CA2148569C - Analytical system for monitoring a substance to be analyzed in patient blood - Google Patents

Analytical system for monitoring a substance to be analyzed in patient blood Download PDF

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Publication number
CA2148569C
CA2148569C CA002148569A CA2148569A CA2148569C CA 2148569 C CA2148569 C CA 2148569C CA 002148569 A CA002148569 A CA 002148569A CA 2148569 A CA2148569 A CA 2148569A CA 2148569 C CA2148569 C CA 2148569C
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Prior art keywords
sensor
analysis
data
unit
patient
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CA002148569A
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French (fr)
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CA2148569A1 (en
Inventor
Dirk Boecker
Hans-Peter Haar
Peter Blasberg
Reinhard Kotulla
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Roche Diagnostics GmbH
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Roche Diagnostics GmbH
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813Specially adapted to be attached to a specific body part
    • A61B5/6822Neck
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0295Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00Surgery
    • Y10S128/903Radio telemetry

Abstract

Analytical system for monitoring patient blood concentration of a substance to be analyzed, comprising analysis-elements (12) containing reagents and an evaluation instrument comprising a measurement device to measure a change resulting from a reaction of the analyte with the reagents in order to determine, from the measurement values so obtained, analytical data representing element analysis data CA.

In order to allow continuous monitoring of the analyte with good accuracy and a reduced number of invasive sample generation steps it is proposed that the analytical system further comprises (i) a sensor unit (2) portable on the patient body, said sensor unit (2) including a sensor (7) borne on the patient body for the direct and reagent-free measurement of a parameter correlating with the concentration of the analyzed substance and a transmitter for the wireless transmission of data signals; and (ii) a sensor-analysis means to ascertain sensor-analysis data CS from the measurement values of said parameter measured by said sensor; and the evaluation instrument further comprises a receiver to receive in wireless manner the data signals from the sensor unit (2), calibration means to calibrate the sensor-analysis data CS on the basis of the element-analysis data CA and (iii) a data memory for the long-term storage of analytical data, whereby said evaluation instrument forms a central unit (3) of an integrated analysis-element/sensor monitoring system (1).
(Fig- 1)

Description

214~~~
The invention concerns an analytical system for monitoring a substance to be analyzed (analyte) which is present in the blood of a patient.
The concentration of analytes in blood in many cases must be monitored regularly. This is especially the case when regular drug treatment is required in relation to the concentration of the particular substance. The most important example is diabetes-mellitus. Patients with this disease should constantly monitor their blood-sugar level to match their insulin injections to their need at the time and thereby to keep their blood-sugar levels (that is, the glucose concentration in blood) within specified limits. Exceeding such limits upward (hyperglycemia) or dropping below them (hypoglycemia) should be avoided with as much reliability as possible to prevent both critical acute conditions and grave long-term disabilities (for instance loss of eyesight).
The present invention in particular relates to monitoring the blood-glucose concentration though it is also applicable to other substances requiring analysis. No limitation on the general applicability of the invention is to be construed from any discussion hereafter relating to glucose determination.
Conventional analytical systems for monitoring blood-glucose concentration are composed of solid-state analysis-elements also called test carriers and an evaluation instrument. As a rule the analysis-elements and the evaluation instrument are specifically mutually matched and are provided as one system from the same manufacturer.
The analysis-elements contain reagents. When the elements are brought into contact with the test sample, the reaction between the analyte in the sample and the reagents causes a physically measurable change correlated to the concentration of said substance, in the analysis element. The evaluation instrument contains a measurement system measuring the said change and electronics to determine the concentration of the analyte on the basis of the measurement value obtained when measuring said change. Modern devices make use of microprocessors for the evaluating electronics, making possible software-controlled digital processing of the measurement values into signals corresponding to the concentration of the substance being analyzed. As a rule these analytical data are displayed in units of concentration on an alphanumeric display. However the expression "analytical data"
in the sense of the invention also covers electrical signals representing the analytical results in other ways, for instance as signals to control offset displays of information relating to the concentration of the analyte such as "ideal range", "upper standard range", "upper danger zone", etc.
Different kinds of analysis-elements are known that involve different physico-chemical principles regarding the principles of reaction and the measurable change correlated to 2448~6~
concentration. Conventional analysis systems are foremost photometric or electrochemical.
As regards photometric analytical systems, the analysis-elements contain a system of reagents. The reaction thereof with the analyte causes a photometrically detectable change (color change). In general the reagents are present in a porous-plastic or paper matrix forming a test zone of the analyzing element, the color of said matrix changing as a function of concentration. This color change can be quantitatively determined using reflection photometry.
Electrochemical analysis-elements contain a system of electrochemical reagents. The reaction thereof with the analyte affects the electrical potential across two terminals of the analysis-elements and/or the current level between two terminals of the analyzing element when the voltage across said terminals is fixed. In this case therefore the changing physically measurable quantity is the voltage or the current and is determined by a corresponding voltage or current sensor integrated into the instrument. The change of said measurement value correlating to the concentration of the analyzed substance is converted, preferably again using microprocessor evaluation electronics, into analytical data (concentration of analyzed substance).
Analytical systems operating by means of reagent containing analysis-elements (hereinafter referred to as "element-analysis systems" have become highly accurate and are handled easily enough that the patient himself/herself may use them for constant monitoring of the blood-glucose concentration (home monitoring). However they entail the 2~48~~~
significant drawback that each particular analysis requires withdrawing a drop of blood which then is placed in contact with an analysis-element. As a rule this procedure is implemented by piercing the finger, in other words, each analysis entails painful skin injury with some danger of infection. Such a procedure is called "invasive analysis".
In order to allow continuous monitoring of the concentration of a substance to be analyzed in blood wile providing good accuracy and a lesser number of invasive interventions to secure samples, the invention, based on an analytical system of the type discussed before, discloses a system which includes a sensor unit portable on the patient body and comprising a sensor which, free of reagents, directly measures at the patient body a parameter correlating with the concentration of the analyzed substance, said unit further comprising a transmitter to wirelessly transmit data signals.
Said system furthermore includes sensor evaluation electronics to determine sensor-analysis data from the sensor measurement values of the measured parameter. The evaluation instrument is the central unit of an integrated analysis-element/sensor monitoring-system and includes a wireless receiver to receive the data signals from the sensor unit, further calibrating means to calibrate the sensor-analysis data on the basis of the analytical data from the analysis-element ("element analysis data") and a data memory for the long-term storage of analytical data.
Reagent-free, sensor-analysis systems for determining blood analytes have been described in various embodiments.: For some substances to be analyzed (especially the blood oxygenation values and the blood gas concentrations) such ~.~ 4 856 systems have become practically significant. However for a number of other substances to be analyzed, in particular glucose, they have not been adequately practical.
A survey of non-invasive methods to determine glucose is given in "PHYSICOCHEMICAL DETERMINATION OF GLUCOSE IN VIVO"
by J.D. Kruse-Jarres, J. Clin. Chem. Clin. Biochem. 26, 1988, pp 201-8.
Foremost the invention concerns systems employing the interaction between irradiated light and the tissue of a living human (preferably the dermal tissue) for the purpose of analytically determining the concentration of an analyte therein. It is assumed that the concentration of the analyte in the (blood-circulating) tissue correlates adequately for practical purposes with the corresponding concentration in the blood. In such systems the sensor unit includes a light emitter irradiating the tissue. Furthermore a light detector is present by means of which, following its interaction with the tissue, light leaving the body part is sensed in order to determine a measurable physical light property which changes by interaction with the tissue. In such methods, this measurable physical property forms a parameter which correlates with the concentration of the analyzed substance.
Most methods of this kind known so-far are based on spectroscopic analysis. The characteristic absorption (caused by the vibrational and rotational states of the molecules of the analyzed substance) is determined therein by ascertaining the dependence of optical absorption on the light wavelength.
In practice typically light of different wavelengths from a narrow-band light emitter is irradiated and the light received 2~ 4 ~~fi~

by the light detector is then measured. Alternatively the irradiation may be from a broad-band light emitter and a wavelength-selective measurement may then be carried out at the detection side. The absorption bands of the molecules under discussion (in particular of glucose) are far into the infrared range of light. However, tissue water causing strong optical absorption in this range, most authors suggest measurement wavelengths in the near infrared, whereby harmonics of the molecular oscillatory and rotational states may be detected. Illustrative such systems are described in EP-A 0 160 768, in WO 93/00856 and in US-patent 5,028,787.
In an especially preferred embodiment of the invention, a sensor system is used wherein a light parameter is determined that depends on the tissue's index of refraction. This method is substantially based on the finding that the change in index of refraction of the liquid in the tissue relating to the glucose concentration may be used as the parameter correlated to the glucose concentration.
For the implementation of this method a measurement-technique has been suggested in which signals are determined which are affected by the multi-scattering of light by scattering centers in the tissue. Such a procedure is described in the international patent application PCT/DE
93/01058. Under the conditions of measurement described in said publication, multi-scattering causes enhancement of the effect tied to the change in index of refraction, and said enhancement can be ascertained as a comparatively strong and hence well measurable signal change. The cited reference contains further deta.iis of interest in the present invention.

Reference is also made to Canadian patent specification 2,174,441 which describes analysis of glucose based on the determination of a light parameter corresponding to the light transit time in the tissue. Such a transit time parameter may be directly the time of travel of an exceedingly short light pulse.
However, it is much simpler to ascertain instead the phaseshift of light within the tissue as a transit-time parameter which correlates with the tissue glucose concentration.
Further reference is made to Canadian patent specification 2,189,047 which describes how to determine changes in tissue index-of refraction using low coherence interferometry. Such determination may take place directly by ascertaining the light's optical path in the tissue or indirectly in such manner that the light scattering coefficient in the tissue is being ascertained. The scattering coefficient is affected decisively by the relation between the index of refraction of the liquid and that of the tissue scattering centers (for instance cells).
In the invention, such a non-invasive sensor-analysis-system is combined with an invasive analytical system operating with a reagent-based analyzing element.
In accordance with one aspect of the invention there is provided an analytical system for monitoring patient blood concentration of a substance to be analyzed, comprising (A) an element analysis system comprising: at least one analysis-element containing reagents for reacting with the analyzed substance after the at least one analysis-element has been brought in contact with a patient blood-drop to cause a measurable change in the analysis-element, the change correlating with the concentration of the analyzed substance, and an evaluation instrument comprising a measurement device to measure the change and an evaluation means to determine, from the measurement values so obtained, analytical data representing element analysis data CA, the analytical system further comprising: (B) a sensor analysis system comprising (i) a sensor unit portable on the patient body, the sensor unit including a sensor borne on the patient body for the direct and reagent-free non-invasive measurement of a parameter correlating with the concentration of the analyzed substance, and a transmitter for the wireless transmission of data signals, and (ii) a sensor-analysis means to ascertain sensor-analysis data Cs from the measurement values of the parameter measured by the sensor; and the evaluation instrument further comprising (a) a receiver to receive in wireless manner the data signals from the sensor unit, (b) calibration means to calibrate the sensor-analysis data Cs on the basis of the element-analysis data CA, and (c) a data memory for the long-term storage of analytical data, whereby the evaluation instrument forms a central unit of an integrated analysis-element/sensor monitoring system.

7a In accordance with a particular embodiment of the invention there is provided an analytical system for monitoring and analyzing a concentration of a substance in blood of a patient, said system comprising: an element-analysis system, said element-analysis system comprising at least one analysis element containing a reagent thereupon, said reagent for reacting with the substance in a sample of the blood when said at least one analysis element has been brought in contact with the sample, thereby causing a measurable change R in the analysis element which correlates with the concentration of the substance and an evaluation instrument having a measuring device therein, said measuring device for measuring the measurable change R in the analysis element, the evaluation instrument also including an evaluation means for determining element-analysis data CA from the measured change R; said analytical system further comprising a sensor-analysis system, said sensor-analysis system comprising: (i) a sensor unit configured to be abed to and thus continuously carried on the body of the patient, said sensor unit including a first sensor means for non-invasive determination of a measured value of a parameter S correlating with the concentration of the substance in the blood of the patient and for generating sensor data signals representing the non-invasively measured parameter S, said sensor unit also including a transmitter means for wireless transmission of data signals representing the non-invasively measured parameter S; and (ii) an evaluation unit remotely disposed from said sensor unit for wirelessly receiving data signals transmitted from said sensor unit, said evaluation unit comprising receiver means for wirelessly receiving the data signals representing the non-invasively measured parameter S from the sensor unit, and sensor analysis means for ascertaining sensor-analysis data Cs from the transmitted data signals;
wherein said evaluation unit of the sensor-analysis system and said evaluation instrument of the element-analysis system are coupled together in a central unit which is remote from said sensor unit, said central unit including a calibration means for performing a calibration of the data representing the non-invasively measured parameter S and for determining sensor-analysis data Cs based upon the element analysis data CA, said central unit also comprising a data memory means coupled to said calibration means for storing data therein.
In accordance with another aspect of the invention there is provided a method of operating a system of the invention in which by the time when a concentration value is ascertained by means of an analysis-element the element-analysis data CA is used as the nominal value for the calibration of the sensor analysis data Cs.

In accordance with still another aspect of the invention there is provided a method of monitoring patient blood concentration of a substance comprising (a) providing an analytical system of the invention, (b) ascertaining a concentration value as element-analysis data CA by means of an analysis element, (c) receiving sensor analysis data Cs with the sensor unit and calibrating the data Cs with the data CA as nominal value for the calibration, and (d) issuing a signal representing the concentration of the substance in response to the calibrated value of data Cs.
In accordance with another particular embodiment of the invention there is provided a method for monitoring and analyzing a concentration of a substance in blood of a patient, comprising the steps of applying a blood sample to an analysis element having a reagent thereupon, wherein said reagent reacts with the substance in the blood sample, thereby causing a measurable change R in the analysis element correlating with the concentration of the substance; measuring the measurable change R in the analysis element with an element-analysis system; inputting measurement values of the measurable change R into an evaluation instrument of said element-analysis system for determining element-analysis data CA based upon the measured change R; non-invasively measuring a parameter S correlating with the concentration of the substance in the blood of the patient with a sensor unit of a sensor-analysis system, said sensor unit aced to a body of the patient and remotely disposed from said evaluation instrument, said step of non-invasively measuring including the steps of irradiating light into living tissue of the patient, and detecting a physical property of light exiting the living tissue which varies based upon an interaction of the light with the tissue, for generating signals corresponding to the parameter S; wirelessly transmitting data signals representing the non-invasively measured value from the sensor unit via a wireless transmitter to a receiver of an evaluation unit which is remotely disposed from said sensor unit and is a part of the sensor analysis system, and which is coupled in a central unit to said element-analysis system; receiving said wirelessly transmitted data signals in the receiver;
determining sensor-analysis data Cs from the transmitted data signals using a calibration based on a comparison of the transmitted data signals to element-analysis data CA in said evaluation unit, said sensor-analysis data Cs representing the concentration of the substance in the blood of the patient.
In accordance with still another particular embodiment of the invention there is provided a method for monitoring and analyzing a concentration, of a substance in blood of a patient, said method comprising the steps of providing an evaluation instrument of an element-analysis system for evaluating a concentration of a substance in a blood sample of the patient; providing a sensor-analysis system 8a including a sensor unit configured to be affixed to and continuously carried on the body of the patient, and an evaluation unit remotely disposed from the sensor unit;
applying the blood sample to an analysis element having a reagent thereupon, wherein said reagent reacts with the substance in the blood sample, thereby causing a measurable change R in the analysis element correlating with the concentration of the substance; measuring the measurable change R in the analysis element;
determining element-analysis data CA based upon the measured change R, inputting the element-analysis data CA to said evaluation unit of said sensor-analysis system, thereby providing calibration information therefor; said method further comprising the steps of non-invasively measuring a parameter S correlating with the concentration of the substance in the blood of the patient with the sensor unit of the sensor-analysis system, said step of non-invasively measuring including the steps of irradiating light into living tissue of the patient, and detecting a physical property of light exiting the living tissue which vanes based upon an interaction of the light with the tissue, for generating signals corresponding to the parameter S;
wirelessly transmitting data signals representing the non-invasively measured value from the sensor unit to a receiver of the sensor-analysis system, said receiver being remotely disposed from said sensor unit and being coupled to said element-analysis system;
receiving said wirelessly transmitted data signals in the receiver; and determining sensor-analysis data Cs from the transmitted data signals using a calibration which is based on a comparison of the transmitted data signals to element-analysis data CA in said evaluation unit, said sensor-analysis data Cs representing the concentration of the substance in the blood of the patient.
The sensor-analysis-system is composed of a movable, battery-operated sensor unit worn on the patient-body and of an evaluating device which is stationary in the sense that it is not born on the patient-body but is situated at an appropriate location, for instance in the dwelling of the patient. Preferably, however, the central unit is small and lightweight 2~48~6~
~'" 9 enough to be easily carried along by the patient if or when leaving said dwelling for some time (for instance for several days). The base unit and the central unit are linked by wireless data transmission. Said link may be implemented in a variety of ways, for instance using IR light, high frequency radio waves or ultrasonics.
The sensor unit borne on the patient-body and the stationary central unit jointly assume the functions of the sensor-analysis-system. The system functions can be assigned to the two units in different ways. Basically a sensor unit may be designed without intelligence of its own, its function being merely to determine the sensor measurement values and to transmit these in wireless manner to the central unit.
Preferably however the sensor unit is designed with its own intelligence, that is, it comprises a microprocessor data-processing system as evaluation means in order to ascertain sensor analysis data from the measurement values of the at least one sensor of the sensor unit that correspond to the concentration of the substance being analyzed. As a result it is possible to provide the sensor unit with its own display for indicating the concentration data of the analyzed substance, illustratively merely issuing an acoustic or optic warning when specified limits of the glucose concentration are crossed, upward or downward. Advantageously furthermore in such embodiment the link between the sensor unit and the central unit is interactive, that is, not only are analytical data from the analysis element transmitted from the sensor unit to the central unit, but vice-versa data from the central unit are also made available to the sensor unit. This feature may apply in particular to calibration required by the sensor unit to determine the concentration of the analyzed substance.

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It is furthermore significant in the present invention that the central unit of the sensor-analysis-system be simultaneously the evaluation instrument of the invasive element-analysis system and that it serves for calibrating the sensor-analysis sub-system on the basis of the test data of the element-analysis sub-system.
Compared with heretofore conventionally used analytical systems, a primary advantage of the analytical system of the invention is that current analytical data are continuously present in real time and that reliable information about the rate of change of the glucose concentration is available any time. This is especially important for groups at risk among the diabetics, for instance diabetics tending toward hypo- or hyper-glycemia during night rest. Furthermore permanent monitoring of glucose values is especially important during times of increased body exertion, for instance sports activities. For diabetics on insulin therapy it is especially important to be provided with the feasibility of determining the instantaneous trend of the glucose value (rising or falling) qualitatively and quantitatively in order to determine the required quantity of insulin.
The invention is elucidated below by means of embodiments illustratively shown in the Figures.
Fig. 1 is a perspective view of the components of an analytical system according to the invention;
Fig. 2 is a functional block diagram, Fig. 3 is a plot of the analytical data as a function of time, explaining a calibration procedure, Fig. 4 is a top view of a central unit with a first embodiment of a graphics display, and Fig. 5 is a top view of a central unit with a second embodiment of a graphics display.
The integrated analysis-element/sensor system IASS 1 shown in Fig. 1 is composed of a sensor unit 2 borne on the body of the patient and of a central unit 3 linked with the sensor unit 2 by wireless data transmission symbolized by the arrow 4. In the shown preferred embodiment, the sensor unit 2 is composed of the base unit 6 and of two sensors 7, 8 connected by cables 9 to the base unit 6. The base unit 6 may be worn by a neck strap 10 around the neck of the patient.
Obviously it may be affixed also in some other way, for instance by a shoulder strap or a belt clip to the patient body.
In principle, operation may be with only one sensor.
However two or more sensors may be advantageous in order to allow measuring of a parameter correlating with the glucose concentration'at several body test sites simultaneously, with an increase in accuracy being provided for instance by averaging the measurement values or by selecting the better test values by means of predetermined reliability criteria.
The central unit 3 comprises the typical features of an evaluation instrument commonly used in element-analysis-- 2148~~~

systems. In the case shown, it serves to evaluate an analysis-element 12 in the form of a glucose test strip 13 with a base layer 14 and a test zone 15. For evaluation, the analysis-element 12 is inserted into a test duct 17 located beneath a flap 18 of the device 3. A keypad 20 is provided to operate the central unit 3. A display 21 serves as information output, in particular to display analytical data.
The evaluation means for evaluating the analysis-element, which is integrated into the central unit 3, ist of conventional design and therefore need not be described in further detail. Relevant information is offered in numerous publications. Illustratively the general instrument design is described in European patent application 0 492 326 and applicable measurement electronics is described in the European patent application 0 075 767.
Fig. 2 is a block diagram of the essential functional components of the central unit 3 and of the sensor unit 2.
The central unit 3 contains a measurement device 23 to measure a change in the analysis-element 12 correlating with the change of the concentration of the analyzed substance, for instance a reflection photometer, allowing to measure a change of the color of the test zone 15. The measurement device 23 generates electrical signals corresponding to the measurement value R of the change correlating with the concentration.
The measurement values R are fed to evaluation electronics 24 which is a part of the a micro-computer 25 which also includes a data memory 26. By means of an evaluation curve stored in the memory 26 which describes the 214~5~~

functional relationship of the sought concentration C and the test value R, namely CA = f (R) , the evaluation electronics 24 computes the sought concentration C of the analyzed substance and feeds these element-analysis data CA to the memory 26 where they are stored. The analysis data CA are displayed automatically or by means of a special command in the display 21.
The evaluation curve CA - f(R) may be permanently stored in the central unit 3. Preferably however a separate, batch-specific evaluation curve shall be used for each new manufactured batch of analysis-elements 12 and shall be transmitted to the central unit by means of a suitable data medium in machine-readable form. For that purpose the central unit comprises a data reader 28, illustratively a bar-code reader, to read a bar code affixed to the analysis-element itself or to an additional code carrier. The bar code is included in each pack of analysis-elements and contains the batch-specific evaluation curve. Further details are provided in the European patent application 0 492 326.
In addition to the above described functional compo-nents which are conventional in analysis-element evaluation instruments, the central unit 3 furthermore comprises a transceiver 29 for wireless transmission of data, and a sensor calibration means 30 which in practice preferably is implemented as software and therefore is shown in Fig. 3 as being part of the microcomputer 25. These components link the analysis-element sub-system to the sensor sub-system in the manner further elucidated below.

2~4~5~

The base unit 6 of the sensor unit 2 contains sensor operation device 32 connected to at least one sensor 7. This sensor electronics 32 contains the elements required to operate the sensor 7 and thereby to measure at the patient body a parameter correlating with the glucose concentration.
The preferred embodiment includes light irradiating means which may be LEDs mounted in the sensor 7 itself and powered through the cable 9. Alternatively one or more light sources may be present in the base unit 6, the cable 9 containing optic fibers transmitting the light into the sensor 7.
Correspondingly semiconducting light detectors are present in the sensor 7 and/or the base unit 6 to detect the light after its interaction with the patient tissue. The sensor operation device 32 furthermore contains electronic components such as - amplifiers to process the received signal into a sensor measurement value S correlating with the concentration of the analyzed substance. The sensor measurement value S is fed to a sensor evaluation-means 33 preferably in the form of components of a micro-computer system 34 which also includes a memory unit and which is integrated into the base unit 6. In practice and like the analysis-element evaluation instrument 24 the sensor evaluation-electronics 33 computes analytical data (concentrations) C, by means of an evaluation curve CS =
g(S) stored in the memory unit 35, from the measurement values S, said calculation being in practice software controlled. The evaluation curve CS - g(S) is transmitted in wireless manner from the central unit 3 to the base unit 6. For that purpose - the base unit 6 is fitted with a transceiver 36 making possible in cooperation with the transceiver 29 of the central unit wireless transmission of data between the two units 3, 6.

214~~~9 The computed concentration data (sensor analysis data CS) are stored in the memory unit 35. They may be output independently of the central unit 3 by an output unit 38, the design of the output unit 38 in the base unit 6 is choosen for minimum size and consumption of battery power. Its main purpose is to issue an alarm in case critical limit values of the glucose concentration are crossed in the dangerous direction. Appropriately the output unit 38 may be embodied as an LED display With three LEDs (normal range, danger of excess sugar, danger of sugar deficiency). Alternatively or in addition, an acoustic signal may be provided.
Fig. 2 shows the power-supply battery 40 being part of the base unit 6. This is important since the power drain of analytic sensors is comparatively high. Therefore the battery 40 should be rechargeable and a voltage monitor (not shown) is integrated into the base unit 6 to alert in timely manner to the need for battery exchange.
When using the analytical system of the invention, the patient fitted with the sensor unit 2 may be away for a substantial time from the stationary central unit 3 without running into problems. During this time the sensor-analysis data CS are stored in the memory 35. Upon returning home, and when the patient is sufficiently close to the central unit 3 to allow wireless exchange of data between the units 3 and 6, the sensor-analysis data CS which were acquired in the meantime are transferred from the memory 35 into the memory 26 of the central unit. The patient is able any time to make a calibration using an analysis-element 12. Appropriately the central unit 3 comprises time-keeping device reminding the patient frequently enough to carry out an analysis by means of an analysis-element for purposes of calibration. Each time such an analysis is performed, a new evaluation curve CS -g(S) is determined in the central unit 3 and transmitted to the sensor unit 2. The cooperation of the units 3 and 6 during calibration of the overall system is discussed further below.
As already described, the element-analysis data CA are calibrated by means of the evaluation curve CA = f(R) which is preferably entered in the form of a machine-readable code through the data reader 28 into the memory 26. Accordingly the analytical data CA generated by means of the analysis-elements will be satisfactorily accurate. A CA value becomes available when the patient stabs his/her finger to obtain a drop of blood 41 which then is analyzed by means of the analysis-element 12 and the measurement device 23 and evaluation electronics 24. Such a measurement may take place at substantial time intervals, for instance once or twice daily.
Fig. 3 shows the analysis data determined at times t1 through t5 in the form of data points 39.
By means of its sensor operation device 32 and evaluation electronics 33, the sensor 7 generates sensor-analysis data CS, said generation taking place continuously or at such minute intervals that a practically continuous sequence of CS values is stored in the memory 35 and can be transferred to the central unit 3 when the units 2 and 3 , are in the mutual data transmission mode. Fig. 3 shows the time-function of the CS values as the dashed line A. Element-analysis data CA are used to calibrate the sensor-analysis data CS. This procedure may be carried out for instance in such a way that at each calibration time t1 through t5 the sensor calibration means 30 compares the analytical data CA

214~~69 ~'S''~ 1 ~
and CS stored in the memory 26. The sensor calibration means 30 determines from said comparison a new corrected evaluation curve CS - g(S) which it then transfers through the transceiver components 29, 36 to the base unit 6 where the new evaluation curve will be used in the memory 35 for future computations of sensor-analysis data CS using the sensor evaluation electronics 33. The new evaluation curve CS = g(S) ascertained during calibration may be used simultaneously to back-correct sensor-analysis data already stored in the memory 26 at least as far back as the time of the preceding element-analysis. Accordingly as regards the example shown in Fig. 3, a backward correction to the time t1 may be achieved on the basis of the concentration value CA(t2) obtained at time t2.
Similar considerations apply to going back from the time t3 to the time t2 etc. The corrected function of the sensor-analysis data following calibration is shown by the solid line B in Fig. 3.
This calibration method was described as an example only. Obviously it may be implemented in a different way, in particular when adapted to specific evaluation methods used for determining the analytical data CS or CA. Numerical mathematical procedures for determining one concentration value CS from a large number of test values (for instance intensity values at many different wavelengths) are especially applicable. Among these procedures is the partial least-squares method.
The storage capacity of the memories 35 and 26 in the sensor and central units 2 and 3 resp. is made to match the particular applications. The memory 35 is used merely for the intermediate storage of relatively small volumes of data, 21~~~~

namely the concentration values for the maximum time interval during which the patient together with his/her sensor unit 2 is away from the central unit 3. Preferably the capacity of the memory 35 is adequate for the amount of data generated in a time interval of at least 2 h, preferably at least 8 h. As a rule the memory 26 of the central unit 3 is substantially larger and may store both analytical and calibration data generated over long time intervals (at least one week).
Appropriately the central unit 3 is fitted with an interface (not shown) whereby said data are transferred as required for further processing for instance to a PC used in the medical off ice to store the patient data.
The display of the analytical data by the central unit 3 may be alpha-numeric as shown in Fig. 1. Preferably the display 21 of the central unit 3 is graphic and allows a graphical representation of the time-sequence of the sensor-analysis data. In the display shown in Fig. 4, for instance, the instantaneous glucose value is symbolized by the central black strip 50. The light-gray display zone 51 corresponds to the standard range of the glucose values, whereas the dark-gray zone 52 shows the upper alarm zone (danger of hyperglycemia) and the lower black zone is the lower alarm range (danger of hypoglycemia). The trend at the time, in this case rising glucose values, is indicated by an arrow 54 in the display.
The time function of the glucose values is shown over a more substantial time interval in the graph display of Fig.
5. The standard range of the glucose values is indicated by two warning limits 56, 57 at the middle of the display. The sequence of the glucose values is shown as a comparatively 214~~~~

broad line 58. Already for some time this line 58 has been in the upper alarm zone of Fig. 5 and, for instance following an injection of insulin, now begins to drop.
The graph displays of Figs. 4 and 5 make use of the special ability of the system of the invention to reliably and practically continuously determine the glucose values. The evaluation means 24 of the central unit 3 (where called for also the evaluation means 33 of the base unit 6) for that purpose again contains a preferably software driven discriminator permitting the determination of the glucose-value sequences at any time and hence the trend. This additional information is highly valuable in the therapy of diabetes mellitus.

Claims (25)

1. An analytical system for monitoring patient blood concentration of a substance to be analyzed, comprising:
A) an element-analysis system comprising:
at least one analysis-element containing a reagent for reacting with the analyzed substance after said at least one analysis element has been brought in contact with a patient blood-drop to cause a measurable change in the analysis-element, said change correlating with the concentration of said analyzed substance, and an evaluation instrument comprising a measurement device to measure said change and an evaluation means to determine, from the measurement values so obtained, analytical data representing element analysis data C A, said analytical system further comprising:
B) a sensor analysis system comprising:
(i) a sensor unit portable on the patient body, said sensor unit including a sensor borne on the patient body for the direct and reagent-free non-invasive measurement of a parameter correlating with the concentration of the analyzed substance, and a transmitter for the wireless transmission of data signals; and (ii) a sensor-analysis means to ascertain sensor-analysis data C S from the measurement values of said parameter measured by said sensor; and said evaluation instrument further comprising:
(a) a receiver to receive in wireless manner the data signals from the sensor unit;
(b) calibration means to calibrate the sensor-analysis data C S on the basis of the element-analysis data C A; and (c) a data memory for the long-term storage of analytical data, whereby said evaluation instrument forms a central unit of an integrated analysis element/sensor monitoring system.
2. An analytical system according to claim 1, wherein said sensor unit comprises a light source irradiating light into the tissue of a patient body-part and a light detector detecting the light after it has interacted with the tissue of said body part in order to determine a physical light property which varies due to the interaction with the tissue thereby forming a parameter correlating with the concentration of the analyzed substance in the patient blood, the sensor-analysis data C S being ascertained from said parameter.
3. An analytical system according to claim 1 or 2, wherein said sensor unit comprises a base unit and a sensor connected by cables to the base unit, said base unit containing the power supply for the sensor unit.
4. An analytical system according to claim 3, wherein said sensor unit comprises at least two sensors connected by cables to a common base unit.
5. An analytical system according to claim 1, 2, 3 or 4, wherein said sensor unit includes said sensor analysis means for ascertaining said sensor-analysis data C S.
6. An analytical system according to claim 5, wherein said sensor unit comprises display means for displaying information representing said sensor-analysis data C S.
7. An analytical system according to claim 5 or 6, wherein said transmitter of said sensor unit and said receiver of said central unit are adapted to form a transceiver system to allow interactive data exchange between the sensor unit and the evaluation instrument.
8. An analytical system according to claim 1, 2, 3, 4, 5, 6 or 7, wherein the sensor unit contains a memory adapted for storing the sensor-analysis data C S ascertained in a time interval of at least 2 hours.
9. An analytical system according to claim 8, wherein said time interval is at least 8 hours.
10. An analytical system according to any one of claims 1 to 9, wherein the central unit comprises a graph display for the graphical repre-sentation of the time dependence of the sensor-analysis data C S.
11. An analytical system according to claim 10, wherein said graph display has a plurality of different display modes for displaying variational trends.
12. An analytical system for monitoring and analyzing a concentration of a substance in blood of a patient, said system comprising:
an element-analysis system, said element-analysis system comprising at least one analysis element containing a reagent thereupon, said reagent for reacting with the substance in a sample of the blood when said at least one analysis element has been brought in contact with the sample, thereby causing a measurable change R in the analysis element which correlates with the concentration of the substance and an evaluation instrument having a measuring device therein, said measuring device for measuring the measurable change R in the analysis element, the evaluation instrument also including an evaluation means for determining element-analysis data C A from the measured change R; said analytical system further comprising:
a sensor-analysis system, said sensor-analysis system comprising:
(i) a sensor unit configured to be affixed to and thus continuously carried on the body of the patient, said sensor unit including a first sensor means for non-invasive determination of a measured value of a parameter S correlating with the concentration of the substance in the blood of the patient and for generating sensor data signals representing the non-invasively measured parameter S, said sensor unit also including a transmitter means for wireless transmission of data signals representing the non-invasively measured parameter S;
and (ii) an evaluation unit remotely disposed from said sensor unit for wirelessly receiving data signals transmitted from said sensor unit, said evaluation unit comprising receiver means for wirelessly receiving the data signals representing the non-invasively measured parameter S from the sensor unit, and sensor analysis means for ascertaining sensor-analysis data C S from the transmitted data signals;
wherein said evaluation unit of the sensor-analysis system and said evaluation instrument of the element-analysis system are coupled together in a central unit which is remote from said sensor unit, said central unit including a calibration means for performing a calibration of the data representing the non-invasively measured parameter S and for determining sensor-analysis data C S based upon the element analysis data C A, said central unit also comprising a data memory means coupled to said calibration means for storing data therein.
13. An analytical system as recited in claim 12, wherein the sensor unit comprises a light source for irradiating light into living tissue of the patient, and a light detector for detecting light exiting the living tissue of the patient, after the light has interacted with the tissue, thereby providing data indicative of a physical light property which varies based upon an interaction of the light with the tissue, thereby resulting in the parameter S which correlates with the concentration of the analyzed substance in the patient blood, and wherein the sensor analysis data C S is ascertained from the parameter S.
14. An analytical system as recited in claim 12 or 13, wherein said sensor unit comprises a base unit and the first sensor means, said base unit and said first sensor means being operably connected by cables, said base unit including a power supply for the first sensor means.
15. An analytical system as recited in claim 14, wherein the sensor unit further comprises a second sensor means, said second sensor means being connected by a cable to the base unit, wherein said first and second sensor means provide first and second measured values for correlation with the concentration of the analyzed substance in the patient blood.
16. An analytical system as recited in claim 12, 13, 14 or 15, wherein the transmitter means of the sensor unit and the receiver means of the evaluation instrument are configured to form a transceiver system, said transceiver system conducting an interactive data exchange between the sensor unit and the evaluation instrument.
17. An analytical system as received in claim 16, wherein the sensor unit also comprises processing means for processing said sensor data signals and for generating sensor-analysis data C S therefrom, and display means for displaying information representing the sensor analysis data.
18. An analytical system as recited in claim 12, 13, 14, 15, 16 or 17, wherein said sensor unit is configured to wirelessly transmit said data signals at random operation intervals.
19. A method for monitoring and analyzing a concentration of a substance in blood of a patient, comprising the steps of:
applying a blood sample to an analysis element having a reagent thereupon, wherein said reagent reacts with the substance in the blood sample, thereby causing a measurable change R in the analysis element correlating with the concentration of the substance;
measuring the measurable change R in the analysis element with an element-analysis system;
inputting measurement values of the measurable change R into an evaluation instrument of said element-analysis system for determining element-analysis data C A based upon the measured change R;
non-invasively measuring a parameter S correlating with the concentration of the substance in the blood of the patient with a sensor unit of a sensor-analysis system, said sensor unit affixed to a body of the patient and remotely disposed from said evaluation instrument, said step of non-invasively measuring including the steps of irradiating light into living tissue of the patient, and detecting a physical property of light exiting the living tissue which varies based upon an interaction of the light with the tissue, for generating signals corresponding to the parameter S;
wirelessly transmitting data signals representing the non-invasively measured value from the sensor unit via a wireless transmitter to a receiver of an evaluation unit which is remotely disposed from said sensor unit and is a part of the sensor analysis system, and which is coupled in a central unit to said element-analysis system;
receiving said wirelessly transmitted data signals in the receiver;
determining sensor-analysis data C S from the transmitted data signals using a calibration based on a comparison of the transmitted data signals to element-analysis data C A in said evaluation unit, said sensor analysis data C S representing the concentration of the substance in the blood of the patient.
20. A method for monitoring and analyzing a concentration, of a substance in blood of a patient, said method comprising the steps of:

providing an evaluation instrument of an element-analysis system for evaluating a concentration of a substance in a blood sample of the patient;
providing a sensor-analysis system including a sensor unit configured to be affixed to and continuously carried on the body of the patient, and an evaluation unit remotely disposed from the sensor unit;
applying the blood sample to an analysis element having a reagent thereupon, wherein said reagent reacts with the substance in the blood sample, thereby causing a measurable change R in the analysis element correlating with the concentration of the substance;
measuring the measurable change R in the analysis element;
determining element-analysis data C A based upon the measured change R, inputting the element-analysis data C A to said evaluation unit of said sensor-analysis system, thereby providing calibration information therefor;
non-invasively measuring a parameter S correlating with the concentration of the substance in the blood of the patient with the sensor unit of the sensor-analysis system, said step of non-invasively measuring including the steps of irradiating light into living tissue of the patient, and detecting a physical property of light exiting the living tissue which varies based upon an interaction of the light with the tissue, for generating signals corresponding to the parameter S; wirelessly transmitting data signals representing the non-invasively measured value from the sensor unit to a receiver of the sensor-analysis system, said receiver being remotely disposed from said sensor unit and being coupled to said element-analysis system;
receiving said wirelessly transmitted data signals in the receiver;
and determining sensor-analysis data C S from the transmitted data signals using a calibration which is based on a comparison of the transmitted data signals to element-analysis data C A in said evaluation unit, said sensor-analysis data C S representing the concentration of the substance in the blood of the patient.
21. A method as recited in claim 20, wherein said evaluation instrument of said element analysis system and said receiver of the sensor-analysis system are remotely disposed in a central unit, said receiver being in wireless communication with said sensor unit.
22. ~A method as recited in claim 19, wherein said step of wirelessly transmitting data signals occurs at random intervals.
23. ~A method as recited in claim 19, wherein the set of steps comprising said applying step, measuring step, and inputting step occurs at random intervals.
24. ~A method as recited in claim 20 or 21, wherein said step of wirelessly transmitting data signals occurs at random intervals.
25. ~A method as recited in claim 20 or 21, wherein the set of steps comprising said applying step, measuring step, and inputting step occurs at random intervals.
CA002148569A 1994-05-05 1995-05-03 Analytical system for monitoring a substance to be analyzed in patient blood Expired - Lifetime CA2148569C (en)

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Families Citing this family (682)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593852A (en) * 1993-12-02 1997-01-14 Heller; Adam Subcutaneous glucose electrode
CA2050057A1 (en) 1991-03-04 1992-09-05 Adam Heller Interferant eliminating biosensors
US7624028B1 (en) * 1992-11-17 2009-11-24 Health Hero Network, Inc. Remote health monitoring and maintenance system
US9215979B2 (en) 1992-11-17 2015-12-22 Robert Bosch Healthcare Systems, Inc. Multi-user remote health monitoring system
US5956501A (en) 1997-01-10 1999-09-21 Health Hero Network, Inc. Disease simulation system and method
US5832448A (en) * 1996-10-16 1998-11-03 Health Hero Network Multiple patient monitoring system for proactive health management
AU1766201A (en) 1992-11-17 2001-05-30 Health Hero Network, Inc. Method and system for improving adherence with a diet program or other medical regimen
US6330426B2 (en) 1994-05-23 2001-12-11 Stephen J. Brown System and method for remote education using a memory card
US20010011224A1 (en) 1995-06-07 2001-08-02 Stephen James Brown Modular microprocessor-based health monitoring system
US5307263A (en) 1992-11-17 1994-04-26 Raya Systems, Inc. Modular microprocessor-based health monitoring system
US6968375B1 (en) 1997-03-28 2005-11-22 Health Hero Network, Inc. Networked system for interactive communication and remote monitoring of individuals
DE4417639A1 (en) * 1994-05-19 1995-11-23 Boehringer Mannheim Gmbh Analysis of concns. of substances in a biological sample
DE19509094A1 (en) * 1995-03-16 1996-09-26 Boehringer Mannheim Gmbh Quantitative transmission spectroscopy using sample carriers with networks
US7016713B2 (en) * 1995-08-09 2006-03-21 Inlight Solutions, Inc. Non-invasive determination of direction and rate of change of an analyte
FI118509B (en) * 1996-02-12 2007-12-14 Nokia Oyj A method and apparatus for predicting blood glucose levels in a patient
FI960636A (en) * 1996-02-12 1997-08-13 Nokia Mobile Phones Ltd A procedure for monitoring the health of a patient
US5989917A (en) * 1996-02-13 1999-11-23 Selfcare, Inc. Glucose monitor and test strip containers for use in same
US20020010406A1 (en) 1996-05-17 2002-01-24 Douglas Joel S. Methods and apparatus for expressing body fluid from an incision
EP1579814A3 (en) 1996-05-17 2006-06-14 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
DE29615910U1 (en) * 1996-08-05 1997-12-04 Lumpert Juerg B Sports equipment with data display for the user
DE19642316A1 (en) * 1996-10-14 1998-04-23 Dirk Krischenowski Alarm system for waking sleeping person
EP1258728B1 (en) 1996-10-30 2012-05-30 F. Hoffmann-La Roche AG Synchronized analyte testing system
DK0958495T3 (en) 1997-02-06 2003-03-10 Therasense Inc In vitro analyzer and small volume sensor
US7657297B2 (en) * 2004-05-03 2010-02-02 Dexcom, Inc. Implantable analyte sensor
US20050033132A1 (en) 1997-03-04 2005-02-10 Shults Mark C. Analyte measuring device
US7899511B2 (en) 2004-07-13 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
US6862465B2 (en) 1997-03-04 2005-03-01 Dexcom, Inc. Device and method for determining analyte levels
US9155496B2 (en) 1997-03-04 2015-10-13 Dexcom, Inc. Low oxygen in vivo analyte sensor
US7192450B2 (en) 2003-05-21 2007-03-20 Dexcom, Inc. Porous membranes for use with implantable devices
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
WO1998041847A1 (en) * 1997-03-14 1998-09-24 Rosemount Analytical Inc. Chemical analyzer with free space communication link
US5961451A (en) * 1997-04-07 1999-10-05 Motorola, Inc. Noninvasive apparatus having a retaining member to retain a removable biosensor
TW357517B (en) * 1997-05-29 1999-05-01 Koji Akai Monitoring system
US5954643A (en) * 1997-06-09 1999-09-21 Minimid Inc. Insertion set for a transcutaneous sensor
US7267665B2 (en) * 1999-06-03 2007-09-11 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
US6558351B1 (en) * 1999-06-03 2003-05-06 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
US5948695A (en) 1997-06-17 1999-09-07 Mercury Diagnostics, Inc. Device for determination of an analyte in a body fluid
US7383069B2 (en) * 1997-08-14 2008-06-03 Sensys Medical, Inc. Method of sample control and calibration adjustment for use with a noninvasive analyzer
FI107080B (en) 1997-10-27 2001-05-31 Nokia Mobile Phones Ltd measuring device
KR100274570B1 (en) * 1997-11-25 2000-12-15 권석명 A treatment method of chemical analysis data and its apparatus
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6134461A (en) 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US20020091324A1 (en) * 1998-04-06 2002-07-11 Nikiforos Kollias Non-invasive tissue glucose level monitoring
AU766166B2 (en) * 1998-04-06 2003-10-09 General Hospital Corporation, The Non-invasive tissue glucose level monitoring
US6728560B2 (en) 1998-04-06 2004-04-27 The General Hospital Corporation Non-invasive tissue glucose level monitoring
US6721582B2 (en) 1999-04-06 2004-04-13 Argose, Inc. Non-invasive tissue glucose level monitoring
US6505059B1 (en) 1998-04-06 2003-01-07 The General Hospital Corporation Non-invasive tissue glucose level monitoring
US7899518B2 (en) * 1998-04-06 2011-03-01 Masimo Laboratories, Inc. Non-invasive tissue glucose level monitoring
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) * 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
WO1999058050A1 (en) * 1998-05-13 1999-11-18 Cygnus, Inc. Signal processing for measurement of physiological analytes
US7384396B2 (en) * 1998-07-21 2008-06-10 Spectrx Inc. System and method for continuous analyte monitoring
US7077328B2 (en) * 1998-07-31 2006-07-18 Abbott Laboratories Analyte test instrument system including data management system
US6248067B1 (en) 1999-02-05 2001-06-19 Minimed Inc. Analyte sensor and holter-type monitor system and method of using the same
US6558320B1 (en) * 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US6251260B1 (en) 1998-08-24 2001-06-26 Therasense, Inc. Potentiometric sensors for analytic determination
DE19840965A1 (en) 1998-09-08 2000-03-09 Disetronic Licensing Ag Device for self-administration of a product fluid
EP0992963A3 (en) * 1998-10-07 2000-08-30 Alcatel Method for signalling status information relative to the traffic
DE19846169A1 (en) 1998-10-07 2000-04-13 Alcatel Sa Signaling method for traffic-related state information using existing terminals, especially mobile telephones, for acoustic and/or optical and/or mechanical signaling
US6338790B1 (en) 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
ATE514372T1 (en) * 1998-10-08 2011-07-15 Medtronic Minimed Inc LICENSE PLATE MONITORING SYSTEM WITH REMOTE MEASUREMENT
US20060202859A1 (en) * 1998-10-08 2006-09-14 Mastrototaro John J Telemetered characteristic monitor system and method of using the same
US6591125B1 (en) 2000-06-27 2003-07-08 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
CZ20011702A3 (en) * 1998-11-30 2001-10-17 Novo Nordisk A/S A method and a system for assisting a user in a medical self treatment, said self treatment comprising a plurality of actions
EP1135055A1 (en) * 1998-12-02 2001-09-26 Sulzer Carbomedics Inc. Method and apparatus for monitoring anticoagulation levels
US6561978B1 (en) * 1999-02-12 2003-05-13 Cygnus, Inc. Devices and methods for frequent measurement of an analyte present in a biological system
US6424847B1 (en) * 1999-02-25 2002-07-23 Medtronic Minimed, Inc. Glucose monitor calibration methods
US8103325B2 (en) * 1999-03-08 2012-01-24 Tyco Healthcare Group Lp Method and circuit for storing and providing historical physiological data
ATE422838T1 (en) * 1999-03-08 2009-03-15 Nellcor Puritan Bennett Llc METHOD AND CIRCUIT FOR STORING AND PROVIDING HISTORICAL PHYSIOLOGICAL DATA
US6305804B1 (en) 1999-03-25 2001-10-23 Fovioptics, Inc. Non-invasive measurement of blood component using retinal imaging
US20060064323A1 (en) * 1999-04-12 2006-03-23 Alleckson Todd D Data management center for patient monitoring
US6442411B1 (en) * 1999-04-21 2002-08-27 Optix, Lp Method for improving calibration of an instrument for non-invasively measuring constituents in arterial blood
US6669663B1 (en) * 1999-04-30 2003-12-30 Medtronic, Inc. Closed loop medicament pump
EP1191875A1 (en) * 1999-06-17 2002-04-03 Medtronic MiniMed, Inc. Characteristic monitor system for use with analyte sensor
EP1192269A2 (en) 1999-06-18 2002-04-03 Therasense, Inc. MASS TRANSPORT LIMITED i IN VIVO /i ANALYTE SENSOR
HK1023262A2 (en) * 1999-07-30 2000-07-28 Chong De Yao Family-use health examination card and its explainer
US20050107676A1 (en) * 2003-03-07 2005-05-19 Acosta George M. Method and apparatus for noninvasive glucose concentration estimation through near-infrared spectroscopy
US7317938B2 (en) * 1999-10-08 2008-01-08 Sensys Medical, Inc. Method of adapting in-vitro models to aid in noninvasive glucose determination
US6527711B1 (en) 1999-10-18 2003-03-04 Bodymedia, Inc. Wearable human physiological data sensors and reporting system therefor
US6616819B1 (en) * 1999-11-04 2003-09-09 Therasense, Inc. Small volume in vitro analyte sensor and methods
US6925393B1 (en) 1999-11-18 2005-08-02 Roche Diagnostics Gmbh System for the extrapolation of glucose concentration
US20030060765A1 (en) * 2000-02-16 2003-03-27 Arthur Campbell Infusion device menu structure and method of using the same
US7890295B2 (en) * 2000-02-23 2011-02-15 Medtronic Minimed, Inc. Real time self-adjusting calibration algorithm
US6895263B2 (en) * 2000-02-23 2005-05-17 Medtronic Minimed, Inc. Real time self-adjusting calibration algorithm
US6706159B2 (en) * 2000-03-02 2004-03-16 Diabetes Diagnostics Combined lancet and electrochemical analyte-testing apparatus
US7606608B2 (en) * 2000-05-02 2009-10-20 Sensys Medical, Inc. Optical sampling interface system for in-vivo measurement of tissue
US20060211931A1 (en) * 2000-05-02 2006-09-21 Blank Thomas B Noninvasive analyzer sample probe interface method and apparatus
US7519406B2 (en) * 2004-04-28 2009-04-14 Sensys Medical, Inc. Noninvasive analyzer sample probe interface method and apparatus
US20070179367A1 (en) * 2000-05-02 2007-08-02 Ruchti Timothy L Method and Apparatus for Noninvasively Estimating a Property of an Animal Body Analyte from Spectral Data
US7689437B1 (en) 2000-06-16 2010-03-30 Bodymedia, Inc. System for monitoring health, wellness and fitness
US20060122474A1 (en) * 2000-06-16 2006-06-08 Bodymedia, Inc. Apparatus for monitoring health, wellness and fitness
US6494830B1 (en) * 2000-06-22 2002-12-17 Guidance Interactive Technologies, Inc. Handheld controller for monitoring/using medical parameters
ES2530878T3 (en) * 2000-06-23 2015-03-06 Bodymedia Inc System to monitor health, well-being and fitness
WO2002000111A1 (en) * 2000-06-23 2002-01-03 Bodymedia, Inc. System for monitoring health, wellness and fitness
US20020019752A1 (en) * 2000-06-23 2002-02-14 Isamu Takase System for therapy management and terminal used therefor
US6540675B2 (en) * 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
JP4823443B2 (en) * 2000-07-14 2011-11-24 日機装株式会社 Implantable artificial pancreas device
US6549861B1 (en) 2000-08-10 2003-04-15 Euro-Celtique, S.A. Automated system and method for spectroscopic analysis
US6553244B2 (en) * 2000-08-18 2003-04-22 Cygnus, Inc. Analyte monitoring device alarm augmentation system
WO2002017210A2 (en) * 2000-08-18 2002-02-28 Cygnus, Inc. Formulation and manipulation of databases of analyte and associated values
US6675030B2 (en) 2000-08-21 2004-01-06 Euro-Celtique, S.A. Near infrared blood glucose monitoring system
WO2002018936A2 (en) * 2000-08-28 2002-03-07 Cygnus, Inc. Methods of monitoring glucose levels in a subject and uses thereof
US6669669B2 (en) 2001-10-12 2003-12-30 Insulet Corporation Laminated patient infusion device
CA2421133C (en) 2000-09-08 2012-06-26 Insulet Corporation Devices, systems and methods for patient infusion
WO2002040083A2 (en) 2000-11-09 2002-05-23 Insulet Corporation Transcutaneous delivery means
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
DE10057832C1 (en) 2000-11-21 2002-02-21 Hartmann Paul Ag Blood analysis device has syringe mounted in casing, annular mounting carrying needles mounted behind test strip and being swiveled so that needle can be pushed through strip and aperture in casing to take blood sample
AU2002239709B2 (en) * 2000-12-21 2007-02-15 Insulet Corporation Medical apparatus remote control and method
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
CN1556716A (en) 2001-02-22 2004-12-22 ���Ͽع����޹�˾ Modular infusion device and method
US7041468B2 (en) 2001-04-02 2006-05-09 Therasense, Inc. Blood glucose tracking apparatus and methods
DE60214375T2 (en) * 2001-05-18 2007-08-30 Polymer Technology Systems, Inc., Indianapolis DEVICE FOR EXAMINING BODY FLUIDS WITH SOLVENTLY FIXED, PORTABLE TEST DEVICE
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
ATE485766T1 (en) 2001-06-12 2010-11-15 Pelikan Technologies Inc ELECTRICAL ACTUATING ELEMENT FOR A LANCET
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
DE60234598D1 (en) 2001-06-12 2010-01-14 Pelikan Technologies Inc SELF-OPTIMIZING LANZET DEVICE WITH ADAPTANT FOR TEMPORAL FLUCTUATIONS OF SKIN PROPERTIES
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
DE60234597D1 (en) 2001-06-12 2010-01-14 Pelikan Technologies Inc DEVICE AND METHOD FOR REMOVING BLOOD SAMPLES
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
AU2002344825A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
US7147615B2 (en) 2001-06-22 2006-12-12 Baxter International Inc. Needle dislodgement detection
US20030032868A1 (en) * 2001-07-09 2003-02-13 Henning Graskov Method and system for controlling data information between two portable apparatuses
US7257438B2 (en) * 2002-07-23 2007-08-14 Datascope Investment Corp. Patient-worn medical monitoring device
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US6544212B2 (en) 2001-07-31 2003-04-08 Roche Diagnostics Corporation Diabetes management system
WO2003014903A2 (en) * 2001-08-09 2003-02-20 Novo Nordisk A/S An operating button with a transparent part for optical communication
US20030072058A1 (en) * 2001-08-09 2003-04-17 Jespersen Soren Kragh Electronic appliance
JP3775263B2 (en) * 2001-08-10 2006-05-17 ニプロ株式会社 Recording medium and blood glucose measurement system using the recording medium
US6678542B2 (en) * 2001-08-16 2004-01-13 Optiscan Biomedical Corp. Calibrator configured for use with noninvasive analyte-concentration monitor and employing traditional measurements
US6827702B2 (en) 2001-09-07 2004-12-07 Medtronic Minimed, Inc. Safety limits for closed-loop infusion pump control
US6650915B2 (en) 2001-09-13 2003-11-18 Fovioptics, Inc. Non-invasive measurement of blood analytes using photodynamics
US20050010091A1 (en) * 2003-06-10 2005-01-13 Woods Joe W. Non-invasive measurement of blood glucose using retinal imaging
US20040078028A1 (en) * 2001-11-09 2004-04-22 Flaherty J. Christopher Plunger assembly for patient infusion device
DE10163774A1 (en) 2001-12-22 2003-07-03 Roche Diagnostics Gmbh Plug-in data transfer module, useful in monitoring medical conditions, comprises an interface at the analysis system, and a communication unit to transmit converted electromagnetic/acoustic signals to a data processing station
US7022072B2 (en) * 2001-12-27 2006-04-04 Medtronic Minimed, Inc. System for monitoring physiological characteristics
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7828728B2 (en) 2003-07-25 2010-11-09 Dexcom, Inc. Analyte sensor
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
DE10208575C1 (en) 2002-02-21 2003-08-14 Hartmann Paul Ag Blood analyzer device comprises needles, test media, analyzer and display, and has carrier turned with respect to main body, to position needle and test media
US6692457B2 (en) 2002-03-01 2004-02-17 Insulet Corporation Flow condition sensor assembly for patient infusion device
US6830558B2 (en) 2002-03-01 2004-12-14 Insulet Corporation Flow condition sensor assembly for patient infusion device
US8718738B2 (en) * 2002-03-08 2014-05-06 Glt Acquisition Corp. Method and apparatus for coupling a sample probe with a sample site
US6998247B2 (en) * 2002-03-08 2006-02-14 Sensys Medical, Inc. Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers
US20050054908A1 (en) * 2003-03-07 2005-03-10 Blank Thomas B. Photostimulation method and apparatus in combination with glucose determination
US20050187439A1 (en) * 2003-03-07 2005-08-25 Blank Thomas B. Sampling interface system for in-vivo estimation of tissue analyte concentration
US20070149868A1 (en) * 2002-03-08 2007-06-28 Blank Thomas B Method and Apparatus for Photostimulation Enhanced Analyte Property Estimation
US8504128B2 (en) * 2002-03-08 2013-08-06 Glt Acquisition Corp. Method and apparatus for coupling a channeled sample probe to tissue
EP1499231A4 (en) * 2002-03-08 2007-09-26 Sensys Medical Inc Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy
US7697966B2 (en) * 2002-03-08 2010-04-13 Sensys Medical, Inc. Noninvasive targeting system method and apparatus
US7027848B2 (en) * 2002-04-04 2006-04-11 Inlight Solutions, Inc. Apparatus and method for non-invasive spectroscopic measurement of analytes in tissue using a matched reference analyte
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7481776B2 (en) 2002-04-19 2009-01-27 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7198606B2 (en) 2002-04-19 2007-04-03 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with analyte sensing
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7232451B2 (en) * 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9848815B2 (en) * 2002-04-22 2017-12-26 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US6960192B1 (en) 2002-04-23 2005-11-01 Insulet Corporation Transcutaneous fluid delivery system
US6656158B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
US20040153032A1 (en) * 2002-04-23 2004-08-05 Garribotto John T. Dispenser for patient infusion device
US20050238507A1 (en) * 2002-04-23 2005-10-27 Insulet Corporation Fluid delivery device
US6656159B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
JP3854190B2 (en) * 2002-04-26 2006-12-06 株式会社ジェイテクト Motor control device
US6801041B2 (en) * 2002-05-14 2004-10-05 Abbott Laboratories Sensor having electrode for determining the rate of flow of a fluid
US7226978B2 (en) 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
GB2389419B (en) * 2002-06-05 2006-02-22 Diabetes Diagnostics Inc Analyte testing device
US6723072B2 (en) 2002-06-06 2004-04-20 Insulet Corporation Plunger assembly for patient infusion device
US7018360B2 (en) * 2002-07-16 2006-03-28 Insulet Corporation Flow restriction system and method for patient infusion device
US7278983B2 (en) 2002-07-24 2007-10-09 Medtronic Minimed, Inc. Physiological monitoring device for controlling a medication infusion device
US20040068230A1 (en) * 2002-07-24 2004-04-08 Medtronic Minimed, Inc. System for providing blood glucose measurements to an infusion device
US7020508B2 (en) * 2002-08-22 2006-03-28 Bodymedia, Inc. Apparatus for detecting human physiological and contextual information
US20070100666A1 (en) * 2002-08-22 2007-05-03 Stivoric John M Devices and systems for contextual and physiological-based detection, monitoring, reporting, entertainment, and control of other devices
US6895264B2 (en) * 2002-08-26 2005-05-17 Fovioptics Inc. Non-invasive psychophysical measurement of glucose using photodynamics
EP1536730A2 (en) * 2002-09-10 2005-06-08 Euro-Celtique, S.A. Apparatus and method for non-invasive measurement of blood constituents
US7128727B2 (en) * 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
US7144384B2 (en) * 2002-09-30 2006-12-05 Insulet Corporation Dispenser components and methods for patient infusion device
US7993108B2 (en) 2002-10-09 2011-08-09 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US20090177068A1 (en) * 2002-10-09 2009-07-09 Stivoric John M Method and apparatus for providing derived glucose information utilizing physiological and/or contextual parameters
DK1552146T3 (en) 2002-10-09 2011-08-15 Abbott Diabetes Care Inc Device for administering fluid, system and method
WO2004032715A2 (en) * 2002-10-09 2004-04-22 Bodymedia, Inc. Method and apparatus for auto journaling of continuous or discrete body states utilizing physiological and/or contextual parameters
US7727181B2 (en) * 2002-10-09 2010-06-01 Abbott Diabetes Care Inc. Fluid delivery device with autocalibration
DE10248682A1 (en) * 2002-10-18 2004-05-13 T-Mobile Deutschland Gmbh Portable diagnostic device and associated method for transferring the diagnostic data
US7381184B2 (en) 2002-11-05 2008-06-03 Abbott Diabetes Care Inc. Sensor inserter assembly
US20040116866A1 (en) * 2002-12-17 2004-06-17 William Gorman Skin attachment apparatus and method for patient infusion device
US20040122353A1 (en) * 2002-12-19 2004-06-24 Medtronic Minimed, Inc. Relay device for transferring information between a sensor system and a fluid delivery system
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7811231B2 (en) 2002-12-31 2010-10-12 Abbott Diabetes Care Inc. Continuous glucose monitoring system and methods of use
US7212925B2 (en) * 2003-01-21 2007-05-01 Bayer Healthcare Llc. Calibration data entry system for a test instrument
WO2004069164A2 (en) * 2003-01-30 2004-08-19 Euro Celtique Sa Wireless blood glucose monitoring system
US20050159656A1 (en) * 2003-03-07 2005-07-21 Hockersmith Linda J. Method and apparatus for presentation of noninvasive glucose concentration information
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US8718943B2 (en) * 2003-04-01 2014-05-06 Abbott Diabetes Care Inc. Method and device for utilizing analyte levels to assist in the treatment of diabetes
US7134999B2 (en) * 2003-04-04 2006-11-14 Dexcom, Inc. Optimized sensor geometry for an implantable glucose sensor
US7587287B2 (en) 2003-04-04 2009-09-08 Abbott Diabetes Care Inc. Method and system for transferring analyte test data
CN101368922B (en) * 2003-04-10 2010-12-15 宇系科技有限公司 Method for judging blood sugar concentration
US20050182366A1 (en) * 2003-04-18 2005-08-18 Insulet Corporation Method For Visual Output Verification
US7182738B2 (en) 2003-04-23 2007-02-27 Marctec, Llc Patient monitoring apparatus and method for orthosis and other devices
US7679407B2 (en) 2003-04-28 2010-03-16 Abbott Diabetes Care Inc. Method and apparatus for providing peak detection circuitry for data communication systems
US7399276B1 (en) 2003-05-08 2008-07-15 Health Hero Network, Inc. Remote health monitoring system
AU2003902187A0 (en) * 2003-05-08 2003-05-22 Aimedics Pty Ltd Patient monitor
AU2004236368B2 (en) * 2003-05-08 2011-08-04 University Of Technology, Sydney Patient moniter
JP2004343275A (en) * 2003-05-14 2004-12-02 Murata Mach Ltd Image processing system and scanner
US7875293B2 (en) * 2003-05-21 2011-01-25 Dexcom, Inc. Biointerface membranes incorporating bioactive agents
WO2004103170A1 (en) * 2003-05-22 2004-12-02 Novo Nordisk A/S A glucose measuring device
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US8071028B2 (en) * 2003-06-12 2011-12-06 Abbott Diabetes Care Inc. Method and apparatus for providing power management in data communication systems
US7695239B2 (en) * 2003-07-14 2010-04-13 Fortrend Engineering Corporation End effector gripper arms having corner grippers which reorient reticle during transfer
WO2005010518A1 (en) * 2003-07-23 2005-02-03 Dexcom, Inc. Rolled electrode array and its method for manufacture
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
JP2007500336A (en) 2003-07-25 2007-01-11 デックスコム・インコーポレーテッド Electrode system for electrochemical sensors
WO2005011520A2 (en) 2003-07-25 2005-02-10 Dexcom, Inc. Oxygen enhancing membrane systems for implantable devices
US8845536B2 (en) 2003-08-01 2014-09-30 Dexcom, Inc. Transcutaneous analyte sensor
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US8160669B2 (en) 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US7519408B2 (en) * 2003-11-19 2009-04-14 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US8060173B2 (en) * 2003-08-01 2011-11-15 Dexcom, Inc. System and methods for processing analyte sensor data
US8622905B2 (en) 2003-08-01 2014-01-07 Dexcom, Inc. System and methods for processing analyte sensor data
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US20070208245A1 (en) * 2003-08-01 2007-09-06 Brauker James H Transcutaneous analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8369919B2 (en) 2003-08-01 2013-02-05 Dexcom, Inc. Systems and methods for processing sensor data
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US7925321B2 (en) 2003-08-01 2011-04-12 Dexcom, Inc. System and methods for processing analyte sensor data
US8626257B2 (en) 2003-08-01 2014-01-07 Dexcom, Inc. Analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US7306641B2 (en) * 2003-09-12 2007-12-11 Hewlett-Packard Development Company, L.P. Integral fuel cartridge and filter
US20070234300A1 (en) * 2003-09-18 2007-10-04 Leake David W Method and Apparatus for Performing State-Table Driven Regression Testing
US20050065760A1 (en) * 2003-09-23 2005-03-24 Robert Murtfeldt Method for advising patients concerning doses of insulin
DE10343863A1 (en) * 2003-09-23 2005-04-14 Roche Diagnostics Gmbh Method and device for continuously monitoring the concentration of an analyte
US20050070847A1 (en) * 2003-09-29 2005-03-31 Van Erp Wilhelmus Petrus Martinus Maria Rapid-exchange balloon catheter with hypotube shaft
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
US20050278194A1 (en) * 2003-10-07 2005-12-15 Holland Geoffrey N Medication management system
US8065161B2 (en) 2003-11-13 2011-11-22 Hospira, Inc. System for maintaining drug information and communicating with medication delivery devices
US20060089854A1 (en) * 2003-10-07 2006-04-27 Holland Geoffrey N Medication management system
US20060089855A1 (en) * 2003-10-07 2006-04-27 Holland Geoffrey N Medication management system
US9123077B2 (en) 2003-10-07 2015-09-01 Hospira, Inc. Medication management system
US7895053B2 (en) * 2003-10-07 2011-02-22 Hospira, Inc. Medication management system
US20060100907A1 (en) * 2003-10-07 2006-05-11 Holland Geoffrey N Medication management system
US7490021B2 (en) * 2003-10-07 2009-02-10 Hospira, Inc. Method for adjusting pump screen brightness
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
US20050090607A1 (en) * 2003-10-28 2005-04-28 Dexcom, Inc. Silicone composition for biocompatible membrane
WO2005041103A2 (en) * 2003-10-29 2005-05-06 Novo Nordisk A/S Medical advisory system
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
US20050096518A1 (en) * 2003-10-31 2005-05-05 Yu-Hong Chang Biological test system
USD914881S1 (en) 2003-11-05 2021-03-30 Abbott Diabetes Care Inc. Analyte sensor electronic mount
WO2005046441A2 (en) * 2003-11-06 2005-05-26 Sensys Medical, Inc. Method of adapting in-vitro models to aid in noninvasive glucose determination
SG179415A1 (en) 2003-11-06 2012-04-27 Lifescan Inc Drug delivery pen with event notification means
US8221332B2 (en) * 2003-11-12 2012-07-17 Facet Technologies, Llc Multi-lancet cartridge and lancing device
JP2007510524A (en) * 2003-11-12 2007-04-26 ファセット・テクノロジーズ・エルエルシー Puncture device and multi-lancet cartridge
US20080082117A1 (en) * 2003-11-12 2008-04-03 Facet Technologies, Llc Lancing device
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8425416B2 (en) * 2006-10-04 2013-04-23 Dexcom, Inc. Analyte sensor
US8425417B2 (en) 2003-12-05 2013-04-23 Dexcom, Inc. Integrated device for continuous in vivo analyte detection and simultaneous control of an infusion device
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
EP2239567B1 (en) 2003-12-05 2015-09-02 DexCom, Inc. Calibration techniques for a continuous analyte sensor
US8287453B2 (en) 2003-12-05 2012-10-16 Dexcom, Inc. Analyte sensor
US8364230B2 (en) * 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8774886B2 (en) 2006-10-04 2014-07-08 Dexcom, Inc. Analyte sensor
EP2316331B1 (en) * 2003-12-09 2016-06-29 Dexcom, Inc. Signal processing for continuous analyte sensor
US7384397B2 (en) 2003-12-30 2008-06-10 Medtronic Minimed, Inc. System and method for sensor recalibration
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
CA2556331A1 (en) 2004-02-17 2005-09-29 Therasense, Inc. Method and system for providing data communication in continuous glucose monitoring and management system
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
CA2460898A1 (en) * 2004-03-09 2005-09-09 James Samsoondar Apparatus and method for combining in vivo and in vitro testing
PL1734858T4 (en) 2004-03-22 2015-04-30 Bodymedia Inc Non-invasive temperature monitoring device
US20060258918A1 (en) * 2004-04-14 2006-11-16 Oculir, Inc. Combination Analyte Measurement Device and Method of Use
US20060258920A1 (en) * 2004-04-14 2006-11-16 Oculir, Inc. Non-Invasive Analyte Measurement Glasses and Method of Use
EP1742574B1 (en) 2004-04-16 2017-11-08 Facet Technologies, LLC Cap displacement mechanism for lancing device and multi-lancet cartridge
DE102004020160A1 (en) * 2004-04-24 2005-11-10 Roche Diagnostics Gmbh Method and device for monitoring a concentration of an analyte in the living body of a human or animal
US8868147B2 (en) * 2004-04-28 2014-10-21 Glt Acquisition Corp. Method and apparatus for controlling positioning of a noninvasive analyzer sample probe
US20080033275A1 (en) * 2004-04-28 2008-02-07 Blank Thomas B Method and Apparatus for Sample Probe Movement Control
WO2005106446A1 (en) * 2004-04-30 2005-11-10 Matsushita Electric Industrial Co., Ltd. Blood sugar level measuring device
US8792955B2 (en) 2004-05-03 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US20050245799A1 (en) * 2004-05-03 2005-11-03 Dexcom, Inc. Implantable analyte sensor
US7474408B2 (en) * 2004-05-14 2009-01-06 Medeikon Corporation Low coherence interferometry utilizing phase
US7190464B2 (en) * 2004-05-14 2007-03-13 Medeikon Corporation Low coherence interferometry for detecting and characterizing plaques
US20050254059A1 (en) * 2004-05-14 2005-11-17 Alphonse Gerard A Low coherence interferometric system for optical metrology
US7242480B2 (en) * 2004-05-14 2007-07-10 Medeikon Corporation Low coherence interferometry for detecting and characterizing plaques
US7327463B2 (en) 2004-05-14 2008-02-05 Medrikon Corporation Low coherence interferometry utilizing magnitude
US7184148B2 (en) 2004-05-14 2007-02-27 Medeikon Corporation Low coherence interferometry utilizing phase
EP1751546A2 (en) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Printable hydrogel for biosensors
US7964146B2 (en) * 2004-05-30 2011-06-21 Agamatrix, Inc. Measuring device and methods for use therewith
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc Method and apparatus for a fluid sampling device
CA3090413C (en) 2004-06-04 2023-10-10 Abbott Diabetes Care Inc. Glucose monitoring and graphical representations in a data management system
DE602005017492D1 (en) * 2004-06-14 2009-12-17 Eyesense Ag COMBINED DEVICE FOR MEASURING BLOOD SUGAR FROM EYES LIQUID
US20050283380A1 (en) * 2004-06-18 2005-12-22 Garduno Ramon S Delivery service for a health management system
EP1804663A4 (en) * 2004-06-30 2015-05-20 Facet Technologies Llc Lancing device and multi-lancet cartridge
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US8565848B2 (en) * 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US7905833B2 (en) 2004-07-13 2011-03-15 Dexcom, Inc. Transcutaneous analyte sensor
US20080242961A1 (en) * 2004-07-13 2008-10-02 Dexcom, Inc. Transcutaneous analyte sensor
WO2006127694A2 (en) * 2004-07-13 2006-11-30 Dexcom, Inc. Analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
US8170803B2 (en) 2004-07-13 2012-05-01 Dexcom, Inc. Transcutaneous analyte sensor
US7640048B2 (en) 2004-07-13 2009-12-29 Dexcom, Inc. Analyte sensor
GB0421793D0 (en) * 2004-10-01 2004-11-03 Univ Aston Sensing device
US20080171913A1 (en) * 2004-11-15 2008-07-17 Novo Nordisk A/S Method and Apparatus for Monitoring Long Term and Short Term Effects of a Treatment
MX2007006959A (en) * 2004-12-17 2007-08-21 Bayer Healthcare Llc Device having a trend-indicating display.
AT7892U3 (en) * 2004-12-21 2006-08-15 Evelyne Lorenz ELECTRONIC DIABETIC DIARY
WO2006070199A1 (en) * 2004-12-29 2006-07-06 Lifescan Scotland Limited An analyte test meter having a test sensor port
US9572534B2 (en) 2010-06-29 2017-02-21 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US7976467B2 (en) 2004-12-29 2011-07-12 Lifescan Scotland, Ltd. Method of inputting data into analyte testing device
US8571624B2 (en) 2004-12-29 2013-10-29 Abbott Diabetes Care Inc. Method and apparatus for mounting a data transmission device in a communication system
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US7731657B2 (en) 2005-08-30 2010-06-08 Abbott Diabetes Care Inc. Analyte sensor introducer and methods of use
US9398882B2 (en) 2005-09-30 2016-07-26 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor and data processing device
US9743862B2 (en) 2011-03-31 2017-08-29 Abbott Diabetes Care Inc. Systems and methods for transcutaneously implanting medical devices
US10226207B2 (en) 2004-12-29 2019-03-12 Abbott Diabetes Care Inc. Sensor inserter having introducer
US7883464B2 (en) 2005-09-30 2011-02-08 Abbott Diabetes Care Inc. Integrated transmitter unit and sensor introducer mechanism and methods of use
US9351669B2 (en) 2009-09-30 2016-05-31 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US8029441B2 (en) 2006-02-28 2011-10-04 Abbott Diabetes Care Inc. Analyte sensor transmitter unit configuration for a data monitoring and management system
US9636450B2 (en) 2007-02-19 2017-05-02 Udo Hoss Pump system modular components for delivering medication and analyte sensing at seperate insertion sites
US20090105569A1 (en) 2006-04-28 2009-04-23 Abbott Diabetes Care, Inc. Introducer Assembly and Methods of Use
US9259175B2 (en) 2006-10-23 2016-02-16 Abbott Diabetes Care, Inc. Flexible patch for fluid delivery and monitoring body analytes
US8333714B2 (en) 2006-09-10 2012-12-18 Abbott Diabetes Care Inc. Method and system for providing an integrated analyte sensor insertion device and data processing unit
US7697967B2 (en) 2005-12-28 2010-04-13 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
ITBO20050002A1 (en) * 2005-01-04 2006-07-05 Giacomo Vespasiani METHOD AND SYSTEM FOR INTERACTIVE MANAGEMENT OF DATA CONCERNING AN INSULIN THERAPY IN SELF-CONTROL FOR A DIABETIC PATIENT
US7547281B2 (en) 2005-02-01 2009-06-16 Medtronic Minimed, Inc. Algorithm sensor augmented bolus estimator for semi-closed loop infusion system
EP1688085A1 (en) * 2005-02-02 2006-08-09 Disetronic Licensing AG Ambulatory medical device and method of communication between medical devices
US20060178633A1 (en) * 2005-02-03 2006-08-10 Insulet Corporation Chassis for fluid delivery device
US7545272B2 (en) * 2005-02-08 2009-06-09 Therasense, Inc. RF tag on test strips, test strip vials and boxes
US20060206018A1 (en) * 2005-03-04 2006-09-14 Alan Abul-Haj Method and apparatus for noninvasive targeting
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
US20090076360A1 (en) 2007-09-13 2009-03-19 Dexcom, Inc. Transcutaneous analyte sensor
ES2315950T3 (en) * 2005-03-15 2009-04-01 F. Hoffmann-La Roche Ag METHOD AND SYSTEM FOR THE ANALYSIS OF THE GLUCOSE METABOLISM.
JP2008535548A (en) 2005-03-21 2008-09-04 アボット ダイアビーティーズ ケア インコーポレイテッド Method and system for providing an integrated pharmaceutical infusion / specimen monitoring system
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
CA2517299A1 (en) * 2005-08-26 2007-02-26 Chromedx Inc. Hollow needle assembly
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
CA2507323A1 (en) * 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
US20100245803A1 (en) * 2005-04-12 2010-09-30 Chromedx Inc. Blood sample holder for spectroscopic analysis
US8060174B2 (en) 2005-04-15 2011-11-15 Dexcom, Inc. Analyte sensing biointerface
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
US7768408B2 (en) 2005-05-17 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US7552240B2 (en) * 2005-05-23 2009-06-23 International Business Machines Corporation Method for user space operations for direct I/O between an application instance and an I/O adapter
US7620437B2 (en) 2005-06-03 2009-11-17 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
US20060281187A1 (en) * 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US9504394B2 (en) * 2005-07-28 2016-11-29 The General Hospital Corporation Electro-optical system, apparatus, and method for ambulatory monitoring
JP5090348B2 (en) * 2005-07-29 2012-12-05 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Monitoring of cardiac natriuretic peptide during diagnosis, treatment and treatment of heart disease
US20080314395A1 (en) 2005-08-31 2008-12-25 Theuniversity Of Virginia Patent Foundation Accuracy of Continuous Glucose Sensors
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US9521968B2 (en) 2005-09-30 2016-12-20 Abbott Diabetes Care Inc. Analyte sensor retention mechanism and methods of use
US7756561B2 (en) 2005-09-30 2010-07-13 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
EP1928304B1 (en) 2005-09-30 2012-10-24 Intuity Medical, Inc. Catalysts for body fluid sample extraction
US8880138B2 (en) 2005-09-30 2014-11-04 Abbott Diabetes Care Inc. Device for channeling fluid and methods of use
US7583190B2 (en) * 2005-10-31 2009-09-01 Abbott Diabetes Care Inc. Method and apparatus for providing data communication in data monitoring and management systems
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
DE102006051562A1 (en) * 2005-11-15 2007-05-16 Weinmann G Geraete Med Signal emitter for forming signals from measured physiological variable values, especially to control therapeutic devices, by detecting electromagnetic waves passed through or reflected from sample
US20070118030A1 (en) * 2005-11-22 2007-05-24 Isense Corporation Method and apparatus for analyte data telemetry
EP1968432A4 (en) 2005-12-28 2009-10-21 Abbott Diabetes Care Inc Medical device insertion
US11298058B2 (en) 2005-12-28 2022-04-12 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US20080015422A1 (en) * 2005-12-29 2008-01-17 Guidance Interactive Healthcare, Inc. Combined peripheral and health monitoring devices
US20070179356A1 (en) * 2005-12-29 2007-08-02 Guidance Interactive Healthcare, Inc. Programmable devices, systems and methods for encouraging the monitoring of medical parameters
US8114268B2 (en) * 2005-12-30 2012-02-14 Medtronic Minimed, Inc. Method and system for remedying sensor malfunctions detected by electrochemical impedance spectroscopy
US7985330B2 (en) 2005-12-30 2011-07-26 Medtronic Minimed, Inc. Method and system for detecting age, hydration, and functional states of sensors using electrochemical impedance spectroscopy
US8114269B2 (en) 2005-12-30 2012-02-14 Medtronic Minimed, Inc. System and method for determining the point of hydration and proper time to apply potential to a glucose sensor
US9757061B2 (en) 2006-01-17 2017-09-12 Dexcom, Inc. Low oxygen in vivo analyte sensor
US7736310B2 (en) 2006-01-30 2010-06-15 Abbott Diabetes Care Inc. On-body medical device securement
US8344966B2 (en) 2006-01-31 2013-01-01 Abbott Diabetes Care Inc. Method and system for providing a fault tolerant display unit in an electronic device
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
US7826879B2 (en) 2006-02-28 2010-11-02 Abbott Diabetes Care Inc. Analyte sensors and methods of use
EP3513708B1 (en) 2006-03-09 2022-12-28 Dexcom, Inc. Systems and methods for processing analyte sensor data
EP2014224A1 (en) * 2006-03-24 2009-01-14 GlucoTel Scientific Inc. Telemedical method and device for the calibration of measured values
US8346335B2 (en) 2008-03-28 2013-01-01 Abbott Diabetes Care Inc. Analyte sensor calibration management
US7618369B2 (en) 2006-10-02 2009-11-17 Abbott Diabetes Care Inc. Method and system for dynamically updating calibration parameters for an analyte sensor
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US7630748B2 (en) 2006-10-25 2009-12-08 Abbott Diabetes Care Inc. Method and system for providing analyte monitoring
US8140312B2 (en) 2007-05-14 2012-03-20 Abbott Diabetes Care Inc. Method and system for determining analyte levels
US7653425B2 (en) 2006-08-09 2010-01-26 Abbott Diabetes Care Inc. Method and system for providing calibration of an analyte sensor in an analyte monitoring system
US7801582B2 (en) 2006-03-31 2010-09-21 Abbott Diabetes Care Inc. Analyte monitoring and management system and methods therefor
US8374668B1 (en) 2007-10-23 2013-02-12 Abbott Diabetes Care Inc. Analyte sensor with lag compensation
US8473022B2 (en) 2008-01-31 2013-06-25 Abbott Diabetes Care Inc. Analyte sensor with time lag compensation
US8219173B2 (en) 2008-09-30 2012-07-10 Abbott Diabetes Care Inc. Optimizing analyte sensor calibration
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US8478557B2 (en) 2009-07-31 2013-07-02 Abbott Diabetes Care Inc. Method and apparatus for providing analyte monitoring system calibration accuracy
US9392969B2 (en) 2008-08-31 2016-07-19 Abbott Diabetes Care Inc. Closed loop control and signal attenuation detection
US9675290B2 (en) 2012-10-30 2017-06-13 Abbott Diabetes Care Inc. Sensitivity calibration of in vivo sensors used to measure analyte concentration
US8224415B2 (en) 2009-01-29 2012-07-17 Abbott Diabetes Care Inc. Method and device for providing offset model based calibration for analyte sensor
US7488930B2 (en) * 2006-06-02 2009-02-10 Medeikon Corporation Multi-channel low coherence interferometer
WO2007143225A2 (en) 2006-06-07 2007-12-13 Abbott Diabetes Care, Inc. Analyte monitoring system and method
KR100735898B1 (en) * 2006-08-25 2007-07-04 한국기계연구원 The portable micro blood separator
US8447376B2 (en) 2006-10-04 2013-05-21 Dexcom, Inc. Analyte sensor
US7831287B2 (en) * 2006-10-04 2010-11-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8298142B2 (en) 2006-10-04 2012-10-30 Dexcom, Inc. Analyte sensor
US8478377B2 (en) 2006-10-04 2013-07-02 Dexcom, Inc. Analyte sensor
US8562528B2 (en) 2006-10-04 2013-10-22 Dexcom, Inc. Analyte sensor
US8275438B2 (en) 2006-10-04 2012-09-25 Dexcom, Inc. Analyte sensor
US8449464B2 (en) 2006-10-04 2013-05-28 Dexcom, Inc. Analyte sensor
EP2092470A2 (en) 2006-10-16 2009-08-26 Hospira, Inc. System and method for comparing and utilizing activity information and configuration information from mulitple device management systems
US20080092638A1 (en) * 2006-10-19 2008-04-24 Bayer Healthcare Llc Wireless analyte monitoring system
CA2667639A1 (en) 2006-10-26 2008-05-02 Abbott Diabetes Care Inc. Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors
EP1918837A1 (en) * 2006-10-31 2008-05-07 F. Hoffmann-La Roche AG Method for processing a chronological sequence of measurements of a time dependent parameter
US8579853B2 (en) 2006-10-31 2013-11-12 Abbott Diabetes Care Inc. Infusion devices and methods
US20080119705A1 (en) * 2006-11-17 2008-05-22 Medtronic Minimed, Inc. Systems and Methods for Diabetes Management Using Consumer Electronic Devices
US7946985B2 (en) * 2006-12-29 2011-05-24 Medtronic Minimed, Inc. Method and system for providing sensor redundancy
EP3391812A1 (en) 2007-01-23 2018-10-24 Ascensia Diabetes Care Holdings AG Analyte-testing device
US20080199894A1 (en) 2007-02-15 2008-08-21 Abbott Diabetes Care, Inc. Device and method for automatic data acquisition and/or detection
US8121857B2 (en) 2007-02-15 2012-02-21 Abbott Diabetes Care Inc. Device and method for automatic data acquisition and/or detection
US20080319855A1 (en) * 2007-02-16 2008-12-25 Stivoric John M Advertising and marketing based on lifeotypes
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US20080208509A1 (en) * 2007-02-27 2008-08-28 Bayer Healthcare, Llc System and method for graphically plotting and displaying analyte concentration data on a calendar
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US8140142B2 (en) 2007-04-14 2012-03-20 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
WO2008130897A2 (en) 2007-04-14 2008-10-30 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in medical communication system
EP2146627B1 (en) 2007-04-14 2020-07-29 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
CA2683721C (en) 2007-04-14 2017-05-23 Abbott Diabetes Care Inc. Method and apparatus for providing dynamic multi-stage signal amplification in a medical device
EP2146625B1 (en) 2007-04-14 2019-08-14 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
ES2461090T3 (en) 2007-04-14 2014-05-16 Abbott Diabetes Care Inc. Procedure and apparatus for providing data treatment and control in a medical communication system
US20080269714A1 (en) 2007-04-25 2008-10-30 Medtronic Minimed, Inc. Closed loop/semi-closed loop therapy modification system
US20080274552A1 (en) * 2007-05-04 2008-11-06 Brian Guthrie Dynamic Information Transfer
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8260558B2 (en) 2007-05-14 2012-09-04 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8103471B2 (en) 2007-05-14 2012-01-24 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US9125548B2 (en) 2007-05-14 2015-09-08 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8560038B2 (en) 2007-05-14 2013-10-15 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US7996158B2 (en) 2007-05-14 2011-08-09 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8444560B2 (en) 2007-05-14 2013-05-21 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US10002233B2 (en) 2007-05-14 2018-06-19 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8239166B2 (en) 2007-05-14 2012-08-07 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8600681B2 (en) 2007-05-14 2013-12-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US20200037875A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
WO2008150917A1 (en) * 2007-05-31 2008-12-11 Abbott Diabetes Care, Inc. Insertion devices and methods
WO2008154312A1 (en) 2007-06-08 2008-12-18 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
CA2690742C (en) 2007-06-21 2018-05-15 Abbott Diabetes Care Inc. Health management devices and methods
JP2010531169A (en) * 2007-06-21 2010-09-24 アボット ダイアベティス ケア インコーポレイテッド Health monitoring device
US8160900B2 (en) 2007-06-29 2012-04-17 Abbott Diabetes Care Inc. Analyte monitoring and management device and method to analyze the frequency of user interaction with the device
US20100094326A1 (en) * 2007-07-05 2010-04-15 Blackrock Kelso Capital Corporation Multi-lancet cartridge and lancing device
US8834366B2 (en) 2007-07-31 2014-09-16 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor calibration
US7768386B2 (en) * 2007-07-31 2010-08-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
DK2185219T3 (en) * 2007-08-01 2019-09-09 Hoffmann La Roche Portable infusion device provided with means for monitoring and controlling fluid delivery
US20090036759A1 (en) * 2007-08-01 2009-02-05 Ault Timothy E Collapsible noninvasive analyzer method and apparatus
EP4098177A1 (en) 2007-10-09 2022-12-07 DexCom, Inc. Integrated insulin delivery system with continuous glucose sensor
US8216138B1 (en) 2007-10-23 2012-07-10 Abbott Diabetes Care Inc. Correlation of alternative site blood and interstitial fluid glucose concentrations to venous glucose concentration
US8409093B2 (en) 2007-10-23 2013-04-02 Abbott Diabetes Care Inc. Assessing measures of glycemic variability
US8377031B2 (en) 2007-10-23 2013-02-19 Abbott Diabetes Care Inc. Closed loop control system with safety parameters and methods
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
US7783442B2 (en) * 2007-10-31 2010-08-24 Medtronic Minimed, Inc. System and methods for calibrating physiological characteristic sensors
CN106227987A (en) * 2007-12-10 2016-12-14 拜尔健康护理有限责任公司 For the interface of health measurement and monitoring system
RU2465811C2 (en) 2007-12-10 2012-11-10 БАЙЕР ХЕЛТКЭА ЭлЭлСи Control of quick charging and supply to metre of analytes in fluid medium arranged with battery supply
US8290559B2 (en) 2007-12-17 2012-10-16 Dexcom, Inc. Systems and methods for processing sensor data
US9026370B2 (en) 2007-12-18 2015-05-05 Hospira, Inc. User interface improvements for medical devices
US20090164239A1 (en) 2007-12-19 2009-06-25 Abbott Diabetes Care, Inc. Dynamic Display Of Glucose Information
CN101680855B (en) * 2008-02-07 2016-08-17 爱科来株式会社 Code reading device and use the data gathering system of this code reading device
EP2244761A2 (en) * 2008-02-20 2010-11-03 Dexcom, Inc. Continous medicament sensor system for in vivo use
WO2009105709A1 (en) 2008-02-21 2009-08-27 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
US8396528B2 (en) 2008-03-25 2013-03-12 Dexcom, Inc. Analyte sensor
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
CA2721214A1 (en) 2008-04-10 2009-10-15 Abbott Diabetes Care Inc. Method and system for sterilizing an analyte sensor
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US8924159B2 (en) 2008-05-30 2014-12-30 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
US8591410B2 (en) 2008-05-30 2013-11-26 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
US7826382B2 (en) 2008-05-30 2010-11-02 Abbott Diabetes Care Inc. Close proximity communication device and methods
CA2725264C (en) 2008-05-30 2017-06-20 Intuity Medical, Inc. Body fluid sampling device -- sampling site interface
US20100069726A1 (en) * 2008-06-04 2010-03-18 Seventh Sense Biosystems, Inc. Compositions and methods for rapid one-step diagnosis
US20090305317A1 (en) * 2008-06-05 2009-12-10 Brauer Jacob S User interface for testing device
EP2299903B1 (en) 2008-06-06 2021-01-27 Intuity Medical, Inc. Detection meter and mode of operation
EP3984454A1 (en) 2008-06-06 2022-04-20 Intuity Medical, Inc. Medical diagnostic devices and methods
WO2010009172A1 (en) 2008-07-14 2010-01-21 Abbott Diabetes Care Inc. Closed loop control system interface and methods
EP2149957B1 (en) * 2008-07-30 2017-06-14 Harman Becker Automotive Systems GmbH Priority based power distribution arrangement
SG193205A1 (en) 2008-08-15 2013-09-30 Lifescan Scotland Ltd Analyte testing method and system
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
CN102204122B (en) * 2008-08-28 2014-12-10 艾森斯公司 Method and system for communication between wireless devices
DE102008044895B4 (en) * 2008-08-29 2018-02-22 Astrium Gmbh Signal branching for use in a communication system
US8734422B2 (en) 2008-08-31 2014-05-27 Abbott Diabetes Care Inc. Closed loop control with improved alarm functions
US20100057040A1 (en) 2008-08-31 2010-03-04 Abbott Diabetes Care, Inc. Robust Closed Loop Control And Methods
US8622988B2 (en) 2008-08-31 2014-01-07 Abbott Diabetes Care Inc. Variable rate closed loop control and methods
US9943644B2 (en) 2008-08-31 2018-04-17 Abbott Diabetes Care Inc. Closed loop control with reference measurement and methods thereof
EP2326944B1 (en) 2008-09-19 2020-08-19 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US8986208B2 (en) 2008-09-30 2015-03-24 Abbott Diabetes Care Inc. Analyte sensor sensitivity attenuation mitigation
US9326707B2 (en) 2008-11-10 2016-05-03 Abbott Diabetes Care Inc. Alarm characterization for analyte monitoring devices and systems
US8437821B2 (en) * 2009-01-06 2013-05-07 Panasonic Corporation Non-invasive body information measurement apparatus
US8103456B2 (en) 2009-01-29 2012-01-24 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US8560082B2 (en) 2009-01-30 2013-10-15 Abbott Diabetes Care Inc. Computerized determination of insulin pump therapy parameters using real time and retrospective data processing
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US20100198034A1 (en) 2009-02-03 2010-08-05 Abbott Diabetes Care Inc. Compact On-Body Physiological Monitoring Devices and Methods Thereof
US20100213057A1 (en) 2009-02-26 2010-08-26 Benjamin Feldman Self-Powered Analyte Sensor
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US20120277629A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Systems and methods for collection and/or manipulation of blood spots or other bodily fluids
EP3566649B1 (en) 2009-03-02 2023-06-07 YourBio Health, Inc. Devices for blood sampling
US9446194B2 (en) * 2009-03-27 2016-09-20 Dexcom, Inc. Methods and systems for promoting glucose management
US8497777B2 (en) 2009-04-15 2013-07-30 Abbott Diabetes Care Inc. Analyte monitoring system having an alert
EP2419015A4 (en) 2009-04-16 2014-08-20 Abbott Diabetes Care Inc Analyte sensor calibration management
US8271106B2 (en) 2009-04-17 2012-09-18 Hospira, Inc. System and method for configuring a rule set for medical event management and responses
US8467972B2 (en) 2009-04-28 2013-06-18 Abbott Diabetes Care Inc. Closed loop blood glucose control algorithm analysis
US9226701B2 (en) 2009-04-28 2016-01-05 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
US8368556B2 (en) 2009-04-29 2013-02-05 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
WO2010127051A1 (en) 2009-04-29 2010-11-04 Abbott Diabetes Care Inc. Method and system for providing real time analyte sensor calibration with retrospective backfill
WO2010138856A1 (en) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
US8613892B2 (en) 2009-06-30 2013-12-24 Abbott Diabetes Care Inc. Analyte meter with a moveable head and methods of using the same
US8798934B2 (en) 2009-07-23 2014-08-05 Abbott Diabetes Care Inc. Real time management of data relating to physiological control of glucose levels
EP3932309A1 (en) 2009-07-23 2022-01-05 Abbott Diabetes Care, Inc. Continuous analyte measurement system
WO2011026147A1 (en) 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Analyte signal processing device and methods
EP3001194B1 (en) 2009-08-31 2019-04-17 Abbott Diabetes Care, Inc. Medical devices and methods
EP3988471B1 (en) 2009-08-31 2023-07-26 Abbott Diabetes Care, Inc. Displays for a medical device
WO2011026148A1 (en) 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Analyte monitoring system and methods for managing power and noise
US8571618B1 (en) * 2009-09-28 2013-10-29 Cercacor Laboratories, Inc. Adaptive calibration system for spectrophotometric measurements
EP2482720A4 (en) 2009-09-29 2014-04-23 Abbott Diabetes Care Inc Method and apparatus for providing notification function in analyte monitoring systems
EP2494323A4 (en) 2009-10-30 2014-07-16 Abbott Diabetes Care Inc Method and apparatus for detecting false hypoglycemic conditions
EP2506768B1 (en) 2009-11-30 2016-07-06 Intuity Medical, Inc. Calibration material delivery devices and methods
USD924406S1 (en) 2010-02-01 2021-07-06 Abbott Diabetes Care Inc. Analyte sensor inserter
WO2011112753A1 (en) 2010-03-10 2011-09-15 Abbott Diabetes Care Inc. Systems, devices and methods for managing glucose levels
CN102573616B (en) 2010-03-24 2016-01-20 雅培糖尿病护理公司 The method of medical treatment device insert and insertion and use medical treatment device
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2011163347A2 (en) 2010-06-23 2011-12-29 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US8635046B2 (en) 2010-06-23 2014-01-21 Abbott Diabetes Care Inc. Method and system for evaluating analyte sensor response characteristics
US10330667B2 (en) 2010-06-25 2019-06-25 Intuity Medical, Inc. Analyte monitoring methods and systems
US9336353B2 (en) 2010-06-25 2016-05-10 Dexcom, Inc. Systems and methods for communicating sensor data between communication devices of a glucose monitoring system
US11064921B2 (en) 2010-06-29 2021-07-20 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US10092229B2 (en) 2010-06-29 2018-10-09 Abbott Diabetes Care Inc. Calibration of analyte measurement system
EP2593014B1 (en) 2010-07-16 2015-11-04 Seventh Sense Biosystems, Inc. Low-pressure environment for fluid transfer devices
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
US8463953B2 (en) 2010-08-18 2013-06-11 Snap-On Incorporated System and method for integrating devices for servicing a device-under-service
US9117321B2 (en) * 2010-08-18 2015-08-25 Snap-On Incorporated Method and apparatus to use remote and local control modes to acquire and visually present data
US9633492B2 (en) 2010-08-18 2017-04-25 Snap-On Incorporated System and method for a vehicle scanner to automatically execute a test suite from a storage card
US8983785B2 (en) 2010-08-18 2015-03-17 Snap-On Incorporated System and method for simultaneous display of waveforms generated from input signals received at a data acquisition device
US8560168B2 (en) 2010-08-18 2013-10-15 Snap-On Incorporated System and method for extending communication range and reducing power consumption of vehicle diagnostic equipment
US11213226B2 (en) 2010-10-07 2022-01-04 Abbott Diabetes Care Inc. Analyte monitoring devices and methods
EP3744249A1 (en) 2010-10-27 2020-12-02 Dexcom, Inc. Continuous analyte monitor data recording device operable in a blinded mode
US9538943B1 (en) * 2010-10-29 2017-01-10 William Howard Cross Blood glucose monitor and method of use thereof
WO2012064802A1 (en) 2010-11-09 2012-05-18 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
US20120226117A1 (en) 2010-12-01 2012-09-06 Lamego Marcelo M Handheld processing device including medical applications for minimally and non invasive glucose measurements
US8532775B2 (en) 2011-02-18 2013-09-10 Medtronic, Inc. Modular medical device programmer
US8352034B2 (en) 2011-02-18 2013-01-08 Medtronic, Inc. Medical device programmer with adjustable kickstand
US10136845B2 (en) 2011-02-28 2018-11-27 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
CA2827196A1 (en) 2011-02-28 2012-11-15 Jai Karan Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
WO2012131827A1 (en) * 2011-03-25 2012-10-04 テルモ株式会社 Body fluid component measurement system
EP2697650B1 (en) 2011-04-15 2020-09-30 Dexcom, Inc. Advanced analyte sensor calibration and error detection
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
AU2012249692A1 (en) 2011-04-29 2013-11-14 Seventh Sense Biosystems, Inc. Delivering and/or receiving fluids
EP4339613A2 (en) 2011-08-03 2024-03-20 Intuity Medical, Inc. Body fluid sampling arrangement
WO2013022775A1 (en) 2011-08-05 2013-02-14 Dexcom, Inc. Systems and methods for detecting glucose level data patterns
AU2012299169B2 (en) 2011-08-19 2017-08-24 Icu Medical, Inc. Systems and methods for a graphical interface including a graphical representation of medical data
US9594875B2 (en) 2011-10-21 2017-03-14 Hospira, Inc. Medical device update system
US9622691B2 (en) 2011-10-31 2017-04-18 Abbott Diabetes Care Inc. Model based variable risk false glucose threshold alarm prevention mechanism
WO2013066873A1 (en) 2011-10-31 2013-05-10 Abbott Diabetes Care Inc. Electronic devices having integrated reset systems and methods thereof
EP2775918B1 (en) 2011-11-07 2020-02-12 Abbott Diabetes Care Inc. Analyte monitoring device and methods
US9317656B2 (en) 2011-11-23 2016-04-19 Abbott Diabetes Care Inc. Compatibility mechanisms for devices in a continuous analyte monitoring system and methods thereof
US8710993B2 (en) 2011-11-23 2014-04-29 Abbott Diabetes Care Inc. Mitigating single point failure of devices in an analyte monitoring system and methods thereof
WO2013078426A2 (en) 2011-11-25 2013-05-30 Abbott Diabetes Care Inc. Analyte monitoring system and methods of use
EP4056105B1 (en) 2011-12-11 2023-10-11 Abbott Diabetes Care, Inc. Analyte sensor devices
US10022498B2 (en) 2011-12-16 2018-07-17 Icu Medical, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
US9445759B1 (en) * 2011-12-22 2016-09-20 Cercacor Laboratories, Inc. Blood glucose calibration system
CA2868801C (en) 2012-03-30 2021-07-13 Hospira, Inc. Air detection system and method for detecting air in a pump of an infusion system
EP2830499B8 (en) 2012-03-30 2019-04-03 Insulet Corporation Fluid delivery device with transcutaneous access tool, insertion mechansim and blood glucose monitoring for use therewith
US11798685B2 (en) * 2012-05-15 2023-10-24 James M. Minor Diagnostic methods and devices for controlling acute glycemia
EP2879733B1 (en) 2012-07-31 2019-06-05 ICU Medical, Inc. Patient care system for critical medications
EP2890297B1 (en) 2012-08-30 2018-04-11 Abbott Diabetes Care, Inc. Dropout detection in continuous analyte monitoring data during data excursions
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
EP2901153A4 (en) 2012-09-26 2016-04-27 Abbott Diabetes Care Inc Method and apparatus for improving lag correction during in vivo measurement of analyte concentration with analyte concentration variability and range data
US9344777B2 (en) 2012-12-20 2016-05-17 Abbott Diabetes Care Inc. Wireless communication authentication for medical monitoring device
US9641432B2 (en) 2013-03-06 2017-05-02 Icu Medical, Inc. Medical device communication method
US10433773B1 (en) 2013-03-15 2019-10-08 Abbott Diabetes Care Inc. Noise rejection methods and apparatus for sparsely sampled analyte sensor data
US9474475B1 (en) 2013-03-15 2016-10-25 Abbott Diabetes Care Inc. Multi-rate analyte sensor data collection with sample rate configurable signal processing
WO2014152034A1 (en) 2013-03-15 2014-09-25 Abbott Diabetes Care Inc. Sensor fault detection using analyte sensor data pattern comparison
WO2014190264A1 (en) 2013-05-24 2014-11-27 Hospira, Inc. Multi-sensor infusion system for detecting air or an occlusion in the infusion system
AU2014274146B2 (en) 2013-05-29 2019-01-24 Icu Medical, Inc. Infusion system which utilizes one or more sensors and additional information to make an air determination regarding the infusion system
EP3003442B1 (en) 2013-05-29 2020-12-30 ICU Medical, Inc. Infusion system and method of use which prevents over-saturation of an analog-to-digital converter
EP3011544A4 (en) 2013-06-21 2017-02-22 Intuity Medical, Inc. Analyte monitoring system with audible feedback
CA2922425C (en) 2013-08-30 2023-05-16 Hospira, Inc. System and method of monitoring and managing a remote infusion regimen
US9662436B2 (en) 2013-09-20 2017-05-30 Icu Medical, Inc. Fail-safe drug infusion therapy system
US10311972B2 (en) 2013-11-11 2019-06-04 Icu Medical, Inc. Medical device system performance index
AU2014353130B9 (en) 2013-11-19 2019-09-05 Icu Medical, Inc. Infusion pump automation system and method
US20150164385A1 (en) 2013-12-16 2015-06-18 Medtronic Minimed, Inc. Methods and systems for improving the reliability of orthogonally redundant sensors
CN105899132B (en) 2013-12-31 2020-02-18 雅培糖尿病护理公司 Self-powered analyte sensor and devices using same
GB2523989B (en) 2014-01-30 2020-07-29 Insulet Netherlands B V Therapeutic product delivery system and method of pairing
JP6636442B2 (en) 2014-02-28 2020-01-29 アイシーユー・メディカル・インコーポレーテッド Infusion systems and methods utilizing dual wavelength optical in-pipe air detection
EP4151150A1 (en) 2014-03-30 2023-03-22 Abbott Diabetes Care, Inc. Method and apparatus for determining meal start and peak events in analyte monitoring systems
EP3138032A4 (en) 2014-04-30 2017-12-20 ICU Medical, Inc. Patient care system with conditional alarm forwarding
US11344673B2 (en) 2014-05-29 2022-05-31 Icu Medical, Inc. Infusion system and pump with configurable closed loop delivery rate catch-up
US9724470B2 (en) 2014-06-16 2017-08-08 Icu Medical, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
US9539383B2 (en) 2014-09-15 2017-01-10 Hospira, Inc. System and method that matches delayed infusion auto-programs with manually entered infusion programs and analyzes differences therein
USD742524S1 (en) 2014-11-17 2015-11-03 Bayer Healthcare Llc Analyte meter
US11344668B2 (en) 2014-12-19 2022-05-31 Icu Medical, Inc. Infusion system with concurrent TPN/insulin infusion
EP3733227A1 (en) 2015-02-18 2020-11-04 Insulet Corporation Fluid delivery and infusion devices
US10850024B2 (en) 2015-03-02 2020-12-01 Icu Medical, Inc. Infusion system, device, and method having advanced infusion features
TWD176176S (en) * 2015-03-20 2016-06-01 五鼎生物技術股份有限公司 Part of a measuring instrument
WO2016183493A1 (en) 2015-05-14 2016-11-17 Abbott Diabetes Care Inc. Compact medical device inserters and related systems and methods
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
WO2016189417A1 (en) 2015-05-26 2016-12-01 Hospira, Inc. Infusion pump system and method with multiple drug library editor source capability
JP6986007B2 (en) 2015-07-10 2021-12-22 アボット ダイアベティス ケア インコーポレイテッドAbbott Diabetes Care Inc. Systems, devices and methods of dynamic glucose profile response to physiological parameters
WO2017091624A1 (en) 2015-11-24 2017-06-01 Insulet Corporation Wearable automated medication delivery system
WO2017091584A1 (en) 2015-11-25 2017-06-01 Insulet Corporation Wearable medication delivery device
WO2017123525A1 (en) 2016-01-13 2017-07-20 Bigfoot Biomedical, Inc. User interface for diabetes management system
AU2017207484B2 (en) 2016-01-14 2021-05-13 Bigfoot Biomedical, Inc. Adjusting insulin delivery rates
ES2912378T3 (en) 2016-05-13 2022-05-25 Icu Medical Inc Common Line Auto Purge Infusion Pump System
AU2017277804B2 (en) 2016-06-10 2022-05-26 Icu Medical, Inc. Acoustic flow sensor for continuous medication flow measurements and feedback control of infusion
WO2018013842A1 (en) 2016-07-14 2018-01-18 Icu Medical, Inc. Multi-communication path selection and security system for a medical device
EP3515535A1 (en) 2016-09-23 2019-07-31 Insulet Corporation Fluid delivery device with sensor
US11071478B2 (en) 2017-01-23 2021-07-27 Abbott Diabetes Care Inc. Systems, devices and methods for analyte sensor insertion
WO2018156548A1 (en) 2017-02-22 2018-08-30 Insulet Corporation Needle insertion mechanisms for drug containers
US11596330B2 (en) 2017-03-21 2023-03-07 Abbott Diabetes Care Inc. Methods, devices and system for providing diabetic condition diagnosis and therapy
EP3687600B1 (en) 2017-09-26 2022-04-27 Insulet Corporation Needle mechanism module for drug delivery device
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
EP3928687A1 (en) 2017-10-24 2021-12-29 Dexcom, Inc. Pre-connected analyte sensors
US11147931B2 (en) 2017-11-17 2021-10-19 Insulet Corporation Drug delivery device with air and backflow elimination
US10089055B1 (en) 2017-12-27 2018-10-02 Icu Medical, Inc. Synchronized display of screen content on networked devices
CA3099113A1 (en) 2018-05-04 2019-11-07 Insulet Corporation Safety constraints for a control algorithm-based drug delivery system
US11483403B2 (en) 2018-07-17 2022-10-25 Icu Medical, Inc. Maintaining clinical messaging during network instability
CA3106516C (en) 2018-07-17 2023-07-25 Icu Medical, Inc. Updating infusion pump drug libraries and operational software in a networked environment
US10861592B2 (en) 2018-07-17 2020-12-08 Icu Medical, Inc. Reducing infusion pump network congestion by staggering updates
NZ793485A (en) 2018-07-17 2023-06-30 Icu Medical Inc Systems and methods for facilitating clinical messaging in a network environment
AU2019309766A1 (en) 2018-07-26 2021-03-18 Icu Medical, Inc. Drug library management system
US10692595B2 (en) 2018-07-26 2020-06-23 Icu Medical, Inc. Drug library dynamic version management
CN112789070A (en) 2018-09-28 2021-05-11 英赛罗公司 Mode of activity of the artificial pancreas System
EP3864668A1 (en) 2018-10-11 2021-08-18 Insulet Corporation Event detection for drug delivery system
USD1002852S1 (en) 2019-06-06 2023-10-24 Abbott Diabetes Care Inc. Analyte sensor device
US11801344B2 (en) 2019-09-13 2023-10-31 Insulet Corporation Blood glucose rate of change modulation of meal and correction insulin bolus quantity
US11935637B2 (en) 2019-09-27 2024-03-19 Insulet Corporation Onboarding and total daily insulin adaptivity
US11278671B2 (en) 2019-12-04 2022-03-22 Icu Medical, Inc. Infusion pump with safety sequence keypad
US11833329B2 (en) 2019-12-20 2023-12-05 Insulet Corporation Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns
US11551802B2 (en) 2020-02-11 2023-01-10 Insulet Corporation Early meal detection and calorie intake detection
US11547800B2 (en) 2020-02-12 2023-01-10 Insulet Corporation User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system
US11324889B2 (en) 2020-02-14 2022-05-10 Insulet Corporation Compensation for missing readings from a glucose monitor in an automated insulin delivery system
US11766221B1 (en) * 2020-03-25 2023-09-26 Tula Health, Inc. Devices, systems, and methods for measurement validation for chronic health condition management
US11607493B2 (en) 2020-04-06 2023-03-21 Insulet Corporation Initial total daily insulin setting for user onboarding
WO2022020184A1 (en) 2020-07-21 2022-01-27 Icu Medical, Inc. Fluid transfer devices and methods of use
US11684716B2 (en) 2020-07-31 2023-06-27 Insulet Corporation Techniques to reduce risk of occlusions in drug delivery systems
USD952860S1 (en) * 2020-10-20 2022-05-24 eTouch Medical Inc. Blood glucose meter
US11135360B1 (en) 2020-12-07 2021-10-05 Icu Medical, Inc. Concurrent infusion with common line auto flush
USD999913S1 (en) 2020-12-21 2023-09-26 Abbott Diabetes Care Inc Analyte sensor inserter
US11904140B2 (en) 2021-03-10 2024-02-20 Insulet Corporation Adaptable asymmetric medicament cost component in a control system for medicament delivery
WO2023049900A1 (en) 2021-09-27 2023-03-30 Insulet Corporation Techniques enabling adaptation of parameters in aid systems by user input
US11439754B1 (en) 2021-12-01 2022-09-13 Insulet Corporation Optimizing embedded formulations for drug delivery

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140963A (en) * 1972-01-03 1979-02-20 Siemens Aktiengesellschaft Device for measuring sugar concentration
GB2054861B (en) * 1979-07-09 1983-04-07 Del Mar Avionics Portable data aquisition and storage system for monitoring patient
IT1131177B (en) * 1980-05-14 1986-06-18 Consiglio Nazionale Ricerche PROGRAMMABLE BAND COMPARATOR, MULTI-CHANNEL, FOR CARDIOSURGICAL UNITS
DE3108767C2 (en) * 1981-03-07 1982-11-25 GMS, Gesellschaft für medizinische Sondentechnik mbH, 2300 Kiel Medical blood pressure transducer
DE3318746C2 (en) * 1983-05-24 1985-08-14 Vladimir Dr.-Ing. 5100 Aachen Blazek Device for recording and analyzing the blood flow condition of the human skin
JPH0737946B2 (en) * 1983-08-05 1995-04-26 株式会社京都第一科学 A device that measures body fluid components and stores and manages test data
DD230730A3 (en) * 1984-01-02 1985-12-11 Zentralinstitut Fuer Diabetes DEVICE FOR THE PROSPECTIVE AUTOMATIC DETERMINATION OF INDIVIDUAL-SPECIFIC GLUCOSE REGULATION PARAMETERS
US4627445A (en) * 1985-04-08 1986-12-09 Garid, Inc. Glucose medical monitoring system
US4935875A (en) * 1987-12-02 1990-06-19 Data Chem, Inc. Chemical analyzer
US4890621A (en) * 1988-01-19 1990-01-02 Northstar Research Institute, Ltd. Continuous glucose monitoring and a system utilized therefor
DE3810008C1 (en) * 1988-03-24 1989-10-26 Johannes Dr. 8000 Muenchen De Buschmann
US5204532A (en) * 1989-01-19 1993-04-20 Futrex, Inc. Method for providing general calibration for near infrared instruments for measurement of blood glucose
WO1990013872A1 (en) * 1989-04-28 1990-11-15 Pa Consulting Services Limited Computer connectors
US5190041A (en) * 1989-08-11 1993-03-02 Palti Yoram Prof System for monitoring and controlling blood glucose
US5140985A (en) * 1989-12-11 1992-08-25 Schroeder Jon M Noninvasive blood glucose measuring device
NZ238717A (en) * 1990-06-27 1994-08-26 Futrex Inc Blood glucose level measured by transmitting near-infrared energy through body part
DE4026426C2 (en) * 1990-08-21 1999-02-11 Siemens Ag Data transmission system
DE4041905A1 (en) * 1990-12-27 1992-07-02 Boehringer Mannheim Gmbh TEST CARRIER ANALYSIS SYSTEM
DE4138702A1 (en) * 1991-03-22 1992-09-24 Madaus Medizin Elektronik METHOD AND DEVICE FOR THE DIAGNOSIS AND QUANTITATIVE ANALYSIS OF APNOE AND FOR THE SIMULTANEOUS DETERMINATION OF OTHER DISEASES
DE4114448C2 (en) * 1991-05-03 1995-04-20 Klaus Latschbacher Device for wireless data transmission between two data devices
DE4130369A1 (en) * 1991-09-12 1993-03-25 Siemens Ag Medical imaging device for measuring blood and tissue changes - measures transmission or reflection of laser source in red to infrared region, with deflector producing fan-shaped beam, and position-resolving two-dimensional sensor
JPH05288756A (en) * 1992-04-13 1993-11-02 Hitachi Ltd Automatic analyzer and automatic analyzing system
DE4212498A1 (en) * 1992-04-14 1993-10-21 Vladimir Dr Blazek Non-invasive detector of variations in blood circulation vol. - includes sample=and=hold circuit for output of reflection photodetector which is switchable for suppression of arterial pulsation component
DE4214263A1 (en) * 1992-05-03 1993-11-04 Maximilian Dr Moser Garment has sensors coming into contact with body parts - where values received by sensors are led to central collector
DE4221848C2 (en) * 1992-07-03 2001-04-12 Eckhard Salzsieder Method and arrangement for automatic in situ calibration of intracorporeal glucose measuring devices
DE4300499A1 (en) * 1993-01-07 1994-07-14 Klein Karl Dittmar Dr Potentiometric relaxation assay method
US5400794A (en) * 1993-03-19 1995-03-28 Gorman; Peter G. Biomedical response monitor and technique using error correction
US5417222A (en) * 1994-01-21 1995-05-23 Hewlett-Packard Company Patient monitoring system

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