CA2129648A1 - Device for cell culture treatment - Google Patents

Device for cell culture treatment

Info

Publication number
CA2129648A1
CA2129648A1 CA002129648A CA2129648A CA2129648A1 CA 2129648 A1 CA2129648 A1 CA 2129648A1 CA 002129648 A CA002129648 A CA 002129648A CA 2129648 A CA2129648 A CA 2129648A CA 2129648 A1 CA2129648 A1 CA 2129648A1
Authority
CA
Canada
Prior art keywords
culture
cell culture
slide
collagen
coating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002129648A
Other languages
French (fr)
Other versions
CA2129648C (en
Inventor
Augustinus Bader
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organogenesis Inc
Original Assignee
Augustinus Bader
Baxter Healthcare Corporation
Organogenesis, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Augustinus Bader, Baxter Healthcare Corporation, Organogenesis, Inc. filed Critical Augustinus Bader
Publication of CA2129648A1 publication Critical patent/CA2129648A1/en
Application granted granted Critical
Publication of CA2129648C publication Critical patent/CA2129648C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/04—Flat or tray type, drawers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/06—Plates; Walls; Drawers; Multilayer plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cultivation Receptacles Or Flower-Pots, Or Pots For Seedlings (AREA)
  • Materials For Medical Uses (AREA)

Abstract

In a device for treating cell cultures, especially hepatocytes, on plate-like culture slides, at least a part of the surfaces of said slides (1) is gaspermeable and oxygen can be introduced inside them. On the culture slide (1) is applied a coating of collagen (5, 7), on or in which is the cell culture (6). The next cell cul-ture slide (1) is arranged closely above the collagen coating (5, 7). The culture medium can be introduced into the space between the collagen coating (5, 7) and the next culture slide (1).
CA002129648A 1992-03-03 1993-03-02 Device for cell culture treatment Expired - Lifetime CA2129648C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4206585.2 1992-03-03
DE4206585A DE4206585C2 (en) 1992-03-03 1992-03-03 Device for mass culture of cells
PCT/EP1993/000468 WO1993018133A1 (en) 1992-03-03 1993-03-02 Device for cell culture treatment

Publications (2)

Publication Number Publication Date
CA2129648A1 true CA2129648A1 (en) 1993-09-16
CA2129648C CA2129648C (en) 2009-08-11

Family

ID=6453071

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002129648A Expired - Lifetime CA2129648C (en) 1992-03-03 1993-03-02 Device for cell culture treatment

Country Status (12)

Country Link
US (1) US5658797A (en)
EP (1) EP0629237B1 (en)
JP (1) JP3176628B2 (en)
AT (1) ATE131867T1 (en)
AU (1) AU668922B2 (en)
CA (1) CA2129648C (en)
DE (2) DE4206585C2 (en)
DK (1) DK0629237T3 (en)
ES (1) ES2083851T3 (en)
GR (1) GR3019255T3 (en)
NO (1) NO315005B1 (en)
WO (1) WO1993018133A1 (en)

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DE4222345A1 (en) * 1992-07-08 1994-01-13 Augustinus Dr Med Bader Process for growing a cell type in a co-culture process with liver cells
DE4322746A1 (en) * 1993-07-08 1995-01-12 Augustinus Dr Med Bader Method and device for the treatment of cell cultures
DE4336399A1 (en) * 1993-10-26 1995-04-27 Augustinus Dr Med Bader Process for improving the matrix conditions of bipolar adhered hepatocytes and for producing a suitably configured cell culture kit
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US5955353A (en) * 1997-05-22 1999-09-21 Excorp Medical, Inc. Hollow fiber bioreactor with an extrafilament flow plug
US6107085A (en) * 1997-07-11 2000-08-22 Corning Incorporated Self contained cell growth system
WO1999047922A2 (en) 1998-03-18 1999-09-23 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
AT407047B (en) * 1998-08-03 2000-11-27 Pfaller Walter Dr CELL CULTURE DEVICE
DE19919242A1 (en) * 1999-04-28 2000-11-02 Creavis Tech & Innovation Gmbh Modular cell support systems for three-dimensional cell growth
DE19919241A1 (en) * 1999-04-28 2000-11-02 Creavis Tech & Innovation Gmbh Porous cell carrier system for preparing 3-D implants or explants and for cultivating connective tissue, comprises segments connected with a channel system
WO2000078920A1 (en) * 1999-06-21 2000-12-28 The General Hospital Corporation Methods and devices for cell culturing and organ assist systems
CA2375505A1 (en) * 1999-06-21 2000-12-28 The General Hospital Corporation Cell culture systems and methods for organ assist devices
AU779900B2 (en) 1999-07-22 2005-02-17 Organogenesis Inc. In vivo induction for enhanced function of isolated hepatocytes
JP3865354B2 (en) 2000-03-02 2007-01-10 高木産業株式会社 Cell or tissue culture method
KR100404296B1 (en) * 2000-06-26 2003-11-07 임승완 Beating media tissues culture method and beating media tissues culture system
DE60013585T2 (en) * 2000-07-19 2005-09-15 Technodop Ltd. (Société de Droit Irlandais) Culture space and bioreactor for out-of-body animal cell culture
US7581076B2 (en) * 2001-03-05 2009-08-25 Pact Xpp Technologies Ag Methods and devices for treating and/or processing data
EP1465979A4 (en) * 2001-12-21 2007-11-14 Organogenesis Inc Chamber with adjustable volume for cell culture and organ assist
ATE402446T1 (en) 2002-02-18 2008-08-15 Pact Xpp Technologies Ag BUS SYSTEMS AND RECONFIGURATION PROCEDURES
WO2003104439A2 (en) * 2002-03-12 2003-12-18 Surface Logix, Inc. Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound
US7160719B2 (en) 2002-06-07 2007-01-09 Mayo Foundation For Medical Education And Research Bioartificial liver system
EP3943591A1 (en) 2003-10-08 2022-01-26 Wilson Wolf Manufacturing Corporation Cell culture methods and devices utilizing gas permeable materials
MXPA06013421A (en) * 2004-05-18 2007-03-01 Australian Nuclear Science Tec Membrane bioreactor.
DK1773978T3 (en) * 2004-05-19 2014-05-26 Univ Pittsburgh Perfused, three-dimensional cell / tissue disease models
US7531351B2 (en) * 2004-06-14 2009-05-12 Probiogen Ag Liquid-gas-phase exposure reactor for cell culturing
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
EP1904619A4 (en) * 2005-07-07 2012-05-02 Univ California Methods and apparatus for cell culture array
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
US9206384B2 (en) 2011-12-03 2015-12-08 Emd Millipore Corporation Micro-incubation systems for microfluidic cell culture and methods
US9376658B2 (en) 2008-01-03 2016-06-28 Emd Millipore Corporation Cell culture array system for automated assays and methods of operation and manufacture thereof
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US7745209B2 (en) * 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
EP1913126B1 (en) 2005-08-12 2019-09-25 Clemson University Research Foundation Co-culture bioreactor system
US7745210B2 (en) * 2006-06-30 2010-06-29 Corning Incorporated Fluid flow diverter for cell culture vessel
CA2671967A1 (en) 2006-12-07 2008-06-19 Wilson Wolf Manufacturing Corporation Highly efficient devices and methods for culturing cells
US7897379B2 (en) * 2007-02-26 2011-03-01 Corning Incorporated Device and method for reducing bubble formation in cell culture
US9309491B2 (en) * 2007-05-29 2016-04-12 Corning Incorporated Cell culture apparatus for co-culture of cells
WO2009108654A2 (en) * 2008-02-25 2009-09-03 Clemson University Differential pressure pump system
CN102421467B (en) 2009-03-13 2015-04-22 梅约医学教育与研究基金会 Bioartificial liver
US8778669B2 (en) 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
DE102010005415B4 (en) 2010-01-22 2015-07-16 Zellwerk Gmbh Method and device for the dynamic expansion and / or differentiation of suspended primary cells or stem cells of human and animal origin
JP5988962B2 (en) * 2010-05-11 2016-09-07 ポール アルテリス ビーブイビーエイＰａｌｌ Ａｒｔｅｌｉｓ ＢＶＢＡ Cell culture device and cell culture method
DE102010064098B4 (en) 2010-12-23 2014-02-13 Hochschule Wismar cell reactor
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
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NL2007734C2 (en) * 2011-11-07 2013-05-08 Tulip Life Science Products B V DEVICE FOR GROWING CELLS.
US9005550B2 (en) 2012-10-29 2015-04-14 Corning Incorporated Multi-layered cell culture vessel with manifold grips
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DE202019001093U1 (en) 2019-03-06 2019-04-11 Zellwerk Gmbh Cell culture carrier for bioreactors
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Also Published As

Publication number Publication date
DK0629237T3 (en) 1996-04-09
JPH07504325A (en) 1995-05-18
NO943242L (en) 1994-09-01
AU668922B2 (en) 1996-05-23
JP3176628B2 (en) 2001-06-18
DE59301218D1 (en) 1996-02-01
EP0629237B1 (en) 1995-12-20
DE4206585C2 (en) 1994-11-24
ATE131867T1 (en) 1996-01-15
AU3745693A (en) 1993-10-05
US5658797A (en) 1997-08-19
NO315005B1 (en) 2003-06-23
ES2083851T3 (en) 1996-04-16
CA2129648C (en) 2009-08-11
EP0629237A1 (en) 1994-12-21
GR3019255T3 (en) 1996-06-30
NO943242D0 (en) 1994-09-01
DE4206585A1 (en) 1993-09-09
WO1993018133A1 (en) 1993-09-16

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Legal Events

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EEER Examination request