CA2125673A1 - Dna structure-specific recognition protein and uses therefor - Google Patents
Dna structure-specific recognition protein and uses thereforInfo
- Publication number
- CA2125673A1 CA2125673A1 CA002125673A CA2125673A CA2125673A1 CA 2125673 A1 CA2125673 A1 CA 2125673A1 CA 002125673 A CA002125673 A CA 002125673A CA 2125673 A CA2125673 A CA 2125673A CA 2125673 A1 CA2125673 A1 CA 2125673A1
- Authority
- CA
- Canada
- Prior art keywords
- specific recognition
- recognition protein
- dna structure
- dna
- uses therefor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
- C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Abstract
DNA structure specific recognition protein of eukaryotic origin and DNA
encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognize and binds DNA damaged or modified by a drug (the anticancer drug, cis-diaminedichloroplatinum (II) or cisplatin) has been identified.
encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognize and binds DNA damaged or modified by a drug (the anticancer drug, cis-diaminedichloroplatinum (II) or cisplatin) has been identified.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/814,964 US5359047A (en) | 1988-09-22 | 1991-12-26 | Nucleic acids encoding DNA structure-specific recognition protein and uses therefor |
US814,964 | 1991-12-26 | ||
PCT/US1992/011107 WO1993013222A1 (en) | 1991-12-26 | 1992-12-18 | Dna structure-specific recognition protein and uses therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2125673A1 true CA2125673A1 (en) | 1993-07-08 |
CA2125673C CA2125673C (en) | 2001-03-13 |
Family
ID=25216483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002125673A Expired - Fee Related CA2125673C (en) | 1991-12-26 | 1992-12-18 | Dna structure-specific recognition protein and uses therefor |
Country Status (7)
Country | Link |
---|---|
US (2) | US5359047A (en) |
EP (1) | EP0621902B1 (en) |
JP (1) | JPH07502415A (en) |
AT (1) | ATE182628T1 (en) |
CA (1) | CA2125673C (en) |
DE (1) | DE69229681T2 (en) |
WO (1) | WO1993013222A1 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5705334A (en) | 1988-09-22 | 1998-01-06 | Massachusetts Institute Of Technology | Uses for DNA structure-specific recognition protein |
US5874218A (en) * | 1990-06-11 | 1999-02-23 | Nexstar Pharmaceuticals, Inc. | Method for detecting a target compound in a substance using a nucleic acid ligand |
US5874283A (en) * | 1995-05-30 | 1999-02-23 | John Joseph Harrington | Mammalian flap-specific endonuclease |
US5912332A (en) * | 1996-07-26 | 1999-06-15 | Hybridon, Inc. | Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides |
US6030783A (en) * | 1997-01-31 | 2000-02-29 | Massachusetts Institute Of Technology | Photo-potentiation of cisplatin chemotherapy |
US6166194A (en) * | 1998-06-29 | 2000-12-26 | Myriad Genetics, Inc. | TMPRSS2 is a tumor suppressor |
US7960540B2 (en) | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US20080318890A1 (en) * | 1999-04-08 | 2008-12-25 | Antisoma Research Limited | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US8114850B2 (en) | 1999-04-08 | 2012-02-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
JP2002541264A (en) | 1999-04-08 | 2002-12-03 | ユーエイビー・リサーチ・ファウンデーション | Anti-proliferative activity of G-rich oligonucleotide and its use for binding to nucleolin |
US20080318889A1 (en) * | 1999-04-08 | 2008-12-25 | Antisoma Research Limited | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
EP1229934B1 (en) | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
US6573050B1 (en) | 1999-10-29 | 2003-06-03 | Sunnybrook & Women's College Health Sciences Centre | Treatment, diagnosis and evaluation of anti-cancer therapy resistance in melanoma |
FR2809417B1 (en) * | 2000-05-24 | 2004-07-30 | Commissariat Energie Atomique | DETECTION AND CHARACTERIZATION OF PROTEIN ACTIVITY INVOLVED IN THE REPAIR OF DNA INJURIES |
DE10030452A1 (en) * | 2000-06-21 | 2002-01-24 | Max Planck Gesellschaft | In vitro detection of DNA damage, useful e.g. for determining genotoxicity of chemicals, comprises measuring specific interaction between DNA and repair proteins |
US6806289B1 (en) | 2000-07-14 | 2004-10-19 | Stephen J. Lippard | Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same |
EP1412746A4 (en) * | 2001-07-12 | 2007-08-08 | Exelixis Inc | HADHs AS MODIFIERS OF THE P21 PATHWAY AND METHODS OF USE |
ITTO20010762A1 (en) * | 2001-07-31 | 2003-01-31 | Consiglio Nazionale Ricerche | ANTI-SSRP-1 MONOCLONAL ANTIBODIES AND HYBRIDS PRODUCING SUCH ANTIBODIES. |
JP4007000B2 (en) * | 2001-12-25 | 2007-11-14 | 富士ゼロックス株式会社 | Conductive organic polymer |
CA2473642A1 (en) * | 2002-01-25 | 2003-08-07 | Sheikh Ismail | Electrophoretic assay to predict risk of cancer and the efficacy and toxicity of cancer therapy |
US7153691B2 (en) * | 2002-11-13 | 2006-12-26 | G6 Science Corp. | Method of identifying and assessing DNA euchromatin in biological cells for detecting disease, monitoring wellness, assessing bio-activity, and screening pharmacological agents |
US20090148958A1 (en) * | 2006-04-27 | 2009-06-11 | Onecell Inc. | Nucleotide-transition metal complex catalyst |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4407942A (en) * | 1981-01-29 | 1983-10-04 | Atomic Energy Of Canada Limited | Fluorescent detection of DNA damage |
US4670388A (en) * | 1982-12-30 | 1987-06-02 | Carnegie Institution Of Washington | Method of incorporating DNA into genome of drosophila |
JPS6343931A (en) * | 1986-08-12 | 1988-02-25 | Diafoil Co Ltd | Polyester film for magnetic recording medium |
WO1990003396A1 (en) * | 1988-09-22 | 1990-04-05 | Massachusetts Institute Of Technology | Dna damage-binding factor and uses therefor |
-
1991
- 1991-12-26 US US07/814,964 patent/US5359047A/en not_active Expired - Fee Related
-
1992
- 1992-12-18 EP EP93901926A patent/EP0621902B1/en not_active Expired - Lifetime
- 1992-12-18 DE DE69229681T patent/DE69229681T2/en not_active Expired - Fee Related
- 1992-12-18 JP JP5511838A patent/JPH07502415A/en not_active Ceased
- 1992-12-18 CA CA002125673A patent/CA2125673C/en not_active Expired - Fee Related
- 1992-12-18 AT AT93901926T patent/ATE182628T1/en not_active IP Right Cessation
- 1992-12-18 WO PCT/US1992/011107 patent/WO1993013222A1/en active IP Right Grant
-
1994
- 1994-06-09 US US08/258,442 patent/US5670621A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1993013222A1 (en) | 1993-07-08 |
EP0621902A1 (en) | 1994-11-02 |
DE69229681T2 (en) | 2000-04-06 |
ATE182628T1 (en) | 1999-08-15 |
US5359047A (en) | 1994-10-25 |
CA2125673C (en) | 2001-03-13 |
EP0621902B1 (en) | 1999-07-28 |
US5670621A (en) | 1997-09-23 |
DE69229681D1 (en) | 1999-09-02 |
JPH07502415A (en) | 1995-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |