CA2160838A1 - Short coherence length, doppler velocimetry system - Google Patents

Short coherence length, doppler velocimetry system

Info

Publication number
CA2160838A1
CA2160838A1 CA002160838A CA2160838A CA2160838A1 CA 2160838 A1 CA2160838 A1 CA 2160838A1 CA 002160838 A CA002160838 A CA 002160838A CA 2160838 A CA2160838 A CA 2160838A CA 2160838 A1 CA2160838 A1 CA 2160838A1
Authority
CA
Canada
Prior art keywords
sample
area
interference signal
reference beam
coherence length
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002160838A
Other languages
French (fr)
Other versions
CA2160838C (en
Inventor
Thomas Hellmuth
Christopher L. Petersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carl Zeiss Inc
Original Assignee
Carl Zeiss Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carl Zeiss Inc filed Critical Carl Zeiss Inc
Publication of CA2160838A1 publication Critical patent/CA2160838A1/en
Application granted granted Critical
Publication of CA2160838C publication Critical patent/CA2160838C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A61B3/1225—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes using coherent radiation
    • A61B3/1233—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes using coherent radiation for measuring blood flow, e.g. at the retina

Abstract

Apparatus for measuring the speed of blood in blood vessels in biological samples, for example, in retinal blood vessels, which apparatus includes: (a) a source of a beam of radiation having a principal wavelength, which radiation is substantially spatially coherent and has a temporal coherence length which is less than 1 picosecond;
(b) a beam splitter for splitting the beam into a sample beam and reference beam; (c) optical apparatus for directing the sample beam to an area within the biological sample; (d) a reflector for reflecting the reference beam; (e) a detector for detecting an interference between the sample beam reflected from the area and the reflected reference beam and for generating an interference signal; (f) apparatus for altering an optical path length of the reference beam from the beam sputter to the detector at an alteration velocity; and (g) an analyzer fur analyzing the interference signal to determine the speed of the blood in the area from a shift of a central frequency of a frequency spectrum of the interference signal from a frequency determined from the alteration velocity and the principal wavelength.
CA002160838A 1994-10-19 1995-10-18 Short coherence length, doppler velocimetry system Expired - Fee Related CA2160838C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/325,675 US5501226A (en) 1994-10-19 1994-10-19 Short coherence length, doppler velocimetry system
US08/325,675 1994-10-19

Publications (2)

Publication Number Publication Date
CA2160838A1 true CA2160838A1 (en) 1996-04-20
CA2160838C CA2160838C (en) 2005-05-17

Family

ID=23268918

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002160838A Expired - Fee Related CA2160838C (en) 1994-10-19 1995-10-18 Short coherence length, doppler velocimetry system

Country Status (7)

Country Link
US (2) US5501226A (en)
EP (1) EP0707823B1 (en)
JP (1) JP3809208B2 (en)
CN (1) CN1129400C (en)
CA (1) CA2160838C (en)
DE (1) DE69519357T2 (en)
SG (1) SG50358A1 (en)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6485413B1 (en) 1991-04-29 2002-11-26 The General Hospital Corporation Methods and apparatus for forward-directed optical scanning instruments
US6111645A (en) 1991-04-29 2000-08-29 Massachusetts Institute Of Technology Grating based phase control optical delay line
JP3332535B2 (en) * 1993-12-14 2002-10-07 キヤノン株式会社 Ophthalmic measurement device
GB9411231D0 (en) * 1994-06-04 1994-07-27 Kellam Keith Laser doppler microscopy methods and instruments
US5751830A (en) * 1995-05-24 1998-05-12 Lockheed Martin Energy Systems, Inc. Method and apparatus for coherent imaging of infrared energy
AU711422B2 (en) * 1996-01-26 1999-10-14 Roche Diagnostics Gmbh Process and device for determining an analyte contained in a scattering matrix
US5900928A (en) * 1996-07-30 1999-05-04 Institut De Recherche En Ophtalmologie Confocal bidirectional laser doppler velocimetry
US5991697A (en) * 1996-12-31 1999-11-23 The Regents Of The University Of California Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media
US5994690A (en) * 1997-03-17 1999-11-30 Kulkarni; Manish D. Image enhancement in optical coherence tomography using deconvolution
JP4138027B2 (en) * 1997-06-02 2008-08-20 イザット，ジョーゼフ，エイ． Imaging Doppler flow using optical coherence tomography
US6002480A (en) 1997-06-02 1999-12-14 Izatt; Joseph A. Depth-resolved spectroscopic optical coherence tomography
US6842639B1 (en) * 1997-10-03 2005-01-11 Intraluminal Therapeutics, Inc. Method and apparatus for determining neovascular flow through tissue in a vessel
US6193676B1 (en) * 1997-10-03 2001-02-27 Intraluminal Therapeutics, Inc. Guide wire assembly
US5951482A (en) * 1997-10-03 1999-09-14 Intraluminal Therapeutics, Inc. Assemblies and methods for advancing a guide wire through body tissue
US6151127A (en) * 1998-05-28 2000-11-21 The General Hospital Corporation Confocal microscopy
US6657727B1 (en) 1998-09-11 2003-12-02 Joseph A. Izatt Interferometers for optical coherence domain reflectometry and optical coherence tomography using nonreciprocal optical elements
US6546272B1 (en) 1999-06-24 2003-04-08 Mackinnon Nicholas B. Apparatus for in vivo imaging of the respiratory tract and other internal organs
US6445939B1 (en) 1999-08-09 2002-09-03 Lightlab Imaging, Llc Ultra-small optical probes, imaging optics, and methods for using same
JP4717308B2 (en) * 1999-11-19 2011-07-06 ザイゴ コーポレーション System and method for quantifying non-linearities in an interferometric measurement system
DE10157842A1 (en) * 2001-11-24 2003-06-05 Zeiss Carl Interferometer and interferometric measuring method
US7747315B2 (en) * 2002-01-15 2010-06-29 Board Of Regents, The University Of Texas System Methods and compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures
US6618128B2 (en) * 2002-01-23 2003-09-09 Csi Technology, Inc. Optical speed sensing system
US20040075824A1 (en) * 2002-05-23 2004-04-22 Mikhail Belenkii Optical flow monitor
US6891984B2 (en) * 2002-07-25 2005-05-10 Lightlab Imaging, Llc Scanning miniature optical probes with optical distortion correction and rotational control
WO2005007215A2 (en) * 2003-07-09 2005-01-27 Glucolight Corporation Method and apparatus for tissue oximetry
US7510849B2 (en) * 2004-01-29 2009-03-31 Glucolight Corporation OCT based method for diagnosis and therapy
US7242480B2 (en) * 2004-05-14 2007-07-10 Medeikon Corporation Low coherence interferometry for detecting and characterizing plaques
US7327463B2 (en) 2004-05-14 2008-02-05 Medrikon Corporation Low coherence interferometry utilizing magnitude
US7190464B2 (en) * 2004-05-14 2007-03-13 Medeikon Corporation Low coherence interferometry for detecting and characterizing plaques
US7474408B2 (en) * 2004-05-14 2009-01-06 Medeikon Corporation Low coherence interferometry utilizing phase
US7184148B2 (en) 2004-05-14 2007-02-27 Medeikon Corporation Low coherence interferometry utilizing phase
US20050254059A1 (en) * 2004-05-14 2005-11-17 Alphonse Gerard A Low coherence interferometric system for optical metrology
US7254429B2 (en) 2004-08-11 2007-08-07 Glucolight Corporation Method and apparatus for monitoring glucose levels in a biological tissue
US7822452B2 (en) * 2004-08-11 2010-10-26 Glt Acquisition Corp. Method for data reduction and calibration of an OCT-based blood glucose monitor
US8036727B2 (en) 2004-08-11 2011-10-11 Glt Acquisition Corp. Methods for noninvasively measuring analyte levels in a subject
US7298469B2 (en) * 2004-10-14 2007-11-20 Nuclear Solutions, Inc. Specific density detector with electro mechanical actuator and improved mirror
JP4597744B2 (en) * 2004-11-08 2010-12-15 株式会社トプコン Optical image measuring device and optical image measuring method
WO2006078802A1 (en) * 2005-01-21 2006-07-27 Massachusetts Institute Of Technology Methods and apparatus for optical coherence tomography scanning
DE102005046605A1 (en) * 2005-09-29 2007-04-05 Robert Bosch Gmbh Optical path difference adjusting device, has interferometric measuring device with two interferometers, where optical path length for partial beams in interferometers can be set by components, which are mechanically coupled to one another
JP4837982B2 (en) * 2005-11-30 2011-12-14 株式会社ニデック Ophthalmic equipment
JP4823693B2 (en) * 2006-01-11 2011-11-24 株式会社トプコン Optical image measuring device
US20070197932A1 (en) * 2006-02-17 2007-08-23 Feke Gilbert T Non-invasive methods for evaluating retinal affecting neurodegenerative diseases
EP2517616A3 (en) * 2006-05-10 2013-03-06 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
US7488930B2 (en) * 2006-06-02 2009-02-10 Medeikon Corporation Multi-channel low coherence interferometer
US20080094608A1 (en) * 2006-10-23 2008-04-24 The Regents Of The University Of California Laser velocimetry system
US7405814B2 (en) * 2006-12-19 2008-07-29 The Boeing Company Frequency multiplexed, multiple channel heterodyne interferometer
WO2009111542A2 (en) 2008-03-04 2009-09-11 Glucolight Corporation Methods and systems for analyte level estimation in optical coherence tomography
DE102008028342A1 (en) * 2008-06-13 2009-12-17 Carl Zeiss Surgical Gmbh Laser doppler imaging method for examining object i.e. human eye, involves assigning analysis image value that depends on amplitude and/or frequencies of temporal changes of image values of pixels
EP2565703B1 (en) * 2010-04-30 2019-12-04 Hamamatsu Photonics K.K. Observation device
JP5721411B2 (en) * 2010-12-02 2015-05-20 キヤノン株式会社 Ophthalmic apparatus, blood flow velocity calculation method and program
JP5721412B2 (en) * 2010-12-02 2015-05-20 キヤノン株式会社 Ophthalmic apparatus, blood flow velocity calculation method and program
US9849034B2 (en) * 2011-11-07 2017-12-26 Alcon Research, Ltd. Retinal laser surgery
JP5900950B2 (en) * 2012-01-05 2016-04-06 国立大学法人 筑波大学 Wavelength scanning optical coherence tomography and its phase stabilization program
CN102551654B (en) * 2012-01-20 2013-09-18 王毅 Optical coherence biological measurer and method for biologically measuring eyes
US9013708B2 (en) * 2012-02-24 2015-04-21 Crystalvue Medical Corporation Optical apparatus and operating method thereof
JP6338255B2 (en) 2013-03-13 2018-06-06 オプティメディカ・コーポレイションＯｐｔｉｍｅｄｉｃａ Ｃｏｒｐｏｒａｔｉｏｎ Free-floating patient interface for laser surgical systems
US9849032B2 (en) 2013-03-13 2017-12-26 Optimedica Corporation Laser eye surgery system
US10307056B2 (en) 2013-12-05 2019-06-04 Bioptigen, Inc. Systems and methods for quantitative doppler optical coherence tomography
WO2015127661A1 (en) * 2014-02-28 2015-09-03 深圳市斯尔顿科技有限公司 Blood flow speed measurement device and method
JP6412710B2 (en) * 2014-04-08 2018-10-24 株式会社ミツトヨ Optical interference measurement device
JP6468907B2 (en) * 2015-03-25 2019-02-13 キヤノン株式会社 Image processing apparatus, image processing method, and program
CN105167766B (en) * 2015-11-03 2018-06-08 深圳市斯尔顿科技有限公司 Blood flow measurement equipment and blood flow measurement method
US10376223B2 (en) * 2016-03-28 2019-08-13 Fuji Xerox Co., Ltd. Living-body information measurement device and non-transitory computer readable medium
CN106054159B (en) * 2016-05-12 2018-09-11 北京航空航天大学 A kind of instantaneous frequency distilling method of Doppler signal
KR102041551B1 (en) 2016-10-06 2019-11-27 최윤석 Asymmetric ellipse chain ring for clipless pedal
EP3517978A1 (en) * 2018-01-24 2019-07-31 Universitat Politécnica De Catalunya Method and device for confocal measurement of displacement, velocity or flow at a point of a sample and uses thereof
CN108957781A (en) * 2018-07-23 2018-12-07 中国科学院苏州生物医学工程技术研究所 Optical lens adjustment and detection system and method
CN110448266B (en) * 2018-12-29 2022-03-04 中国科学院宁波工业技术研究院慈溪生物医学工程研究所 Random laser confocal line scanning three-dimensional ophthalmoscope and imaging method

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2555134C2 (en) * 1975-12-08 1977-12-29 Siemens AG, 1000 Berlin und 8000 München Device for flow measurements according to the ultrasonic Doppler method
GB1564315A (en) * 1976-04-01 1980-04-10 Secr Defence Method and apparatus for measuring retinal blood flow
US4142796A (en) * 1977-04-20 1979-03-06 Eye Research Institute Of Retina Foundation, Inc. Blood flow measurement
US4346991A (en) * 1979-10-31 1982-08-31 National Research Development Corporation Method and apparatus for measuring retinal blood flow
US4402601A (en) * 1980-12-31 1983-09-06 Riva Charles E Fundus camera-based retinal laser doppler velocimeter
FR2531854A1 (en) * 1982-08-23 1984-02-24 Cird Non-invasive instrument for measuring the mean rate of blood flow in living tissue
DE3235369A1 (en) * 1982-09-24 1984-03-29 Basf Ag, 6700 Ludwigshafen FIBER OPTICAL DOPPLER ANEMOMETER
SE8400289D0 (en) * 1984-01-20 1984-01-20 Perimed Kb SET AND DEVICE FOR DETERMINATION OF THE BLOOD FLOOD IN THE EXTRA BLOCK CARTRIDGE OF A TISSUE
US4818071A (en) * 1985-03-26 1989-04-04 Andrew Corporation Fiber optic doppler anemometer
JPH0428348A (en) * 1990-05-24 1992-01-30 Hitoshi Fujii Blood flow state image formation device
US5106184A (en) * 1990-08-13 1992-04-21 Eye Research Institute Of Retina Foundation Retinal laser doppler apparatus having eye tracking system
WO1992019930A1 (en) * 1991-04-29 1992-11-12 Massachusetts Institute Of Technology Method and apparatus for optical imaging and measurement

Also Published As

Publication number Publication date
US5501226A (en) 1996-03-26
US5549114A (en) 1996-08-27
CN1135043A (en) 1996-11-06
CN1129400C (en) 2003-12-03
CA2160838C (en) 2005-05-17
SG50358A1 (en) 1998-07-20
JPH08206086A (en) 1996-08-13
DE69519357T2 (en) 2001-06-07
JP3809208B2 (en) 2006-08-16
DE69519357D1 (en) 2000-12-14
EP0707823B1 (en) 2000-11-08
EP0707823A1 (en) 1996-04-24

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