CA2132269A1 - Interactive Automated Cytology Method and System - Google Patents
Interactive Automated Cytology Method and SystemInfo
- Publication number
- CA2132269A1 CA2132269A1 CA2132269A CA2132269A CA2132269A1 CA 2132269 A1 CA2132269 A1 CA 2132269A1 CA 2132269 A CA2132269 A CA 2132269A CA 2132269 A CA2132269 A CA 2132269A CA 2132269 A1 CA2132269 A1 CA 2132269A1
- Authority
- CA
- Canada
- Prior art keywords
- cytologist
- cells
- statistical analysis
- automated
- questionable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002452 interceptive effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000007619 statistical method Methods 0.000 abstract 3
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 238000012552 review Methods 0.000 abstract 1
Classifications
-
- G01N15/1433—
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0181—Memory or computer-assisted visual determination
Landscapes
- Engineering & Computer Science (AREA)
- Multimedia (AREA)
- Biomedical Technology (AREA)
- Theoretical Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Image Processing (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
- Image Analysis (AREA)
- Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
- Manipulator (AREA)
- Electrotherapy Devices (AREA)
Abstract
An automated interactive cytology system provides expedited handling of samples, minimizing false negatives, while not substantially increasing the number false positives. A computerized system identifies and displays the cells which are of greatest interest to the cytologist. The system then processes this information on all cells identified to classify the slide as normal, abnormal, or questionable based on a statistical analysis of cells meeting given criteria. Before displaying the results of the statistical analysis, a cytologist reviews the cells which the computer has determined to be most significant. It is only then after the cytologist has determined whether the cells are positive, negative, or questionable, that the determination is inputted into the automated system. The automated system then compares the cytologist's analysis with its own statistical analysis. Based on the two opinions, the cytologist determines how to advise a doctor regarding the sample.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13564093A | 1993-10-12 | 1993-10-12 | |
US08/135,640 | 1993-10-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2132269A1 true CA2132269A1 (en) | 1995-04-13 |
CA2132269C CA2132269C (en) | 2000-02-01 |
Family
ID=22468976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002132269A Expired - Fee Related CA2132269C (en) | 1993-10-12 | 1994-09-16 | Interactive automated cytology method and system |
Country Status (6)
Country | Link |
---|---|
US (1) | US5677966A (en) |
EP (1) | EP0647844B1 (en) |
JP (1) | JP2831282B2 (en) |
AT (1) | ATE187819T1 (en) |
CA (1) | CA2132269C (en) |
DE (1) | DE69422128T2 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3189608B2 (en) * | 1995-02-01 | 2001-07-16 | 株式会社日立製作所 | Flow type particle image analysis method |
US5889880A (en) * | 1995-06-07 | 1999-03-30 | Autocyte, Inc. | Interactive automated cytology method incorporating both manual and automatic determinations |
US6148096A (en) * | 1995-09-15 | 2000-11-14 | Accumed International, Inc. | Specimen preview and inspection system |
US6091842A (en) * | 1996-10-25 | 2000-07-18 | Accumed International, Inc. | Cytological specimen analysis system with slide mapping and generation of viewing path information |
US6430309B1 (en) | 1995-09-15 | 2002-08-06 | Monogen, Inc. | Specimen preview and inspection system |
CA2185511C (en) * | 1995-09-15 | 2008-08-05 | Vladimir Dadeshidze | Cytological specimen analysis system with individualized patient data |
US6122396A (en) * | 1996-12-16 | 2000-09-19 | Bio-Tech Imaging, Inc. | Method of and apparatus for automating detection of microorganisms |
WO1998029825A2 (en) * | 1996-12-16 | 1998-07-09 | Neopath, Inc. | Method and apparatus for efficacy improvement in management of cases with equivocal screening results |
CA2297119A1 (en) * | 1997-07-17 | 1999-01-28 | Accumed International, Inc. | Inspection system with specimen preprocessing |
CA2295918A1 (en) * | 1997-07-17 | 1999-01-28 | Accumed International, Inc. | Inspection system with specimen preview |
US6181811B1 (en) | 1998-01-13 | 2001-01-30 | Neopath, Inc. | Method and apparatus for optimizing biological and cytological specimen screening and diagnosis |
WO1999063320A2 (en) | 1998-05-29 | 1999-12-09 | The Brigham And Women's Hospital, Inc. | Computer system and computer-implemented process for analyzing results of cytology tests for performance evaluation of cytologists |
US6665060B1 (en) | 1999-10-29 | 2003-12-16 | Cytyc Corporation | Cytological imaging system and method |
US7369304B2 (en) * | 1999-10-29 | 2008-05-06 | Cytyc Corporation | Cytological autofocusing imaging systems and methods |
AU1476801A (en) * | 1999-11-10 | 2001-06-06 | Lucid, Inc. | System for optically sectioning and mapping surgically excised tissue |
US6535626B1 (en) | 2000-01-14 | 2003-03-18 | Accumed International, Inc. | Inspection system with specimen preview |
US7366695B1 (en) * | 2000-02-29 | 2008-04-29 | First Data Corporation | Electronic purchase method and funds transfer system |
US20030126036A1 (en) * | 2000-02-29 | 2003-07-03 | First Data Corporation | Online payments |
US20030126075A1 (en) * | 2001-11-15 | 2003-07-03 | First Data Corporation | Online funds transfer method |
US7194118B1 (en) | 2000-11-10 | 2007-03-20 | Lucid, Inc. | System for optically sectioning and mapping surgically excised tissue |
US7027628B1 (en) | 2000-11-14 | 2006-04-11 | The United States Of America As Represented By The Department Of Health And Human Services | Automated microscopic image acquisition, compositing, and display |
DE10124340A1 (en) | 2001-05-18 | 2002-12-05 | Fraunhofer Ges Forschung | Method of analyzing a biological sample |
US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
US7216081B1 (en) * | 2003-03-27 | 2007-05-08 | Psyche Systems Corporation | Interactive process and system for screening cytological specimens |
US20050009032A1 (en) * | 2003-07-07 | 2005-01-13 | Cytokinetics, Inc. | Methods and apparatus for characterising cells and treatments |
GB0503629D0 (en) | 2005-02-22 | 2005-03-30 | Durand Technology Ltd | Method and apparatus for automated analysis of biological specimen |
US8326014B2 (en) * | 2007-09-28 | 2012-12-04 | Cytyc Corporation | Methods and systems for processing biological specimens utilizing multiple wavelengths |
US8119363B2 (en) * | 2008-05-02 | 2012-02-21 | Cellsolutions, Llc | Cell sample preparation method and apparatus |
US9786047B2 (en) * | 2011-05-18 | 2017-10-10 | Nec Corporation | Information processing system, method, and apparatus supporting a pathological diagnosis, and control method and control program thereof |
CA2839531A1 (en) | 2011-06-17 | 2012-12-20 | Constitution Medical, Inc. | Systems and methods for sample display and review |
US9646376B2 (en) | 2013-03-15 | 2017-05-09 | Hologic, Inc. | System and method for reviewing and analyzing cytological specimens |
US10304188B1 (en) | 2015-03-27 | 2019-05-28 | Caleb J. Kumar | Apparatus and method for automated cell analysis |
US11071517B2 (en) * | 2015-11-10 | 2021-07-27 | The Trustees Of The University Of Pennsylvania | Machine implemented methods, systems, and apparatuses for improving diagnostic performance |
US20210233647A1 (en) * | 2018-11-02 | 2021-07-29 | Hologic, Inc. | Digital imaging system and method |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2903855A1 (en) * | 1979-02-01 | 1980-08-14 | Bloss Werner H Prof Dr Ing | METHOD FOR AUTOMATICALLY MARKING CELLS AND DETERMINING THE CHARACTERISTICS OF CELLS FROM CYTOLOGICAL MEASUREMENT DEVICES |
JPS5698635A (en) * | 1980-01-11 | 1981-08-08 | Omron Tateisi Electronics Co | Cell analyzing device |
US4612614A (en) * | 1980-09-12 | 1986-09-16 | International Remote Imaging Systems, Inc. | Method of analyzing particles in a fluid sample |
JPS6447948A (en) * | 1987-08-19 | 1989-02-22 | Hitachi Ltd | Automatic cell sorter |
US4965725B1 (en) * | 1988-04-08 | 1996-05-07 | Neuromedical Systems Inc | Neural network based automated cytological specimen classification system and method |
DE3836716A1 (en) * | 1988-10-28 | 1990-05-03 | Zeiss Carl Fa | METHOD FOR EVALUATING CELL IMAGES |
US5073857A (en) * | 1989-06-01 | 1991-12-17 | Accuron Corporation | Method and apparatus for cell analysis |
US5072382A (en) * | 1989-10-02 | 1991-12-10 | Kamentsky Louis A | Methods and apparatus for measuring multiple optical properties of biological specimens |
ATE155592T1 (en) * | 1990-03-30 | 1997-08-15 | Neuromedical Systems Inc | AUTOMATIC CELL CLASSIFICATION SYSTEM AND METHOD |
JPH06503415A (en) * | 1990-11-07 | 1994-04-14 | ニューロメディカル システムズ インコーポレイテッド | Device and method for inspecting images displayed on a display while performing inspection audits |
US5257182B1 (en) * | 1991-01-29 | 1996-05-07 | Neuromedical Systems Inc | Morphological classification system and method |
US5428690A (en) * | 1991-09-23 | 1995-06-27 | Becton Dickinson And Company | Method and apparatus for automated assay of biological specimens |
WO1993016436A1 (en) * | 1992-02-18 | 1993-08-19 | Neopath, Inc. | Method for identifying normal biomedical specimens |
-
1994
- 1994-09-16 CA CA002132269A patent/CA2132269C/en not_active Expired - Fee Related
- 1994-10-04 DE DE69422128T patent/DE69422128T2/en not_active Expired - Lifetime
- 1994-10-04 EP EP94115546A patent/EP0647844B1/en not_active Expired - Lifetime
- 1994-10-04 AT AT94115546T patent/ATE187819T1/en not_active IP Right Cessation
- 1994-10-11 JP JP6245363A patent/JP2831282B2/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/483,637 patent/US5677966A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0647844A3 (en) | 1995-09-20 |
EP0647844A2 (en) | 1995-04-12 |
DE69422128T2 (en) | 2000-08-31 |
ATE187819T1 (en) | 2000-01-15 |
JP2831282B2 (en) | 1998-12-02 |
US5677966A (en) | 1997-10-14 |
DE69422128D1 (en) | 2000-01-20 |
CA2132269C (en) | 2000-02-01 |
JPH07225190A (en) | 1995-08-22 |
EP0647844B1 (en) | 1999-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed | ||
MKLA | Lapsed |
Effective date: 20120917 |