CA2129969A1 - DNA Encoding 5-HT4 Serotonin Receptors and Uses Thereof - Google Patents

DNA Encoding 5-HT4 Serotonin Receptors and Uses Thereof

Info

Publication number
CA2129969A1
CA2129969A1 CA2129969A CA2129969A CA2129969A1 CA 2129969 A1 CA2129969 A1 CA 2129969A1 CA 2129969 A CA2129969 A CA 2129969A CA 2129969 A CA2129969 A CA 2129969A CA 2129969 A1 CA2129969 A1 CA 2129969A1
Authority
CA
Canada
Prior art keywords
receptor
human
nucleic acid
mammalian
acid molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2129969A
Other languages
French (fr)
Other versions
CA2129969C (en
Inventor
Christophe Gerald
Paul R. Hartig
Theresa A. Branchek
Richard L. Weinshank
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lundbeck Research USA Inc
Original Assignee
Christophe Gerald
Paul R. Hartig
Theresa A. Branchek
Richard L. Weinshank
Synaptic Pharmaceutical Corporation
Lundbeck Research Usa, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christophe Gerald, Paul R. Hartig, Theresa A. Branchek, Richard L. Weinshank, Synaptic Pharmaceutical Corporation, Lundbeck Research Usa, Inc. filed Critical Christophe Gerald
Publication of CA2129969A1 publication Critical patent/CA2129969A1/en
Application granted granted Critical
Publication of CA2129969C publication Critical patent/CA2129969C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Abstract

This invention provides an isolated nucleic acid molecule encoding mammalian 5-HT4 and an isolated nucleic acid molecule encoding a human 5-HT4 receptor, an isolated protein which is a mammalian 5-HT4 receptor, an isolated which is a human 3-HT4 receptor, vectors comprising an isolated nucleic acid molecule encoding a mammalian 5-HT4 receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT4 receptor, mammalian cells comprising such vectors, antibodies directed to the 5-HT4 receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian or human 5-HT4 receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian or human 5-HT4 receptor, pharmaceutical compounds related to the human 5-HT4 receptor, and nonhuman transgenic animals which express DNA
encoding a normal or a mutant mammalian or human 5-HT4 receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with a human 5-HT4 receptor.
CA002129969A 1992-12-24 1993-12-22 Dna encoding 5-ht4 serotonin receptors and uses thereof Expired - Lifetime CA2129969C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/996,772 1992-12-24
US07/996,772 US5472866A (en) 1992-12-24 1992-12-24 DNA encoding 5-HT4A serotonin receptors
PCT/US1993/012586 WO1994014957A2 (en) 1992-12-24 1993-12-22 Dna encoding 5-ht4 serotonin receptors and uses thereof

Publications (2)

Publication Number Publication Date
CA2129969A1 true CA2129969A1 (en) 1994-07-07
CA2129969C CA2129969C (en) 2000-05-16

Family

ID=25543297

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002129969A Expired - Lifetime CA2129969C (en) 1992-12-24 1993-12-22 Dna encoding 5-ht4 serotonin receptors and uses thereof

Country Status (5)

Country Link
US (3) US5472866A (en)
EP (1) EP0642578A4 (en)
AU (1) AU685076B2 (en)
CA (1) CA2129969C (en)
WO (1) WO1994014957A2 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661024A (en) 1989-10-31 1997-08-26 Synaptic Pharmaceutical Corporation DNA encoding a human serotonic (5-HT2) receptor and uses thereof
US5935925A (en) * 1990-05-08 1999-08-10 Synaptic Pharmaceutical Corporation Methods of treating migraine and compounds useful for such methods
US5155218A (en) * 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
WO1993011147A1 (en) * 1991-12-02 1993-06-10 Synaptic Pharmaceutical Corporation Dna encoding a human 5-ht1e receptor and uses thereof
US5360735A (en) * 1992-01-08 1994-11-01 Synaptic Pharmaceutical Corporation DNA encoding a human 5-HT1F receptor, vectors, and host cells
US6406859B1 (en) * 1992-01-08 2002-06-18 Synaptic Pharmaceutical Corporation DNA encoding a 5-HT 1F receptor and uses thereof
WO1994010310A1 (en) 1992-10-26 1994-05-11 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services THE St-B17 SEROTONIN RECEPTOR
US5472866A (en) * 1992-12-24 1995-12-05 Synaptic Pharmaceutical Corporation DNA encoding 5-HT4A serotonin receptors
US20020115149A1 (en) * 1993-01-08 2002-08-22 Synaptic Pharmaceutical Corporation DNA encoding human 5-HT1D receptors and uses thereof
US5698766A (en) * 1995-04-05 1997-12-16 The Regents Of The University Of California Transgenic animal model for testing drugs for treating eating disorders and epilepsy
US6280739B1 (en) 1996-04-18 2001-08-28 Genetics Institute, Inc. Method of inhibiting angiogenesis using secreted proteins
US5871967A (en) * 1997-01-24 1999-02-16 Smithkline Beecham Corporation Cloning of a novel G-Protein coupled 7TM receptor
US6252131B1 (en) 1997-10-15 2001-06-26 University Of New Mexico Transgenic mammal having 5-HT3 transgene overexpression in the CMS
FR2771741B1 (en) * 1997-11-28 2001-07-13 Inst Nat Sante Rech Med SPLICE VARIANTS OF THE HUMAN 5-HT4 SEROTONINERGIC RECEPTOR AND THEIR APPLICATIONS, ESPECIALLY FOR SCREENING
ATE357443T1 (en) 1998-09-10 2007-04-15 Hoffmann La Roche DIHYDROBENZODIOXINECARBONIC ACID AMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS
US6221660B1 (en) 1999-02-22 2001-04-24 Synaptic Pharmaceutical Corporation DNA encoding SNORF25 receptor
CA2374432A1 (en) * 1999-05-24 2000-11-30 Ortho-Mcneil Pharmaceutical, Inc. Dna encoding a human subunit of the 5-ht3 serotonin receptor
GB9913850D0 (en) * 1999-06-14 1999-08-11 Janssen Pharmaceutica Nv Cloning and expression of a novel receptor
CA2409267C (en) 2000-05-26 2017-02-28 Immunex Corporation Interleukin-4 antagonists and compositions thereof
US20030126627A1 (en) * 2001-11-05 2003-07-03 Laferla Frank M. Transgenic mouse model of inclusion body myositis
GB0211230D0 (en) * 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
AU2003250112A1 (en) * 2002-07-22 2004-02-09 Bayer Healthcare Ag Regulation of human serotonin receptor
FR2846559B1 (en) * 2002-10-31 2007-06-15 Centre Nat Rech Scient PHARMACEUTICAL COMPOSITION FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT AND / OR PREVENTION OF A PATHOLOGY RELATED TO OBSESSIVE DRIVING
US20050010967A1 (en) * 2003-02-28 2005-01-13 The Regents Of The University Of California SK3-1B GFP transgenic mouse model for spinocerebellar ataxia and hyperexcitable behavior
US20070065801A1 (en) * 2003-05-21 2007-03-22 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with 5-hydroxytryptamine (seotonin) receptor 4 (5-ht4)
US20070128603A1 (en) * 2003-05-28 2007-06-07 Bayer Healthcare Ag Diagnostic and therapeutics for diseases associated with 5-hydroxytryptamine (serotonin) receptor 7 (5-ht7)
US8138204B2 (en) * 2004-01-07 2012-03-20 Aryx Therapeutics, Inc. Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
US8524736B2 (en) 2004-01-07 2013-09-03 Armetheon, Inc. Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
EP2194053B1 (en) * 2004-01-07 2013-03-27 Armetheon, Inc. Methoxy piperidine derivatives for use inr the treatment of gastrointestinal and central nervous system disorders
US20070270339A1 (en) * 2004-04-23 2007-11-22 Serono, Inc. Use of GPCR54 Ligands for the Treatment of Infertility
US20080014172A1 (en) * 2004-05-28 2008-01-17 Applied Research Systems Ars Holding N.V. Use of Il-17 in the Treatment of Fertility-Related Disorders
AU2006284601B2 (en) * 2005-08-31 2012-12-20 Renexxion, Llc Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders
US20080085915A1 (en) * 2006-06-23 2008-04-10 Cyrus Becker Compounds and methods for the treatment of gastrointestinal and central nervous system disorders
WO2008019123A2 (en) 2006-08-04 2008-02-14 Georgia State University Research Foundation, Inc. Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity
US10300043B2 (en) 2015-08-12 2019-05-28 Mayo Foundation For Medical Education And Research Method for treating a gastrointestinal disorder in a mammal using bacteroides thetaiotaomicron and compositions thereof
US10570127B1 (en) 2018-11-05 2020-02-25 Renexxion, Llc Material and methods for the treatment of gastro-intestinal disorders
WO2024023313A1 (en) 2022-07-29 2024-02-01 Fundación Para La Investigación Médica Aplicada Genetically engineered mice models for multiple myeloma

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4985352A (en) * 1988-02-29 1991-01-15 The Trustees Of Columbia University In The City Of New York DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof
FR2628750B1 (en) * 1988-03-21 1991-11-08 Pasteur Institut SEQUENCE MODIFIED VECTOR ENCODING AMINO ACID SEQUENCE CONTAINED IN MAMMALIAN PROTEIN HAVING BIOLOGICAL MEMBRANE RECEPTOR ACTIVITY
US5225323A (en) * 1988-11-21 1993-07-06 Baylor College Of Medicine Human high-affinity neurotransmitter uptake system
US5155218A (en) 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
WO1993011147A1 (en) * 1991-12-02 1993-06-10 Synaptic Pharmaceutical Corporation Dna encoding a human 5-ht1e receptor and uses thereof
US5360735A (en) * 1992-01-08 1994-11-01 Synaptic Pharmaceutical Corporation DNA encoding a human 5-HT1F receptor, vectors, and host cells
CA2147838C (en) * 1992-10-26 2004-09-28 Frederick J. Monsma, Jr. The pct-65 serotonin receptor
CA2147839C (en) 1992-10-26 2009-12-29 David R. Sibley The st-b17 serotonin receptor
US5472866A (en) * 1992-12-24 1995-12-05 Synaptic Pharmaceutical Corporation DNA encoding 5-HT4A serotonin receptors

Also Published As

Publication number Publication date
EP0642578A1 (en) 1995-03-15
US5472866A (en) 1995-12-05
AU5960694A (en) 1994-07-19
WO1994014957A3 (en) 1994-08-18
EP0642578A4 (en) 1997-06-04
US5766879A (en) 1998-06-16
CA2129969C (en) 2000-05-16
AU685076B2 (en) 1998-01-15
US6331401B1 (en) 2001-12-18
WO1994014957A2 (en) 1994-07-07

Similar Documents

Publication Publication Date Title
CA2129969A1 (en) DNA Encoding 5-HT4 Serotonin Receptors and Uses Thereof
CA2082390A1 (en) Dna encoding human 5-ht1d receptors and uses thereof
EP0574579A4 (en)
CA2156272A1 (en) Dna encoding a human neuropeptide y/peptide yy/pancreatic polypeptide receptor (y4) and uses thereof
CA2145182A1 (en) Dna encoding human alpha 1 adrenergic receptors and uses thereof
EP1325130B1 (en) Nogo receptor homologs
KR0149012B1 (en) Human fc-gamma receptor ñ
EP0585415A4 (en)
WO2000015826A2 (en) Leptin induced genes
CA2127117A1 (en) DNA Encoding a Human Serotonin Receptor (5-HT4B) and Uses Thereof
EP0538395A4 (en) Nucleic acid sequences encoding a human dopamine d 1? receptor
Bard et al. DNA encoding human alpha1 adrenegric receptors and uses thereof

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20131223