CA2188029A1 - Porphocyanine and cnc-expanded porphyrins - Google Patents

Porphocyanine and cnc-expanded porphyrins

Info

Publication number
CA2188029A1
CA2188029A1 CA002188029A CA2188029A CA2188029A1 CA 2188029 A1 CA2188029 A1 CA 2188029A1 CA 002188029 A CA002188029 A CA 002188029A CA 2188029 A CA2188029 A CA 2188029A CA 2188029 A1 CA2188029 A1 CA 2188029A1
Authority
CA
Canada
Prior art keywords
formula
independently
linkage
cnc
porphocyanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002188029A
Other languages
French (fr)
Other versions
CA2188029C (en
Inventor
Ross W. Boyle
Hang Tang
Lily Xie
Tilak Wijesekera
David Dolphin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2188029A1 publication Critical patent/CA2188029A1/en
Application granted granted Critical
Publication of CA2188029C publication Critical patent/CA2188029C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Abstract

Compounds of formula (1) and the metalated forms and salts thereof; wherein n is an integer of 1-4; and wherein each Pi is independently a pyrrole residue of formula (II), wherein each Ria and Rib is independently a noninterfering substituent, and wherein each Zi is independently a covalent bond; or is a meso bridging group of formula (III); or is an N-meso bridging group of formula (IV); or is a CC linkage of formula (V) or is a CNCCNC linkage of formula (VI), wherein each Ric, Rid, Rie, Rif and Rig is independently a noninterfering substituent; or is a CNC linkage of formula (VII), wherein at least one Zi is said CNC linkage, are disclosed. These compounds are useful in photodynamic therapy and diagnosis. The metalated forms when the metal is paramagnetic are useful as MRI contrast agents.
CA002188029A 1994-04-26 1995-04-26 Porphocyanine and cnc-expanded porphyrins Expired - Fee Related CA2188029C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/233,632 1994-04-26
US08/233,632 US5726304A (en) 1992-10-30 1994-04-26 Porphocyanine and CNC-expanded porphyrins
PCT/CA1995/000242 WO1995029180A1 (en) 1994-04-26 1995-04-26 Porphocyanine and cnc-expanded porphyrins

Publications (2)

Publication Number Publication Date
CA2188029A1 true CA2188029A1 (en) 1995-11-02
CA2188029C CA2188029C (en) 2008-07-08

Family

ID=22878063

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002188029A Expired - Fee Related CA2188029C (en) 1994-04-26 1995-04-26 Porphocyanine and cnc-expanded porphyrins

Country Status (13)

Country Link
US (1) US5726304A (en)
EP (1) EP0757689A1 (en)
JP (1) JPH10500942A (en)
KR (1) KR100241853B1 (en)
AU (1) AU697139B2 (en)
CA (1) CA2188029C (en)
CZ (1) CZ288186B6 (en)
FI (1) FI964267A (en)
HU (1) HUT77405A (en)
NO (1) NO309481B1 (en)
NZ (1) NZ284413A (en)
PL (1) PL317024A1 (en)
WO (1) WO1995029180A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2206203A1 (en) * 1997-05-27 1998-11-27 University Of British Columbia Photoactivation of endogenous porphyrins for treatment of psoriasis
WO2000061585A2 (en) 1999-04-14 2000-10-19 The University Of British Columbia (Ubc) 1,3-dipolar cycloadditions to polypyrrolic macrocycles
US20020022032A1 (en) * 1999-04-23 2002-02-21 Curry Patrick Mark Immuno-adjuvant PDT treatment of metastatic tumors
BR0013171A (en) 1999-07-29 2002-05-28 Epix Medical Inc Multimedia agents for objectification imaging via multi-site connection
AU2001258117A1 (en) 2000-05-08 2001-11-20 The University Of British Columbia Supports for photosensitizer formulations
US6693093B2 (en) * 2000-05-08 2004-02-17 The University Of British Columbia (Ubc) Drug delivery systems for photodynamic therapy
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
US20120034157A1 (en) * 2010-08-03 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Artificial cells
KR101692459B1 (en) 2008-12-16 2017-01-03 밸리언트 파마슈티컬즈 인터내셔널, 인코퍼레이션 Combination of photodynamic therapy and anti-vegf agents in the treatment of unwanted choroidal neovasculature
RS56231B1 (en) 2010-02-04 2017-11-30 Morphotek Inc Chlorotoxin polypeptides and conjugates and uses thereof
WO2013003507A1 (en) 2011-06-27 2013-01-03 Morphotek, Inc. Multifunctional agents
AU2012328679C1 (en) 2011-10-25 2018-10-25 Memorial Sloan-Kettering Cancer Center Free PSA antibodies as diagnostics, prognostics and therapeutics for prostate cancer
WO2014066799A2 (en) 2012-10-26 2014-05-01 Memorial Sloan-Kettering Cancer Center Modulators of resistant androgen receptor
EP3087182B1 (en) 2013-12-23 2019-03-20 Memorial Sloan-Kettering Cancer Center Methods and compositions for treating cancer using peptide nucleic acid-based agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935498A (en) * 1989-03-06 1990-06-19 Board Of Regents, The University Of Texas System Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US5405957A (en) * 1992-10-30 1995-04-11 The University Of British Columbia Wavelength-specific photosensitive compounds and expanded porphyrin-like compounds and methods of use

Also Published As

Publication number Publication date
PL317024A1 (en) 1997-03-03
EP0757689A1 (en) 1997-02-12
JPH10500942A (en) 1998-01-27
FI964267A (en) 1996-12-19
FI964267A0 (en) 1996-10-23
HUT77405A (en) 1998-04-28
AU2300795A (en) 1995-11-16
NO964541D0 (en) 1996-10-25
CZ288186B6 (en) 2001-05-16
CA2188029C (en) 2008-07-08
CZ314296A3 (en) 1997-05-14
NO964541L (en) 1996-12-23
WO1995029180A1 (en) 1995-11-02
HU9602956D0 (en) 1997-01-28
AU697139B2 (en) 1998-09-24
US5726304A (en) 1998-03-10
NZ284413A (en) 1998-08-26
KR970702861A (en) 1997-06-10
KR100241853B1 (en) 2000-03-02
NO309481B1 (en) 2001-02-05

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