CA2166108A1 - Insulin preparations for inhalation - Google Patents

Insulin preparations for inhalation

Info

Publication number
CA2166108A1
CA2166108A1 CA002166108A CA2166108A CA2166108A1 CA 2166108 A1 CA2166108 A1 CA 2166108A1 CA 002166108 A CA002166108 A CA 002166108A CA 2166108 A CA2166108 A CA 2166108A CA 2166108 A1 CA2166108 A1 CA 2166108A1
Authority
CA
Canada
Prior art keywords
inhalation
insulin preparations
insulin
enhances
absorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002166108A
Other languages
French (fr)
Other versions
CA2166108C (en
Inventor
Kjell Goran Erik Backstrom
Carl Magnus Olof Dahlback
Peter Edman
Ann Charlotte Birgit Johansson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Kjell Goran Erik Backstrom
Carl Magnus Olof Dahlback
Peter Edman
Ann Charlotte Birgit Johansson
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9302198A external-priority patent/SE9302198D0/en
Priority claimed from SE9400370A external-priority patent/SE9400370L/en
Application filed by Kjell Goran Erik Backstrom, Carl Magnus Olof Dahlback, Peter Edman, Ann Charlotte Birgit Johansson, Astra Aktiebolag filed Critical Kjell Goran Erik Backstrom
Publication of CA2166108A1 publication Critical patent/CA2166108A1/en
Application granted granted Critical
Publication of CA2166108C publication Critical patent/CA2166108C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Abstract

A therapeutic preparation for inhalation which comprises insulin and a substance which enhances the absorption of insulin in the lower respiratory tract, is provided in the form of a powder preparation suitable for inhalation.
CA002166108A 1993-06-24 1994-06-23 Insulin preparations for inhalation Expired - Fee Related CA2166108C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE9302198A SE9302198D0 (en) 1993-06-24 1993-06-24 POWDER PREPARATION FOR INHALATION
SE9302198-8 1994-02-04
SE9400370-4 1994-02-04
SE9400370A SE9400370L (en) 1994-02-04 1994-02-04 Therapeutic composition for inhalation
PCT/SE1994/000633 WO1995000127A1 (en) 1993-06-24 1994-06-23 Therapeutic preparation for inhalation

Publications (2)

Publication Number Publication Date
CA2166108A1 true CA2166108A1 (en) 1995-01-05
CA2166108C CA2166108C (en) 2008-10-21

Family

ID=26661778

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002166108A Expired - Fee Related CA2166108C (en) 1993-06-24 1994-06-23 Insulin preparations for inhalation

Country Status (32)

Country Link
US (3) US5518998C1 (en)
EP (1) EP0706382B1 (en)
JP (2) JP3874789B2 (en)
KR (1) KR100372673B1 (en)
CN (1) CN1110301C (en)
AT (1) ATE183920T1 (en)
AU (1) AU692780B2 (en)
BR (1) BR9406907A (en)
CA (1) CA2166108C (en)
CZ (1) CZ287314B6 (en)
DE (1) DE69420412T2 (en)
DK (1) DK0706382T3 (en)
EE (1) EE03221B1 (en)
EG (1) EG20599A (en)
ES (1) ES2138087T3 (en)
FI (1) FI111688B (en)
GR (1) GR3031974T3 (en)
HK (1) HK1009584A1 (en)
HU (1) HU228129B1 (en)
IL (1) IL110084A (en)
IS (1) IS1768B (en)
MX (1) MX9404761A (en)
MY (1) MY112098A (en)
NO (1) NO313657B1 (en)
NZ (1) NZ268137A (en)
PL (1) PL178403B1 (en)
RU (1) RU2148398C1 (en)
SA (1) SA94150030B1 (en)
SK (1) SK283145B6 (en)
TW (1) TW402506B (en)
UA (1) UA49794C2 (en)
WO (1) WO1995000127A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399102B1 (en) 1996-05-24 2002-06-04 The Penn State Research Foundation Aerodynamically light particles for pulmonary drug delivery
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7048908B2 (en) 2000-12-29 2006-05-23 Advanced Inhalation Research, Inc. Particles for inhalation having sustained release properties

Families Citing this family (207)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5645820A (en) * 1987-06-24 1997-07-08 Autoimmune, Inc. Treatment of autoimmune diseases by aerosol administration of autoantigens
US6645504B1 (en) 1987-06-24 2003-11-11 Autoimmune Inc. Bystander suppression of type I diabetes by oral administration of glucagon
IL99699A (en) * 1990-10-10 2002-04-21 Autoimmune Inc Pharmaceutical oral, enteral or by-inhalation dosage form for suppressing an autoimmune response associated with type i diabetes
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US7448375B2 (en) * 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
EP1607086A1 (en) * 1993-01-29 2005-12-21 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
IS1796B (en) * 1993-06-24 2001-12-31 Ab Astra Inhaled polypeptide formulation composition which also contains an enhancer compound
US5830853A (en) * 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
US5747445A (en) * 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US20010003739A1 (en) * 1993-06-24 2001-06-14 Astrazeneca Ab Systemic administration of a therapeutic preparation
US6794357B1 (en) 1993-06-24 2004-09-21 Astrazeneca Ab Compositions for inhalation
US6632456B1 (en) * 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
GB9322014D0 (en) 1993-10-26 1993-12-15 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
ES2218543T3 (en) * 1994-03-07 2004-11-16 Nektar Therapeutics PROCEDURE AND PREPARATION FOR THE ADMINISTRATION OF INSULIN BY PULMONARY ROUTE.
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US6165976A (en) 1994-06-23 2000-12-26 Astra Aktiebolag Therapeutic preparation for inhalation
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
MX9704550A (en) 1994-12-22 1997-10-31 Astra Ab Aerosol drug formulations.
SE9404468D0 (en) * 1994-12-22 1994-12-22 Astra Ab Powder formulations
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
JPH10511090A (en) * 1994-12-22 1998-10-27 アストラ・アクチエボラーグ Parathyroid hormone, PTH-containing therapeutic preparation for inhalation
GB9501841D0 (en) * 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US5612053A (en) 1995-04-07 1997-03-18 Edward Mendell Co., Inc. Controlled release insufflation carrier for medicaments
GB9508691D0 (en) * 1995-04-28 1995-06-14 Pafra Ltd Stable compositions
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
US5714007A (en) * 1995-06-06 1998-02-03 David Sarnoff Research Center, Inc. Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate
US5669973A (en) * 1995-06-06 1997-09-23 David Sarnoff Research Center, Inc. Apparatus for electrostatically depositing and retaining materials upon a substrate
US5654007A (en) * 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
GB9515182D0 (en) * 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
US5642727A (en) * 1995-07-25 1997-07-01 David Sarnoff Research Center, Inc. Inhaler apparatus using a tribo-electric charging technique
US5855913A (en) * 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US6254854B1 (en) 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US6503480B1 (en) 1997-05-23 2003-01-07 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
USRE37053E1 (en) 1996-05-24 2001-02-13 Massachusetts Institute Of Technology Particles incorporating surfactants for pulmonary drug delivery
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US5871010A (en) 1996-06-10 1999-02-16 Sarnoff Corporation Inhaler apparatus with modified surfaces for enhanced release of dry powders
US5857456A (en) * 1996-06-10 1999-01-12 Sarnoff Corporation Inhaler apparatus with an electronic means for enhanced release of dry powders
US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
US6043214A (en) * 1997-03-20 2000-03-28 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US6310038B1 (en) 1997-03-20 2001-10-30 Novo Nordisk A/S Pulmonary insulin crystals
CO4750643A1 (en) * 1997-06-13 1999-03-31 Lilly Co Eli STABLE FORMULATION OF INSULIN CONTAINING L-ARGININ AND PROTAMINE
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6946117B1 (en) * 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US20020017295A1 (en) * 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US20010007853A1 (en) * 1998-01-08 2001-07-12 Dimarchi Richard Dennis Method for administering monomeric insulin analogs
US7070799B1 (en) * 1998-02-10 2006-07-04 Generex Pharmaceuticals, Inc. Method for administering insulin to the buccal region
US6221378B1 (en) 1998-02-10 2001-04-24 Generex Pharmaceuticals Incorporated Mixed micellar delivery system and method of preparation
US6149774A (en) 1998-06-10 2000-11-21 Delsys Pharmaceutical Corporation AC waveforms biasing for bead manipulating chucks
US6451349B1 (en) 1998-08-19 2002-09-17 Quadrant Healthcare (Uk) Limited Spray-drying process for the preparation of microparticles
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US6294153B1 (en) 1998-12-21 2001-09-25 Generex Pharmaceuticals, Inc. Aerosol pharmaceutical formulation for pulmonary and nasal delivery
US20040214747A1 (en) * 1999-01-06 2004-10-28 Dimarchi Richard Dennis Method for administering monomeric insulin
WO2000047203A1 (en) * 1999-02-12 2000-08-17 Mqs, Inc. Formulation and system for intra-oral delivery of pharmaceutical agents
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US6350432B1 (en) 1999-03-19 2002-02-26 Generex Pharmaceuticals Incorporated Pressurized container having an aerosolized pharmaceutical composition
US6923979B2 (en) * 1999-04-27 2005-08-02 Microdose Technologies, Inc. Method for depositing particles onto a substrate using an alternating electric field
CA2375914A1 (en) 1999-06-04 2000-12-14 Delrx Pharmaceutical Corporation Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6858199B1 (en) 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
US9006175B2 (en) * 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
PT1196430E (en) * 1999-06-29 2012-04-18 Mannkind Corp Purification and stabilization of peptide and protein pharmaceutical agents
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
JP2003507410A (en) * 1999-08-25 2003-02-25 アドバンスト インハレーション リサーチ，インコーポレイテッド Controlled release from dry powder formulations
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
WO2001051030A1 (en) 2000-01-10 2001-07-19 Dura Pharmaceuticals, Inc. Pharmaceutical formulation and method for pulmonary and oral delivery
GB0004827D0 (en) * 2000-02-29 2000-04-19 Quadrant Holdings Cambridge Compositions
JP2001240558A (en) * 2000-02-29 2001-09-04 Nippon Suisan Kaisha Ltd Solid preparation containing polyvalent-unsaturated fatty acid as transmucosal absorption promoter
GB0008660D0 (en) 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
ES2525087T5 (en) * 2000-05-10 2018-06-28 Novartis Ag Phospholipid-based powders for drug administration
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
GB0011807D0 (en) * 2000-05-16 2000-07-05 Quadrant Holdings Cambridge Formulation for inhalation
US7575761B2 (en) * 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
US6444619B1 (en) 2000-09-28 2002-09-03 Rohm And Haas Company Delivery system for cyclopropenes
IL145476A (en) 2000-09-29 2006-07-05 Rohm & Haas Delivery systems for cyclopropenes requiring less water
US6953540B2 (en) 2000-09-29 2005-10-11 Rohm And Haas Company Continuous process for the preparation of encapsulated cyclopropenes
IT1319201B1 (en) * 2000-10-12 2003-09-26 Nicox Sa DRUGS FOR DIABETES.
CA2430318C (en) * 2000-11-29 2009-10-27 Itoham Foods Inc. Powder formulation and method for producing the same
ES2689704T3 (en) * 2000-11-30 2018-11-15 Vectura Limited Particles for use in a pharmaceutical composition
ES2474199T3 (en) 2000-11-30 2014-07-08 Vectura Limited Pharmaceutical compositions for inhalation
WO2002051428A1 (en) * 2000-12-25 2002-07-04 Shiseido Company, Ltd. Sympathetic-activating perfume composition
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
US6867183B2 (en) * 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
KR20030094377A (en) * 2001-05-04 2003-12-11 화이자 프로덕츠 인코포레이티드 Method of preventing type 2 diabetes with aerosolized insulin
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) * 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
GB0114033D0 (en) * 2001-06-09 2001-08-01 Innovata Biomed Ltd Process
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
EP1446104B2 (en) 2001-11-01 2011-08-03 Novartis AG Spray drying methods
PT1455755E (en) * 2001-11-20 2013-06-18 Civitas Therapeutics Inc Improved particulate compositions for pulmonary delivery
US20030129250A1 (en) * 2001-11-20 2003-07-10 Advanced Inhalation Research Inc. Particulate compositions for improving solubility of poorly soluble agents
ES2364636T3 (en) 2001-12-19 2011-09-08 Novartis Ag PULMONARY ADMINISTRATION OF AMINOGLUCOSIDS.
EP1894591B1 (en) 2002-03-20 2013-06-26 MannKind Corporation Cartridge for an inhalation apparatus
US7582284B2 (en) * 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
AU2003226603A1 (en) * 2002-04-19 2003-11-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders
GB0216562D0 (en) * 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US7601688B2 (en) * 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
DE10234165B4 (en) * 2002-07-26 2008-01-03 Advanced Micro Devices, Inc., Sunnyvale A method of filling a trench formed in a substrate with an insulating material
CN1694689A (en) * 2002-09-30 2005-11-09 阿库斯菲尔公司 Sustained release pharmaceutical formulation for inhalation
WO2004037843A2 (en) * 2002-10-25 2004-05-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
CN1311868C (en) * 2003-06-10 2007-04-25 上海兴康医药研究开发有限公司 Preparing process of insulin powder inhalant
US8921311B2 (en) 2003-08-01 2014-12-30 Mannkind Corporation Method for treating hyperglycemia
JP4880461B2 (en) * 2003-08-13 2012-02-22 バイオコン・リミテッド Microparticulate fatty acid salt solid formulation for therapeutics
PT1699434E (en) * 2003-09-02 2011-05-03 Norton Healthcare Ltd Process for preparing a medicament
JP2007505136A (en) * 2003-09-10 2007-03-08 マツプ・フアーマシユーテイカルズ・インコーポレーテツド Aerosol formulation for delivering dihydroergotamine to systemic circulation by pulmonary inhalation
US7338171B2 (en) * 2003-10-27 2008-03-04 Jen-Chuen Hsieh Method and apparatus for visual drive control
CN101027082A (en) * 2004-01-12 2007-08-29 曼恩坎德公司 Method of reducing serum proinsulin levels in type 2 diabetics
WO2005089722A1 (en) * 2004-03-12 2005-09-29 Biodel, Inc. Rapid acting drug delivery compositions
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
US7625865B2 (en) * 2004-03-26 2009-12-01 Universita Degli Studi Di Parma Insulin highly respirable microparticles
CA2563533C (en) * 2004-04-15 2013-10-01 Shmuel A. Ben-Sasson Compositions capable of facilitating penetration across a biological barrier
US20070219131A1 (en) * 2004-04-15 2007-09-20 Ben-Sasson Shmuel A Compositions capable of facilitating penetration across a biological barrier
CN101098678A (en) 2004-04-23 2008-01-02 锡德克斯公司 Dpi formulation containing sulfoalkyl ether cyclodextrin
RU2393168C2 (en) * 2004-07-19 2010-06-27 Биокон Лимитед Insulin-oligomer conjugates, preparations and use thereof
CN101010305B (en) 2004-08-20 2010-08-11 曼金德公司 Catalysis of diketopiperazine synthesis
PL2322180T3 (en) 2004-08-23 2015-10-30 Mannkind Corp Diketopiperazine salts for drug delivery
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
CN104324362B (en) 2005-09-14 2018-04-24 曼金德公司 Method for preparation of drug based on improving affinity of the active agent to crystalline microparticle surfaces
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US20070086952A1 (en) * 2005-09-29 2007-04-19 Biodel, Inc. Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
US8084420B2 (en) * 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
PT1934252E (en) * 2005-10-13 2015-10-12 Biocon Ltd Process for the preparation of insulin conjugates.
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
AU2005338631B2 (en) * 2005-11-30 2011-12-01 Generex Pharmaceuticals Inc. Orally absorbed pharmaceutical formulation and method of administration
US20070148211A1 (en) * 2005-12-15 2007-06-28 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
CA2631493A1 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
TWI299993B (en) 2005-12-15 2008-08-21 Dev Center Biotechnology Aqueous inhalation pharmaceutical composition
CN104383546B (en) 2006-02-22 2021-03-02 曼金德公司 Method for improving the pharmaceutical properties of microparticles comprising diketopiperazines and an active agent
ES2622493T3 (en) 2006-02-24 2017-07-06 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibiting the JAK route
BRPI0710503A2 (en) 2006-04-07 2011-08-16 Merrion Res Iii Ltd use of a pharmaceutical composition, pharmaceutical composition, and oral dosage form
AU2007238114B2 (en) * 2006-04-12 2010-10-14 Biodel, Inc. Rapid acting and long acting insulin combination formulations
ES2538082T3 (en) * 2007-02-11 2015-06-17 Map Pharmaceuticals Inc Therapeutic administration method of DHE to allow rapid migraine relief while minimizing the side effects profile
KR100785656B1 (en) 2007-05-14 2007-12-17 재단법인서울대학교산학협력재단 Sodium glycocholate or derivatives thereof used as anti-inflammatory agents
KR101234540B1 (en) * 2007-10-16 2013-02-19 바이오콘 리미티드 An orally administerable solid pharmaceutical composition and a process thereof
WO2011163272A1 (en) 2010-06-21 2011-12-29 Mannkind Corporation Dry powder drug delivery system and methods
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
WO2009055740A2 (en) 2007-10-24 2009-04-30 Mannkind Corporation Method of preventing adverse effects by glp-1
WO2009079078A1 (en) 2007-12-14 2009-06-25 Labogroup S.A.S. Delivering aerosolizable food products
US20090271021A1 (en) * 2008-04-28 2009-10-29 Popp Shane M Execution system for the monitoring and execution of insulin manufacture
JP5671451B2 (en) 2008-05-07 2015-02-18 メリオン・リサーチ・Ｉｉｉ・リミテッド Compositions and preparation processes for GnRH related compounds
DK2293833T3 (en) 2008-06-13 2016-05-23 Mannkind Corp DRY POWDER INHALER AND MEDICINAL ADMINISTRATION SYSTEM
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
KR101628410B1 (en) 2008-06-20 2016-06-08 맨카인드 코포레이션 An interactive apparatus and method for real-time profiling of inhalation efforts
TWI494123B (en) 2008-08-11 2015-08-01 Mannkind Corp Use of ultrarapid acting insulin
ES2629131T3 (en) 2008-09-17 2017-08-07 Chiasma Inc. Pharmaceutical compositions and related delivery methods.
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2853268A1 (en) 2009-01-08 2015-04-01 Mannkind Corporation Treatment of hyperglycemia with GLP-1
DK2389372T3 (en) 2009-01-23 2015-12-14 Rigel Pharmaceuticals Inc COMPOSITIONS AND METHODS FOR INHIBITION OF JAK pathway
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
DK2405963T3 (en) 2009-03-11 2013-12-16 Mannkind Corp DEVICE, SYSTEM AND PROCEDURE FOR MEASURING RESISTANCE IN AN INHALATOR
US20100310660A1 (en) * 2009-06-08 2010-12-09 Taipei Medical University Dry powder microparticles for pulmonary delivery
BRPI1013154B1 (en) 2009-06-12 2020-04-07 Mannkind Corp MICROPARTICLES OF DICETOPIPERAZINE WITH SPECIFIC SURFACE AREAS DEFINED, DRY POWDER UNDERSTANDING THE REFERRED MICROPARTICLES, METHOD FOR FORMATION OF THE REFERENCESMICROPARTICLES AND THE FORMATION OF MICROPARTYSTEMS
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
EP2528601A1 (en) 2010-01-26 2012-12-05 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Compositions and methods for prevention and treatment of pulmonary hypertension
WO2011120033A1 (en) 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
JP2014501784A (en) 2011-01-07 2014-01-23 メリオン・リサーチ・Ｉｉｉ・リミテッド Pharmaceutical composition of iron for oral administration
SG194034A1 (en) 2011-04-01 2013-11-29 Mannkind Corp Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
US8877967B2 (en) 2012-03-23 2014-11-04 Oxigene, Inc. Compositions and methods for inhibition of cathepsins
CN108057154B (en) 2012-07-12 2021-04-16 曼金德公司 Dry powder drug delivery system and method
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
ES2928365T3 (en) 2013-03-15 2022-11-17 Mannkind Corp Microcrystalline diketopiperazine compositions, methods of preparation and use thereof
GB201305825D0 (en) 2013-03-28 2013-05-15 Vectura Ltd New use
EP3607941A1 (en) 2013-04-30 2020-02-12 Otitopic Inc. Dry powder formulations and methods of use
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
CN105517607A (en) 2013-08-05 2016-04-20 曼金德公司 Insufflation apparatus and methods
CN106102748A (en) 2014-02-20 2016-11-09 奥迪托皮克股份有限公司 For the dry powder formulations sucked
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2016120378A1 (en) 2015-01-29 2016-08-04 Novo Nordisk A/S Tablets comprising glp-1 agonist and enteric coating
US10238709B2 (en) 2015-02-03 2019-03-26 Chiasma, Inc. Method of treating diseases
WO2017193110A1 (en) * 2016-05-06 2017-11-09 Stites Adam Cannabinoid compositions for sublingual spray nebulizer
HUE059420T2 (en) 2018-04-16 2022-11-28 Ioulia Tseti A pharmaceutical dry powder composition for inhalation comprising a thyroid hormone
US20220000880A1 (en) 2018-11-01 2022-01-06 Rigel Pharmaceuticals, Inc. Method and composition embodiments for treating acute myeloid leukemia
US20200377518A1 (en) 2019-05-29 2020-12-03 Rigel Pharmaceuticals, Inc. Method of preventing and treating thrombosis
CA3147443A1 (en) 2019-08-08 2021-02-11 Rigel Pharmaceuticals, Inc. Compounds and method for treating cytokine release syndrome
MX2022001890A (en) 2019-08-14 2022-04-26 Rigel Pharmaceuticals Inc Method of blocking or ameliorating cytokine release syndrome.
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods
WO2023183377A1 (en) 2022-03-23 2023-09-28 Rigel Pharmaceuticals, Inc. Pyrimid-2-yl-pyrazole compounds as irak inhibitors

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE556587A (en) 1957-01-31 1957-04-11
GB1527605A (en) * 1975-08-20 1978-10-04 Takeda Chemical Industries Ltd Insulin preparation for intranasal administration
JPS6034925B2 (en) 1979-07-31 1985-08-12 帝人株式会社 Long-acting nasal preparation and its manufacturing method
JPS5795920A (en) 1980-12-04 1982-06-15 Teijin Ltd Remedy for respiratory disease
US4900730A (en) * 1981-01-14 1990-02-13 Toyo Jozo Co., Ltd. Preparation which promotes the absorption of peptides
SE438261B (en) * 1981-07-08 1985-04-15 Draco Ab USE IN A DOSHALATOR OF A PERFORED MEMBRANE
CY1492A (en) * 1981-07-08 1990-02-16 Draco Ab Powder inhalator
US5260306A (en) 1981-07-24 1993-11-09 Fisons Plc Inhalation pharmaceuticals
JPS59163313A (en) 1983-03-09 1984-09-14 Teijin Ltd Peptide hormone composition for nasal administration
US4959358A (en) * 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
US4746508A (en) 1983-06-06 1988-05-24 Beth Israel Hospital Assn. Drug administration
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US5288498A (en) 1985-05-01 1994-02-22 University Of Utah Research Foundation Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
JPS61267528A (en) * 1984-11-26 1986-11-27 Yamanouchi Pharmaceut Co Ltd Transnasal calcitonin agent containing absorbefacient
SE448277B (en) * 1985-04-12 1987-02-09 Draco Ab INDICATOR DEVICE WITH A DOSAGE DEVICE FOR MEDICINAL PRODUCTS
CA1274774A (en) 1985-04-15 1990-10-02 Kenneth S. Su Method for administering insulin
US5122127A (en) 1985-05-01 1992-06-16 University Of Utah Apparatus and methods for use in administering medicaments by direct medicament contact to mucosal tissues
JPS63500175A (en) 1985-05-22 1988-01-21 リポソ−ム　テクノロジ−，インコ−ポレイテツド Liposome inhalation method and inhalation system
US4847298A (en) 1985-08-16 1989-07-11 Merck & Co., Inc. Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments
IL77186A0 (en) * 1985-11-29 1986-04-29 Touitou Elka Pharmaceutical insulin composition
SE453566B (en) * 1986-03-07 1988-02-15 Draco Ab POWDER INHALATOR DEVICE
JPS632932A (en) 1986-06-23 1988-01-07 Teijin Ltd Powdery composition for nasal administration
WO1988001165A1 (en) 1986-08-11 1988-02-25 Innovata Biomed Limited Pharmaceutical formulations comprising microcapsules
US5179079A (en) * 1986-12-16 1993-01-12 Novo Nordisk A/S Nasal formulation and intranasal administration therewith
NZ222907A (en) * 1986-12-16 1990-08-28 Novo Industri As Preparation for intranasal administration containing a phospholipid absorption enhancing system
GB8712176D0 (en) * 1987-05-22 1987-06-24 Cosmas Damian Ltd Drug delivery system
JPH01117825A (en) 1987-10-28 1989-05-10 Sanwa Kagaku Kenkyusho Co Ltd Pharmaceutical for nasal cavity and paranasal sinuses administration and use, form and use tool thereof
EP0360340A1 (en) * 1988-09-19 1990-03-28 Akzo N.V. Composition for nasal administration containing a peptide
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
SE8803935L (en) * 1988-10-31 1990-05-01 Kabivitrum Ab LAEKEMEDELSKOMPOSITION
US5006343A (en) 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
GB8900267D0 (en) 1989-01-06 1989-03-08 Riker Laboratories Inc Narcotic analgesic formulations and apparatus containing same
US4994439A (en) 1989-01-19 1991-02-19 California Biotechnology Inc. Transmembrane formulations for drug administration
US5011678A (en) 1989-02-01 1991-04-30 California Biotechnology Inc. Composition and method for administration of pharmaceutically active substances
ATE138071T1 (en) 1989-02-17 1996-06-15 Liposome Co Inc LIPID AIDS FOR ADMINISTRATION THROUGH THE NOSE AND TOPICAL APPLICATION
IT8920486A0 (en) 1989-05-12 1989-05-12 Isf Spa PHARMACEUTICAL COMPOSITIONS.
US5176132A (en) 1989-05-31 1993-01-05 Fisons Plc Medicament inhalation device and formulation
JP2642486B2 (en) * 1989-08-04 1997-08-20 田辺製薬株式会社 Ultrafine particle method for poorly soluble drugs
US5258185A (en) * 1989-08-23 1993-11-02 Bauer Kurt H Highly active, rapidly absorbable formulations of glibenclamide, processes for the production thereof and their use
GB8921222D0 (en) 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
GB9001635D0 (en) 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
US5376386A (en) 1990-01-24 1994-12-27 British Technology Group Limited Aerosol carriers
US5118494A (en) 1990-03-23 1992-06-02 Minnesota Mining And Manufacturing Company Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
JPH05963A (en) * 1990-04-13 1993-01-08 Toray Ind Inc Polypeptide composition
US5192548A (en) * 1990-04-30 1993-03-09 Riker Laboratoires, Inc. Device
AU7908791A (en) 1990-05-08 1991-11-27 Liposome Technology, Inc. Direct spray-dried drug/lipid powder composition
JP3219096B2 (en) 1990-05-10 2001-10-15 ニコメド ファーマ エイエス Pharmaceutical preparations containing n-glycolfurols and n-ethylene glycols
JPH0441421A (en) 1990-06-07 1992-02-12 Taisho Pharmaceut Co Ltd Pulmonary absorbable composition
JPH04149126A (en) 1990-10-09 1992-05-22 Mitsubishi Kasei Corp Pharmaceutical composition for transmucous administration
IL99699A (en) 1990-10-10 2002-04-21 Autoimmune Inc Pharmaceutical oral, enteral or by-inhalation dosage form for suppressing an autoimmune response associated with type i diabetes
GB9024365D0 (en) 1990-11-09 1991-01-02 Glaxo Group Ltd Medicaments
JP3507486B2 (en) 1991-03-15 2004-03-15 アムジエン・インコーポレーテツド Intrapulmonary administration of granulocyte colony-stimulating factor
US5320094A (en) 1992-01-10 1994-06-14 The Johns Hopkins University Method of administering insulin
WO1993013752A1 (en) * 1992-01-21 1993-07-22 Sri International Improved process for preparing micronized polypeptide drugs
CA2094217A1 (en) * 1992-04-17 1993-10-18 Yasutaka Igari Transmucosal therapeutic composition
WO1993025198A1 (en) 1992-06-12 1993-12-23 Teijin Limited Ultrafine powder for inhalation and production thereof
US5376359A (en) * 1992-07-07 1994-12-27 Glaxo, Inc. Method of stabilizing aerosol formulations
CA2145418A1 (en) * 1992-09-29 1994-04-14 John S. Patton Pulmonary delivery of active fragments of parathyroid hormone
US5364838A (en) 1993-01-29 1994-11-15 Miris Medical Corporation Method of administration of insulin
EP0681491B1 (en) * 1993-01-29 2000-12-13 Aradigm Corporation Intrapulmonary delivery of hormones
BE1006873A6 (en) 1993-03-26 1995-01-10 Merkus Franciscus W H M Administration for drafting nasal insulin delivery.
WO1994023772A2 (en) 1993-04-06 1994-10-27 Minnesota Mining And Manufacturing Company Deagglomerators for dry powder inhalers
US5506203C1 (en) * 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
IS1796B (en) * 1993-06-24 2001-12-31 Ab Astra Inhaled polypeptide formulation composition which also contains an enhancer compound
US5830853A (en) * 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
US5747445A (en) 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US5661130A (en) 1993-06-24 1997-08-26 The Uab Research Foundation Absorption enhancers for drug administration
GB9314614D0 (en) 1993-07-14 1993-08-25 Minnesota Mining & Mfg Dry powder inhalers
US5514670A (en) 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
ES2218543T3 (en) * 1994-03-07 2004-11-16 Nektar Therapeutics PROCEDURE AND PREPARATION FOR THE ADMINISTRATION OF INSULIN BY PULMONARY ROUTE.
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
SE9404468D0 (en) * 1994-12-22 1994-12-22 Astra Ab Powder formulations

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399102B1 (en) 1996-05-24 2002-06-04 The Penn State Research Foundation Aerodynamically light particles for pulmonary drug delivery
US6635283B2 (en) 1996-05-24 2003-10-21 Penn State Res Found Aerodynamically light particles for pulmonary drug delivery
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US6942868B2 (en) 1996-05-24 2005-09-13 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7048908B2 (en) 2000-12-29 2006-05-23 Advanced Inhalation Research, Inc. Particles for inhalation having sustained release properties

Also Published As

Publication number Publication date
EP0706382A1 (en) 1996-04-17
SK160195A3 (en) 1997-02-05
NO955226L (en) 1996-02-15
TW402506B (en) 2000-08-21
JPH08512027A (en) 1996-12-17
NO313657B1 (en) 2002-11-11
PL178403B1 (en) 2000-04-28
HUT75065A (en) 1997-03-28
CN1129904A (en) 1996-08-28
DE69420412D1 (en) 1999-10-07
FI111688B (en) 2003-09-15
IL110084A (en) 1999-07-14
CZ287314B6 (en) 2000-10-11
CZ342895A3 (en) 1996-05-15
PL312205A1 (en) 1996-04-01
DE69420412T2 (en) 2000-04-13
WO1995000127A1 (en) 1995-01-05
DK0706382T3 (en) 2000-03-13
ATE183920T1 (en) 1999-09-15
US6306440B1 (en) 2001-10-23
IS1768B (en) 2001-05-02
SA94150030B1 (en) 2006-04-04
JP2006089496A (en) 2006-04-06
HU228129B1 (en) 2012-12-28
UA49794C2 (en) 2002-10-15
NZ268137A (en) 1997-10-24
FI956227A0 (en) 1995-12-22
AU7090194A (en) 1995-01-17
EE03221B1 (en) 1999-10-15
JP3874789B2 (en) 2007-01-31
SK283145B6 (en) 2003-03-04
EG20599A (en) 1999-09-30
CA2166108C (en) 2008-10-21
RU2148398C1 (en) 2000-05-10
GR3031974T3 (en) 2000-03-31
US5518998A (en) 1996-05-21
EP0706382B1 (en) 1999-09-01
KR100372673B1 (en) 2003-05-12
JP4294635B2 (en) 2009-07-15
CN1110301C (en) 2003-06-04
NO955226D0 (en) 1995-12-21
AU692780B2 (en) 1998-06-18
FI956227A (en) 1995-12-22
MX9404761A (en) 1995-01-31
US5658878A (en) 1997-08-19
HU9503659D0 (en) 1996-02-28
IL110084A0 (en) 1994-10-07
MY112098A (en) 2001-04-30
IS4178A (en) 1994-12-25
ES2138087T3 (en) 2000-01-01
BR9406907A (en) 1996-04-02
US5518998C1 (en) 2001-02-13
HK1009584A1 (en) 1999-06-04

Similar Documents

Publication Publication Date Title
CA2166108A1 (en) Insulin preparations for inhalation
EP1224929A3 (en) Powder formulations containing melezitose as a diluent
CA2195065A1 (en) Inhalation composition
CA2123909A1 (en) New combination of formoterol and budesonide
AU4359096A (en) An inhalation device, a method of dispersing a pharmaceutically active substance and a method of administering a dose of pharmaceutically active substance
CA2628857A1 (en) Formulation and method for treating neoplasms by inhalation
CA2024916A1 (en) Respiratory disorder medicaments comprising salmeterol and fluticasone propionate
CA2062137A1 (en) Method for anesthesia
USD304384S (en) Combined respiratory mask and inflatable head straps
AU4357393A (en) Prophylactic and remedy for viral diseases in respiratory tract
AU650484B2 (en) Isoxazole compound, pharmaceutically acceptable salt thereof, and medicinal use thereof
AU2791689A (en) Medicinal preparation comprising the association of colistin,tobramycin and amphotericin b administered by atomization
AU7454191A (en) Derivatives of glycinamide, their preparation and medicaments containing them
GR900300044T1 (en) Use of monosubstitute selenium compounds in the preparation of a pharmaceutical, pharmaceutical and preparation thereof
AU3257993A (en) 3-methylsulphonylhydrazono and 3-oxyimino steroids, a method of preparing them, pharmaceutical preparations containing them and their use in the preparation of drugs
WO1998022099A3 (en) New use of creatine
GB9323998D0 (en) Rebreathing bag inhaler
GR3035710T3 (en) Substituted benzenesulfonylureas and -thioureas, process for their preparation and the use of pharmaceutical preparations based on these compounds as well as medicaments containing them
AU1219092A (en) Substituted 2', 3'-dideoxy-5-trifluoromethyluridines, processes for their preparation and their use in medicaments
ZA961314B (en) Substituted benzenesulfonylureas and -thioreas processes for their preparation their use for the production of pharmaceutical preparations and medicaments containing them
IL108121A0 (en) Dry powder medicine inhaler
GB9108361D0 (en) A pharmaceutical composition suitable for treatment of colds,coughs and related illnesses
GB9307840D0 (en) Breath activated powder inhaler
EP0334440A3 (en) Respirating apparatus for patients

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130626