CA2167573A1 - Sleeve catheter - Google Patents

Sleeve catheter

Info

Publication number
CA2167573A1
CA2167573A1 CA002167573A CA2167573A CA2167573A1 CA 2167573 A1 CA2167573 A1 CA 2167573A1 CA 002167573 A CA002167573 A CA 002167573A CA 2167573 A CA2167573 A CA 2167573A CA 2167573 A1 CA2167573 A1 CA 2167573A1
Authority
CA
Canada
Prior art keywords
catheter
head portion
balloon
sleeve
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002167573A
Other languages
French (fr)
Inventor
Berthold Hofling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bavaria Medizin Technologie GmbH
Original Assignee
Berthold Hofling
Bavaria Medizin Technologie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berthold Hofling, Bavaria Medizin Technologie Gmbh filed Critical Berthold Hofling
Publication of CA2167573A1 publication Critical patent/CA2167573A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M25/0029—Multi-lumen catheters with stationary elements characterized by features relating to least one lumen located at the middle part of the catheter, e.g. slots, flaps, valves, cuffs, apertures, notches, grooves or rapid exchange ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22001—Angioplasty, e.g. PCTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M2025/0036—Multi-lumen catheters with stationary elements with more than four lumina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M2025/004—Multi-lumen catheters with stationary elements characterized by lumina being arranged circumferentially
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1068—Balloon catheters with special features or adapted for special applications having means for varying the length or diameter of the deployed balloon, this variations could be caused by excess pressure

Abstract

In a sleeve catheter (10) for supplying medicine to the walls of a vessel or tubular organ in which a number of outer lumina (18) extend longitudinally around a central lumen, the outer lumina have radial discharge openings (24) in the area of the head portion (16) of the catheter, which is slidable onto a balloon catheter (11) in order to be disposed at least partially on the balloon of the balloon catheter so as to be expandable thereby into abutment with the inner wall of a vessel to be dilated whereby medicine can be supplied through the discharge openings (24) in the outer lumina under pressure directly to the tissue of the vessel adjacent the outer lumina, thereby applying the medicine solely to the area engaged by the outer surface of the head portion (16).

Description

SLEE~E CATHETER

~KGROUND OF T~F I~F~TIoN
-- The invention relates to a 5t ee~e catheter for the wetting and infiltration o~ a veSsel wall with 2 fluid partic41arlY. medicine, preferably durins ro~tine treatment with a balloon cathete,-.
For the tr~tment of constricted Pas6ages in arteries, ~alloon dilation ~s recogni2ed as an only lit-tle invasl~e ~ut very effective and eleg~nt method.
ExPerie~re however shows that this treatment method h2; a high recurrence rate in the order of ~bout 30~ of the treated patient 5 , tha t i S , W i thin a Peri G d of seve ~2 1 months, for examP~e, between 3 ~nd 6 months, Passage c~r,-5triction will reoccur. It has bean shown that this i5 at least partly caused by ce~l growth which is caus~d bY
the balloon dilation, that is, bY exp~nsion and rupture ~f the tissue. It i5 theref2~e desirable to pro~ide for the vessel area which is subiected to such balloor, dila-tion additional treatment which counteracts such tissue growth.
Various methods for growth-inhi~iting treatment are kno~n, p~rticularly, the aPPlication of energy, for example, bY ~eans of a laser or th~ ~oc~lized treat~ent with sPecial medicine. As carrier for the localized treatment with medicine it is known to use wire wall sup-~S ports ~so-c~lled stents) whcse use however is comPlicaie~
and which cannot be remo~ed.

- 2l 6-1573 It has al 50 been ProPosed to use ball~on catheters with perfo~ated b~lloons so that J during the dilation Procedure, medication can be 2dministered for penetration into the tissue. ~o~e~er. this proposa~ was S found to be unsu~table since already at the beginnin~ o~, and durins, balloon exPansion, uncontr~llable amrunts of medicine are lost s~ t hat i t becomes imposs i b 1 P t o ap? 1 y a defined amount of medicine to th~ tissue wal 1 areas to be treated for wetting of th. tissue and infiltrztian into the tissue wall. 0urin inflation of the ballc3n.
that is, before the ~lloon w~ll abuts the ~essel wall, a - subst~ntial amrunt of the med~cine is released and this prenlaturel y rel ~s~d amount Or medIcine d~es n~t re~ch the vessel l~yers to be treated snd, conse~uentlY, an undesirably hi~h dosage is required if the Particulsr vessel area ta be treated is to be expGse~ to a suffi-cient amount sf ~edicine. Another disad~antage is seen in the fact that onlY an i~sufficient amount of pressure c~n ~e generated with a perforated balloon which maY not ~e enough to ~xPand the restricted vessel area.
It is desirable to overcome the disad~ntaces as described ln connection with a perforate4 bal)oon, wherein however the effectiveness and the ele~anc~ of balloon dil~tion shauld be maintained and m~dication
2~ t~atment 4f the tissue and the v~ssel wall should be facilitated durins the same prcoedure without essential additional time inPut. It i 5 therefure the object of the invention to imProve the established balloon c~th~ter procedure such that, on one hand. the high recurrence rate can be reduced by the simultaneou~ administration of med3cinet and, on the other hand, tne medieir,e is admin-istered in the desired dosage and is applied es5entiallY
only to the tissue areas to be treated.
SU~MAR~ OF THF INVFNTION
In a sleeve catheter for 5uppl ying medicine to the walls of a vessel or tubular or~an in which a num~er of outer lumina extend longitudinallY around a c~ntral lumen, the outer lumina have radial discharge o~enings in the area of the head portion of the catheter, which i5 slidable onto a balloon catheter in order ta be dispose~
at least P~rtiallY on the ballo~n of the balloon cathete~
s so as to ~e expandable therebY into abutment with the inner wa1l of a ~essel to be dil~tet wherPby medicine can be supplied through the discha~ge openings in the auter tumina under pressure directty to the tissue cf the ves-sel adjacent the outer lu~ina, thereby ~pplyin~ the medicine solely to the area engaged by the outer surfac~
Gf ~he head portion.
The arrangement according ta the invention h~s the ~d~antag~ that the ~lee~e catheter i5 51 idable onto a ?ortion of the de~lated balloon Or a b~lloon catheter. so ~5 that the low balloon Profile as required for the inser-tion Or the catheter into constricted ~essel area is essentially mainta1ned. Inflation o~ the ballo3n forces the head porticn of the sleeve c~theter into engage~ent with the tissue t~ be treated 50 that, during the dila-tioo procedure the medicine can b~ appl ied, under pres-sure, through the outer l~mina directlY to the tissue to be treated whereby it entens solely this t~sl~e. In this manner all toxic c~mpounds or gene-technologicallY desig-n~ted medicine adaP~ed to inhibit undesirable cell growth 2s in the tr~eated area can be inJected directl y and onl y into the tissue a~ea to be tre.atet.
In a further embodiment accordin~ to the inven-tion the Perforation; are pre~ormed such that they are oPened by application Gf the b~llaon Pressure. They may also be prefarmed in suoh a manner that they are oPened by the applicatiQn of additi~nal pressure to the outer 1umlna.
In order to facil itate the exPansion of the head portion o~ the slee~e catheter, in ~nnther embodi-ment, the head portion is P~o~ided at its outside ~etweenthe dischar~e oPenings with largitudinally extending r~dial notches. ExPansion c~n be fu~ther facilitated by providing longitudinally extenting radial notches al~o in the inner w~ll, bet~een the outer lumina, ~hich i5 dIS-Posed adjacent the inner lumen of the catheter.
In order to administer the medicine as locally as possible. that is, only in the close Pno~imity of the constricted vessel area, or stenosis, it is advan~ageous if the discharge openings are preformed in such a mznner thAt they are oPened sradually with increasing pressure.
beg~nning at the distal end, to~rd the proximal end of IO the head portion. ~epending on the locatiGn where the sleeve catheter i5 to be used in ~onnection wit~ a bal-loon catheter, in vessels or in crgans, it may ~e advan-tageou$ to ~dminister di~ferent am~unts of med~cine for ~etting the tl55ue Qr infiltration into the tissue. It 1~ ls therefore within the scoPe of the presert invention to provide distributed over the circum~erence Or the head portion, 5iX tD twentY outer lumina.
pRIF~ DFSCRLPTI~N ~F THF D~INGS
Th~ advant~ges and features o~ the lnvention are aPParent from the following descriPtion of an embodi-ment d~scribed below with reference to the drawings and def$ne~ in the claims.
Figure 1 shows the head porticn of a 51 eeve catheter disPosed on a ~alloon ~atheter;
Fig. 2 is a cross-sactional view cf the front end o~ the balloon catheter with the h~ad portion of the slee~e catheter disPosed therean Fig. 3 is a c~o~s-sectiona1 view of the inflated ballnon with an exPanded head portion of the 30 51 eeve c~thater, ~ ig. 4 is a cross-sectional view along l ines T~-IV of Fig. 1; and Fig. 5 sho~s the connecting struct~re ~or the operation of the baltoon catheter and the sleeve catheter.

D~$CRIPT~ON OF T~F PRFFRRFD F~ODI~FNT
Figs . 1. ~ and 3 show the detail5 o~ a 51 eeve catheter 1~ dispcsed Gn a bal~oon catheter 11. The sleeve catheter is sliPped onto the bal~oon catheter such that the head Pcrtion 16 extends at least PartiallY oYer the ~allGon 12 which i5 mounted on a flexible guide rod 14 as shown in Fig. 2. In these relative Positions the two catheters are inserted into a vessel or an organ.
~he cuter lumina 18 ter~inate in the head portion cf the 10 51 e~ve catheter and they extend ove~ the full length of the 51 eeve catheter uP to the conneoting structure which is sh~wn in Fig. 5 and explained be~Gw. As shown the outer lumina 18 are arranged in a circle around a central lu~en 20 wherein 6 to 20 4uter lumina maY be pro~ided dePendin~ on the 5ize and the applica~ion area of the sleeve catheter.
It is al S4 p055i~1 e to provide only one or t~o lumina which extend along the sleeve catheter and ~hich ~re divided ~n the head portion inta several outer lumina. The cross-secticn and the arrangement of the lumina are ad~pted to a particular aPp~ication.
In the cross-sectional ~iew of Fig. 4 which is t~ken acr~ss a head porti~n 16 disPoset on a balloon catheter 11. t~ere are ei~ht outer lumin 18 which are - 23 proYided with discharge oPenings 24 leading to the out-side of the head portion. These discharge openings 24 are so designed that theY open only toward the end of balloon pressure aPPlication and then discharge a medicine contained in the outer lumina 1~. It is alsa Possible to preform the discharge ~Penings in 5vch a way that theY open ~nly bY ~PPlication of additional Pressure applied via the connectin~ structure.
In orde~ to facilitate expansion of the head portion 16 it is proY~ded~ at least on the outside, with radial grooves 22 which extent longitudinally between the discharge ~Penings 24 and to a li~ited dePth sPaced from the inner wall of the head Po~tion 50 as to provide for a hin~e structure allowing the radial Sr~oves 22 tc open up and exPand the head portion with on~y sma~l pressure re~uirements. ~n order to ~urther reduce the pressure required for the exPansion of the head portion further radial grooves 23 may ~e provided at the inside of the head portion adjacent the central lumer, 20, the gr~oves 23 extending lon~itudinally between the outer lumin~ 18.
I~ t!~o radial grooves 23 are provided at ~PPosite sides Ot a radial gr~ove ~, three-hinse structures ane form~d which further facilitate exPansion of the head portion.
: With this arran~ement the head portion can be Pressed in sufficiently tight cnntact with the ves~el ~all 5 bY the pressure of, for example, 5 to 8 bar required for full exPansion of the balloon 50 that the medicine, when aPPlied throu~h the oute~ luminc 18 ~nt the disc~arge openin~s 24, will not ~low ~aY but will be applied tn the inner ~all surface in a highly locati~ed fashior, such that it ~ill Penetr~te the wall a~d then infiltrate the inner layers in sufficientlY high concen-trations~
For good distribution ~f the me~icine duringdilation when the head PGrtion is firmlY pressed against the expanded tissue by the pressure built up in ths inner ball~on, that isJ in onder to inject the medicine e55en-~5 ti~l ly in the center area of the constriction beingtreated, the discharge openings 24 are preferably pre-formed in such a manner that theY oPen with incre2sing pressure b2gir,nin~ at the distal end of the head portion to~ard the proximal end. ~ith this arran~ement it is insured that the iniected medicine is not carried away but is applied in sufficiently high concentration to the tissue layers as desired ~nd ~ubsequentlY infiltrates into the deeper wall laye~s. T~e amo~nt of meticine released into the vessel after deflation of the c~theter ~hich normally takes place after about 60 seconds i5 ther, relatively smal~ and it is diluted in a material waY so that a5 far as the dose is concernet it is ~nrelev2nt for the total body system even i~ a large dose was apPlied localized to the treated vessel area. For aPPlication, pr$marily alreadY ~ell known cell-toxic comPounds are used whose effects can be well determined but also Senet-ic~tly designed medicine mzY be used.
Utilization of Pressure generators (indeflator) as n4rmally used in connection with ~alloon dilation per-~its injection and infiltration of medicine into the tis-sue under anY desired pressure 2nt in anY desired prede-termined amount.
tig. S shQws a connectlng strùcture fQr anindeflator ard for an oPerating m~chanism for inJectin~ a medicine. The connectinS structure comPrises a Y connec-tor with a terminal 32 for scavenging ~nd 2 terminal 3-~
1~ far the indeflator. The baltoon catheter 11 i5 connectedto this Y connector. The sleeve catheter 10 which sur-rounds the ~alloQn catheter 11 is provided at its rear end with a connecting struct~re 36 which h~s a terminal 37 through ~hich the ~edicine is supPlied bY means of a p~e5suri2e~ which is not shown in the drawing. Within the connecting structure 3~ the termin~l 37 is connected t~ the outer lumina 18 of the sleeva catheter.
With this connecting structure arrangement the balloon dilation can be Perf~rmed indePendently o~ the application of the medicine so that the medicine can be adminlstered indePendently and in Predetermined am3unts.
Frr the treatment of coronary vessels the invention pr~vides for a substantial advantage in that the elegance of the balloon dilation method is ma;ntained and the procedur~ i5 nat extended because the medicine is injected during the normal dilation procedure during which, furthermore, an exactly defined amount of medicine is administered within a well determined vessel area.
Ho~ever the arrange~ent according to the inven-tion is suitable nat onlY for treatment o~ coronary ves-sels but ~lso for kidney vessel 5 and vessels in sxtremi-ties and, dePendlng on the conditions, also for vessels in the head of a Patient~ It maY al 50 ~e used for the wetting and infiltration of growth-inhibitins comPounds in vessel pont1ons ~f o~gans or tubular systems such as the urethra or the bile duct or other ~essel-like organs.
The arrangement accord1ns ta the invention i5 al50 Par-ticularly well suitet for the treatment of cancerous areas with gr~wth-inhibiting compounds ~in this case cYtostatics). The arrangement ~urther Permits treatment cf tubular structures ridtled with carcinoma without lQ endangering or blocking Passage therethrough that is a1so malicious sicknesses in the area cf the trachea or the intestines can be trea'ed in 2ccord~nce w-th the inven-tion with~ut distunbing passage throu~h the affected ~reaS. Also for the treatment of prostate hypertrophy medicine can ~e ad~inistered in the describet manner.

Claims (5)

1. A sleeve catheter for the wetting and infiltration of a vessel wall or other tubular organ by a fluid, particularly a liquid medicine, said sleeve catheter (10) comprising a head portion (16) with a central lumen (20) and a number of outer lumina (18) extending in cross section in a circle around said central lumen, each having discharge openings (24) formed in the head portion (16) thereof, said sleeve catheter (10) being adapted to be slidable onto a balloon catheter (11), so as to be disposed at least partially on the balloon of said balloon catheter, said head portion (16) including, at its outside, longitudinally extending radial grooves (22) arranged between said discharge openings (24) so as to provide a hinge structure adjacent the inner wall of said sleeve, said discharge openings (24) being perforated such that they open by the application of the balloon pressure, said head portion (16) of said sleeve catheter being expandable for engaging the inner wall of a vessel to be expanded upon inflation of said balloon (12), and said fluid being supplied to said outer lumina (18) under pressure so as to be applied to said vessel wall via said discharge openings (24) when said head portion is in engagement with the inner wall of the vessel wall to be treated.
2. A sleeve catheter according to claim 1, wherein said discharge openings (24) are performed such that they open by the application of the balloon pressure.
3. A sleeve catheter according to claim 1, wherein longitudinally extending radial grooves (23) are provided between said outer lumina (18) also in the inner wall adjacent the central lumen (20) so as to provide a hinge structure adjacent the outer wall of said sleeve,
4. A sleeve catheter according to one or several of the claims 1 to 3, wherein said discharge openings (24) are perforated in such a way that they are opened successively with increasing pressure beginning at the distal end of the head portion (16).
5. A sleeve catheter according to one or several of the claims 1 to 4, wherein said head portion (16) includes six to twenty outer lumina (18) distributed over its circumference.
CA002167573A 1993-07-19 1993-10-13 Sleeve catheter Abandoned CA2167573A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4324218A DE4324218A1 (en) 1993-07-19 1993-07-19 Cuff catheter
DEP4324218.9 1993-07-19

Publications (1)

Publication Number Publication Date
CA2167573A1 true CA2167573A1 (en) 1995-02-02

Family

ID=6493202

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002167573A Abandoned CA2167573A1 (en) 1993-07-19 1993-10-13 Sleeve catheter

Country Status (21)

Country Link
US (1) US5364356A (en)
EP (1) EP0710132B1 (en)
JP (1) JPH09500303A (en)
KR (1) KR960703634A (en)
CN (1) CN1097633A (en)
AT (1) ATE148352T1 (en)
AU (1) AU5177593A (en)
CA (1) CA2167573A1 (en)
CZ (1) CZ284434B6 (en)
DE (2) DE4324218A1 (en)
DK (1) DK0710132T3 (en)
ES (1) ES2096951T3 (en)
FI (1) FI960219A (en)
GR (1) GR3022431T3 (en)
HU (1) HUT73327A (en)
NO (1) NO960201L (en)
PL (1) PL172711B1 (en)
SG (1) SG46505A1 (en)
SK (1) SK8696A3 (en)
TW (1) TW235246B (en)
WO (1) WO1995003081A1 (en)

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EP0710132A1 (en) 1996-05-08
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NO960201D0 (en) 1996-01-17
CZ284434B6 (en) 1998-11-11
DE4324218A1 (en) 1995-01-26
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NO960201L (en) 1996-01-17
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AU5177593A (en) 1995-02-20
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WO1995003081A1 (en) 1995-02-02
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US5364356A (en) 1994-11-15
DE59305366D1 (en) 1997-03-13
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CN1097633A (en) 1995-01-25
KR960703634A (en) 1996-08-31

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