CA2168012A1 - Polymeric matrices and their uses in pharmaceutical compositions - Google Patents
Polymeric matrices and their uses in pharmaceutical compositionsInfo
- Publication number
- CA2168012A1 CA2168012A1 CA002168012A CA2168012A CA2168012A1 CA 2168012 A1 CA2168012 A1 CA 2168012A1 CA 002168012 A CA002168012 A CA 002168012A CA 2168012 A CA2168012 A CA 2168012A CA 2168012 A1 CA2168012 A1 CA 2168012A1
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutical compositions
- polymeric matrices
- ethylenecarbonate
- tnf
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/18—Block or graft polymers
- C08G64/183—Block or graft polymers containing polyether sequences
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/02—Aliphatic polycarbonates
- C08G64/0208—Aliphatic polycarbonates saturated
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/20—General preparatory processes
- C08G64/32—General preparatory processes using carbon dioxide
- C08G64/34—General preparatory processes using carbon dioxide and cyclic ethers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
This invention provides pharmaceutical compositions comprising polymeric matrices, especially those comprising IL-6 as an active ingredient. Specific novel poly(ethylenecarbonate) polymers are also provided for more general use as matrix materials in sustained release compositions containing pharmacologically active compounds, as are methods of using of IL-6 for treatment of conditions mediated by IL-1 and/or TNF.alpha., e.g., certain autoimmune and inflammatory conditions, as well as septic shock.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002474988A CA2474988C (en) | 1993-08-27 | 1994-08-26 | Polymeric matrices and their uses in pharmaceutical compositions |
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9317822.6 | 1993-08-27 | ||
GB939317822A GB9317822D0 (en) | 1993-08-27 | 1993-08-27 | Organic compounds |
GB939320240A GB9320240D0 (en) | 1993-10-01 | 1993-10-01 | Improvements in or relating to organic compounds |
GB9320240.6 | 1993-10-01 | ||
GB9325900.0 | 1993-12-17 | ||
GB939325900A GB9325900D0 (en) | 1993-12-17 | 1993-12-17 | Organic compounds |
GB9407156A GB9407156D0 (en) | 1994-04-11 | 1994-04-11 | Organic compounds |
GB9407156.0 | 1994-04-11 | ||
PCT/EP1994/002833 WO1995006077A2 (en) | 1993-08-27 | 1994-08-26 | Polymeric matrices and their uses in pharmaceutical compositions |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002474988A Division CA2474988C (en) | 1993-08-27 | 1994-08-26 | Polymeric matrices and their uses in pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2168012A1 true CA2168012A1 (en) | 1995-03-02 |
CA2168012C CA2168012C (en) | 2005-08-09 |
Family
ID=27451062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002168012A Expired - Lifetime CA2168012C (en) | 1993-08-27 | 1994-08-26 | Polymeric matrices and their uses in pharmaceutical compositions |
Country Status (24)
Country | Link |
---|---|
US (2) | US6083521A (en) |
EP (2) | EP1028137A3 (en) |
JP (2) | JP3343124B2 (en) |
KR (1) | KR100341995B1 (en) |
CN (3) | CN1326568C (en) |
AT (1) | ATE327273T1 (en) |
AU (1) | AU697995B2 (en) |
BR (1) | BR9407370A (en) |
CA (1) | CA2168012C (en) |
CZ (1) | CZ55296A3 (en) |
DE (1) | DE69434743T2 (en) |
DK (1) | DK0719295T3 (en) |
ES (1) | ES2262135T3 (en) |
FI (1) | FI960892A (en) |
HU (1) | HU220637B1 (en) |
IL (1) | IL110787A0 (en) |
NO (2) | NO960721L (en) |
NZ (1) | NZ273319A (en) |
PL (1) | PL182569B1 (en) |
PT (1) | PT719295E (en) |
SG (2) | SG87847A1 (en) |
SK (1) | SK25496A3 (en) |
TW (1) | TW492863B (en) |
WO (1) | WO1995006077A2 (en) |
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US6620382B1 (en) * | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
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GB9406094D0 (en) * | 1994-03-28 | 1994-05-18 | Univ Nottingham And University | Polymer microspheres and a method of production thereof |
US5665428A (en) * | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
US5702717A (en) * | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
JP3028227B1 (en) | 1998-12-15 | 2000-04-04 | 穎助 藤本 | Disposal needleless syringe |
-
1994
- 1994-08-25 IL IL11078794A patent/IL110787A0/en unknown
- 1994-08-26 WO PCT/EP1994/002833 patent/WO1995006077A2/en active IP Right Grant
- 1994-08-26 CN CNB2003101239083A patent/CN1326568C/en not_active Expired - Lifetime
- 1994-08-26 CZ CZ96552A patent/CZ55296A3/en unknown
- 1994-08-26 SG SG9905441A patent/SG87847A1/en unknown
- 1994-08-26 PL PL94312717A patent/PL182569B1/en unknown
- 1994-08-26 PT PT94926894T patent/PT719295E/en unknown
- 1994-08-26 AU AU76557/94A patent/AU697995B2/en not_active Expired
- 1994-08-26 CA CA002168012A patent/CA2168012C/en not_active Expired - Lifetime
- 1994-08-26 KR KR1019960700900A patent/KR100341995B1/en not_active IP Right Cessation
- 1994-08-26 NZ NZ273319A patent/NZ273319A/en unknown
- 1994-08-26 EP EP00107410A patent/EP1028137A3/en not_active Withdrawn
- 1994-08-26 DK DK94926894T patent/DK0719295T3/en active
- 1994-08-26 EP EP94926894A patent/EP0719295B1/en not_active Expired - Lifetime
- 1994-08-26 HU HU9600456A patent/HU220637B1/en not_active IP Right Cessation
- 1994-08-26 DE DE69434743T patent/DE69434743T2/en not_active Expired - Lifetime
- 1994-08-26 JP JP50735695A patent/JP3343124B2/en not_active Expired - Lifetime
- 1994-08-26 AT AT94926894T patent/ATE327273T1/en active
- 1994-08-26 SG SG1996009717A patent/SG50724A1/en unknown
- 1994-08-26 ES ES94926894T patent/ES2262135T3/en not_active Expired - Lifetime
- 1994-08-26 CN CN94193197A patent/CN1085687C/en not_active Expired - Lifetime
- 1994-08-26 BR BR9407370A patent/BR9407370A/en not_active IP Right Cessation
- 1994-08-26 SK SK254-96A patent/SK25496A3/en unknown
- 1994-09-24 TW TW083108873A patent/TW492863B/en not_active IP Right Cessation
-
1996
- 1996-02-23 NO NO960721A patent/NO960721L/en not_active Application Discontinuation
- 1996-02-26 FI FI960892A patent/FI960892A/en unknown
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1998
- 1998-09-28 US US09/162,019 patent/US6083521A/en not_active Expired - Lifetime
-
1999
- 1999-07-20 US US09/357,193 patent/US6262127B1/en not_active Expired - Lifetime
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2001
- 2001-06-15 CN CNB011210958A patent/CN1258551C/en not_active Expired - Lifetime
-
2002
- 2002-03-07 NO NO20021141A patent/NO20021141D0/en unknown
- 2002-06-19 JP JP2002178506A patent/JP4477813B2/en not_active Expired - Lifetime
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