CA2129242A1 - Method and apparatus for controlled environment electrotransport - Google Patents
Method and apparatus for controlled environment electrotransportInfo
- Publication number
- CA2129242A1 CA2129242A1 CA002129242A CA2129242A CA2129242A1 CA 2129242 A1 CA2129242 A1 CA 2129242A1 CA 002129242 A CA002129242 A CA 002129242A CA 2129242 A CA2129242 A CA 2129242A CA 2129242 A1 CA2129242 A1 CA 2129242A1
- Authority
- CA
- Canada
- Prior art keywords
- electrotransport
- methods
- control
- arrangement
- active electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/0436—Material of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0444—Membrane
Abstract
Methods for conducting controlled environment electrotransport are described.
The methods generally concern control of the ionic environment of the active electrode reservoir, in an electrotransport system. This control may be utilized, for example, to maintain a constant extraneous ion presence, such as pH. It may also be applied in a preferred manner to maintain selected con-trol over the delivery rate of a target species, in time, in the presence of extraneous ions. Apparatus usable to provide for con-trolled environment electrotransport are also described. In general the apparatus comprises an electrotransport system (5) includ-ing an active electrode reservoir (6) having therein both a primary electrode arrangement (30) and a secondary electrode arrange-ment (50), with a control arrangement (40) for selected operation of both. The secondary electrode arrangement (50), being operated different from the primary electrode arrangement (30), is selected for operation to selectively enhance or otherwise mod-ify ion presence in the active electrode reservoir (6), to achieve application of the general methods described. The apparatus may include a sensor means (60) therein, for use as feedback to a control system (40) during operation. Methods and systems involv-ing diffusion type delivery are also described.
The methods generally concern control of the ionic environment of the active electrode reservoir, in an electrotransport system. This control may be utilized, for example, to maintain a constant extraneous ion presence, such as pH. It may also be applied in a preferred manner to maintain selected con-trol over the delivery rate of a target species, in time, in the presence of extraneous ions. Apparatus usable to provide for con-trolled environment electrotransport are also described. In general the apparatus comprises an electrotransport system (5) includ-ing an active electrode reservoir (6) having therein both a primary electrode arrangement (30) and a secondary electrode arrange-ment (50), with a control arrangement (40) for selected operation of both. The secondary electrode arrangement (50), being operated different from the primary electrode arrangement (30), is selected for operation to selectively enhance or otherwise mod-ify ion presence in the active electrode reservoir (6), to achieve application of the general methods described. The apparatus may include a sensor means (60) therein, for use as feedback to a control system (40) during operation. Methods and systems involv-ing diffusion type delivery are also described.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/502,232 US5125894A (en) | 1990-03-30 | 1990-03-30 | Method and apparatus for controlled environment electrotransport |
EP92905287A EP0625061B1 (en) | 1990-03-30 | 1992-02-03 | Apparatus for controlled iontophoresis |
PCT/US1992/000796 WO1993014813A1 (en) | 1990-03-30 | 1992-02-03 | Method and apparatus for controlled iontophoresis |
JP50573692A JP3368322B2 (en) | 1990-03-30 | 1992-02-03 | Controlled ion introduction method and apparatus |
CA002129242A CA2129242C (en) | 1990-03-30 | 1992-02-03 | Method and apparatus for controlled environment electrotransport |
AU13593/92A AU1359392A (en) | 1990-03-30 | 1992-02-03 | Method and apparatus for controlled iontophoresis |
DE69218629T DE69218629T2 (en) | 1990-03-30 | 1992-02-03 | DEVICE FOR REGULATED IONTOPHORESIS |
US08/173,149 US5443442A (en) | 1990-03-30 | 1993-12-22 | Method and apparatus for controlled environment electrotransport |
US08/452,403 US5591124A (en) | 1990-03-30 | 1995-05-26 | Method and apparatus for controlled environment electrotransport |
US08/451,119 US5622530A (en) | 1990-03-30 | 1995-05-26 | Method and apparatus for controlled environment electrotransport |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/502,232 US5125894A (en) | 1990-03-30 | 1990-03-30 | Method and apparatus for controlled environment electrotransport |
PCT/US1992/000796 WO1993014813A1 (en) | 1990-03-30 | 1992-02-03 | Method and apparatus for controlled iontophoresis |
CA002129242A CA2129242C (en) | 1990-03-30 | 1992-02-03 | Method and apparatus for controlled environment electrotransport |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2129242A1 true CA2129242A1 (en) | 1993-08-05 |
CA2129242C CA2129242C (en) | 2001-12-25 |
Family
ID=25677410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002129242A Expired - Lifetime CA2129242C (en) | 1990-03-30 | 1992-02-03 | Method and apparatus for controlled environment electrotransport |
Country Status (7)
Country | Link |
---|---|
US (4) | US5125894A (en) |
EP (1) | EP0625061B1 (en) |
JP (1) | JP3368322B2 (en) |
AU (1) | AU1359392A (en) |
CA (1) | CA2129242C (en) |
DE (1) | DE69218629T2 (en) |
WO (1) | WO1993014813A1 (en) |
Cited By (1)
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---|---|---|---|---|
US6330471B1 (en) | 1996-03-17 | 2001-12-11 | Hisamitsu Pharmaceutical Co., Ltd. | Iontophoresis electrode device |
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-
1990
- 1990-03-30 US US07/502,232 patent/US5125894A/en not_active Expired - Fee Related
-
1992
- 1992-02-03 CA CA002129242A patent/CA2129242C/en not_active Expired - Lifetime
- 1992-02-03 AU AU13593/92A patent/AU1359392A/en not_active Abandoned
- 1992-02-03 WO PCT/US1992/000796 patent/WO1993014813A1/en active IP Right Grant
- 1992-02-03 DE DE69218629T patent/DE69218629T2/en not_active Expired - Lifetime
- 1992-02-03 JP JP50573692A patent/JP3368322B2/en not_active Expired - Lifetime
- 1992-02-03 EP EP92905287A patent/EP0625061B1/en not_active Expired - Lifetime
-
1993
- 1993-12-22 US US08/173,149 patent/US5443442A/en not_active Expired - Lifetime
-
1995
- 1995-05-26 US US08/452,403 patent/US5591124A/en not_active Expired - Lifetime
- 1995-05-26 US US08/451,119 patent/US5622530A/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6330471B1 (en) | 1996-03-17 | 2001-12-11 | Hisamitsu Pharmaceutical Co., Ltd. | Iontophoresis electrode device |
Also Published As
Publication number | Publication date |
---|---|
JPH07502905A (en) | 1995-03-30 |
CA2129242C (en) | 2001-12-25 |
WO1993014813A1 (en) | 1993-08-05 |
AU1359392A (en) | 1993-09-01 |
EP0625061B1 (en) | 1997-03-26 |
US5591124A (en) | 1997-01-07 |
DE69218629D1 (en) | 1997-04-30 |
EP0625061A1 (en) | 1994-11-23 |
US5125894A (en) | 1992-06-30 |
JP3368322B2 (en) | 2003-01-20 |
DE69218629T2 (en) | 1997-07-31 |
US5443442A (en) | 1995-08-22 |
US5622530A (en) | 1997-04-22 |
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MKEX | Expiry |