING PCR AND FRET
CA2447089A1 (en) * 2001-05-24 2002-11-28 University Of Saskatchewan Technologies Inc. Nucleic acid circuit elements and methods
AU2002327184A1 (en) * 2001-06-27 2003-03-03 The Uab Research Foundation Biophotonic sensors and methods of use thereof
DE10133308A1 (en) * 2001-07-12 2003-01-23 Praenadia Gmbh Identifying target cells, useful e.g. for prenatal diagnosis, comprises hybridizing a cellular nucleic acid with energy-transfer donor and acceptor probes
US20030022150A1 (en) * 2001-07-24 2003-01-30 Sampson Jeffrey R. Methods for detecting a target molecule
US20030148314A1 (en) * 2001-08-01 2003-08-07 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of colon cancer
US6593091B2 (en) * 2001-09-24 2003-07-15 Beckman Coulter, Inc. Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer
US7774711B2 (en) 2001-09-28 2010-08-10 Aol Inc. Automatic categorization of entries in a contact list
US20030082563A1 (en) * 2001-10-15 2003-05-01 Bell Constance A. Detection of bacillus anthracis
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
US20040086924A1 (en) * 2001-10-26 2004-05-06 Research Development Foundation In vitro selection of signaling aptamers
ATE328119T1 (en) * 2001-11-02 2006-06-15 Roche Diagnostics Gmbh DETECTION OF VARIOLA VIRUS
DE10153829A1 (en) * 2001-11-05 2003-05-28 Bayer Ag Assay based on doped nanoparticles
US20030124599A1 (en) * 2001-11-14 2003-07-03 Shiping Chen Biochemical analysis system with combinatorial chemistry applications
US7462325B2 (en) * 2001-11-30 2008-12-09 Nomadics, Inc. Luminescent polymer particles
US7432371B2 (en) * 2002-02-07 2008-10-07 Covalent Partners, Llc Nanofilm and membrane compositions
US20040034223A1 (en) * 2002-02-07 2004-02-19 Covalent Partners, Llc. Amphiphilic molecular modules and constructs based thereon
US6593093B1 (en) * 2002-02-20 2003-07-15 Mayo Foundation For Medical Education And Research Detection of group a Streptococcus
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US20050065330A1 (en) * 2002-04-24 2005-03-24 The Cleveland Clinic Foundation Identification of Histoplasma capsulatum using a PCR assay
US20030215814A1 (en) * 2002-05-17 2003-11-20 Cockerill Franklin R. Detection of Shiga toxin- or Shiga-like toxin-producing organisms
JP4457001B2 (en) * 2002-05-31 2010-04-28 セクレタリー・デパートメント・オブ・アトミック・エナジー MET / FRET based method for target nucleic acid detection in which donor / acceptor moieties are on complementary strands
WO2003106637A2 (en) * 2002-06-12 2003-12-24 Datascope Investment Corp. Polymeric label molecules
US7041910B2 (en) * 2002-07-15 2006-05-09 Massachusetts Institute Of Technology Emissive, high charge transport polymers
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
EP1389638A1 (en) * 2002-08-06 2004-02-18 Roche Diagnostics GmbH Improved fluorescent resonance energy transfer probes
EP1403382A3 (en) * 2002-08-06 2004-05-06 Roche Diagnostics GmbH Improved fluorescent resonance energy transfer probes
US20040106741A1 (en) * 2002-09-17 2004-06-03 Kriesel Joshua W. Nanofilm compositions with polymeric components
CA2498320A1 (en) * 2002-09-20 2004-04-01 Integrated Dna Technologies, Inc. Anthraquinone quencher dyes, their methods of preparation and use
US7074598B2 (en) * 2002-09-25 2006-07-11 Mayo Foundation For Medical Education And Research Detection of vancomycin-resistant enterococcus spp.
US7365176B2 (en) * 2002-09-26 2008-04-29 Mayo Foundation For Medical Education And Research Detection of Epstein-Barr virus
US7074599B2 (en) * 2002-09-27 2006-07-11 Mayo Foundation For Medical Education And Research Detection of mecA-containing Staphylococcus spp.
US20070184453A1 (en) * 2002-10-02 2007-08-09 Roche Molecular Systems, Inc Fret process
EP1405920A3 (en) * 2002-10-02 2004-04-14 Roche Diagnostics GmbH Improved FRET process
US20040101860A1 (en) * 2002-11-27 2004-05-27 Jones Alison M. Predicting animal performance
US20040259226A1 (en) * 2003-05-30 2004-12-23 Robey W. Wade Monitoring for and detecting microbes used in bioterrorism
US20040121337A1 (en) * 2002-12-19 2004-06-24 Nomadics, Inc. Luminescent polymers and methods of use thereof
US7560231B2 (en) * 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
WO2004063339A2 (en) 2003-01-08 2004-07-29 Lesley Davenport G-quadruplex binding assays and compounds therefor
CN100439515C (en) * 2003-03-03 2008-12-03 清华大学 Laboratory nucleic acid analyzing chip system and its application
US20040185446A1 (en) * 2003-03-18 2004-09-23 Jones Alison M. Cpn60 targets for quantification of microbial species
US7282331B2 (en) * 2003-03-18 2007-10-16 Advandx, Inc. Method for improved specificity in probe based assays
US20040185434A1 (en) * 2003-03-21 2004-09-23 Robey W. Wade Detecting microbial contamination in animal by-products
US20040185454A1 (en) * 2003-03-21 2004-09-23 Jones Alison M. Identification and quantification of microbial species in a sample
CA2463719A1 (en) * 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
WO2004092418A2 (en) 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
PT1626714E (en) 2003-05-20 2007-08-24 Bayer Pharmaceuticals Corp Diaryl ureas for diseases mediated by pdgfr
US20040241662A1 (en) * 2003-05-30 2004-12-02 Robey W. Wade Detecting microbial contamination in grain and related products
US20050170367A1 (en) * 2003-06-10 2005-08-04 Quake Stephen R. Fluorescently labeled nucleoside triphosphates and analogs thereof for sequencing nucleic acids
EP2308889B1 (en) 2003-06-20 2018-05-23 Mayo Foundation For Medical Education And Research Isoforms of brain natriuretic peptide
WO2005003373A2 (en) * 2003-06-26 2005-01-13 Proligo, Llc Fluorogenic nucleic acid probes including lna for methods to detect and/or quantify nucleic acid analytes
GB0315121D0 (en) * 2003-06-27 2003-08-06 Matforsk Norwegian Food Res In Methods of nucleic acid analysis
EP2402089A1 (en) 2003-07-31 2012-01-04 Handylab, Inc. Processing particle-containing samples
US20060040275A1 (en) * 2003-10-16 2006-02-23 David Rosmarin C-shaped probe
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US7439341B2 (en) 2003-11-14 2008-10-21 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
WO2005054441A2 (en) * 2003-12-01 2005-06-16 California Institute Of Technology Device for immobilizing chemical and biomedical species and methods of using same
ATE557100T1 (en) 2003-12-03 2012-05-15 Abbott Lab DOUBLE STRANDED LINEAR NUCLEIC ACID PROBE AND USE THEREOF
EP2251441B1 (en) 2004-02-10 2013-05-08 F. Hoffmann-La Roche AG Detection of parvovirus B19
DE602005020421D1 (en) 2004-02-19 2010-05-20 Helicos Biosciences Corp METHOD FOR THE ANALYSIS OF POLYNUCLEOTIDE SEQUENCES
US20060046258A1 (en) * 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
KR100906749B1 (en) * 2004-03-25 2009-07-09 (주)바이오니아 Methods for Detecting Nucleic Acid Amplification Using Probe Labeled with Intercalating Dye
US20050233332A1 (en) * 2004-04-14 2005-10-20 Collis Matthew P Multiple fluorophore detector system
US20050239085A1 (en) * 2004-04-23 2005-10-27 Buzby Philip R Methods for nucleic acid sequence determination
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
EP2345739B8 (en) 2004-05-03 2016-12-07 Handylab, Inc. A microfluidic device for processing polynucleotide-containing samples
US20070117104A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US7476734B2 (en) * 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US20070117103A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US7635562B2 (en) * 2004-05-25 2009-12-22 Helicos Biosciences Corporation Methods and devices for nucleic acid sequence determination
EP3144066A1 (en) 2004-05-28 2017-03-22 Board of Regents, The University of Texas System Programmable fluidic processors
US8655370B2 (en) * 2004-06-25 2014-02-18 Qualcomm Incorporated Geographical location information sharing among wireless devices
KR100724314B1 (en) 2004-07-22 2007-06-04 주식회사 엘지생명과학 Ball shaped photonic crystal attaching with bioreceptor, preparation method thereof and using method thereof
US20060024678A1 (en) * 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
FR2874811B1 (en) * 2004-09-03 2006-11-24 Anteis Sa ANTIPHOTOPHOBIC OCULAR DEVICE AND METHOD FOR PREPARING THE SAME
WO2006034081A2 (en) 2004-09-17 2006-03-30 Massachusetts Institute Of Technology Polymers for analyte detection
US7828954B2 (en) * 2004-09-21 2010-11-09 Gamida For Life B.V. Electrode based patterning of thin film self-assembled nanoparticles
SG155995A1 (en) 2004-09-24 2009-10-29 Ingeneus Inc Genomic assay
US20060067889A1 (en) * 2004-09-27 2006-03-30 Light Sciences Corporation Singlet oxygen photosensitizers activated by target binding enhancing the selectivity of targeted PDT agents
ES2391744T3 (en) 2004-11-01 2012-11-29 George Mason University Compositions and procedures for diagnosing colon disorders
US20060118754A1 (en) * 2004-12-08 2006-06-08 Lapen Daniel C Stabilizing a polyelectrolyte multilayer
US7220549B2 (en) * 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US20060172328A1 (en) * 2005-01-05 2006-08-03 Buzby Philip R Methods and compositions for correcting misincorporation in a nucleic acid synthesis reaction
US7482120B2 (en) * 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US20090203547A1 (en) * 2005-02-18 2009-08-13 Albert Banes Gene and Cognate Protein Profiles and Methods to Determine Connective Tissue Markers in Normal and Pathologic Conditions
JP2006246854A (en) * 2005-03-14 2006-09-21 Kyoto Univ Method for detecting gene utilizing photosensitized reduction reaction and kit for detecting the gene
DE102005000021A1 (en) * 2005-03-16 2006-09-21 Köhler, Thomas, Dr. Method and test kit for the detection of target nucleic acids
US20070026423A1 (en) * 2005-03-16 2007-02-01 Thomas Koehler Method and test kit for the detection of target nucleic acids
WO2006127507A2 (en) 2005-05-20 2006-11-30 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
US20060263790A1 (en) * 2005-05-20 2006-11-23 Timothy Harris Methods for improving fidelity in a nucleic acid synthesis reaction
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
WO2007030759A2 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
US7569367B2 (en) 2005-09-07 2009-08-04 Roche Diagnostics Operations, Inc. Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy
CN101321878B (en) * 2005-10-05 2013-03-27 霍夫曼-拉罗奇有限公司 Non-fluorescent energy transfer
US8123834B2 (en) 2005-10-06 2012-02-28 The Board Of Trustees Of The University Of Illinois High gain selective metal organic framework preconcentrators
US20070128610A1 (en) * 2005-12-02 2007-06-07 Buzby Philip R Sample preparation method and apparatus for nucleic acid sequencing
US7981606B2 (en) * 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
US20080309926A1 (en) * 2006-03-08 2008-12-18 Aaron Weber Systems and methods for reducing detected intensity non uniformity in a laser beam
US7397546B2 (en) * 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
EP2001990B1 (en) 2006-03-24 2016-06-29 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US20070238093A1 (en) * 2006-04-11 2007-10-11 Espy Mark J Detection of influenza A virus
US20070238095A1 (en) * 2006-04-11 2007-10-11 Mayo Foundation For Medical Education And Research , A Minnesota Corporation Detection of Influenza A Virus
WO2008057140A2 (en) * 2006-04-14 2008-05-15 The Board Of Trustees Of The University Of Illinois Rapid metal organic framework molecule synthesis method
GB0609370D0 (en) * 2006-05-11 2006-06-21 Mock Graham A Process for cross-linking macromolecules
US8158437B2 (en) * 2006-08-04 2012-04-17 Massachusetts Institute Of Technology Luminescent detection of hydrazine and hydrazine derivatives
BRPI0716416A2 (en) 2006-08-08 2016-10-11 Mayo Foundation substantially pure polypeptide between 37 and 47 amino acid in length, isolated nucleic acid, vector: host cell and pharmaceutical composition
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US8084443B2 (en) 2007-10-01 2011-12-27 Longhorn Vaccines & Diagnostics Llc Biological specimen collection and transport system and methods of use
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US8652782B2 (en) 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
US8283423B2 (en) 2006-09-29 2012-10-09 Massachusetts Institute Of Technology Polymer synthetic technique
US8802447B2 (en) 2006-10-05 2014-08-12 Massachusetts Institute Of Technology Emissive compositions with internal standard and related techniques
US20090215189A1 (en) 2006-10-27 2009-08-27 Massachusetts Institute Of Technology Sensor of species including toxins and chemical warfare agents
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP2091647A2 (en) 2006-11-14 2009-08-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
CN101657548B (en) 2006-12-13 2012-10-10 卢米耐克斯公司 Systems and methods for multiplex analysis of PCR in real time
JP2010514692A (en) 2006-12-20 2010-05-06 バイエル ヘルスケア リミティド ライアビリティ カンパニー Hydroxymethylphenylpyrazolylurea compounds useful for the treatment of cancer
US8535888B2 (en) * 2006-12-29 2013-09-17 Mayo Foundation For Medical Education And Research Compositions and methods for detecting methicillin-resistant S. aureus
WO2008093336A2 (en) * 2007-01-29 2008-08-07 Noga Porat Genome determination assay
US7794939B2 (en) * 2007-02-26 2010-09-14 University Of Idaho Methods of DNA methylation detection
FI20070163A0 (en) * 2007-02-27 2007-02-27 Hidex Oy Improved homogeneous luminescence bioassay
US8017104B2 (en) * 2007-02-28 2011-09-13 Carestream Health, Inc. Large stoke shift dye used for optical imaging
US8906354B2 (en) 2007-02-28 2014-12-09 Bruker Biospin Corporation Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes
US20110020239A1 (en) * 2007-05-14 2011-01-27 The Johns Hopkins University Methods for in vivo imaging of cells
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
EP3741869A1 (en) 2007-07-13 2020-11-25 Handylab, Inc. Polynucleotide capture materials and methods of using same
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
US9683256B2 (en) 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
EP3058954B1 (en) 2007-08-27 2017-03-01 Longhorn Vaccines and Diagnostics, LLC Immunogenic compositions and methods
US10004799B2 (en) 2007-08-27 2018-06-26 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
US8357656B2 (en) * 2007-09-15 2013-01-22 Mayo Foundation For Medical Education And Research Natriuretic peptide receptor-C agonists
CA2700532A1 (en) * 2007-09-28 2009-04-02 3M Innovative Properties Company Dual oligonucleotide method of nucleic acid detection
US11041216B2 (en) 2007-10-01 2021-06-22 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
US20090111100A1 (en) * 2007-10-30 2009-04-30 Eugene Lukhtanov Minor groove binder - energy transfer oligonucleotides and methods for their use
US8123841B2 (en) 2008-01-16 2012-02-28 The Board Of Trustees Of The University Of Illinois Column design for micro gas chromatograph
JP5665548B2 (en) * 2008-02-08 2015-02-04 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ Clostridium difficile detection
US20090203531A1 (en) 2008-02-12 2009-08-13 Nurith Kurn Method for Archiving and Clonal Expansion
GB2470672B (en) 2008-03-21 2012-09-12 Nugen Technologies Inc Methods of RNA amplification in the presence of DNA
US8269029B2 (en) 2008-04-08 2012-09-18 The Board Of Trustees Of The University Of Illinois Water repellent metal-organic frameworks, process for making and uses regarding same
US20090270269A1 (en) * 2008-04-28 2009-10-29 Ashok Kumar Nano-scale fluoro-biosensors exhibiting a low false alarm rate for rapid detection of biological contaminants
WO2009152492A1 (en) * 2008-06-13 2009-12-17 University Of Connecticut Nucleic acid materials for nonradiative energy transfer and methods of production and use
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
US8097412B2 (en) * 2008-07-12 2012-01-17 Biodiagnostics, Inc. DNA-based test for detection of annual and intermediate ryegrass
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US20110218158A1 (en) * 2008-09-22 2011-09-08 Harris Reuben S Dna cytosine deaminase inhibitors
SG173081A1 (en) 2009-01-30 2011-08-29 Kantonsspital Aarau Ag Gene dosage analysis
WO2010135319A1 (en) * 2009-05-18 2010-11-25 University Of Connecticut Nucleic acid-based photovoltaic cell
CN102482714B (en) 2009-07-30 2018-04-06 霍夫曼-拉罗奇有限公司 Oligonucleotide probe group and relative method and purposes
US20110045458A1 (en) * 2009-08-20 2011-02-24 Mayo Foundation For Medical Education And Research Detection of Enterovirus
EP2553123B1 (en) * 2010-03-26 2016-08-24 Integrated DNA Technologies, Inc. Methods for enhancing nucleic acid hybridization
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
CN103079567A (en) 2010-04-17 2013-05-01 拜尔健康护理有限责任公司 Synthetic metabolites of fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention diseases and conditions
CA2809457C (en) 2010-09-07 2019-07-30 Integrated Dna Technologies, Inc. Modifications for antisense compounds
ES2472965T3 (en) 2011-03-04 2014-07-03 F. Hoffmann-La Roche Ag New type of universal probes for the detection of genomic variants
ES2769028T3 (en) 2011-04-15 2020-06-24 Becton Dickinson Co Real-time scanning microfluidic thermocycler
US9034581B2 (en) 2011-05-26 2015-05-19 Roche Molecular Systems, Inc. Compositions and methods for detection of Staphylococcus aureus
EP2751136B1 (en) 2011-08-30 2017-10-18 Mayo Foundation For Medical Education And Research Natriuretic polypeptides
US8756890B2 (en) 2011-09-28 2014-06-24 Romeo Ilarian Ciuperca Insulated concrete form and method of using same
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
CA2849917C (en) 2011-09-30 2020-03-31 Becton, Dickinson And Company Unitized reagent strip
EP2773892B1 (en) 2011-11-04 2020-10-07 Handylab, Inc. Polynucleotide sample preparation device
WO2013103896A1 (en) 2012-01-06 2013-07-11 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases
CA3207612A1 (en) 2012-01-26 2013-08-01 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
RU2658773C2 (en) 2012-02-03 2018-06-22 Бектон, Дикинсон Энд Компани System and method of implementation of automated assays on plurality of biological samples
US9982313B2 (en) 2012-08-17 2018-05-29 Roche Molecular Systems, Inc. Compositions and methods for detection of herpes simplex virus 1 and 2
US8636941B1 (en) 2012-09-25 2014-01-28 Romeo Ilarian Ciuperca Methods of making concrete runways, roads, highways and slabs on grade
US9458637B2 (en) 2012-09-25 2016-10-04 Romeo Ilarian Ciuperca Composite insulated plywood, insulated plywood concrete form and method of curing concrete using same
US9593371B2 (en) * 2013-12-27 2017-03-14 Intel Corporation Integrated photonic electronic sensor arrays for nucleic acid sequencing
JP2016509480A (en) 2013-01-24 2016-03-31 カリフォルニア インスティチュート オブ テクノロジー Chromophore-based characterization and detection methods
US20140249037A1 (en) 2013-03-04 2014-09-04 Fry Laboratories, LLC Method and kit for characterizing microorganisms
US8844227B1 (en) 2013-03-15 2014-09-30 Romeo Ilarian Ciuperca High performance, reinforced insulated precast concrete and tilt-up concrete structures and methods of making same
US10065339B2 (en) 2013-05-13 2018-09-04 Romeo Ilarian Ciuperca Removable composite insulated concrete form, insulated precast concrete table and method of accelerating concrete curing using same
WO2014186299A1 (en) 2013-05-13 2014-11-20 Ciuperca Romeo Llarian Insulated concrete battery mold, insulated passive concrete curing system, accelerated concrete curing apparatus and method of using same
EP3019559A4 (en) 2013-08-22 2017-04-05 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
US9862118B2 (en) 2013-09-09 2018-01-09 Romeo Ilarian Ciuperca Insulated flying table concrete form, electrically heated flying table concrete form and method of accelerating concrete curing using same
US9776920B2 (en) * 2013-09-09 2017-10-03 Romeo Ilarian Ciuperca Insulated concrete slip form and method of accelerating concrete curing using same
US10072288B2 (en) 2013-11-11 2018-09-11 Roche Molecular Systems, Inc. Detecting single nucleotide polymorphism using overlapped primer and melting probe
US9745618B2 (en) 2014-11-19 2017-08-29 Roche Molecular Systems, Inc. Photoblocked probes and methods for sequential detection of nucleic acids
US9920381B2 (en) 2014-12-02 2018-03-20 Roche Molecular Systems, Inc. Compositions and methods for detecting MECC-containing methicillin-resistant Staphylococcus aureus
KR20170120677A (en) 2015-02-26 2017-10-31 소니 주식회사 Water-soluble fluorescent or colored dyes including conjugated groups
EP3262022A4 (en) 2015-02-26 2018-08-15 Sony Corporation Phenylethynylnaphthalene dyes and methods for their use
US10968475B2 (en) 2015-05-01 2021-04-06 Vanderbilt University Monitoring and analysis of nucleic acid hybridization state and amplification using L-DNA
JP6849599B2 (en) 2015-05-11 2021-03-24 ソニー株式会社 Super bright dimer or polymer dye
CA2985652C (en) 2015-05-14 2020-03-10 Gerald W. FISHER Rapid methods for the extraction of nucleic acids from biological samples
US10280622B2 (en) 2016-01-31 2019-05-07 Romeo Ilarian Ciuperca Self-annealing concrete forms and method of making and using same
CA3017265C (en) 2016-03-11 2022-08-16 F. Hoffmann-La Roche Ag Compositions and methods for detection of zika virus
KR102530707B1 (en) 2016-04-01 2023-05-11 소니그룹주식회사 Ultra bright dimeric or polymeric dyes
WO2017173348A1 (en) 2016-04-01 2017-10-05 Sony Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
CA3019951A1 (en) 2016-04-06 2017-10-12 Sony Corporation Ultra bright dimeric or polymeric dyes with spacing linker groups
WO2017196954A1 (en) 2016-05-10 2017-11-16 Sony Corporation Ultra bright polymeric dyes with peptide backbones
US11390754B2 (en) 2016-05-10 2022-07-19 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
KR102526802B1 (en) 2016-05-11 2023-05-02 소니그룹주식회사 Ultra high brightness dimeric or polymeric dyes
US10612101B2 (en) 2016-05-27 2020-04-07 Roche Molecular Systems, Inc. Compositions and methods for detection of Mycoplasma genitalium
WO2017202894A1 (en) 2016-05-27 2017-11-30 Roche Diagnostics Gmbh Compositions and methods for detection of trichomonas vaginalis
US11377563B2 (en) 2016-06-06 2022-07-05 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups
US11421287B2 (en) 2016-07-29 2022-08-23 Juno Therapeutics, Inc. Methods for assessing the presence or absence of replication competent virus
US10443095B2 (en) 2016-08-02 2019-10-15 Roche Molecular Systems, Inc. Helper oligonucleotide for improved efficiency of amplification and detection/quantitation of nucleic acids
US10793923B2 (en) 2016-11-09 2020-10-06 Roche Molecular Systems, Inc. Compositions and methods for detection of BK virus
US20190211377A1 (en) 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
WO2018231805A2 (en) * 2017-06-16 2018-12-20 Duke University Resonator networks for improved label detection, computation, analyte sensing, and tunable random number generation
US10760137B2 (en) 2017-07-18 2020-09-01 Roche Molecular Systems, Inc. Compositions and methods for detection of Babesia
TWI829642B (en) * 2017-07-24 2024-01-21 美商寬騰矽公司 High intensity labeled reactant compositions and methods for sequencing
WO2019063661A1 (en) 2017-09-29 2019-04-04 Roche Diagnostics Gmbh Compositions and methods for detection of trichomonas vaginalis
WO2019071208A1 (en) 2017-10-05 2019-04-11 Sony Corporation Programmable polymeric drugs
WO2019099789A1 (en) 2017-11-16 2019-05-23 Sony Corporation Programmable polymeric drugs
WO2021130199A2 (en) 2019-12-27 2021-07-01 F. Hoffmann-La Roche Ag Compositions and methods for detecting methicillin-resistant staphylococcus aureus
US11535903B2 (en) 2018-01-31 2022-12-27 Juno Therapeutics, Inc. Methods and reagents for assessing the presence or absence of replication competent virus
US11874280B2 (en) 2018-03-19 2024-01-16 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
EP3768689A1 (en) * 2018-03-21 2021-01-27 Sony Corporation Polymeric tandem dyes with linker groups
US20220017973A1 (en) 2018-12-03 2022-01-20 Roche Molecular Systems, Inc. Compositions and methods for detection of candida auris
JP2022518056A (en) 2019-01-23 2022-03-11 クアンタム－エスアイ インコーポレイテッド Reaction Compositions and Methods for High Intensity Labeled Sequencing
EP3963102A1 (en) 2019-05-02 2022-03-09 F. Hoffmann-La Roche AG Utilization of ditp for preferential/selective amplification of rna versus dna targets based on strand-separation temperature
CN113795596A (en) 2019-05-07 2021-12-14 豪夫迈·罗氏有限公司 Compositions and methods for detecting neisseria gonorrhoeae
US20220251670A1 (en) 2019-07-25 2022-08-11 Roche Molecular Systems, Inc. Compositions and methods for detection of epstein barr virus (ebv)
EP4022086A1 (en) 2019-08-27 2022-07-06 F. Hoffmann-La Roche AG Compositions and methods for amplification and detection of hepatitis b virus rna, including hbv rna transcribed from cccdna
CN113383043A (en) 2019-09-26 2021-09-10 索尼集团公司 Polymer tandem dyes with linker groups
US11441167B2 (en) 2019-11-20 2022-09-13 Roche Molecular Systems, Inc. Compositions and methods for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria and fungi
EP4085156B1 (en) 2019-12-31 2023-10-25 F. Hoffmann-La Roche AG Quantitative pcr screening of inducible prophage from bacterial isolates
JP2023516472A (en) 2020-03-09 2023-04-19 エフ． ホフマン－ラ ロシュ アーゲー Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), influenza A and influenza B
WO2022029157A2 (en) 2020-08-06 2022-02-10 F. Hoffmann-La Roche Ag Compositions and methods for the detection of severe acute respiratory syndrome coronavirus 2 (sars-2), influenza a, and influenza b
US20240102110A1 (en) 2020-12-04 2024-03-28 Roche Molecular Systems, Inc. Compositions and methods for detection of malaria
US20220205020A1 (en) 2020-12-30 2022-06-30 Roche Molecular Systems, Inc. Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
EP4288567A1 (en) 2021-02-05 2023-12-13 F. Hoffmann-La Roche AG Compositions and methods for detection of human parainfluenza viruses 1-4 (hpiv 1-4)
US20220290221A1 (en) 2021-03-15 2022-09-15 Roche Molecular Systems, Inc. Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2) variants having spike protein mutations
EP4334472A1 (en) 2021-05-06 2024-03-13 F. Hoffmann-La Roche AG Compositions and methods for detecting hepatitis delta virus by a dual-target assay
WO2023038907A1 (en) * 2021-09-07 2023-03-16 Naio, Inc. Compositions, systems, and methods for nucleic acid data storage
WO2023079032A1 (en) 2021-11-05 2023-05-11 F. Hoffmann-La Roche Ag Compositions and methods for detection of malaria
WO2023089186A1 (en) 2021-11-22 2023-05-25 F. Hoffmann-La Roche Ag Compositions and methods for detecting vana and/or vanb genes associated with multidrug resistance
WO2023118399A1 (en) 2021-12-24 2023-06-29 F. Hoffmann-La Roche Ag Improved detection of lamp amplification products
WO2024003260A1 (en) 2022-06-30 2024-01-04 F. Hoffmann-La Roche Ag Compositions and methods for detecting lymphogranuloma venereum (lgv) serovars of chlamydia trachomatis
WO2024042042A1 (en) 2022-08-24 2024-02-29 F. Hoffmann-La Roche Ag Compositions and methods for detecting monkeypox virus

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
ATE88761T1 (en) * 1986-01-10 1993-05-15 Amoco Corp COMPETITIVE HOMOGENEOUS TEST.
US4868103A (en) * 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US4822746A (en) 1986-06-25 1989-04-18 Trustees Of Tufts College Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors
US5322770A (en) * 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5237515A (en) * 1991-04-10 1993-08-17 University Of Utah Research Foundation Method of determining energy transfer efficiency of a donor-acceptor pair of fluorescent dyes
US5405747A (en) * 1991-09-25 1995-04-11 The Regents Of The University Of California Office Of Technology Transfer Method for rapid base sequencing in DNA and RNA with two base labeling
DE69233391D1 (en) * 1991-11-07 2004-09-02 Nanotronics Inc Hybridization of polynucleotides conjugated with chromophores and fluorophores to create a donor-donor energy transfer system
US5332659A (en) * 1992-04-09 1994-07-26 The United States Of America As Represented By The Secretary Of The Navy Light emission-or absorbance-based binding assays for polynucleic acids

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CA2123133C (en) 2005-01-04
EP0620822A1 (en) 1994-10-26
US5565322A (en) 1996-10-15
US6162603A (en) 2000-12-19
GR3036456T3 (en) 2001-11-30
DE69233391D1 (en) 2004-09-02
JPH07502992A (en) 1995-03-30
AU3136493A (en) 1993-06-07
EP1067134A3 (en) 2001-05-02
EP1067134B1 (en) 2004-07-28
US5849489A (en) 1998-12-15
US6416953B1 (en) 2002-07-09
US6911310B2 (en) 2005-06-28
US20070042386A1 (en) 2007-02-22
EP1067134A2 (en) 2001-01-10
DE69231853T2 (en) 2001-09-13
DK0620822T3 (en) 2001-08-27
US5532129A (en) 1996-07-02
ATE201692T1 (en) 2001-06-15
ATE272068T1 (en) 2004-08-15
WO1993009128A1 (en) 1993-05-13
JP3509859B2 (en) 2004-03-22
AU667497B2 (en) 1996-03-28
DE69231853D1 (en) 2001-07-05
ES2159282T3 (en) 2001-10-01
EP0620822B1 (en) 2001-05-30

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