CA2150944A1 - Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
CA2150944A1
CA2150944A1 CA002150944A CA2150944A CA2150944A1 CA 2150944 A1 CA2150944 A1 CA 2150944A1 CA 002150944 A CA002150944 A CA 002150944A CA 2150944 A CA2150944 A CA 2150944A CA 2150944 A1 CA2150944 A1 CA 2150944A1
Authority
CA
Canada
Prior art keywords
sub
radical
pharmaceutical compositions
compositions containing
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002150944A
Other languages
English (en)
Other versions
CA2150944C (fr
Inventor
Herve Bouchard
Jean-Dominique Bourzat
Alain Commercon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Herve Bouchard
Jean-Dominique Bourzat
Alain Commercon
Rhone-Poulenc Rorer S.A.
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9436375&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2150944(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Herve Bouchard, Jean-Dominique Bourzat, Alain Commercon, Rhone-Poulenc Rorer S.A., Aventis Pharma S.A. filed Critical Herve Bouchard
Publication of CA2150944A1 publication Critical patent/CA2150944A1/fr
Application granted granted Critical
Publication of CA2150944C publication Critical patent/CA2150944C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Nouveaux taxoïdes de formule générale (I), leur préparation et les compositions pharmaceutiues qui les contiennent. Dans la formule générale (I), Ar représente un radical aryle, R représente un atome d'hydrogène ou un radical acétyle, alcoxyacétyle, ou alcoyle, R1 représente un radical benzoyle ou un radical de formule R2-O-CO- dans lequel R2 représente un radical alcoyle éventuellement substitué, alcényle, alcynyle, cycloalcoyle, cycloalcényle, bicycloalcoyle, phényle, hétérocyclyle. Les nouveaux produits de formule générale (I) présente une activité antitumorale remarquable.
CA002150944A 1992-12-09 1993-12-07 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related CA2150944C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9214813A FR2698871B1 (fr) 1992-12-09 1992-12-09 Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR9214813 1992-12-09
PCT/FR1993/001201 WO1994013654A1 (fr) 1992-12-09 1993-12-07 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
CA2150944A1 true CA2150944A1 (fr) 1994-06-23
CA2150944C CA2150944C (fr) 2004-02-24

Family

ID=9436375

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002150944A Expired - Fee Related CA2150944C (fr) 1992-12-09 1993-12-07 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Country Status (30)

Country Link
US (9) US7074821B1 (fr)
EP (1) EP0673372B1 (fr)
JP (2) JP2785248B2 (fr)
KR (1) KR100346328B1 (fr)
CN (1) CN1055467C (fr)
AT (1) ATE243688T1 (fr)
AU (2) AU685415B2 (fr)
BG (1) BG61726B1 (fr)
BR (1) BR9307613A (fr)
CA (1) CA2150944C (fr)
CZ (1) CZ289851B6 (fr)
DE (1) DE69333064T2 (fr)
DK (1) DK0673372T3 (fr)
ES (1) ES2202319T3 (fr)
FI (1) FI110941B (fr)
FR (1) FR2698871B1 (fr)
HU (1) HU227872B1 (fr)
MX (1) MX9307748A (fr)
NO (1) NO310555B1 (fr)
NZ (1) NZ258592A (fr)
OA (1) OA10166A (fr)
PL (3) PL175111B1 (fr)
PT (1) PT673372E (fr)
RO (1) RO112281B1 (fr)
RU (1) RU2139864C1 (fr)
SG (1) SG67338A1 (fr)
SK (1) SK282139B6 (fr)
TW (1) TW408120B (fr)
UA (1) UA51612C2 (fr)
WO (1) WO1994013654A1 (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
US5814658A (en) 1992-12-09 1998-09-29 Rhone-Poulenc Rorer S.A. Taxoids, their preparation and pharmaceutical compositions containing them
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
AU7138894A (en) * 1993-06-11 1995-01-03 Pharmacia & Upjohn Company Delta 6,7--taxols antineoplastic use and pharmaceutical compositions containing them
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
FR2712288B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
IL127597A (en) * 1994-01-28 2003-07-31 Upjohn Co Iso-taxol analogs
FR2721024B1 (fr) * 1994-06-09 1996-07-12 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2721023B1 (fr) * 1994-06-09 1996-07-12 Rhone Poulenc Rorer Sa Nouveaux Taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2726272B1 (fr) * 1994-10-26 1996-12-06 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
CA2170661A1 (fr) 1995-03-22 1996-09-23 John K. Thottathil Methodes pour la preparation de taxanes a l'aide d'oxazolidines comme produits intermediaires
FR2732342B1 (fr) * 1995-04-03 1997-04-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2732968B1 (fr) * 1995-04-14 1997-05-16 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2742438B1 (fr) * 1995-12-14 1998-01-16 Rhone Poulenc Rorer Sa Dihydrate du (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy- 3-phenylpropionate de 4,10beta-diacetoxy-2alpha-benzoyloxy- 5beta,2o-epoxy-1-hydroxy-9-oxo-19-nor-cyclopropa(g)tax-11- ene-13alpha-yle, et son procede de preparation
FR2742357B1 (fr) * 1995-12-19 1998-01-09 Rhone Poulenc Rorer Sa Nanoparticules stabilisees et filtrables dans des conditions steriles
FR2742753B1 (fr) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
ES2151277T3 (es) * 1996-05-22 2000-12-16 Protarga Inc Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere.
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US5919815A (en) * 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
DE69734060T2 (de) 1996-05-24 2006-06-29 Angiotech Pharmaceuticals, Inc., Vancouver Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege
FR2750989B1 (fr) * 1996-07-09 1998-09-25 Rhone Poulenc Rorer Sa Procede de monoacylation d'hydroxy taxanes
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
AU4768797A (en) 1996-10-24 1998-05-15 Institute Armand-Frappier A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US20030157187A1 (en) * 1996-12-02 2003-08-21 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory diseases
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
CA2288306A1 (fr) * 1997-04-28 1998-11-05 Rhone-Poulenc Rorer S.A. Apport intratumoral, induit par un adenovirus, d'un antagoniste d'angiogenese destine au traitement de tumeurs
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
ATE234800T1 (de) 1997-08-21 2003-04-15 Univ Florida State Verfahren zur synthese von taxanen
US6831057B2 (en) * 1997-10-28 2004-12-14 The University Of North Carolina At Chapel Hill Use of NF-κB inhibition in combination therapy for cancer
US6150537A (en) * 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
ES2178369T3 (es) * 1998-01-14 2002-12-16 Bristol Myers Squibb Co Nuevos complejos cristalinos dce baccatina iii con imidazol, 2-metilimidazol o isopropanol.
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
US6391911B1 (en) * 1999-02-26 2002-05-21 Robert E. Bases Coadministration of lucanthone and radiation for treatment of cancer
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
EP1176957A1 (fr) * 1999-05-03 2002-02-06 Aventis Pharma S.A. Methode de traitement d'une proliferation de cellules anormales dans le cerveau
FR2794771B1 (fr) * 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
CA2385528C (fr) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques
JP2004501143A (ja) 2000-06-22 2004-01-15 ニトロメド　インコーポレーテッド ニトロソ化およびニトロシル化タキサン、組成物および使用方法
PL366100A1 (en) * 2000-09-22 2005-01-24 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
US20040132991A1 (en) * 2002-10-09 2004-07-08 Phytogen Life Sciences Inc. Novel taxanes and methods related to use and preparation thereof
US7787855B2 (en) * 2003-03-31 2010-08-31 Motorola, Inc. Establishing emergency sessions in packet data networks for wireless devices having invalid subscriber identities
US6956124B2 (en) 2003-04-14 2005-10-18 Aventis Pharma S.A. Process for the preparation of 4,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
CA2865410C (fr) * 2005-11-18 2022-04-26 Mark Gelfand Systeme et procede pour moduler le nerf phrenique et prevenir l'apnee du sommeil
EP2001874A4 (fr) * 2006-03-21 2010-04-07 Reddys Lab Ltd Dr Polymorphes de docétaxel et procédés
CN100588643C (zh) * 2006-11-02 2010-02-10 南京航空航天大学 一种含有二取代金刚烷基的维甲酸类化合物制备方法
US20090076127A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched larotaxel
CN101863861A (zh) * 2009-04-16 2010-10-20 山东靶点药物研究有限公司 一种简便高效地制备紫杉醇类似物Larotaxel的方法
CA2779009A1 (fr) 2009-10-29 2011-05-05 Aventis Pharma S.A. Nouvelle utilisation antitumorale du cabazitaxel
EA027666B1 (ru) 2010-05-03 2017-08-31 ТЕИКОКУ ФАРМА ЮСЭй, ИНК. Неводные лекарственные средства в форме проэмульсии на основе таксанов и способы их приготовления и использования
ES2704632T3 (es) 2011-09-08 2019-03-19 Univ New York Virus de herpes simplex oncolítico y sus usos terapéuticos
WO2013096455A1 (fr) 2011-12-20 2013-06-27 Dana-Farber Cancer Institute, Inc. Méthodes de diagnostic et de traitement d'un cancer associé à kras oncogène
WO2013177426A2 (fr) 2012-05-24 2013-11-28 Dana-Farber Cancer Institute, Inc. Ciblage de la voie allant de la glutamine au pyruvate pour traiter un cancer associé à l'oncogène kras
WO2014014518A1 (fr) 2012-07-18 2014-01-23 Dana-Farber Cancer Institute, Inc. Méthodes de traitement, de prévention et de prédiction du risque de développer le cancer du sein
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
WO2014149871A1 (fr) 2013-03-14 2014-09-25 Icahn School Of Medicine At Mount Sinai Vaccin de cellule dendritique chargée en lysat de tumeur autologue pour le traitement du cancer du foie
WO2015050844A1 (fr) 2013-10-01 2015-04-09 Dana-Farber Cancer Institute, Inc. Procédés de traitement anticancéreux par des composés apparentés à l'atovaquone
WO2015149006A2 (fr) 2014-03-27 2015-10-01 Dana-Farber Cancer Institute, Inc. Compositions et procédés de modulation du ciblage autophagique de la ferritine médié par ncoa4
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
US10967015B2 (en) 2015-06-15 2021-04-06 New York University Method of treatment using oncolytic viruses
CN112574134A (zh) * 2020-12-30 2021-03-30 重庆市碚圣医药科技股份有限公司 一种多西紫杉醇侧链的合成方法

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US487399A (en) * 1892-12-06 Timepiece repeating mechanism
US4534899A (en) 1981-07-20 1985-08-13 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4507217A (en) 1983-03-07 1985-03-26 Lipid Specialties, Inc. Magnetic compositions and magnetic memory devices prepared therefrom
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4876399A (en) 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
GB8806224D0 (en) 1988-03-16 1988-04-13 Johnson Matthey Plc Platinum chemotherapeutic product
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
MY110249A (en) 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5411947A (en) 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US5645988A (en) 1991-05-08 1997-07-08 The United States Of America As Represented By The Department Of Health And Human Services Methods of identifying drugs with selective effects against cancer cells
WO1992019765A1 (fr) 1991-05-08 1992-11-12 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Procede de conception de traitements du cancer, procedes et compositions pharmaceutiques de traitements du cancer
US5698582A (en) 1991-07-08 1997-12-16 Rhone-Poulenc Rorer S.A. Compositions containing taxane derivatives
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5284865A (en) 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5399726A (en) 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5739362A (en) 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5489601A (en) 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5250683A (en) 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5229526A (en) 1991-09-23 1993-07-20 Florida State University Metal alkoxides
SG46582A1 (en) 1991-09-23 1998-02-20 Univ Florida State 10-Desacetoxytaxol derivatives
US5338872A (en) 1993-01-15 1994-08-16 Florida State University Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof
US5728725A (en) 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5728850A (en) 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5654447A (en) 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5262409A (en) 1991-10-11 1993-11-16 Fred Hutchinson Cancer Research Center Binary tumor therapy
US5294737A (en) 1992-02-27 1994-03-15 The Research Foundation State University Of New York Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom
ES2148223T3 (es) 1992-03-23 2000-10-16 Univ Georgetown Taxol encapsulado en liposomas y metodo para su uso.
US5254703A (en) 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
US5254580A (en) 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
US5294637A (en) 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5319112A (en) 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
FR2696459B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5814658A (en) 1992-12-09 1998-09-29 Rhone-Poulenc Rorer S.A. Taxoids, their preparation and pharmaceutical compositions containing them
IL107950A (en) * 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
MX9308012A (es) 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
ZA94128B (en) 1993-02-01 1994-08-19 Univ New York State Res Found Process for the preparation of taxane derivatives and betalactam intermediates therefor
FR2703049B1 (fr) 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
AU6833994A (en) 1993-05-17 1994-12-12 Liposome Company, Inc., The Incorporation of taxol into liposomes and gels
WO1994026253A1 (fr) 1993-05-19 1994-11-24 The Liposome Company, Inc. Liposome ayant une couche a composants multiples qui contient un agent bioactif en tant que composants integres dans la bicouche
US5405972A (en) 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
CA2129288C (fr) 1993-08-17 2000-05-16 Jerzy Golik Esters phosphonooxymethyliques de derives de taxane
FR2712288B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US6441026B1 (en) 1993-11-08 2002-08-27 Aventis Pharma S.A. Antitumor compositions containing taxane derivatives
US5415869A (en) 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
FR2718963B1 (fr) 1994-04-25 1996-05-24 Rhone Poulenc Rorer Sa Nouvelle composition pharmaceutique à base de taxoïdes.
NZ288802A (en) 1994-06-28 1998-05-27 Upjohn Co Ether taxol derivatives, preparation and pharmaceutical compositions thereof
FR2721928A1 (fr) 1994-07-04 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US6201140B1 (en) 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives
FR2726272B1 (fr) 1994-10-26 1996-12-06 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5635531A (en) 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US6156789A (en) 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
EP0982028A1 (fr) 1998-08-20 2000-03-01 Aventis Pharma S.A. Nouvelle utilisation de dérivés de taxoides

Also Published As

Publication number Publication date
DE69333064D1 (de) 2003-07-31
CZ289851B6 (cs) 2002-04-17
JPH10291930A (ja) 1998-11-04
EP0673372B1 (fr) 2003-06-25
US5580998A (en) 1996-12-03
FI110941B (fi) 2003-04-30
TW408120B (en) 2000-10-11
ES2202319T3 (es) 2004-04-01
JPH08504425A (ja) 1996-05-14
AU685415B2 (en) 1998-01-22
US5532388A (en) 1996-07-02
FI952825A (fi) 1995-06-08
FR2698871B1 (fr) 1995-02-24
NO952264L (no) 1995-06-08
PL175539B1 (pl) 1999-01-29
WO1994013654A1 (fr) 1994-06-23
US5587493A (en) 1996-12-24
SK75295A3 (en) 1995-11-08
PL175111B1 (pl) 1998-11-30
CN1094720A (zh) 1994-11-09
KR950704287A (ko) 1995-11-17
PT673372E (pt) 2003-11-28
BG99713A (bg) 1996-02-28
EP0673372A1 (fr) 1995-09-27
US5576450A (en) 1996-11-19
BR9307613A (pt) 1999-05-25
CA2150944C (fr) 2004-02-24
CZ145595A3 (en) 1995-10-18
DK0673372T3 (da) 2003-10-13
ATE243688T1 (de) 2003-07-15
US5550261A (en) 1996-08-27
NZ258592A (en) 1996-12-20
NO310555B1 (no) 2001-07-23
RO112281B1 (ro) 1997-07-30
HUT73134A (en) 1996-06-28
BG61726B1 (bg) 1998-04-30
KR100346328B1 (ko) 2002-11-30
MX9307748A (es) 1994-06-30
SK282139B6 (sk) 2001-11-06
US5571917A (en) 1996-11-05
DE69333064T2 (de) 2004-08-19
PL174830B1 (pl) 1998-09-30
HU227872B1 (en) 2012-05-29
PL309293A1 (en) 1995-10-02
JP2785248B2 (ja) 1998-08-13
US5599942A (en) 1997-02-04
FI952825A0 (fi) 1995-06-08
FR2698871A1 (fr) 1994-06-10
RU2139864C1 (ru) 1999-10-20
SG67338A1 (en) 1999-09-21
US5580997A (en) 1996-12-03
AU4187097A (en) 1998-01-08
OA10166A (fr) 1996-12-18
AU704663B2 (en) 1999-04-29
HU9501662D0 (en) 1995-08-28
CN1055467C (zh) 2000-08-16
US7074821B1 (en) 2006-07-11
UA51612C2 (uk) 2002-12-16
AU5653194A (en) 1994-07-04
NO952264D0 (no) 1995-06-08

Similar Documents

Publication Publication Date Title
CA2150944A1 (fr) Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
AU6144694A (en) Novel taxoids, preparation thereof and pharmaceutical compositions containing same
EA199800588A1 (ru) Новые таксоиды, их получение и содержащие их фармацевтические композиции
RU95112464A (ru) Способ получения производных таксана
MX9707427A (es) Nuevos taxoides, su preparacion y las composiciones farmaceuticas que los contienen.
TW235961B (fr)
CA2153419A1 (fr) Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20131209