CA2164498A1 - Assay for ykl-40 as a marker for degradation of mammalian connective tissue matrices - Google Patents

Assay for ykl-40 as a marker for degradation of mammalian connective tissue matrices

Info

Publication number
CA2164498A1
CA2164498A1 CA002164498A CA2164498A CA2164498A1 CA 2164498 A1 CA2164498 A1 CA 2164498A1 CA 002164498 A CA002164498 A CA 002164498A CA 2164498 A CA2164498 A CA 2164498A CA 2164498 A1 CA2164498 A1 CA 2164498A1
Authority
CA
Canada
Prior art keywords
ykl
degradation
connective tissue
marker
assay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002164498A
Other languages
French (fr)
Other versions
CA2164498C (en
Inventor
Paul A. Price
Julia S. Johansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
Paul A. Price
Julia S. Johansen
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paul A. Price, Julia S. Johansen, The Regents Of The University Of California filed Critical Paul A. Price
Priority claimed from PCT/US1993/006579 external-priority patent/WO1995002188A1/en
Publication of CA2164498A1 publication Critical patent/CA2164498A1/en
Application granted granted Critical
Publication of CA2164498C publication Critical patent/CA2164498C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/10Musculoskeletal or connective tissue disorders
    • G01N2800/105Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808Automated or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/811Test for named disease, body condition or organ function
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/811Test for named disease, body condition or organ function
    • Y10S436/813Cancer

Abstract

The invention is a method of identifying the presence of a disease state in a mammal which is associated with degradation of connective tissue in the mammal which contains the protein known as YKL-40.
The method is a competitive immunoassay for YKL-40.
It can be used, for example, to identify the presence of inflammatory or degenetative joint disease and tumor metastasis (to the extent it can be correlated to serum YKL-40 levels). Serum YKL-40 levels as detected and quantified by the inventive method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers.
CA002164498A 1993-07-09 1993-07-12 Assay for ykl-40 as a marker for degradation of mammalian connective tissue matrices Expired - Lifetime CA2164498C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8998993A 1993-07-09 1993-07-09
US08/089,989 1993-07-09
PCT/US1993/006579 WO1995002188A1 (en) 1993-07-12 1993-07-12 Assay for ykl-40 as a marker for degradation of mammalian connective tissue matrices

Publications (2)

Publication Number Publication Date
CA2164498A1 true CA2164498A1 (en) 1995-01-19
CA2164498C CA2164498C (en) 2007-09-11

Family

ID=22220557

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002164498A Expired - Lifetime CA2164498C (en) 1993-07-09 1993-07-12 Assay for ykl-40 as a marker for degradation of mammalian connective tissue matrices
CA002166292A Expired - Lifetime CA2166292C (en) 1993-07-09 1994-07-08 Assay for ykl-40 as a marker for degradation of mammalian connective tissue matrices

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002166292A Expired - Lifetime CA2166292C (en) 1993-07-09 1994-07-08 Assay for ykl-40 as a marker for degradation of mammalian connective tissue matrices

Country Status (6)

Country Link
US (4) US5935798A (en)
EP (1) EP0710251B1 (en)
JP (1) JP2878455B2 (en)
CA (2) CA2164498C (en)
DE (1) DE69434230T2 (en)
WO (1) WO1995001995A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2164498C (en) 1993-07-09 2007-09-11 Paul A. Price Assay for ykl-40 as a marker for degradation of mammalian connective tissue matrices
US7229770B1 (en) * 1998-10-01 2007-06-12 The Regents Of The University Of California YKL-40 as a marker and prognostic indicator for cancers
IL115744A (en) * 1994-10-27 2000-07-16 Akzo Nobel Nv Peptides comprising a subsequence of human cartilage glycoprotein - 39
US5773259A (en) * 1996-03-20 1998-06-30 Smithkline Beecham Corporation Tissue remodeling proteins
US5843449A (en) * 1996-03-25 1998-12-01 Akzo Nobel N.V. Proteins and novel peptides derived from autoantigen for use in immunotherapy of autoimmune diseases
TW575583B (en) * 1996-04-24 2004-02-11 Akzo Nobel Nv Novel peptides suitable for use in antigen specific immunosuppressive therapy
US6881824B1 (en) 1996-04-24 2005-04-19 Akzo Nobel N.V. Peptides suitable for use in antigen specific immunosuppressive therapy
US5726061A (en) * 1996-10-08 1998-03-10 Smithkline Beechum Corporation Method of diagnosing and monitoring colorectal cancer
US6464975B2 (en) * 1998-12-11 2002-10-15 The Research Foundation Of State University Of New York Compositions and methods for altering cell migration
ES2261239T3 (en) 1999-08-30 2006-11-16 Interleukin Genetics, Inc. DIAGNOSIS AND THERAPY FOR OSTEOPOROSIS.
IL154000A0 (en) * 2000-08-14 2003-07-31 Akzo Nobel Nv Use of antibodies against specific mhc-peptide complexes
WO2002016949A1 (en) * 2000-08-21 2002-02-28 Assistance Publique - Hopitaux De Paris Diagnosis method of fibrotic disease using biochemical markers
US6631330B1 (en) * 2000-08-21 2003-10-07 Assistance Publique-Hopitaux De Paris (Ap-Hp) Diagnosis method of inflammatory, fibrotic or cancerous disease using biochemical markers
BR0211468A (en) * 2001-07-24 2004-11-23 Univ Yale Methods of Treating and Preventing an Inflammatory Disease in a Mammal and Identifying a Compound Useful for Treating an Inflammatory Disease in a Mammal, Compound, and Kits for Treating and Preventing an Inflammatory Disease in a Mammal
DE602004030367D1 (en) 2003-08-08 2011-01-13 Interleukin Genetics Inc DIAGNOSTIC FOR OSTEOPOROSIS
WO2005039487A2 (en) * 2003-09-10 2005-05-06 Sloan-Kettering Institute For Cancer Research Method for early detection of ovarian cancer
US20050214297A1 (en) * 2004-02-25 2005-09-29 Medimmune, Inc. Methods and compositions relating to chitinases and chitinase-like molecules and modulation of osteoclasts
ATE454474T1 (en) * 2004-08-10 2010-01-15 Cardiff Biolog Ltd METHOD AND KIT FOR PROGNOSIS OF BREAST CANCER
WO2006089549A1 (en) * 2005-02-28 2006-08-31 Bio-Y A/S Ykl-40 monoclonal antibodies
US20070071746A1 (en) * 2005-08-31 2007-03-29 Medimmune, Inc. C/CLP antagonists and methods of use thereof
US20110143380A1 (en) * 2006-03-14 2011-06-16 The Washington University Alzheimer's disease biomarkers and methods of use
US20100003189A1 (en) 2006-07-14 2010-01-07 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
US8697384B2 (en) 2008-01-23 2014-04-15 Herlev Hospital YKL-40 as a general marker for non-specific disease
KR20100128281A (en) * 2008-01-23 2010-12-07 릭스하스피탈렛 Classification of individuals suffering from cardiovascular diseases according to survival prognoses as found by measuring the levels of biomarker ykl-40
US11480574B2 (en) * 2008-05-21 2022-10-25 Biaoyang Lin Reagent kits for diagnosis of hepatocarcinoma
CN101587125B (en) * 2008-05-21 2013-07-24 林标扬 High expression cancer marker and low expression tissue organ marker kit
US20120040355A1 (en) * 2008-09-15 2012-02-16 Julia Sidenius Johansen Ykl-40 as a marker for selection of treatment and monitoring of a disease
NZ592241A (en) 2008-09-15 2012-11-30 Herlev Hospital Ykl-40 as a marker for gastrointestinal cancers
CA2762903C (en) 2009-05-22 2013-07-30 Soft Tissue Regeneration, Inc. Mechanically competent scaffold for ligament and tendon regeneration
WO2011139721A1 (en) 2010-04-27 2011-11-10 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
WO2012136548A1 (en) * 2011-04-04 2012-10-11 Universiteit Gent Biomarkers for acute kidney injury
WO2016090323A1 (en) 2014-12-05 2016-06-09 Prelude, Inc. Dcis recurrence and invasive breast cancer
RU2623869C1 (en) * 2016-07-29 2017-06-29 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский государственный университет" (ТГУ, НИ ТГУ) Method of forecasting personsive survivability in patients with breast cancer
AU2019339508A1 (en) 2018-09-14 2021-04-15 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
CA3118890A1 (en) * 2018-11-07 2020-05-14 Brown University Methods and compositions relating to anti-chi3l1 antibody reagents for the treatment of fibrosis

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4628027A (en) * 1982-05-19 1986-12-09 Molecular Engineering Associates, Ltd. Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
GB8516081D0 (en) * 1985-06-25 1985-07-31 Ciba Geigy Ag Assay & purification of amyloid components
JPS6323898A (en) * 1986-07-16 1988-02-01 Dainippon Pharmaceut Co Ltd Novel polypeptide, dna coding said polypeptide and production thereof
US4782017A (en) * 1986-08-25 1988-11-01 Eastman Kodak Company Analytical element and method for determination of theophylline by enzyme inhibition
WO1990008195A1 (en) * 1989-01-13 1990-07-26 President And Fellows Of Harvard College Monoclonal antibody to human type ix collagen
JP2877509B2 (en) * 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド Metalloproteinase inhibitors
US5427954A (en) * 1992-04-29 1995-06-27 Shriner's Hospitals For Crippled Children Compositions and methods for detection and treatment of human osteoarthritis
CA2164498C (en) 1993-07-09 2007-09-11 Paul A. Price Assay for ykl-40 as a marker for degradation of mammalian connective tissue matrices
US5773259A (en) * 1996-03-20 1998-06-30 Smithkline Beecham Corporation Tissue remodeling proteins
EP0805206A3 (en) 1996-05-03 1999-09-15 Smithkline Beecham Corporation Human cartilage glycoprotein
AU6693996A (en) 1996-08-09 1998-03-06 Human Genome Sciences, Inc. Human chitinase alpha and chitinase alpha-2
US5811535A (en) 1996-08-09 1998-09-22 Smithkline Beecham Corporation Human cartilege gp39-like gene
US5726061A (en) * 1996-10-08 1998-03-10 Smithkline Beechum Corporation Method of diagnosing and monitoring colorectal cancer

Also Published As

Publication number Publication date
EP0710251A1 (en) 1996-05-08
US6579684B2 (en) 2003-06-17
US20020031793A1 (en) 2002-03-14
CA2166292A1 (en) 1995-01-19
JP2878455B2 (en) 1999-04-05
US20020090658A1 (en) 2002-07-11
US6794150B2 (en) 2004-09-21
US5935798A (en) 1999-08-10
CA2166292C (en) 2007-04-17
EP0710251B1 (en) 2005-01-12
CA2164498C (en) 2007-09-11
EP0710251A4 (en) 1997-12-10
DE69434230T2 (en) 2005-12-08
US20050065325A1 (en) 2005-03-24
DE69434230D1 (en) 2005-02-17
US7230086B2 (en) 2007-06-12
JPH09500209A (en) 1997-01-07
WO1995001995A1 (en) 1995-01-19

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