CA2190344A1 - Quillaja saponin adjuvant and vaccine formulation containing same - Google Patents
Quillaja saponin adjuvant and vaccine formulation containing sameInfo
- Publication number
- CA2190344A1 CA2190344A1 CA002190344A CA2190344A CA2190344A1 CA 2190344 A1 CA2190344 A1 CA 2190344A1 CA 002190344 A CA002190344 A CA 002190344A CA 2190344 A CA2190344 A CA 2190344A CA 2190344 A1 CA2190344 A1 CA 2190344A1
- Authority
- CA
- Canada
- Prior art keywords
- vaccine formulation
- formulation containing
- containing same
- adjuvant
- saponin adjuvant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
Abstract
A novel saponin component having a molecular weight of about 956 daltons, a process for isolating the saponin component from the bark of Quillaja saponaria Molina, a vaccine formulation comprising the saponin component as an immune adjuvant, a method for increasing the immune response to an antigen by employing an adjuvant composition comprising saponin component and a second adjuvant.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR19950008589 | 1995-04-13 | ||
KR1995/8589 | 1995-04-13 | ||
KR19950008590 | 1995-04-13 | ||
KR1995/8590 | 1995-04-13 | ||
PCT/KR1996/000053 WO1996032401A1 (en) | 1995-04-13 | 1996-04-12 | Quillaja saponin adjuvant and vaccine formulation containing same |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2190344A1 true CA2190344A1 (en) | 1996-10-16 |
CA2190344C CA2190344C (en) | 2001-04-10 |
Family
ID=37027969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002190344A Expired - Fee Related CA2190344C (en) | 1995-04-13 | 1996-04-12 | Quillaja saponin adjuvant and vaccine formulation containing same |
Country Status (16)
Country | Link |
---|---|
US (1) | US5817314A (en) |
EP (1) | EP0765333B1 (en) |
JP (1) | JP2761809B2 (en) |
KR (1) | KR0184779B1 (en) |
CN (2) | CN1044478C (en) |
AR (1) | AR001618A1 (en) |
AT (1) | ATE186541T1 (en) |
AU (1) | AU678941B2 (en) |
BR (1) | BR9606311A (en) |
CA (1) | CA2190344C (en) |
DE (1) | DE69605094T2 (en) |
DK (1) | DK0765333T3 (en) |
ES (1) | ES2140837T3 (en) |
MX (1) | MX9601378A (en) |
TW (1) | TW442293B (en) |
WO (1) | WO1996032401A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6080725A (en) * | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
WO1999010008A1 (en) * | 1997-08-29 | 1999-03-04 | Aquila Biopharmaceuticals, Inc. | Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient |
US6262029B1 (en) | 1998-08-14 | 2001-07-17 | Galenica Pharmaceuticals, Inc. | Chemically modified saponins and the use thereof as adjuvants |
TW586935B (en) * | 1998-09-14 | 2004-05-11 | Kitasato Inst | Saponin-containing vaccine preparation |
KR100629028B1 (en) * | 1998-10-16 | 2006-09-26 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | Adjuvant systems and vaccines |
EP1235591A1 (en) * | 1999-12-08 | 2002-09-04 | Statens Veterinärmedicinska Anstalt | Vaccine adjuvants comprising ginseng plant extract and added aluminium salt |
US6905712B2 (en) * | 1999-12-08 | 2005-06-14 | Statens Veterinarmedicinska Anstalt | Vaccine adjuvants comprising ginseng plant extract and added aluminum salt |
US8883170B2 (en) * | 2008-09-03 | 2014-11-11 | Western Illinois University Research Foundation | Adjuvant |
EP2359702B1 (en) | 2010-01-22 | 2014-06-04 | Symrise AG | Solubilization agent for solubilizing polyphenols, flavonoids and/or diterpenoid glucosides |
EP2359698B1 (en) | 2010-01-22 | 2013-12-04 | Symrise AG | Compositions with a surfactant system comprising saponins, and lecithin |
US10434058B2 (en) | 2010-12-09 | 2019-10-08 | Y&B Mother's Choice Ltd. | Natural formulations |
CN103347529B (en) | 2010-12-09 | 2016-10-26 | Y&B妈妈之选有限公司 | Preparation comprising saponin and application thereof |
EP2648809B1 (en) | 2010-12-09 | 2019-04-03 | Y&B Mother's Choice Ltd. | Natural formulations |
EP2628398B1 (en) | 2012-02-19 | 2016-09-07 | Symrise AG | Compositions of matter |
IL229836A0 (en) | 2013-12-08 | 2014-03-31 | Y & B Mother S Choice Ltd | Preparations for suppressing or attenuating ocular irritancy |
CN105213471A (en) * | 2014-05-29 | 2016-01-06 | 江口县苗药生物科技有限公司 | A kind of extraction process of soapbark total saponins |
CN111372604A (en) * | 2017-12-01 | 2020-07-03 | 葛兰素史密丝克莱恩生物有限公司 | Extraction of saponins |
WO2019106192A1 (en) | 2017-12-01 | 2019-06-06 | Glaxosmithkline Biologicals Sa | Saponin purification |
TWI820099B (en) * | 2018-03-28 | 2023-11-01 | 台灣浩鼎生技股份有限公司 | Novel saponin adjuvant and evaluation method thereof |
CN116355035B (en) * | 2021-12-28 | 2024-03-12 | 成都迈科康生物科技有限公司 | Preparation method of QS21 immunoadjuvant |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
ES2199227T5 (en) * | 1993-03-29 | 2007-12-01 | Pfizer Inc. | MULTICOMPONENT CLOSTRIDIAL VACCINES USING SAPONINA ASSISTANTS. |
-
1996
- 1996-04-09 KR KR1019960010630A patent/KR0184779B1/en not_active IP Right Cessation
- 1996-04-12 CN CN96190306A patent/CN1044478C/en not_active Expired - Fee Related
- 1996-04-12 ES ES96909390T patent/ES2140837T3/en not_active Expired - Lifetime
- 1996-04-12 AT AT96909390T patent/ATE186541T1/en not_active IP Right Cessation
- 1996-04-12 WO PCT/KR1996/000053 patent/WO1996032401A1/en active IP Right Grant
- 1996-04-12 EP EP96909390A patent/EP0765333B1/en not_active Expired - Lifetime
- 1996-04-12 MX MX9601378A patent/MX9601378A/en unknown
- 1996-04-12 BR BR9606311A patent/BR9606311A/en not_active Application Discontinuation
- 1996-04-12 DE DE69605094T patent/DE69605094T2/en not_active Expired - Fee Related
- 1996-04-12 AR AR33616096A patent/AR001618A1/en not_active Application Discontinuation
- 1996-04-12 CA CA002190344A patent/CA2190344C/en not_active Expired - Fee Related
- 1996-04-12 JP JP8530907A patent/JP2761809B2/en not_active Expired - Fee Related
- 1996-04-12 US US08/750,461 patent/US5817314A/en not_active Expired - Fee Related
- 1996-04-12 DK DK96909390T patent/DK0765333T3/en active
- 1996-04-12 AU AU52900/96A patent/AU678941B2/en not_active Ceased
- 1996-05-08 TW TW085105448A patent/TW442293B/en not_active IP Right Cessation
-
1998
- 1998-10-13 CN CN98120160A patent/CN1262958A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR960037694A (en) | 1996-11-19 |
AU678941B2 (en) | 1997-06-12 |
AR001618A1 (en) | 1997-11-26 |
MX9601378A (en) | 1997-04-30 |
CA2190344C (en) | 2001-04-10 |
DE69605094D1 (en) | 1999-12-16 |
KR0184779B1 (en) | 1999-04-01 |
EP0765333B1 (en) | 1999-11-10 |
AU5290096A (en) | 1996-10-30 |
JPH09510740A (en) | 1997-10-28 |
CN1149875A (en) | 1997-05-14 |
TW442293B (en) | 2001-06-23 |
BR9606311A (en) | 1997-09-16 |
ATE186541T1 (en) | 1999-11-15 |
EP0765333A1 (en) | 1997-04-02 |
DE69605094T2 (en) | 2000-07-06 |
ES2140837T3 (en) | 2000-03-01 |
DK0765333T3 (en) | 2000-03-13 |
WO1996032401A1 (en) | 1996-10-17 |
JP2761809B2 (en) | 1998-06-04 |
CN1044478C (en) | 1999-08-04 |
US5817314A (en) | 1998-10-06 |
CN1262958A (en) | 2000-08-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |