CA2169478A1 - Electron Beam Sterilization of Biological Tissues - Google Patents

Electron Beam Sterilization of Biological Tissues

Info

Publication number
CA2169478A1
CA2169478A1 CA2169478A CA2169478A CA2169478A1 CA 2169478 A1 CA2169478 A1 CA 2169478A1 CA 2169478 A CA2169478 A CA 2169478A CA 2169478 A CA2169478 A CA 2169478A CA 2169478 A1 CA2169478 A1 CA 2169478A1
Authority
CA
Canada
Prior art keywords
biological tissues
electron beam
beam sterilization
sterilization
tissues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2169478A
Other languages
French (fr)
Other versions
CA2169478C (en
Inventor
Thomas L. Odland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
St Jude Medical LLC
Original Assignee
Thomas L. Odland
St. Jude Medical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas L. Odland, St. Jude Medical, Inc. filed Critical Thomas L. Odland
Publication of CA2169478A1 publication Critical patent/CA2169478A1/en
Application granted granted Critical
Publication of CA2169478C publication Critical patent/CA2169478C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029Radiation
    • A61L2/007Particle radiation, e.g. electron-beam, alpha or beta radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029Radiation
    • A61L2/0035Gamma radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08Radiation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915Method or apparatus for preparing biological material
    • Y10S623/918Heart

Abstract

The invention involves a method for sterilizing biological tissues. The invention also includes sterilized biological tissues.
CA002169478A 1994-03-04 1995-03-06 Electron beam sterilization of biological tissues Expired - Fee Related CA2169478C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/205,781 1994-03-04
US08/205,781 US6203755B1 (en) 1994-03-04 1994-03-04 Electron beam sterilization of biological tissues

Publications (2)

Publication Number Publication Date
CA2169478A1 true CA2169478A1 (en) 1995-09-08
CA2169478C CA2169478C (en) 1999-03-16

Family

ID=22763622

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002169478A Expired - Fee Related CA2169478C (en) 1994-03-04 1995-03-06 Electron beam sterilization of biological tissues

Country Status (6)

Country Link
US (2) US6203755B1 (en)
EP (1) EP0715524A1 (en)
AU (1) AU2096995A (en)
CA (1) CA2169478C (en)
WO (1) WO1995023616A1 (en)
ZA (1) ZA951841B (en)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362442A (en) 1993-07-22 1994-11-08 2920913 Canada Inc. Method for sterilizing products with gamma radiation
US20040067157A1 (en) * 1993-07-22 2004-04-08 Clearant, Inc. Methods for sterilizing biological materials
US6203755B1 (en) * 1994-03-04 2001-03-20 St. Jude Medical, Inc. Electron beam sterilization of biological tissues
IT1289708B1 (en) * 1996-12-03 1998-10-16 Hospal Dasco Spa PRODUCT STERILIZATION SYSTEM THROUGH IRRADIANCE.
US6214054B1 (en) * 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
EP1117446B1 (en) 1998-09-30 2004-11-24 Medtronic, Inc. Process for reducing mineralization of tissue used in transplantation
US6471723B1 (en) * 2000-01-10 2002-10-29 St. Jude Medical, Inc. Biocompatible prosthetic tissue
US20030012687A1 (en) * 2000-03-23 2003-01-16 Macphee Martin J. Methods of sterilizing biological materials
US6698162B2 (en) * 2000-03-23 2004-03-02 Teikoku Pharma Usa, Inc. Methods of producing a terminally sterilized topical patch preparation
MXPA02009321A (en) * 2000-03-23 2003-05-23 Clearant Inc Methods for sterilizing biological materials.
US6739112B1 (en) * 2000-08-21 2004-05-25 Nu Vasive, Inc. Bone allograft packaging system
US7183563B2 (en) * 2000-12-13 2007-02-27 Advanced Electron Beams, Inc. Irradiation apparatus
WO2002058742A1 (en) * 2000-12-13 2002-08-01 Advanced Electron Beams, Inc. Decontamination apparatus
US20020177223A1 (en) * 2001-03-12 2002-11-28 Ogle Mathew F. Methods and compositions for crosslinking tissue
US6682695B2 (en) * 2001-03-23 2004-01-27 Clearant, Inc. Methods for sterilizing biological materials by multiple rates
US7078163B2 (en) * 2001-03-30 2006-07-18 Medtronic, Inc. Process for reducing mineralization of tissue used in transplantation
US6696060B2 (en) 2001-06-14 2004-02-24 Clearant, Inc. Methods for sterilizing preparations of monoclonal immunoglobulins
US6946098B2 (en) 2001-08-10 2005-09-20 Clearant, Inc. Methods for sterilizing biological materials
US7252799B2 (en) * 2001-08-31 2007-08-07 Clearant, Inc. Methods for sterilizing preparations containing albumin
US6749851B2 (en) 2001-08-31 2004-06-15 Clearant, Inc. Methods for sterilizing preparations of digestive enzymes
US20030185702A1 (en) * 2002-02-01 2003-10-02 Wilson Burgess Methods for sterilizing tissue
US20030064000A1 (en) * 2001-09-24 2003-04-03 Wilson Burgess Methods of sterilizing biological mixtures using stabilizer mixtures
US20030059338A1 (en) * 2001-09-24 2003-03-27 Mann David M. Methods for sterilizing biological materials using flavonoid/flavonol stabilizers
US20030095890A1 (en) * 2001-09-24 2003-05-22 Shirley Miekka Methods for sterilizing biological materials containing non-aqueous solvents
AU2002347834A1 (en) * 2001-10-05 2003-04-22 Idaho State University A method of inhibiting sprouting in plant products
US6923936B2 (en) * 2001-10-23 2005-08-02 Medtronic Minimed, Inc. Sterile device and method for producing same
US20030124023A1 (en) * 2001-12-21 2003-07-03 Wilson Burgess Method of sterilizing heart valves
US6878168B2 (en) * 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US20030180181A1 (en) * 2002-02-01 2003-09-25 Teri Greib Methods for sterilizing tissue
US20030187515A1 (en) * 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
WO2003086480A1 (en) * 2002-04-10 2003-10-23 Clearant, Inc. Methods for sterilizing biological materials
WO2004043338A2 (en) * 2002-05-10 2004-05-27 The Ohio State University Flavin n-oxides: new anti-cancer agents and pathogen eradication agents
US6908591B2 (en) * 2002-07-18 2005-06-21 Clearant, Inc. Methods for sterilizing biological materials by irradiation over a temperature gradient
US20040013562A1 (en) * 2002-07-18 2004-01-22 Wilson Burgess Methods for sterilizing milk.
WO2004047622A2 (en) * 2002-11-26 2004-06-10 Crosscart, Inc. Substantially non-immunogenic injectable collagen
WO2004052098A1 (en) * 2002-12-11 2004-06-24 Cryolife, Inc. Radical retardant cryopreservation solutions
US7077922B2 (en) * 2003-07-02 2006-07-18 Owens Corning Composites S.P.R.L. Technique to fill silencers
US7955788B2 (en) * 2003-10-30 2011-06-07 Medtronic, Inc. Bioprosthetic tissue preparation with synthetic hydrogels
JP2005169008A (en) * 2003-12-15 2005-06-30 Nipro Corp Method of sterilizing biocompatible material
US20050266390A1 (en) * 2004-06-01 2005-12-01 Yuichiro Ueda Processes for removing cells and cell debris from tissue and tissue constructs used in transplantation and tissue reconstruction
US20060110370A1 (en) * 2004-11-23 2006-05-25 Pathak Chandrashenkhar P Treatments for reduction of cytotoxicity and viral contamination of implantable medical devices
EP1919365A2 (en) * 2005-07-13 2008-05-14 Anthrogenesis Corporation Ocular plug formed from placenta derived collagen biofabric
US8187639B2 (en) 2005-09-27 2012-05-29 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
EP1933852B1 (en) 2005-09-27 2018-12-19 TissueTech, Inc. Amniotic membrane preparations and purified compositions and methods of use
TWI277734B (en) * 2005-10-26 2007-04-01 Li Bing Huan Method for observing living bodies using an electron microscopy
US8460860B2 (en) * 2006-05-08 2013-06-11 Nuvasive, Inc. Cancellous bone treated with collagenase and essentially free of blood cells
US20080262633A1 (en) 2006-05-08 2008-10-23 Williams Michelle Leroux Cancellous bone treated with collagenase and essentially free of blood cells
CA2666485C (en) 2006-10-27 2015-10-06 Edwards Lifesciences Corporation Biological tissue for surgical implantation
GB0626021D0 (en) * 2006-12-29 2007-02-07 Insense Ltd The stabilisation of proteins
FR2911071A1 (en) * 2007-01-09 2008-07-11 Becton Dickinson France Soc Pa METHOD AND EQUIPMENT FOR RADIATION DECONTAMINATION OF A PRODUCT SUCH AS A PACKAGE CONTAINING MEDICAL DEVICES
FR2911072B1 (en) * 2007-01-09 2010-10-22 Becton Dickinson France PACKAGING FOR PRODUCTS WHICH MUST BE DECONTAMINATED BY RADIATION
US9101691B2 (en) * 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
US20100291532A1 (en) * 2007-06-12 2010-11-18 Musculoskeletal Transplant Foundation Process for sterilizing acellular soft tissue with irradiation
ITBO20070702A1 (en) * 2007-10-19 2009-04-20 A U S L Azienda Unita Sanitari METHOD OF TREATMENT OF CONNECTIVE FABRIC AND RELATED APPLICATIONS OF USE OF SUCH TISSUE.
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
US9480549B2 (en) 2008-04-25 2016-11-01 Allosource Multi-layer tissue patches
US9358320B2 (en) 2008-04-25 2016-06-07 Allosource Multi-layer tissue patches
US8008640B2 (en) * 2008-07-01 2011-08-30 The Texas A&M University System Maxim electron scatter chamber
US20100233669A1 (en) * 2009-03-11 2010-09-16 Cryolife, Inc. Bioburden-reducing antibiotic composition and method of use
FR2951549B1 (en) 2009-10-15 2013-08-23 Olivier Schussler PROCESS FOR OBTAINING IMPLANTABLE MEDICAL BIOPROTHESES
BR112012023769B1 (en) 2010-03-23 2020-11-10 Edwards Lifesciences Corporation method for preparing bioprosthetic tissue membrane material
WO2011119393A2 (en) 2010-03-26 2011-09-29 3M Innovative Properties Company Method of sterilization of wound dressings
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8906601B2 (en) 2010-06-17 2014-12-09 Edwardss Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
US8377143B2 (en) 2010-07-06 2013-02-19 Cryolife, Inc. Tissue implants for implantation and methods for preparing the same
US8475827B2 (en) 2010-07-06 2013-07-02 Cryolife, Inc. Tissue implants for implantation and methods for preparing the same
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
CA2837878A1 (en) 2011-06-10 2012-12-13 Tissuetech, Inc. Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
US9931423B2 (en) 2011-08-26 2018-04-03 Tissuetech, Inc. Methods of sterilizing fetal support tissues
KR101446265B1 (en) * 2011-10-17 2014-11-03 메디칸(주) Bio-Fat material eliminated immunity
US9162011B2 (en) 2011-12-19 2015-10-20 Allosource Flowable matrix compositions and methods
CA2878163A1 (en) 2012-07-11 2014-01-16 Tissuetech, Inc. Compositions containing hc-ha/ptx3 complexes and methods of use thereof
US10780197B1 (en) 2012-10-29 2020-09-22 Nuvasive, Inc. Malleable, cryopreserved osteogenic compositions with viable cells
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
AU2014248873B2 (en) 2013-03-13 2017-03-23 Allosource Fascia fibrous compositions and methods for their use and manufacture
WO2014150784A1 (en) 2013-03-15 2014-09-25 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
US10016528B2 (en) 2013-09-09 2018-07-10 Eran Rosines Biologic prosthesis and methods of production and use
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US10959839B2 (en) 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
KR101832203B1 (en) 2013-12-06 2018-02-27 알로소스 Method of drying sheets of tissue
TW201603818A (en) 2014-06-03 2016-02-01 組織科技股份有限公司 Compositions and methods
US20160243288A1 (en) 2015-02-23 2016-08-25 Tissuetech, Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
TWI720984B (en) 2015-05-20 2021-03-11 美商帝聖工業公司 Compositions and methods for preventing the proliferation and epithelial-mesenchymal transition of epithelial cells
TW201733600A (en) 2016-01-29 2017-10-01 帝聖工業公司 Fetal support tissue products and methods of use
US11278603B2 (en) 2016-03-28 2022-03-22 Abbvie Inc. Enzyme compositions with reduced viral and microbial contamination
DE102016121982B3 (en) 2016-11-16 2017-11-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Process for preparing a transplant
US10772986B2 (en) 2017-01-26 2020-09-15 Allosource Fascia fibrous compositions and methods for their use and manufacture
WO2019074838A2 (en) 2017-10-13 2019-04-18 Edwards Lifesciences Corporation Method for sterilizing heart valves
US11026980B1 (en) 2018-02-26 2021-06-08 Triad Life Sciences, Inc. Flowable birth tissue composition and related methods
US11602548B1 (en) 2018-02-26 2023-03-14 Convatec, Inc Fibrous birth tissue composition and method of use
KR102144710B1 (en) * 2018-10-15 2020-08-14 주식회사 노블바이오 Medium composition reduced degradation of ingredient by gamma-ray irradiation
WO2020092205A1 (en) 2018-11-01 2020-05-07 Edwards Lifesciences Corporation Transcatheter pulmonic regenerative valve

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785313A (en) * 1952-07-26 1957-03-12 High Voltage Engineering Corp Method and apparatus for sterilizing by electron bombardment
US3451394A (en) 1961-04-04 1969-06-24 Ethicon Inc Radiating tanned and untanned collagen prosthesis with 5 to 25 megarads of ionizing radiation
JPS494559B1 (en) 1970-08-06 1974-02-01
US3779706A (en) * 1971-10-04 1973-12-18 Energy Sciences Inc Process for bulk sterilization, minimizing chemical and physical damage
US3948601A (en) 1972-12-11 1976-04-06 The Boeing Company Sterilizing process and apparatus utilizing gas plasma
IL47062A (en) 1975-04-10 1979-07-25 Yeda Res & Dev Process for diminishing antigenicity of tissues to be usedas transplants by treatment with glutaraldehyde
US4264155A (en) 1979-07-09 1981-04-28 Opticol Corporation Collagen contact lens
US4466139A (en) 1980-07-01 1984-08-21 Vettivetpillai Ketharanathan Vascular prostheses
US4378224A (en) 1980-09-19 1983-03-29 Nimni Marcel E Coating for bioprosthetic device and method of making same
US4582640A (en) 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
FR2523810B1 (en) 1982-03-23 1988-11-25 Carpentier Alain ORGANIC GRAFT FABRIC AND PROCESS FOR ITS PREPARATION
US4456589A (en) 1982-07-08 1984-06-26 Genetic Laboratories, Inc. Preparation of animal tissues for surgical implantation in human recipients
US4620908A (en) * 1983-10-03 1986-11-04 Biocell Laboratories, Inc. Method for destroying microbial contamination in protein materials
EP0160025B1 (en) 1983-10-20 1989-12-13 KETHARANATHAN, Vettivetpillai Biomaterial
US4837024A (en) 1984-02-24 1989-06-06 The Regents Of The University Of California Compositions, articles and mehtod for improving wound healing
US4553974A (en) 1984-08-14 1985-11-19 Mayo Foundation Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor
BR8404772A (en) 1984-09-21 1986-04-29 Mario Osvaldo Vrandecic Peredo HETEROLOGICAL ARTERIAL BIOENGESTURE AND PROCESS FOR THE TREATMENT OF BIOLOGICAL MATERIAL
US4714595A (en) * 1984-12-27 1987-12-22 Baxter Travenol Laboratories, Inc. Tissue storage system
US4652763A (en) * 1985-03-29 1987-03-24 Energy Sciences, Inc. Electron-beam irradiation sterilization process
US5096553A (en) 1986-09-11 1992-03-17 Ionizing Energy Company Of Canada Limited Treatment of raw animal hides and skins
US4798611A (en) 1986-10-14 1989-01-17 Hancock Jaffe Laboratories Enhancement of xenogeneic tissue
US4800603A (en) 1987-01-30 1989-01-31 Jaffe Norman R Tissue fixation with vapor
FR2617488B1 (en) 1987-07-01 1990-03-09 Tab PROCESS FOR THE MANUFACTURE OF ORGANIZED COLLAGEN STRUCTURES, PARTICULARLY OF HUMAN ORIGIN, AND ORGANIZED COLLAGEN STRUCTURES THEREOF
US5141747A (en) 1989-05-23 1992-08-25 Minnesota Mining And Manufacturing Company Denatured collagen membrane
US5366746A (en) * 1990-08-27 1994-11-22 Utah State University Foundation Ultra-high temperature pasteurization and electron beam technology for sterilization of meat and meat products
US5336616A (en) * 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
JPH04288165A (en) * 1991-03-18 1992-10-13 Terumo Corp Organ implant and manufacture thereof
US6203755B1 (en) * 1994-03-04 2001-03-20 St. Jude Medical, Inc. Electron beam sterilization of biological tissues

Also Published As

Publication number Publication date
EP0715524A1 (en) 1996-06-12
AU2096995A (en) 1995-09-18
US5989498A (en) 1999-11-23
WO1995023616A1 (en) 1995-09-08
ZA951841B (en) 1996-01-15
CA2169478C (en) 1999-03-16
US6203755B1 (en) 2001-03-20

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