CA2153994A1 - Noninvasive pulsed infrared spectrophotometer - Google Patents

Noninvasive pulsed infrared spectrophotometer

Info

Publication number
CA2153994A1
CA2153994A1 CA002153994A CA2153994A CA2153994A1 CA 2153994 A1 CA2153994 A1 CA 2153994A1 CA 002153994 A CA002153994 A CA 002153994A CA 2153994 A CA2153994 A CA 2153994A CA 2153994 A1 CA2153994 A1 CA 2153994A1
Authority
CA
Canada
Prior art keywords
bursts
energy
shutter
finger
during
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002153994A
Other languages
French (fr)
Other versions
CA2153994C (en
Inventor
James R. Braig
Daniel S. Goldberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Optiscan Inc
Original Assignee
James R. Braig
Daniel S. Goldberger
Optiscan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by James R. Braig, Daniel S. Goldberger, Optiscan, Inc. filed Critical James R. Braig
Publication of CA2153994A1 publication Critical patent/CA2153994A1/en
Application granted granted Critical
Publication of CA2153994C publication Critical patent/CA2153994C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3581—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation

Abstract

A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range. The long wavelength infrared energy generated by source (400) is passed through a finger (406). To prevent the high energy source from burning or causing patient discomfort, shutter (404) and bandpass filters (410) cause only short bursts of energy to be sent through the finger with a very low duty cycle and low optical bandwidth. The bursts are further synchronized by shutter (404) with systole and diastole of the cardiac cycle so that only two pulses are sent per heart beat, one during diastole and one during systole. The detection signals measured at detectors (412) during application of these bursts of energy are used to calculate the concentration of blood constituents in accordance with a polynomial equation.
CA002153994A 1993-01-28 1994-01-21 Noninvasive pulsed infrared spectrophotometer Expired - Fee Related CA2153994C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/010,634 US5313941A (en) 1993-01-28 1993-01-28 Noninvasive pulsed infrared spectrophotometer
US08/010,634 1993-01-28
PCT/US1994/000489 WO1994016614A1 (en) 1993-01-28 1994-01-21 Noninvasive pulsed infrared spectrophotometer

Publications (2)

Publication Number Publication Date
CA2153994A1 true CA2153994A1 (en) 1994-08-04
CA2153994C CA2153994C (en) 2004-05-11

Family

ID=21746650

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002153994A Expired - Fee Related CA2153994C (en) 1993-01-28 1994-01-21 Noninvasive pulsed infrared spectrophotometer

Country Status (11)

Country Link
US (1) US5313941A (en)
EP (1) EP0682494B1 (en)
JP (1) JP3452065B2 (en)
AT (1) ATE215796T1 (en)
AU (1) AU675827B2 (en)
CA (1) CA2153994C (en)
DE (1) DE69430366T2 (en)
DK (1) DK0682494T3 (en)
ES (1) ES2174871T3 (en)
PT (1) PT682494E (en)
WO (1) WO1994016614A1 (en)

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US5313941A (en) 1994-05-24

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