CA2147126A1 - Piperidine Derivatives and Process for Their Production - Google Patents

Piperidine Derivatives and Process for Their Production

Info

Publication number
CA2147126A1
CA2147126A1 CA2147126A CA2147126A CA2147126A1 CA 2147126 A1 CA2147126 A1 CA 2147126A1 CA 2147126 A CA2147126 A CA 2147126A CA 2147126 A CA2147126 A CA 2147126A CA 2147126 A1 CA2147126 A1 CA 2147126A1
Authority
CA
Canada
Prior art keywords
hydrogen
production
piperidine derivatives
substituents
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2147126A
Other languages
French (fr)
Other versions
CA2147126C (en
Inventor
Thomas E. D'ambra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curia Global Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22176189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2147126(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Priority to CA002181089A priority Critical patent/CA2181089C/en
Priority to CA002254506A priority patent/CA2254506C/en
Publication of CA2147126A1 publication Critical patent/CA2147126A1/en
Application granted granted Critical
Publication of CA2147126C publication Critical patent/CA2147126C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/86Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Abstract

The present invention relates to substantially pure piperidine derivative compounds of formulae (I) or (II) wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; R3 is -COOH or -COOR4; R4 has 1 to 6 carbon atoms; A, B, and D are the substituents of their respective rings each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents. A
process of preparing such piperidine derivative compounds in substantially pure form is also disclosed.
CA002147126A 1993-06-24 1994-06-21 Piperidine derivatives and process for their production Expired - Lifetime CA2147126C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002181089A CA2181089C (en) 1993-06-24 1994-06-21 Piperidine derivatives and process for their production
CA002254506A CA2254506C (en) 1993-06-24 1994-06-21 Piperidine derivatives and process for their production

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8310293A 1993-06-24 1993-06-24
US08/083,102 1993-06-24
PCT/US1994/006873 WO1995000482A1 (en) 1993-06-24 1994-06-21 Piperidine derivatives and process for their production

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CA002181089A Division CA2181089C (en) 1993-06-24 1994-06-21 Piperidine derivatives and process for their production
CA002254506A Division CA2254506C (en) 1993-06-24 1994-06-21 Piperidine derivatives and process for their production

Publications (2)

Publication Number Publication Date
CA2147126A1 true CA2147126A1 (en) 1995-01-05
CA2147126C CA2147126C (en) 1999-08-24

Family

ID=22176189

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002147126A Expired - Lifetime CA2147126C (en) 1993-06-24 1994-06-21 Piperidine derivatives and process for their production

Country Status (16)

Country Link
US (9) US5750703A (en)
EP (4) EP1369409B1 (en)
JP (4) JP3034047B2 (en)
KR (2) KR100387347B1 (en)
AT (3) ATE174589T1 (en)
AU (1) AU670004B2 (en)
CA (1) CA2147126C (en)
DE (3) DE69433346T2 (en)
DK (3) DK1026147T3 (en)
ES (3) ES2129130T3 (en)
FI (1) FI109691B (en)
HU (1) HU226559B1 (en)
NO (2) NO308599B1 (en)
NZ (1) NZ268513A (en)
PT (2) PT1369409E (en)
WO (1) WO1995000482A1 (en)

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Also Published As

Publication number Publication date
NO955023L (en) 1995-12-12
EP0703902A4 (en) 1996-04-10
EP1026147B1 (en) 2003-11-19
NO308599B1 (en) 2000-10-02
JPH08511806A (en) 1996-12-10
KR960703398A (en) 1996-08-17
HUT73235A (en) 1996-07-29
CA2147126C (en) 1999-08-24
NO955023D0 (en) 1995-12-12
DK1369409T3 (en) 2006-08-14
DE69434696D1 (en) 2006-05-18
FI956270A (en) 1995-12-27
ATE254594T1 (en) 2003-12-15
US20060052610A1 (en) 2006-03-09
AU7174894A (en) 1995-01-17
EP1026147A1 (en) 2000-08-09
NO994582D0 (en) 1999-09-21
US5994549A (en) 1999-11-30
US5663412A (en) 1997-09-02
ES2211444T3 (en) 2004-07-16
ATE174589T1 (en) 1999-01-15
JP2002212166A (en) 2002-07-31
ATE322473T1 (en) 2006-04-15
EP0703902B1 (en) 1998-12-16
FI956270A0 (en) 1995-12-27
NO994582L (en) 1995-12-12
DE69434696T2 (en) 2006-11-16
NZ268513A (en) 1996-09-25
HU9503719D0 (en) 1996-02-28
EP1369409B1 (en) 2006-04-05
EP0703902A1 (en) 1996-04-03
JPH11236373A (en) 1999-08-31
FI109691B (en) 2002-09-30
US5750703A (en) 1998-05-12
PT1026147E (en) 2004-04-30
US20060241303A1 (en) 2006-10-26
AU670004B2 (en) 1996-06-27
HU226559B1 (en) 2009-03-30
US5581011A (en) 1996-12-03
JP4124998B2 (en) 2008-07-23
US20080227983A1 (en) 2008-09-18
DK1026147T3 (en) 2004-03-22
US7238834B2 (en) 2007-07-03
EP1369409A1 (en) 2003-12-10
ES2261871T3 (en) 2006-11-16
DE69415319D1 (en) 1999-01-28
US5578610A (en) 1996-11-26
JP3034047B2 (en) 2000-04-17
DE69415319T2 (en) 1999-06-10
DK0703902T3 (en) 1999-08-23
KR100387348B1 (en) 2003-06-12
US5589487A (en) 1996-12-31
KR100387347B1 (en) 2003-11-28
US7390906B2 (en) 2008-06-24
PT1369409E (en) 2006-08-31
JP2001031650A (en) 2001-02-06
WO1995000482A1 (en) 1995-01-05
JP3195297B2 (en) 2001-08-06
JP3658291B2 (en) 2005-06-08
EP0723958A1 (en) 1996-07-31
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DE69433346T2 (en) 2004-09-09

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