CA2190528A1 - Primate embryonic stem cells - Google Patents

Primate embryonic stem cells

Info

Publication number
CA2190528A1
CA2190528A1 CA002190528A CA2190528A CA2190528A1 CA 2190528 A1 CA2190528 A1 CA 2190528A1 CA 002190528 A CA002190528 A CA 002190528A CA 2190528 A CA2190528 A CA 2190528A CA 2190528 A1 CA2190528 A1 CA 2190528A1
Authority
CA
Canada
Prior art keywords
cells
preparation
differentiate
embryonic stem
ssea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002190528A
Other languages
French (fr)
Other versions
CA2190528C (en
Inventor
James A. Thomson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23484566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2190528(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2190528A1 publication Critical patent/CA2190528A1/en
Application granted granted Critical
Publication of CA2190528C publication Critical patent/CA2190528C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0605Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Abstract

A purified preparation of primate embryonic stem cells is disclosed. This preparation is characterized by the following cell surface markers: SSEA-1 (-); SSEA-3 (+); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+); and alkaline phosphatase (+). In a paricularly advantageous embodiment, the cells of the preparation have normal karyotypes and continue to proliferate in an undifferentiated state after continuous culture for eleven months. The embryonic stem cell lines also retain the ability, throughout the culture, to form trophoblast and to differentiate into all tissues derived from all three embryonic germ layers (endoderm, mesoderm and ectoderm). A method for isolating a primate embryonic stem cell line is also disclosed.

Claims (11)

1. A purified preparation of primate embryonic stem cells which (i) is capable of proliferation in vitro culture for over one year, (ii) maintains a normal karyotype through prolonged culture, (iii) maintains the potential to differentiate to derivatives of endoderm, mesoderm, and ectoderm tissues throughout the culture, and (iv) will not differentiate when cultured on a fibroblast feeder layer.
2. The preparation of claim 1 wherein the stem cells will spontaneously differentiate to trophoblast and produce chorionic gonadotropin when cultured to high density.
3. A purified preparation of primate embryonic stem cells wherein the cells are negative for the SSEA-1 marker, positive for the SSEA-3 marker, positive for the SSEA-4 marker, express alkaline phosphatase activity, are pluripotent, and have normal karyotypes.
4. The preparation of claim 3 wherein the cells are positive for the TRA-1-60, and TRA-1-81 markers.
5. The preparation of claim 3 wherein the cells continue to proliferate in an undifferentiated state after continuous culture for at least one year.
6. The preparation of claim 3 wherein the cells will differentiate to trophoblast when cultured beyond confluence and will produce chorionic gonadotropin.
7. The preparation of claim 3 wherein the cells remain euploid for more than one year of continuous culture.
8. The preparation of claim 3 wherein the cells differentiate into cells derived from mesoderm, endoderm and ectoderm germ layers when the cells are injected into a SCID mouse.
9. A method of isolating a primate embryonic stem cell line, comprising the steps of:
(a) isolating a primate blastocyst;
(b) isolating cells from the inner cell mass of the blastocyte of (a);
(c) plating the inner cell mass cells on embryonic fibroblasts, wherein inner cell mass-derived cell masses are formed;
(d) dissociating the mass into dissociated cells;
(e) replating the dissociated cells on embryonic feeder cells;
(f) selecting colonies with compact morphologies and cells with high nucleus to cytoplasm ratios and prominent nucleoli; and (g) culturing the cells of the selected colonies.
10. A method as claimed in claim 9 further comprising maintaining the isolated cells on a fibroblast feeder layer to prevent differentiation.
11. A cell line developed by the method of step 9.
CA2190528A 1995-01-20 1996-01-19 Primate embryonic stem cells Expired - Lifetime CA2190528C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37632795A 1995-01-20 1995-01-20
US08/376,327 1995-01-20
PCT/US1996/000596 WO1996022362A1 (en) 1995-01-20 1996-01-19 Primate embryonic stem cells

Publications (2)

Publication Number Publication Date
CA2190528A1 true CA2190528A1 (en) 1996-07-25
CA2190528C CA2190528C (en) 2010-04-27

Family

ID=23484566

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2190528A Expired - Lifetime CA2190528C (en) 1995-01-20 1996-01-19 Primate embryonic stem cells

Country Status (5)

Country Link
US (11) US5843780A (en)
EP (2) EP1640448A3 (en)
AU (1) AU4758496A (en)
CA (1) CA2190528C (en)
WO (1) WO1996022362A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7413902B2 (en) 1997-10-23 2008-08-19 Geron Corporation Feeder-free culture method for embryonic stem cells or primate primordial stem cells
US8637311B2 (en) 1998-10-23 2014-01-28 Asterias Biotherapeutics, Inc. Human embryonic stem cells genetically modified to contain a nucleic acid and cultured with fibroblast growth factor

Families Citing this family (803)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030032178A1 (en) * 1988-08-04 2003-02-13 Williams Robert Lindsay In vitro propagation of embryonic stem cells
US7153684B1 (en) * 1992-10-08 2006-12-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
CA2157931A1 (en) * 1993-03-12 1994-09-15 Clague P. Hodgson Improved vectors for gene therapy
US20040071637A1 (en) * 1993-04-27 2004-04-15 Elia James P. Method for repairing a damaged portion of a human organ
US5874301A (en) * 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US7112440B2 (en) 1995-02-02 2006-09-26 Ghazi Jaswinder Dhoot Method of increasing the relative number of CD45 low cells in a cell population
US9068164B1 (en) 1995-02-02 2015-06-30 Tristem Trading (Cyprus) Limited Method of preparing an undifferentiated cell
US7410773B2 (en) * 1995-02-02 2008-08-12 Ghazi Jaswinder Dhoot Method of preparing an undifferentiated cell
GB9502022D0 (en) * 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
GB9518606D0 (en) * 1995-09-12 1995-11-15 Inst Of Psychiatry Neural transplantation
US20030190753A1 (en) * 1995-11-09 2003-10-09 Nature Technology Corporation Vectors for gene transfer
US7544511B2 (en) * 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
WO1997047734A1 (en) * 1996-06-14 1997-12-18 The Regents Of The University Of California In vitro derivation and culture of primate pluripotent stem cells and therapeutic uses thereof
US20020194637A1 (en) * 2001-06-06 2002-12-19 University Of Massachussetts Embryonic or stem-like cell lines produced by cross species nuclear transplantation
US7696404B2 (en) * 1996-08-19 2010-04-13 Advanced Cell Technology, Inc. Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6090622A (en) * 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
DE69840439D1 (en) 1997-04-24 2009-02-26 Univ Washington TARGETED GENERIC CHANGE WITH PARVOVIRAL VECTORS
WO1999001763A2 (en) * 1997-07-02 1999-01-14 Board Of Regents, The University Of Texas System p53 AS A REGULATOR OF CELL DIFFERENTIATION
WO1999027076A1 (en) * 1997-11-25 1999-06-03 Arc Genomic Research Pluripotent embryonic stem cells and methods of obtaining them
US20050096274A1 (en) * 1998-04-07 2005-05-05 Lough John W. Bone morphogenetic protein and fibroblast growth factor compositions and methods for the induction of cardiogenesis
ES2246085T3 (en) * 1998-05-07 2006-02-01 University Of South Florida OSEA MEDULA CELLS AS A SOURCE OF NEURONS USEFUL TO REPAIR THE SPINAL MEDULA AND THE BRAIN.
US20080206206A1 (en) 1998-05-07 2008-08-28 University Of South Florida Bone marrow-derived neuronal cells
US6767737B1 (en) * 1998-08-31 2004-07-27 New York University Stem cells bearing an FGF receptor on the cell surface
AU3881499A (en) * 1998-09-01 2000-03-21 Wisconsin Alumni Research Foundation Primate embryonic stem cells with compatible histocompatibility genes
WO2000017325A1 (en) * 1998-09-23 2000-03-30 Mount Sinai Hospital Trophoblast cell preparations
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US7413904B2 (en) * 1998-10-23 2008-08-19 Geron Corporation Human embryonic stem cells having genetic modifications
US20020168766A1 (en) * 2000-01-11 2002-11-14 Gold Joseph D. Genetically altered human pluripotent stem cells
IL142748A0 (en) * 1998-11-09 2002-03-10 Univ Monash Embryonic stem cells
GB9907243D0 (en) * 1999-03-29 1999-05-26 Reneuron Ltd Therapy
US6455311B1 (en) * 1999-04-30 2002-09-24 The General Hospital Corporation Fabrication of vascularized tissue
US7759113B2 (en) * 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US7371400B2 (en) 2001-01-02 2008-05-13 The General Hospital Corporation Multilayer device for tissue engineering
IL129966A (en) * 1999-05-14 2009-12-24 Technion Res & Dev Foundation ISOLATED HUMAN EMBRYOID BODIES (hEB) DERIVED FROM HUMAN EMBRYONIC STEM CELLS
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
US10638734B2 (en) 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
CN1379814A (en) * 1999-09-14 2002-11-13 马萨诸塞大学 Embryonic or stem-like cell lines produced by cross species nuclear transpcantation and methods for enhancing mebryonic development by genetic alteration of donor cells or by tissue culture conditions
EP1218489B1 (en) * 1999-09-24 2009-03-18 Cybios LLC Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
AUPQ307399A0 (en) * 1999-09-24 1999-10-21 Luminis Pty Limited Cell cycle control
CA2388497A1 (en) * 1999-10-15 2001-04-26 Advanced Cell Technology, Inc. Method of producing differentiated progenitor cells by culturing morula or inner cell mass cells
US20030129745A1 (en) 1999-10-28 2003-07-10 Robl James M. Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues
AU1581001A (en) * 1999-11-02 2001-05-14 University Of Massachusetts Use of haploid genomes for genetic diagnosis, modification and multiplication
US6280718B1 (en) 1999-11-08 2001-08-28 Wisconsin Alumni Reasearch Foundation Hematopoietic differentiation of human pluripotent embryonic stem cells
EP1241935A2 (en) * 1999-12-17 2002-09-25 Gerald Schatten Methods for producing transgenic animals
AU2927501A (en) * 2000-01-07 2001-07-24 Oregon Health And Science University Clonal propagation of primate offspring by embryo splitting
US20050042749A1 (en) * 2001-05-16 2005-02-24 Carpenter Melissa K. Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease
US7455983B2 (en) * 2000-01-11 2008-11-25 Geron Corporation Medium for growing human embryonic stem cells
US20030134413A1 (en) * 2000-01-14 2003-07-17 Rathjen Peter David Cell production
US6602711B1 (en) 2000-02-21 2003-08-05 Wisconsin Alumni Research Foundation Method of making embryoid bodies from primate embryonic stem cells
US7541184B2 (en) * 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
US7439064B2 (en) 2000-03-09 2008-10-21 Wicell Research Institute, Inc. Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium
US7005252B1 (en) 2000-03-09 2006-02-28 Wisconsin Alumni Research Foundation Serum free cultivation of primate embryonic stem cells
US6619693B1 (en) * 2000-03-10 2003-09-16 Days Corporation Apparatus and method for automatically leveling an object
US7226057B2 (en) * 2000-03-10 2007-06-05 Days Corporation Apparatus and method for automatically leveling an object
JP4889902B2 (en) * 2000-03-14 2012-03-07 イーエス・セル・インターナショナル・プライヴェート・リミテッド Method for producing human neural progenitor cells from human embryonic stem (hES) cells, method for producing neurons using the method, method for producing oligodendrocytes or astrocytes
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
US6828145B2 (en) 2000-05-10 2004-12-07 Cedars-Sinai Medical Center Method for the isolation of stem cells by immuno-labeling with HLA/MHC gene product marker
NL1017973C2 (en) 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Design.
US8273570B2 (en) * 2000-05-16 2012-09-25 Riken Process of inducing differentiation of embryonic cell to cell expressing neural surface marker using OP9 or PA6 cells
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
AU6319901A (en) * 2000-05-17 2001-11-26 Geron Corp Neural progenitor cell populations
US7270998B2 (en) * 2000-06-01 2007-09-18 Japan Science And Technology Corporation Method of concentrating and separating dopaminergic neurons
CA2411849A1 (en) * 2000-06-05 2001-12-13 The Burnham Institute Methods of differentiating and protecting cells by modulating the p38/mef2 pathway
US20020012905A1 (en) 2000-06-14 2002-01-31 Snodgrass H. Ralph Toxicity typing using liver stem cells
JP5014535B2 (en) * 2000-06-15 2012-08-29 田辺三菱製薬株式会社 Cynomolgus monkey-derived embryonic stem cells
WO2001096532A2 (en) * 2000-06-15 2001-12-20 Tanja Dominko Method of generating pluripotent mammalian cells by fusion of a cytoplast fragment with a karyoplast
CN100523174C (en) * 2000-06-15 2009-08-05 田边三菱制药株式会社 Monkey-origin embryonic stem cells
EP1294855A4 (en) * 2000-06-20 2004-09-15 Es Cell Int Pte Ltd Method of controlling differentiation of embryonic stem (es) cells by culturing es cells in the presence of bmp-2 pathway antagonists
CA2417356A1 (en) * 2000-08-01 2002-02-07 Yissum Research Development Company Directed differentiation of embryonic cells
WO2002014469A2 (en) * 2000-08-15 2002-02-21 Geron Corporation Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells
US20040053869A1 (en) * 2000-08-19 2004-03-18 Peter Andrews Stem cell differentiation
US6921632B2 (en) 2000-08-30 2005-07-26 Maria Biotech Co., Ltd. Human embryonic stem cells derived from frozen-thawed embryo
US6534052B1 (en) 2000-09-05 2003-03-18 Yong-Fu Xiao Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated
US6607720B1 (en) 2000-09-05 2003-08-19 Yong-Fu Xiao Genetically altered mammalian embryonic stem cells, their living progeny, and their therapeutic application for improving cardiac function after myocardial infarction
EP1323821A4 (en) * 2000-09-14 2005-01-12 Atsushi Yuki Process for producing normal parenchymal cells, tissue or organ by bioincubator
AUPR095200A0 (en) * 2000-10-24 2000-11-16 Bresagen Limited Cell production
WO2002038741A1 (en) * 2000-11-09 2002-05-16 Bresagen Limited Cell reprogramming
KR20040029311A (en) * 2000-11-22 2004-04-06 제론 코포레이션 Tolerizing allografts of pluripotent stem cells
US6921665B2 (en) * 2000-11-27 2005-07-26 Roslin Institute (Edinburgh) Selective antibody targeting of undifferentiated stem cells
US6576464B2 (en) 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
US20030027331A1 (en) * 2000-11-30 2003-02-06 Yan Wen Liang Isolated homozygous stem cells, differentiated cells derived therefrom, and materials and methods for making and using same
AU2001297880B2 (en) * 2000-11-30 2007-05-31 Stemron Inc. Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same
US20020068046A1 (en) * 2000-12-04 2002-06-06 Jianwu Dai Use of stem cells derived from dermal skin
AU2002251681A1 (en) * 2000-12-05 2002-08-28 Layton Bioscience Inc. Production and use of dopaminergic cells to treat dopaminergic deficiencies
KR20030088023A (en) 2001-01-02 2003-11-15 스템론 인크. A Method for Producing a Population of Homozygous Stem Cells Having a Pre-selected Immunotype and/or Genotype, Cells Suitable for Transplant Derived therefrom, and Materials and Methods Using Same
CA2435826A1 (en) * 2001-01-24 2002-08-01 The Government Of The United States Of America Differentiation of stem cells to pancreatic endocrine cells
EP1367899A4 (en) * 2001-02-14 2004-07-28 Leo T Furcht Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
AUPR349501A0 (en) * 2001-03-02 2001-03-29 Bresagen Limited Cellular production control
US7126039B2 (en) * 2001-03-21 2006-10-24 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
CA2442177A1 (en) * 2001-03-29 2002-10-10 Ixion Biotechnology, Inc. Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway
US7838292B1 (en) 2001-03-29 2010-11-23 University Of Louisville Research Foundation, Inc. Methods for obtaining adult human olfactory progenitor cells
US20030082806A1 (en) * 2001-04-27 2003-05-01 Xcyte Therapies, Inc. Maturation of antigen-presenting cells using activated T cells
US20030211605A1 (en) * 2001-05-01 2003-11-13 Lee Sang-Hun Derivation of midbrain dopaminergic neurons from embryonic stem cells
US20050176665A1 (en) * 2001-05-18 2005-08-11 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA)
AU2002322379B2 (en) * 2001-07-06 2007-02-15 Asterias Biotherapeutics, Inc. Mesenchymal cells and osteoblasts from human embryonic stem cell
CN1543500B (en) * 2001-07-12 2014-04-09 杰龙公司 Cardiomyocyte precursors from human embryonic stem cells
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
US20030017587A1 (en) * 2001-07-18 2003-01-23 Rader William C. Embryonic stem cells, clinical applications and methods for expanding in vitro
DE10136719A1 (en) * 2001-07-27 2003-02-20 Georg S Wengler Recovering omnipotent human embryonic stem cells, comprises separating them from a blastocyte which remains viable, useful for gene therapy especially autotransplants
AU2002319780A1 (en) * 2001-08-06 2003-02-24 Bresagen, Ltd. Alternative compositions and methods for the culture of stem cells
US20030211603A1 (en) * 2001-08-14 2003-11-13 Earp David J. Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells
US20040092013A1 (en) * 2001-08-14 2004-05-13 Snyder Evan Y. Method of treating alzheimer's disease with cell therapy
CN1545549A (en) * 2001-08-23 2004-11-10 �Ϻ���ͨ��ѧ Isolation of inner cell mass for the establishment of human embryonic stem cell (hESC) lines
DE10144326B4 (en) * 2001-09-10 2005-09-22 Siemens Ag Method and system for monitoring a tire air pressure
US7588937B2 (en) * 2001-10-03 2009-09-15 Wisconsin Alumni Research Foundation Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
US6887706B2 (en) * 2001-10-03 2005-05-03 Wisconsin Alumni Research Foundation Method of in vitro differentiation of transplantable neural precursor cells from primate embryonic stem cells
US8153424B2 (en) * 2001-10-03 2012-04-10 Wisconsin Alumni Research Foundation Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
WO2003040319A2 (en) * 2001-11-02 2003-05-15 Wisconsin Alumni Research Foundation Endothelial cells derived from primate embryonic stem cells
US6759244B2 (en) * 2001-11-08 2004-07-06 Art Institute Of New York And New Jersey, Inc. Composite blastocysts (CBs) from aggregates of dissociated cells of non-viable pre-embryos
US7491690B2 (en) * 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
EP1442115B9 (en) * 2001-11-15 2009-12-16 Children's Medical Center Corporation Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof
JP5364224B2 (en) 2001-12-07 2013-12-11 ジェロン・コーポレーション Hematopoietic cells derived from human embryonic stem cells
IL162132A0 (en) * 2001-12-07 2005-11-20 Geron Corp Chondrocyte precursors derived from human embryonic stem cells
US20040224403A1 (en) * 2001-12-07 2004-11-11 Robarts Research Institute Reconstituting hematopoietic cell function using human embryonic stem cells
EP1463798A4 (en) * 2001-12-07 2005-01-19 Geron Corp Islet cells from human embryonic stem cells
US7799324B2 (en) * 2001-12-07 2010-09-21 Geron Corporation Using undifferentiated embryonic stem cells to control the immune system
US20030113910A1 (en) * 2001-12-18 2003-06-19 Mike Levanduski Pluripotent stem cells derived without the use of embryos or fetal tissue
GB0220145D0 (en) * 2002-08-30 2002-10-09 Thromb X Nv Novel compositions for the in vitro derivation and culture of embryonic stem (ES) cell lines with germline transmission capability
ATE501167T1 (en) 2001-12-21 2011-03-15 Thrombogenics Nv COMPOSITIONS FOR THE IN VITRO GENERATION AND CULTURE OF EMBRYONAL STEM CELL LINES WITH GERMANY TRANSMISSION ABILITY AND FOR THE CULTURE OF ADULT STEM CELLS
CN1671835A (en) * 2001-12-28 2005-09-21 塞拉提斯股份公司 A method for the establishment of a pluripotent human blastocyst-derived stem cell line
US20040043482A1 (en) * 2002-01-04 2004-03-04 Kye-Hyung Paik Method of producing stem cell lines
US7190781B2 (en) * 2002-01-04 2007-03-13 Telefonaktiebolaget Lm Ericsson (Publ) Message transfer part point code mapping method and node
US20050170506A1 (en) * 2002-01-16 2005-08-04 Primegen Biotech Llc Therapeutic reprogramming, hybrid stem cells and maturation
US20050090004A1 (en) * 2003-01-16 2005-04-28 Sayre Chauncey B. Stem cell maturation for all tissue lines
US20030134422A1 (en) * 2002-01-16 2003-07-17 Sayre Chauncey Bigelow Stem cell maturation for all tissue lines
US20030162290A1 (en) * 2002-01-25 2003-08-28 Kazutomo Inoue Method for inducing differentiation of embryonic stem cells into functioning cells
CA2474968A1 (en) * 2002-01-31 2003-08-07 Asahi Techno Glass Corporation Cryopreservation medium for primate embryo stem cells and cryopreservation method
EP1472340A4 (en) * 2002-02-05 2006-11-08 Rappaport Family Inst For Res Lineage committed stem cells selected for telomerase promoter activity
US20050106724A1 (en) * 2002-02-06 2005-05-19 Joerg Schierholz Pluripotent embryonic-like stem cells derived from teeth and uses thereof
WO2003070749A2 (en) * 2002-02-15 2003-08-28 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7736892B2 (en) * 2002-02-25 2010-06-15 Kansas State University Research Foundation Cultures, products and methods using umbilical cord matrix cells
US20030161818A1 (en) * 2002-02-25 2003-08-28 Kansas State University Research Foundation Cultures, products and methods using stem cells
US20060057657A1 (en) * 2002-03-12 2006-03-16 Oregon Health & Science University Technology & Research Collaborations Stem cell selection and differentiation
WO2003075648A1 (en) * 2002-03-13 2003-09-18 Fundacion Ivi Para El Estudio De La Reproduccion Humana (Fivier) Method of producing cell lines
EP1490506A4 (en) 2002-03-15 2005-06-08 Wicell Res Inst Inc Method for generating primate trophoblasts
EP1490486A4 (en) * 2002-03-15 2006-05-03 Wisconsin Alumni Res Found Method of identifying genes controlling diferentiation
GB0207440D0 (en) * 2002-03-28 2002-05-08 Ppl Therapeutics Scotland Ltd Tolerogenic antigen-presenting cells
US20040111285A1 (en) * 2002-04-09 2004-06-10 Mark Germain Method for human pluripotent stem cells
CA2484223A1 (en) * 2002-04-25 2003-11-06 Wisconsin Alumni Research Foundation Use of human neural stem cells secreting gdnf for treatment of parkinson's and other neurodegenerative diseases
US20030207448A1 (en) * 2002-05-06 2003-11-06 Revera Gregory Henry Methodologies for the creation of pluripotent or multipotent human stem cells without creating or destroying a human embryo
US6816665B2 (en) * 2002-05-09 2004-11-09 Lynx Photonic Networks Inc. Constant power operation thermo-optic switch
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
CA2684022C (en) * 2002-05-17 2014-09-23 Mount Sinai School Of Medicine Of New York University Mesoderm and definitive endoderm cell populations
CA2505598A1 (en) 2002-05-24 2003-12-04 Advanced Cell Technology, Inc. A bank of stem cells for transplantation
US7410797B2 (en) * 2002-06-11 2008-08-12 Ogle Roy C Meningeal-derived stem cells
US9321992B2 (en) * 2002-06-14 2016-04-26 Case Western Reserve University Cell targeting methods and compositions
US20050101014A1 (en) * 2002-07-11 2005-05-12 Keirstead Hans S. Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US7285415B2 (en) * 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US20110158966A1 (en) * 2002-07-23 2011-06-30 Judith Seligman Stem cells characterized by expression of germline specific genes
WO2007116408A2 (en) * 2006-04-11 2007-10-18 Nanodiagnostics Israel Ltd. Pluripotent stem cells characterized by expression of germline specific genes
CA2493768A1 (en) * 2002-07-23 2004-01-29 Nanodiagnostics, Inc. Embryonic stem cell markers and uses thereof
US7422736B2 (en) * 2002-07-26 2008-09-09 Food Industry Research And Development Institute Somatic pluripotent cells
US8876532B2 (en) 2002-07-31 2014-11-04 Dentsply International Inc. Bone repair putty
US7462448B2 (en) * 2002-08-02 2008-12-09 Stratatech Corporation Species specific DNA detection
EP1534068A4 (en) * 2002-08-08 2006-08-23 Univ Georgia Res Found Compositions and methods for neural differentiation of embryonic stem cells
US20060110375A1 (en) * 2002-08-09 2006-05-25 Herbert Zech Method for producing cell lines and organs by means of differentiable cells
WO2004018628A2 (en) 2002-08-21 2004-03-04 Northwestern University Charged peptide-amphiphile solutions & self-assembled peptide nanofiber networks formed therefrom
CA2404540A1 (en) * 2002-09-20 2004-03-20 Institut Pasteur A method for measuring a marker indicative of the exposure of a patient to nicotine; a kit for measuring such a marker
AU2003276924A1 (en) * 2002-09-25 2004-04-19 Bresagen, Inc. Compositions and methods for enrichment of neural stem cells using ceramide analogs
US7267981B2 (en) * 2002-10-07 2007-09-11 Technion Research & Development Foundation Ltd. Human foreskin fibroblasts for culturing ES cells
CN1717478A (en) * 2002-10-25 2006-01-04 湖南惠霖生命科技有限公司 Be used for the feeder layer of hESC's vitro culture and the method for cultivating embryonic stem cell
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003298647A1 (en) 2002-11-14 2004-06-15 Claussen, Randal, C. Synthesis and self-assembly of abc triblock bola peptide
AU2003302701A1 (en) * 2002-11-29 2004-06-23 Technion Research And Development Foundation Ltd. Method of dynamically culturing embryonic stem cells
US20040110286A1 (en) * 2002-12-06 2004-06-10 The John P. Robarts Research Institute Method for making hematopoietic cells
CA2508880C (en) 2002-12-16 2018-02-06 Technion Research And Development Foundation Ltd. Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and stem cell cultures prepared using same
WO2004076624A2 (en) * 2002-12-18 2004-09-10 Bresagen, Inc. Compositions and methods for neural cell production and stabilization
WO2004065616A2 (en) 2003-01-16 2004-08-05 The General Hospital Corporation Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications
AU2004210853A1 (en) * 2003-02-11 2004-08-26 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
US7674620B2 (en) * 2003-03-12 2010-03-09 Reliance Life Sciences Pvt. Ltd. Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells
US7153650B2 (en) * 2003-03-13 2006-12-26 Geron Corporation Marker system for preparing and characterizing high-quality human embryonic stem cells
US20030224411A1 (en) * 2003-03-13 2003-12-04 Stanton Lawrence W. Genes that are up- or down-regulated during differentiation of human embryonic stem cells
WO2004087885A2 (en) * 2003-03-27 2004-10-14 Ixion Biotechnology, Inc. Method for transdifferentiation of non-pancreatic stem cells to the pancreatic pathway
JP4502317B2 (en) * 2003-03-28 2010-07-14 独立行政法人農業生物資源研究所 Method for selecting undifferentiated cells and use thereof
US20040191839A1 (en) * 2003-03-28 2004-09-30 National Institute Of Agrobiological Sciences Japan Methods for sorting undifferentiated cells and uses thereof
JP2004298108A (en) * 2003-03-31 2004-10-28 Japan Science & Technology Agency Method for producing lens cell, and lens cell obtained by the method
AU2004227204B2 (en) 2003-04-08 2010-06-03 Yeda Research And Development Co. Ltd Stem cells having increased sensitivity to SDF-1 and methods of generating and using same
US20060037086A1 (en) * 2003-04-09 2006-02-16 Schatten Gerald P Methods for correcting mitotic spindle defects and optimizing preimplantation embryonic developmental rates associated with somatic cell nuclear transfer in animals
FR2853551B1 (en) 2003-04-09 2006-08-04 Lab Francais Du Fractionnement STABILIZING FORMULATION FOR IMMUNOGLOBULIN G COMPOSITIONS IN LIQUID FORM AND LYOPHILIZED FORM
EP1615492A4 (en) * 2003-04-09 2010-07-14 Magee Womens Health Corp Methods for correcting mitotic spindle defects associated with somatic cell nuclear transfer in animals
IL155783A (en) 2003-05-05 2010-11-30 Technion Res & Dev Foundation Multicellular systems of pluripotent human embryonic stem cells and cancer cells and uses thereof
US7638328B2 (en) * 2003-05-08 2009-12-29 Cellartis Ab Method for efficient transfer of human blastocyst-derived stem cells (hBS cells) from a feeder-supported to a feeder-free culture system, long-term propagation of hBS cells under feeder-free conditions and use of cultured hBS cells for applications in myocardial regeneration
WO2004099395A2 (en) * 2003-05-08 2004-11-18 Cellartis Ab A method for the generation of neural progenitor cells
US20090203141A1 (en) * 2003-05-15 2009-08-13 Shi-Lung Lin Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant RNA agents
US9567591B2 (en) 2003-05-15 2017-02-14 Mello Biotechnology, Inc. Generation of human embryonic stem-like cells using intronic RNA
US7960166B2 (en) 2003-05-21 2011-06-14 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
EP1702062A2 (en) * 2003-06-11 2006-09-20 Jan Remmereit Differentiation of stem cells for therapeutic use
WO2004108882A2 (en) * 2003-06-11 2004-12-16 Yeda Research And Development Co. Ltd. Neural stem cells and methods of generating and utilizing same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US7875273B2 (en) 2004-12-23 2011-01-25 Ethicon, Incorporated Treatment of Parkinson's disease and related disorders using postpartum derived cells
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US8491883B2 (en) 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US7413734B2 (en) 2003-06-27 2008-08-19 Ethicon, Incorporated Treatment of retinitis pigmentosa with human umbilical cord cells
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
US20050019907A1 (en) * 2003-07-22 2005-01-27 Santiago Munne Obtaining normal disomic stem cells from chromosomally abnormal embryos
US7674291B2 (en) 2003-08-01 2010-03-09 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
US7569385B2 (en) * 2003-08-14 2009-08-04 The Regents Of The University Of California Multipotent amniotic fetal stem cells
US7820439B2 (en) * 2003-09-03 2010-10-26 Reliance Life Sciences Pvt Ltd. In vitro generation of GABAergic neurons from pluripotent stem cells
US20050054100A1 (en) * 2003-09-08 2005-03-10 Rennard Stephen I. Methods for fibroblast differentiation
WO2005033297A1 (en) * 2003-09-19 2005-04-14 The Rockefeller University Compositions, methods and kits relating to reprogramming adult differentiated cells and production of embryonic stem cell-like cells
EP1677594B1 (en) * 2003-10-09 2011-01-12 Core Dynamics Limited Method for freezing, thawing and transplantation of viable cartilage
US20050100924A1 (en) * 2003-11-06 2005-05-12 National University Of Singapore C/EBPalpha gene targeting constructs and uses thereof
IL158868A0 (en) * 2003-11-13 2004-05-12 Yeda Res & Dev Methods of generating and using stem cells enriched with immature primitive progenitor
EP1530970A1 (en) * 2003-11-13 2005-05-18 Medizinische Hochschule Hannover Composition and method for inducing immune tolerance towards cell, tissue and/or organ transplants
WO2005052138A1 (en) * 2003-11-19 2005-06-09 Wisconsin Alumni Research Foundation Cryopreservation of pluripotent stem cells
US20050106725A1 (en) * 2003-11-19 2005-05-19 Palecek Sean P. Method of reducing cell differentiation
US20080220520A1 (en) * 2003-11-19 2008-09-11 Palecek Sean P Cryopreservation of human embryonic stem cells in microwells
US20080026460A1 (en) * 2006-06-20 2008-01-31 Palecek Sean P Method for culturing stem cells
US7790039B2 (en) * 2003-11-24 2010-09-07 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for stem cell enrichment
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
US20070269412A1 (en) * 2003-12-02 2007-11-22 Celavie Biosciences, Llc Pluripotent cells
CN101065478B (en) * 2003-12-02 2012-07-04 塞拉维生物科学公司 Compositions and methods for propagation of neural progenitor cells
CN1905892A (en) * 2003-12-05 2007-01-31 西北大学 Self-assembling peptide amphiphiles and related methods for growth factor delivery
MXPA06006387A (en) * 2003-12-05 2006-09-04 Univ Northwestern Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof.
TWI280280B (en) * 2003-12-09 2007-05-01 Ind Tech Res Inst Culture system and method for expansion and undifferentiated growth of human embryonic stem cells
US20060030042A1 (en) * 2003-12-19 2006-02-09 Ali Brivanlou Maintenance of embryonic stem cells by the GSK-3 inhibitor 6-bromoindirubin-3'-oxime
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US20050214257A1 (en) 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
DK2722387T3 (en) 2003-12-23 2020-01-20 Viacyte Inc Definitely endoderm
WO2007059007A2 (en) * 2005-11-14 2007-05-24 Cythera, Inc. Markers of definitive endoderm
US7625753B2 (en) * 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US7541185B2 (en) * 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US20050266554A1 (en) * 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
WO2005065354A2 (en) * 2003-12-31 2005-07-21 The Burnham Institute Defined media for pluripotent stem cell culture
CA2552288C (en) 2004-01-02 2015-02-24 Advanced Cell Technology, Inc. Novel culture systems for ex vivo development
EP2319544A1 (en) 2004-01-16 2011-05-11 Carnegie Mellon University Cellular labeling for nuclear magnetic resonance techniques
US20080241107A1 (en) * 2004-01-23 2008-10-02 Copland Iii John A Methods and Compositions For Preparing Pancreatic Insulin Secreting Cells
US20050186672A1 (en) * 2004-01-27 2005-08-25 Reliance Life Sciences Pvt. Ltd. Tissue system with undifferentiated stem cells derived from corneal limbus
US8196416B2 (en) * 2004-02-02 2012-06-12 Core Dynamics Limited Device for directional cooling of biological matter
JP4777908B2 (en) * 2004-02-02 2011-09-21 コア・ダイナミクス・リミテッド Biological materials and methods and solutions for storage of biological materials
WO2005080551A2 (en) * 2004-02-12 2005-09-01 University Of Newcastle Upon Tyne Stem cells
US20060216821A1 (en) * 2004-02-26 2006-09-28 Reliance Life Sciences Pvt. Ltd. Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof
BRPI0506536C1 (en) * 2004-02-26 2007-05-22 Reliance Life Sciences Pvt Ltd corneal limbus-derived dopaminergic neurons, isolation methods and uses
US8187875B2 (en) 2004-02-26 2012-05-29 Reliance Life Sciences Pvt. Ltd. Dopaminergic neurons derived from corneal limbus, methods of isolation and uses thereof
US20050214938A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
US7452718B2 (en) * 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
CA2563518C (en) 2004-04-23 2014-09-02 Bioe, Inc. Multi-lineage progenitor cells
US7622108B2 (en) 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
EP2377922B1 (en) 2004-04-27 2020-04-08 Viacyte, Inc. PDX1 expressing endoderm
EP1743023A1 (en) * 2004-05-07 2007-01-17 Wisconsin Alumni Research Foundation Method of forming mesenchymal stem cells from embryonic stem cells
JP5096148B2 (en) * 2004-06-07 2012-12-12 コア・ダイナミクス・リミテッド Method for disinfecting biological samples
CN103146649B (en) * 2004-06-09 2018-05-22 爱丁堡大学管理处 Neural stem cell
US20060008451A1 (en) * 2004-07-06 2006-01-12 Michigan State University In vivo methods for effecting tissue specific differentiation of embryonic stem cells
CA2573354C (en) 2004-07-09 2015-02-24 Cythera, Inc. Preprimitive streak and mesendoderm cells
WO2006016999A1 (en) 2004-07-09 2006-02-16 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
EP2267116B1 (en) 2004-07-13 2017-05-31 Asterias Biotherapeutics, Inc. Growth medium for primate embryonic stem cells
BRPI0513897A (en) * 2004-07-29 2008-05-20 Stem Cell Innovations Inc stem cell differentiation
WO2006016372A1 (en) * 2004-08-12 2006-02-16 I.M.T. Interface Multigrad Technology Ltd. Method and apparatus for freezing or thawing of a biological material
AU2005272681B2 (en) * 2004-08-13 2009-11-19 University Of Georgia Research Foundation, Inc. Compositions and methods for self-renewal and differentiation in human embryonic stem cells
EP1802744A4 (en) * 2004-09-03 2008-06-18 Agency Science Tech & Res Method for maintaining pluripotency of stem/progenitor cells
US20060177926A1 (en) * 2004-09-07 2006-08-10 Erika Sasaki Common marmoset embryonic stem cell lines
EP1819809A4 (en) * 2004-09-21 2008-08-06 Nvr Labs Ltd Compositions and methods for stem cell expansion and differentiation
ES2294650T3 (en) * 2004-09-30 2008-04-01 Reneuron Limited CELLPHONE LINE.
US20070077654A1 (en) * 2004-11-01 2007-04-05 Thomson James A Platelets from stem cells
AU2005304978A1 (en) 2004-11-04 2006-05-18 Advanced Cell Technology, Inc. Derivation of embryonic stem cells
US7893315B2 (en) * 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
WO2006053378A1 (en) * 2004-11-16 2006-05-26 Sydney Ifv Limited Derivation and culture of human embryo-derived cells
US7691629B2 (en) 2004-11-17 2010-04-06 Neuralstem, Inc. Transplantation of human neural cells for treatment of neurodegenerative conditions
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
WO2006083394A2 (en) * 2004-12-21 2006-08-10 Ethicon, Inc. Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
US20060171930A1 (en) * 2004-12-21 2006-08-03 Agnieszka Seyda Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
US20060153815A1 (en) * 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
DE102004062184B4 (en) * 2004-12-23 2013-08-01 Wolfgang Würfel Embryo-preserving production of pluripotent embryonic stem cells, stem cells thus obtained and use thereof
CA2589041C (en) 2004-12-23 2019-08-20 Ethicon, Incorporated Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
AU2005322007B2 (en) 2004-12-23 2011-06-30 Viacyte, Inc. Expansion of definitive endoderm cells
US8597947B2 (en) * 2004-12-29 2013-12-03 Hadasit Medical Research Services & Development Limited Undifferentiated stem cell culture systems
EP1844136B1 (en) 2004-12-29 2014-08-27 Hadasit Medical Research Services And Development Ltd. Stem cells culture systems
US20060275899A1 (en) * 2004-12-30 2006-12-07 Stemlifeline, Inc. Methods and compositions relating to embryonic stem cell lines
EP1844139A1 (en) * 2004-12-30 2007-10-17 Stemlifeline, Inc. Methods and systems relating to embryonic stem cell lines
US20060247165A1 (en) * 2005-01-21 2006-11-02 Stupp Samuel I Methods and compositions for encapsulation of cells
US7022518B1 (en) * 2005-01-31 2006-04-04 Glen Feye Apparatus and method for co-culturing of cells
WO2006084314A1 (en) * 2005-02-09 2006-08-17 Australian Stem Cell Centre Limited Stem cell populations and classification system
EP1850661A2 (en) * 2005-02-22 2007-11-07 Interface Multigrad Technology (IMT) Ltd. Preserved viable cartilage, method for its preservation, and system and devices used therefor
MX2007010771A (en) * 2005-03-04 2008-03-10 Univ Northwestern Angiogenic heparin binding peptide amphiphiles.
US20070048865A1 (en) * 2005-03-15 2007-03-01 Kenzaburo Tani Method for acceleration of stem cell differentiation
ES2622508T3 (en) 2005-03-17 2017-07-06 Stratatech Corporation Skin substitutes with enhanced purity
US8012751B2 (en) * 2005-03-31 2011-09-06 Wisconsin Alumni Research Foundation Differentiation of pluripotent embryonic stem cells
WO2007021321A2 (en) * 2005-04-01 2007-02-22 Wake Forest University Health Sciences Transcriptional profiling of stem cells and their multilineage differentiation
US7811817B2 (en) * 2005-05-17 2010-10-12 Reliance Life Sciences Pvt. Ltd. Establishment of a human embryonic stem cell line using mammalian cells
AU2006202209B2 (en) * 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
AU2006255183B2 (en) * 2005-06-08 2012-02-02 Centocor, Inc. A cellular therapy for ocular degeneration
EP1910518B1 (en) 2005-06-22 2019-05-08 Asterias Biotherapeutics, Inc. Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells
GB2441488C (en) 2005-06-22 2011-10-05 Geron Corp Suspension culture of human embryonic stem cells
JP2008546417A (en) * 2005-06-22 2008-12-25 シーエックスアール バイオサイエンス リミテッド Reporter hepatocytes and other cells for drug screening and toxicity testing
US20060292694A1 (en) * 2005-06-22 2006-12-28 Roslin Institute Reporter hepatocytes and other cells for drug screening and toxicity testing
US20060292695A1 (en) * 2005-06-22 2006-12-28 Roslin Institute Methods and kits for drug screening and toxicity testing using promoter-reporter cells derived from embryonic stem cells
WO2007014373A2 (en) * 2005-07-29 2007-02-01 Stem Cell Innovations Novel cells, compositions, and methods
US8198085B2 (en) * 2005-08-03 2012-06-12 Core Dynamics Limited Somatic cells for use in cell therapy
US20090035257A1 (en) 2005-08-25 2009-02-05 Repair Technologies, Inc. Devices, compositions and methods for the protection and repair of cells and tissues
EP1962719A4 (en) 2005-08-29 2011-05-04 Technion Res And Dev Of Foundation Ltd Media for culturing stem cells
WO2008020815A1 (en) 2006-08-15 2008-02-21 Agency For Science, Technology And Research Mesenchymal stem cell conditioned medium
EP2796544B1 (en) 2005-09-09 2019-04-03 Duke University Tissue engineering methods and compositions
ES2687233T3 (en) 2005-10-27 2018-10-24 Viacyte, Inc. Endoderm of the dorsal and ventral proximal intestine expressing PDX-1
US7413900B2 (en) * 2005-10-31 2008-08-19 President And Fellows Of Harvard College Immortalized fibroblasts
CA2626728A1 (en) 2005-11-10 2007-05-24 Genervon Biopharmaceuticals L.L.C. Mntf differentiation and growth of stem cells
US7521221B2 (en) * 2005-11-21 2009-04-21 Board Of Trustees Of The University Of Arknasas Staphylococcus aureus strain CYL1892
WO2007067280A2 (en) 2005-12-08 2007-06-14 University Of Louisville Research Foundation, Inc. Very small embryonic-like (vsel) stem cells and methods of isolating and using the same
US9155762B2 (en) * 2005-12-08 2015-10-13 University Of Louisville Research Foundation, Inc. Uses and isolation of stem cells from bone marrow
US8278104B2 (en) * 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US20090227032A1 (en) * 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8129187B2 (en) * 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
CN103773804A (en) * 2005-12-13 2014-05-07 国立大学法人京都大学 Nuclear reprogramming factor
PL1971681T3 (en) 2005-12-16 2018-01-31 Depuy Synthes Products Inc Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation
AU2006327073B2 (en) 2005-12-19 2012-08-30 Ethicon, Inc. In vitro expansion of postpartum derived cells in roller bottles
AU2006330409B2 (en) * 2005-12-28 2012-07-19 Ethicon, Incorporated Treatment of peripheral vascular disease using postpartum-derived cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US8153429B2 (en) 2006-02-23 2012-04-10 Viacyte, Inc. Compositions and methods useful for culturing differentiable cells
SG170068A1 (en) 2006-03-02 2011-04-29 Cythera Inc Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
EP2522352B1 (en) 2006-03-02 2017-01-11 Agency for Science, Technology and Research Methods for stem cells modulation
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells
US7695965B2 (en) * 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
AU2007257594B2 (en) 2006-03-07 2012-11-01 Geeta Shroff Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
US20070269411A1 (en) * 2006-03-10 2007-11-22 Wei Sun Porous silicon materials and devices
SE1050445A1 (en) * 2006-04-10 2010-05-04 Wisconsin Alumni Res Found Reagents and Methods for Use of Human Embryonic Stem Cells to Evaluate Toxicity of Pharmaceutical Compounds and Other Chemicals
WO2008054509A2 (en) * 2006-04-14 2008-05-08 Celsense, Inc. Methods for assessing cell labeling
US8263043B2 (en) * 2006-04-14 2012-09-11 Carnegie Mellon University Cellular labeling and quantification for nuclear magnetic resonance techniques
EP2019858B1 (en) 2006-04-17 2012-06-13 BioE LLC Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
ES2725601T3 (en) 2006-04-28 2019-09-25 Lifescan Inc Differentiation of human embryonic stem cells
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
WO2007127454A2 (en) * 2006-04-28 2007-11-08 Cythera, Inc. Hepatocyte lineage cells
KR101234544B1 (en) * 2006-04-28 2013-03-07 다이이찌 산쿄 가부시키가이샤 Method for differentiation induction of myocardial cell from pluripotent stem cell
EP2656832B1 (en) 2006-05-11 2018-12-19 Regenics AS Compositions for use in wound healing
WO2007139929A2 (en) 2006-05-25 2007-12-06 The Burnham Institute For Medical Research Methods for culture and production of single cell populations of human embryonic stem cells
CA2654196A1 (en) * 2006-06-02 2007-12-13 University Of Georgia Research Foundation, Inc. Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems
WO2007149182A2 (en) 2006-06-19 2007-12-27 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
US20080003676A1 (en) * 2006-06-26 2008-01-03 Millipore Corporation Growth of embryonic stem cells
CN101511307A (en) 2006-07-24 2009-08-19 国际干细胞公司 Synthetic cornea from retinal stem cells
CA2661232A1 (en) * 2006-08-31 2008-03-06 The University Of Louisville Research Foundation, Inc. Transcription factors for differentiation of adult human olfactory progenitor cells
US20100323442A1 (en) * 2006-10-17 2010-12-23 Emmanuel Edward Baetge Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells
WO2008066658A2 (en) * 2006-11-03 2008-06-05 The Trustees Of Princeton University Engineered cellular pathways for programmed autoregulation of differentiation
WO2008067142A2 (en) * 2006-11-08 2008-06-05 Wisconsin Alumni Research Foundation In vitro differentiation of hematopoietic cells from primate embryonic stem cells
CA2670497A1 (en) * 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
US7883698B2 (en) * 2007-01-17 2011-02-08 Maria Michejda Isolation and preservation of fetal hematopoietic and mesencymal system cells from non-controversial materials and/or tissues resulting from miscarriages and methods of therapeutic use
AU2008206884B2 (en) 2007-01-18 2012-07-05 Glykos Finland Oy Novel methods and reagents directed to production of cells
AU2008206885B2 (en) 2007-01-18 2011-02-03 Glykos Finland Oy Novel carbohydrate from human cells and methods for analysis and modification thereof
US8084023B2 (en) 2007-01-22 2011-12-27 The Board Of Trustees Of The University Of Arkansas Maintenance and propagation of mesenchymal stem cells
KR20090115142A (en) * 2007-01-30 2009-11-04 유니버시티 오브 조지아 리서치 파운데이션, 인코포레이티드 Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells(mmc)
US8097588B2 (en) * 2007-02-08 2012-01-17 Sanford-Burnham Medical Research Institute Trophinin-binding peptides and uses thereof
CN101679942A (en) 2007-02-23 2010-03-24 先进细胞技术公司 Highly efficient methods for reprogramming differentiated cells and for generating animals and embryonic stem cells from reprogrammed cells
WO2008118820A2 (en) 2007-03-23 2008-10-02 Wisconsin Alumni Research Foundation Somatic cell reprogramming
CA2678901C (en) * 2007-03-26 2017-11-14 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for modulating embryonic stem cell differentiation
US20080267874A1 (en) * 2007-03-28 2008-10-30 The Buck Institute For Age Research Targeted Neuronal And Glial Human Embryonic Stem Cell Line
EP2626416A3 (en) * 2007-04-07 2013-12-18 The Whitehead Institute for Biomedical Research Reprogramming of somatic cells
US8076295B2 (en) * 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
EP3640326A1 (en) 2007-04-18 2020-04-22 Hadasit Medical Research Services & Development Limited Stem cell-derived retinal pigment epithelial cells
EP2154242B1 (en) * 2007-06-07 2016-01-06 Keiichi Fukuda Method of inducing differentiation into myocardial cells using g-csf
US9213999B2 (en) * 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
JP2008307007A (en) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag Human pluripotent stem cell induced from human tissue-originated undifferentiated stem cell after birth
DK3293256T3 (en) 2007-06-29 2019-08-12 Fujifilm Cellular Dynamics Inc Automated method and apparatus for culturing embryonic stem cells
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
MX2010000348A (en) * 2007-07-01 2010-04-12 Lifescan Inc Single pluripotent stem cell culture.
WO2009009105A2 (en) * 2007-07-10 2009-01-15 Carnegie Mellon University Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques
EP3957716A1 (en) 2007-07-18 2022-02-23 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CA2693827A1 (en) * 2007-07-25 2009-01-29 Bioe, Inc. Differentiation of multi-lineage progenitor cells to chondrocytes
RU2473685C2 (en) * 2007-07-31 2013-01-27 Лайфскен, Инк. Differentiation of human embryo stem cells
WO2009048675A1 (en) 2007-07-31 2009-04-16 Lifescan, Inc. Pluripotent stem cell differentiation by using human feeder cells
CA2695321A1 (en) 2007-08-16 2009-02-26 Andreas Androutsellis-Theotokis Methods for promoting stem cell proliferation and survival
JP6151879B2 (en) 2007-08-31 2017-06-21 ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ Stimulation of the WNT pathway in reprogramming somatic cells
US10925903B2 (en) 2007-09-13 2021-02-23 Reprobiogen Inc. Use of cells derived from first trimester umbilical cord tissue
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
US20110236971A2 (en) * 2007-09-25 2011-09-29 Maksym Vodyanyk Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions
BRPI0818183A2 (en) 2007-10-05 2019-07-16 Ethicon Inc Renal tissue repair and regeneration using cells derived from human umbilical cord tissue
US8623650B2 (en) 2007-10-19 2014-01-07 Viacyte, Inc. Methods and compositions for feeder-free pluripotent stem cell media containing human serum
EP2214497A4 (en) * 2007-10-30 2010-11-24 Univ Louisville Res Found Uses and isolation of very small embryonic-like (vsel) stem cells
WO2009070592A2 (en) * 2007-11-27 2009-06-04 Lifescan, Inc. Differentiation of human embryonic stem cells
US8609413B2 (en) * 2007-12-11 2013-12-17 Research Development Foundation Neurons, astrocytes and oligodendrocytes differentiated from a mammalian pluripotent or neural stem cells exposed to a pyridine deriviative
US8236538B2 (en) 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
US20110111492A1 (en) 2008-01-18 2011-05-12 Regents Of The University Of Minnesota Stem Cell Aggregates and Methods for Making and Using
CN105331577A (en) 2008-01-30 2016-02-17 阿斯特利亚斯生物治疗股份公司 Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells
US8241907B2 (en) * 2008-01-30 2012-08-14 Geron Corporation Synthetic surfaces for culturing stem cell derived cardiomyocytes
EP3095470A1 (en) 2008-02-07 2016-11-23 Shahar Cohen Compartmental extract compositions for tissue engineering
US20090202978A1 (en) * 2008-02-13 2009-08-13 Ginadi Shaham Method and apparatus for freezing of a biological material
BRPI0908033A2 (en) * 2008-02-21 2015-08-04 Centocor Ortho Biotech Inc Surface modified plate method and compositions for cell adhesion, culture and detachment
US20100087002A1 (en) * 2008-02-21 2010-04-08 Benjamin Fryer Methods, Surface Modified Plates and Compositions for Cell Attachment, Cultivation and Detachment
EP2100954A1 (en) 2008-03-10 2009-09-16 Assistance Publique - Hopitaux de Paris Method for generating primate cardiac progenitor cells for clinical use from primate embryonic stem cells, and their applications
DE102008013854A1 (en) * 2008-03-12 2009-09-24 Siemens Aktiengesellschaft Catheter and associated medical examination and treatment facility
SG188918A1 (en) 2008-03-17 2013-04-30 Agency Science Tech & Res
JP5951254B2 (en) 2008-03-17 2016-07-13 ザ スクリプス リサーチ インスティテュート A combination of chemical and genetic techniques to generate induced pluripotent stem cells
SG10201610881UA (en) 2008-03-27 2017-03-30 Asterias Biotherapeutics Inc Differentiation of primate pluripotent stem cells to hematopoietic lineage cells
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
DK2283117T3 (en) 2008-04-21 2014-01-20 Viacyte Inc PROCEDURE FOR CLEANING PANCREATIC ENDODERM CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
EP2274430B1 (en) * 2008-04-30 2016-09-14 SanBio, Inc. Neural regenerating cells with alterations in dna methylation
US20100279404A1 (en) * 2008-05-02 2010-11-04 Shinya Yamanaka Method of nuclear reprogramming
CA2723171C (en) * 2008-05-02 2018-03-27 Celsense, Inc. Emulsion compositions and methods for nuclear magnetic resonance and other imaging
US9102920B2 (en) * 2008-05-06 2015-08-11 Agency For Science, Technology And Research Method of effecting de-differentiation of a cell
US9394538B2 (en) 2008-05-07 2016-07-19 Shi-Lung Lin Development of universal cancer drugs and vaccines
DK2296676T3 (en) 2008-05-09 2016-12-19 Regenics As cellular extracts
US20090280096A1 (en) * 2008-05-09 2009-11-12 Atsushi Kubo Pancreatic endocrine progenitor cells derived from pluripotent stem cells
EP2300023A2 (en) * 2008-05-16 2011-03-30 Genelux Corporation Microorganisms for preventing and treating neoplasms accompanying cellular therapy
CA2724839A1 (en) * 2008-05-21 2009-11-26 Bioe Llc Differentiation of multi-lineage progenitor cells to pancreatic cells
DK2993226T3 (en) 2008-06-03 2021-02-22 Viacyte Inc GROWTH FACTORS FOR THE PRODUCTION OF A DEFINITIVE ENDODERM
US20090298178A1 (en) * 2008-06-03 2009-12-03 D Amour Kevin Allen Growth factors for production of definitive endoderm
WO2009149233A1 (en) 2008-06-04 2009-12-10 Stem Cell Products, Inc. Methods for the production of ips cells using non-viral approach
CA3060170A1 (en) 2008-06-13 2009-12-17 Whitehead Institute For Biomedical Research Programming and reprogramming of cells
US8871900B2 (en) 2008-06-16 2014-10-28 University Of Rochester Fibroblast growth factor (FGF) analogs and uses thereof
WO2010008486A2 (en) 2008-06-24 2010-01-21 Parkinsons Institute Pluripotent cell lines and methods of use thereof
CN102159703B (en) 2008-06-30 2015-11-25 森托科尔奥索生物科技公司 The differentiation of multipotential stem cell
US20110305672A1 (en) 2008-07-25 2011-12-15 University Of Georgia Research Foundation, Inc. COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME
US20100028307A1 (en) * 2008-07-31 2010-02-04 O'neil John J Pluripotent stem cell differentiation
KR101712085B1 (en) 2008-10-31 2017-03-03 얀센 바이오테크 인코포레이티드 Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
CN107435038B (en) 2008-10-31 2021-07-09 詹森生物科技公司 Differentiation of human embryonic stem cells into the pancreatic endocrine lineage
NZ592622A (en) 2008-11-04 2012-10-26 Viacyte Inc Stem cell aggregate suspension compositions and methods for differentiation thereof
US8956867B2 (en) * 2008-11-07 2015-02-17 Wisconsin Alumni Research Foundation Method for culturing stem cells
EP2356227B1 (en) 2008-11-14 2018-03-28 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
AU2009316580B2 (en) 2008-11-20 2016-04-14 Janssen Biotech, Inc. Pluripotent stem cell culture on micro-carriers
CA2744227C (en) * 2008-11-20 2018-10-02 Centocor Ortho Biotech Inc. Methods and compositions for cell attachment and cultivation on planar substrates
EP3312269A1 (en) 2008-12-17 2018-04-25 The Scripps Research Institute Generation and maintenance of stem cells
EP2379088B1 (en) 2008-12-19 2018-02-28 DePuy Synthes Products, Inc. Treatment of lung and pulmonary diseases and disorders
AU2009327383B2 (en) * 2008-12-19 2014-08-28 DePuy Synthes Products, LLC Regeneration and repair of neural tissue following injury
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
AU2009327382B2 (en) * 2008-12-19 2014-07-17 DePuy Synthes Products, LLC Umbilical cord tissue derived cells for treating neuropathic pain and spasticity
WO2010075500A1 (en) 2008-12-23 2010-07-01 Stemcells California, Inc Target populations of oligodendrocyte precursor cells and methods of making and using same
CA2787708A1 (en) 2009-01-22 2010-07-29 Iti Scotland Limited Stem cell culture methods
US20100209399A1 (en) * 2009-02-13 2010-08-19 Celavie Biosciences, Llc Brain-derived stem cells for repair of musculoskeletal system in vertebrate subjects
EP2233566A1 (en) 2009-03-17 2010-09-29 Vrije Universiteit Brussel Generation of pancreatic progenitor cells
JP5908394B2 (en) 2009-03-26 2016-04-26 デピュイ・シンセス・プロダクツ・インコーポレイテッド Human umbilical cord tissue cells as a therapy for Alzheimer's disease
GB0906424D0 (en) 2009-04-09 2009-05-20 Antoxis Ltd Use of compounds for differentiation of cells
EP2419116A1 (en) * 2009-04-13 2012-02-22 North Western University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
WO2010124142A2 (en) 2009-04-22 2010-10-28 Cythera, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
US8193235B2 (en) * 2009-06-12 2012-06-05 University Of Kansas Compositions and methods for establishing and maintaining stem cells in an undifferentiated state
KR20120065966A (en) 2009-06-12 2012-06-21 난양 폴리테크닉 Novel uses
GB0911060D0 (en) 2009-06-26 2009-08-12 Ge Healthcare Uk Ltd Methods for predicting the toxicity of a chemical
WO2011005326A1 (en) 2009-07-09 2011-01-13 Massachusetts Institute Of Technology Methods and compositions for increased safety of stem cell-derived populations
RU2540016C2 (en) 2009-07-20 2015-01-27 Янссен Байотек, Инк. Differentiating human embryonic stem cells
WO2011011300A2 (en) 2009-07-20 2011-01-27 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells
MX340952B (en) * 2009-07-20 2016-07-29 Janssen Biotech Inc Differentiation of human embryonic stem cells.
CN102625829B (en) 2009-07-21 2015-05-06 Abt控股公司 Use of stem cells to reduce leukocyte extravasation
ES2690199T3 (en) 2009-07-21 2018-11-19 Abt Holding Company Use of stem cells to reduce leukocyte extravasation
AU2010279572B2 (en) 2009-08-03 2017-02-02 Recombinetics, Inc. Methods and compositions for targeted gene modification
CA2770753C (en) 2009-08-12 2019-01-15 Kyoto University Method for inducing differentiation of pluripotent stem cells into neural precursor cells
EP2467470A2 (en) 2009-08-17 2012-06-27 Technion Research & Development Foundation Ltd. Pericyte progenitor cells and methods of generating and using same
ES2500057T3 (en) 2009-08-22 2014-09-29 The Board Of Trustees Of The University Of The Leland Stanford Junior University Obtaining images and evaluation of embryos, oocytes and stem cells
CA2772619C (en) 2009-09-04 2019-07-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for enhancing genome stability and telomere elongation in embryonic stem cells
ES2938049T3 (en) 2009-10-16 2023-04-04 Scripps Research Inst Induction of stem cells
AU2010315712B2 (en) 2009-10-19 2014-04-17 FUJIFILM Cellular Dynamics, Inc. Cardiomyocyte production
BR112012010136A2 (en) * 2009-10-29 2015-09-15 Janssen Biotech Inc pluripotent stem cells
EP2498796B1 (en) 2009-11-09 2017-12-27 AAL Scientifics, Inc. Treatment of heart disease
EP2499236B1 (en) 2009-11-12 2020-01-01 Technion Research & Development Foundation Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
KR20120093407A (en) * 2009-12-02 2012-08-22 리서치 디벨럽먼트 파운데이션 Selection of stem cell clones with defined differentiation capabilities
FI20096288A0 (en) 2009-12-04 2009-12-04 Kristiina Rajala Formulations and Methods for Culturing Stem Cells
EP2513297B1 (en) 2009-12-18 2016-09-21 Shanghai iCell Biotechnology Co., Ltd. Materials and methods for generating pluripotent stem cells
RU2586506C2 (en) 2009-12-23 2016-06-10 Янссен Байотек, Инк. Differentiation of human embryonic stem cells
SG10201408552YA (en) 2009-12-23 2015-02-27 Janssen Biotech Inc Differentiation of human embryonic stem cells
WO2011091945A1 (en) 2010-01-26 2011-08-04 Université Libre de Bruxelles Tools for isolating and following cardiovascular progenitor cells
US8778416B2 (en) 2010-02-10 2014-07-15 Nayacure Therapeutics Ltd. Pharmaceutical compositions and methods for the treatment and prevention of cancer
WO2011106521A1 (en) 2010-02-25 2011-09-01 Abt Holding Company Modulation of macrophage activation
KR101900507B1 (en) 2010-02-25 2018-09-19 에이비티 홀딩 컴퍼니 Modulation of angiogenesis
RU2607380C2 (en) 2010-03-01 2017-01-10 Янссен Байотек, Инк. Methods of purifying cells, derived from pluripotent stem cells
US8662085B2 (en) * 2010-03-02 2014-03-04 Siemens Aktiengesellschaft Magnetic nanoparticle and group of nanoparticles
US8703424B2 (en) 2010-03-22 2014-04-22 Stemina Biomarker Discovery, Inc. Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics
CN102906248A (en) 2010-03-25 2013-01-30 国际干细胞公司 Method of altering differentiative state of cell and compositions thereof
JP5909482B2 (en) 2010-03-31 2016-04-26 ザ スクリプス リサーチ インスティテュート Cell reprogramming
CA2828315A1 (en) 2010-04-08 2011-10-13 The University Court Of The University Of Edinburgh Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof
US8927274B2 (en) 2010-04-12 2015-01-06 Technion Research & Development Foundation Limited Populations of pancreatic progenitor cells and methods of isolating and using same
WO2011133661A2 (en) 2010-04-21 2011-10-27 Research Development Foundation Methods and compositions related to dopaminergic neuronal cells
JP5841322B2 (en) 2010-04-22 2016-01-13 オレゴン ヘルス アンド サイエンス ユニバーシティ Fumaryl acetoacetate hydrolase (FAH) deficient pig and use thereof
HUE040278T2 (en) 2010-04-23 2019-02-28 Cold Spring Harbor Laboratory NOVEL STRUCTURALLY DESIGNED shRNAs
CA2798137C (en) 2010-05-06 2016-06-28 Regenics As Use of fish egg extracts for cellular rejuvenation
CN102242146B (en) * 2010-05-10 2015-11-25 高丽大学校产学协力团 Composition and the method with its generation generate induced pluripotent stem cells
SG185511A1 (en) 2010-05-12 2012-12-28 Centocor Ortho Biotech Inc Differentiation of human embryonic stem cells
CA2798895A1 (en) 2010-05-12 2011-11-17 Abt Holding Company Modulation of splenocytes in cell therapy
WO2011159726A2 (en) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
US9090878B2 (en) 2010-06-17 2015-07-28 Katholieke Universiteit Leuven Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells
EP2582792B1 (en) 2010-06-18 2018-10-31 FUJIFILM Cellular Dynamics, Inc. Cardiomyocyte medium with dialyzed serum
JP6660080B2 (en) 2010-07-01 2020-03-04 リジェネレイティブ リサーチ ファウンデーション Undifferentiated cell culture method using sustained release composition
CA2804595C (en) 2010-07-07 2018-11-13 Cellular Dynamics International, Inc. Endothelial cell production by programming
US8808687B2 (en) 2010-07-12 2014-08-19 Mark Humayun Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same
EP2596096B1 (en) 2010-07-21 2018-01-31 Kyoto University Method for inducing differentiation of human pluripotent stem cell into intermediate mesoderm cell
CA2843050A1 (en) 2010-07-26 2012-02-02 The University Of Manchester Targeted differentiation of stem cells
WO2012014207A2 (en) * 2010-07-27 2012-02-02 Technion Research & Development Foundation Ltd. Method for generating induced pluripotent stem cells from keratinocytes derived from plucked hair follicles
US9144585B2 (en) 2010-07-27 2015-09-29 Technion Research & Development Foundation Limited Isolated mesenchymal progenitor cells and extracellular matrix produced thereby
KR101765980B1 (en) 2010-07-28 2017-08-07 뉴럴스템, 인크. Methods for treating and/or reversing neurodegenerative diseases and/or disorders
SG10201506264QA (en) 2010-08-12 2015-09-29 Janssen Biotech Inc Treatment of diabetes with pancreatic endocrine precursor cells
CA2838330C (en) 2010-08-23 2021-01-26 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
US8609406B2 (en) 2010-08-24 2013-12-17 Regents Of The University Of Minnesota Non-static suspension culture of cell aggregates
KR101836855B1 (en) 2010-08-31 2018-04-19 얀센 바이오테크 인코포레이티드 Differentiation of pluripotent stem cells
EP3372672A1 (en) 2010-08-31 2018-09-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
KR101836850B1 (en) 2010-08-31 2018-03-09 얀센 바이오테크 인코포레이티드 Differentiation of human embryonic stem cells
JP5986570B2 (en) 2010-09-01 2016-09-06 トーマス・ジェファーソン・ユニバーシティThomas Jefferson University Compositions and methods for muscle repair and regeneration
EP2614145B1 (en) 2010-09-07 2020-12-02 The Board of Regents of The University of Texas System Tissue-specific differentiation matrices and uses thereof
JP6283223B2 (en) 2010-09-07 2018-02-21 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド Novel method and culture medium for culturing pluripotent stem cells
CN103459611B (en) 2010-09-17 2016-11-02 哈佛大学校长及研究员协会 The functional genomics research that effectiveness and the safety of pluripotent stem cell are characterized
AU2011308567B2 (en) 2010-10-01 2015-09-03 Fundacion Centro Nacional De Investigaciones Oncologicas, Carlos Iii Manipulation of stem cell function by p53 isoforms
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
WO2012054896A1 (en) 2010-10-22 2012-04-26 Biotime Inc. Methods of modifying transcriptional regulatory networks in stem cells
KR20200113286A (en) 2010-12-22 2020-10-06 페이트 세러퓨틱스, 인코포레이티드 Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs
US20130280804A1 (en) 2010-12-31 2013-10-24 Stephen Dalton Differentiation of human pluripotent stem cells to multipotent neural crest cells
PL2667878T3 (en) 2011-01-25 2016-10-31 Compositions and methods for cell transplantation
US9102914B2 (en) 2011-02-03 2015-08-11 Empire Technology Development Llc 3D trophoblast matrix for preparing organ-specific stem cells
US9574179B2 (en) 2011-02-08 2017-02-21 Cellular Dynamics International, Inc. Hematopoietic precursor cell production by programming
WO2012115276A1 (en) 2011-02-23 2012-08-30 Kyoto University Method for producing dendritic cells from pluripotent stem cells
CN103460038A (en) 2011-02-23 2013-12-18 里兰斯坦福初级大学理事会 Methods of detecting aneuploidy in human embryos
WO2012148549A1 (en) 2011-02-25 2012-11-01 Benaroya Research Institute Detection of an immune response
KR102351944B1 (en) 2011-02-28 2022-01-18 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Cell culture system
WO2012121971A2 (en) 2011-03-04 2012-09-13 The Regents Of The University Of California Locally released growth factors to mediate motor recovery after stroke
CA2829804A1 (en) 2011-03-29 2012-10-04 Geron Corporation Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
JP5840855B2 (en) 2011-03-30 2016-01-06 学校法人東京女子医科大学 Method for producing myocardial sheet from embryonic stem cells
CA2831609C (en) 2011-03-30 2019-06-11 Cellular Dynamics International, Inc. Priming of pluripotent stem cells for neural differentiation
CN106692193B (en) 2011-04-06 2021-01-05 桑比欧公司 Methods and compositions for modulating peripheral immune function
JP5745919B2 (en) * 2011-04-28 2015-07-08 浜松ホトニクス株式会社 Cell analysis method, cell analysis apparatus, and cell analysis program
WO2012149468A2 (en) 2011-04-29 2012-11-01 University Of Southern California Instruments and methods for the implantation of cell-seeded substrates
US8877489B2 (en) 2011-12-05 2014-11-04 California Institute Of Technology Ultrathin parylene-C semipermeable membranes for biomedical applications
SG10201914092XA (en) 2011-06-06 2020-03-30 ReGenesys BVBA Expansion of stem cells in hollow fiber bioreactors
GB201110331D0 (en) 2011-06-16 2011-08-03 Isis Innovation Method of cryopreserving pluripotent stem cells
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
WO2013010965A1 (en) 2011-07-15 2013-01-24 Universite Libre De Bruxelles Generation of mesodermal cells from pluripotent stem cells
DK2737056T3 (en) 2011-07-29 2018-05-22 Cellular Dynamics Int Inc Metabolic maturation in stem cell-derived tissue cells
US9499793B2 (en) 2011-08-09 2016-11-22 Yeda Research And Development Co. Ltd. Downregulation of miR-7 for promotion of beta cell differentiation and insulin production
EP2747551B1 (en) 2011-08-26 2020-02-12 Yecuris Corporation Fumarylacetoacetate hydrolase (fah)-deficient and immunodeficient rats and uses thereof
US20140271578A1 (en) 2011-09-30 2014-09-18 University Of Miami Renal stem cells isolated from kidney
GB201117469D0 (en) 2011-10-10 2011-11-23 Cell Guidance Systems Ltd Culture media for pluripotent stem cells
EP2770051B1 (en) 2011-10-21 2017-09-27 ARKRAY, Inc. Method for culturing pluripotency-maintained singly dispersed cells by means of laminar flow
GB201119335D0 (en) 2011-11-09 2011-12-21 Univ Leuven Kath Hepatitis virus infectable stem cells
EP2594635A1 (en) 2011-11-18 2013-05-22 Univercell Biosolutions Method for generating primate cardiovascular progenitor cells for clinical and drug cells testing use from primate embryonic stem cells or embryonic-like state cells, and their applications
WO2013077423A1 (en) 2011-11-25 2013-05-30 国立大学法人京都大学 Method for culturing pluripotent stem cell
US10238755B2 (en) 2011-11-30 2019-03-26 The Wistar Institute Of Anatomy And Biology Methods and compositions for regulation of cell aging, carcinogenesis and reprogramming
EP2785829B1 (en) 2011-12-01 2019-10-16 New York Stem Cell Foundation, Inc. Automated system for producing induced pluripotent stem cells or differentiated cells
US20150004144A1 (en) 2011-12-02 2015-01-01 The General Hospital Corporation Differentiation into brown adipocytes
EP2788033B1 (en) 2011-12-05 2017-05-31 Factor Bioscience Inc. Methods and products for transfecting cells
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
US9248013B2 (en) 2011-12-05 2016-02-02 California Institute Of Technology 3-Dimensional parylene scaffold cage
JP6143268B2 (en) 2011-12-19 2017-06-07 国立大学法人京都大学 Method for inducing differentiation from human pluripotent stem cells to intermediate mesoderm cells
JP6441080B2 (en) 2011-12-22 2018-12-19 ヤンセン バイオテツク,インコーポレーテツド Differentiation of human embryonic stem cells into single hormone insulin-positive cells
WO2013096686A1 (en) 2011-12-23 2013-06-27 Advanced Technologies And Regenerative Medicine, Llc Detection of human umbilical cord tissue-derived cells
EP2615176A1 (en) 2012-01-11 2013-07-17 Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe Novel pseudotyped lentiviral particles and their use in the in vitro targeted transduction of undifferentiated pluripotent human embryonic stem cells and induced pluripotent stem cells
WO2013106677A1 (en) 2012-01-13 2013-07-18 The General Hospital Corporation Isolated human lung progenitor cells and uses thereof
ES2726802T3 (en) 2012-01-25 2019-10-09 Univ Catholique Louvain Compositions and methods for cell transplantation
EP2809152B1 (en) 2012-02-01 2019-11-20 Nayacure Therapeutics Ltd Method for inducing immune tolerance to organ transplants
WO2013124816A2 (en) 2012-02-22 2013-08-29 Brainstem Biotec Ltd. Generation of neural stem cells and motor neurons
US9434920B2 (en) 2012-03-07 2016-09-06 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
WO2013151186A1 (en) 2012-04-06 2013-10-10 国立大学法人京都大学 Method for inducing erythropoietin-producing cell
AU2013251749B2 (en) 2012-04-24 2019-01-17 International Stem Cell Corporation Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells
SG11201407768QA (en) 2012-04-24 2015-01-29 Brigham & Womens Hospital Generating pluripotent cells de novo
US20150104430A1 (en) 2012-04-30 2015-04-16 University Health Network Methods and Compositions for Generating Pancreatic Progenitors and Functional Beta Cells from hPSCs
JP5432322B2 (en) 2012-05-08 2014-03-05 株式会社大塚製薬工場 Mammalian cell suspension for prevention of pulmonary embolism containing trehalose
HUE043861T2 (en) 2012-05-25 2019-09-30 Univ California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
CA2875038A1 (en) 2012-05-31 2013-12-05 Auxogyn, Inc. In vitro embryo blastocyst prediction methods
CN108103006A (en) 2012-06-08 2018-06-01 詹森生物科技公司 Differentiation of the human embryo stem cell to pancreatic endocrine cell
KR102055438B1 (en) 2012-07-31 2019-12-19 에이지엑스 쎄라퓨틱스, 인크. Hla g-modified cells and methods
JP2015526469A (en) 2012-08-20 2015-09-10 ボリス, マルコシアンMarkosian, Boris Placental vaccination therapy for cancer
US10724005B2 (en) 2012-09-28 2020-07-28 Scripps Health Methods of differentiating stem cells into chondrocytes
AU2013237760A1 (en) 2012-10-08 2014-04-24 Biotime, Inc. Differentiated progeny of clonal progenitor cell lines
WO2014070796A1 (en) 2012-10-29 2014-05-08 Scripps Health Methods of transplanting chondrocytes
JP6399558B2 (en) 2012-10-29 2018-10-03 スクリップス ヘルス Method for producing pluripotent stem cells from chondrocytes
AU2013337651B2 (en) 2012-11-01 2018-12-13 Factor Bioscience Inc. Methods and products for expressing proteins in cells
JP6339581B2 (en) 2012-11-02 2018-06-06 ステミナ バイオマーカー ディスカバリー, インコーポレイテッド Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomic ratios
AU2013248265B2 (en) 2012-11-08 2018-11-01 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
CA2894448C (en) 2012-12-10 2019-09-17 Regenics As Use of cellular extracts for skin rejuvenation
EP2938721B1 (en) 2012-12-28 2019-10-16 Kyoto University Method for inducing astrocytes
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
MX2015008578A (en) 2012-12-31 2015-09-07 Janssen Biotech Inc Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators.
AU2013370228B2 (en) 2012-12-31 2018-10-18 Janssen Biotech, Inc. Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
AU2013368221B2 (en) 2012-12-31 2018-11-01 Janssen Biotech, Inc. Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells
EP2950726B1 (en) 2013-02-01 2019-10-23 Ares Trading S.A. Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower developmental potential
JP6495658B2 (en) 2013-02-08 2019-04-03 国立大学法人京都大学 Method for producing megakaryocytes and platelets
JP2016508520A (en) 2013-02-15 2016-03-22 インターナショナル ステム セル コーポレイション Use of neurons derived from human pluripotent stem cells for the treatment of neurodegenerative diseases
CA2901747A1 (en) 2013-02-22 2014-08-28 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
JP6292415B2 (en) 2013-03-06 2018-03-14 国立大学法人京都大学 Pluripotent stem cell culture system and pluripotent stem cell passage method
WO2014143383A1 (en) 2013-03-13 2014-09-18 Agilent Technologies, Inc. Transposome tethered to a gene delivery vehicle
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
CA2899507A1 (en) 2013-03-14 2014-09-25 The Regents Of The University Of California In vitro production of medial ganglionic eminence precursor cells
CN105247070A (en) 2013-03-15 2016-01-13 怀特黑德生物医学研究院 Cellular discovery platform for neurodegenerative diseases
SG11201507829SA (en) 2013-03-21 2015-12-30 Univ Kyoto Pluripotent stem cell for neuronal differentiation induction
EP2980207B1 (en) 2013-03-25 2018-12-05 Foundation for Biomedical Research and Innovation at Kobe Cell sorting method
CN105358680B (en) 2013-04-03 2019-06-25 富士费勒姆细胞动力学有限公司 Method and composition for the culture entoderm progenitor cells that suspend
WO2014161075A1 (en) 2013-04-05 2014-10-09 University Health Network Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue
WO2014168585A1 (en) 2013-04-10 2014-10-16 Agency For Science, Technology And Research Polycaprolactone microcarriers for stem cell culture and fabrication thereof
EP2985344B1 (en) 2013-04-12 2018-07-18 Kyoto University Method for inducing alveolar epithelium progenitor cells
HUE052516T2 (en) 2013-04-12 2021-05-28 Houston Methodist Hospital Improving organs for transplantation
WO2014174470A1 (en) 2013-04-23 2014-10-30 Yeda Research And Development Co. Ltd. Isolated naive pluripotent stem cells and methods of generating same
ES2753323T3 (en) 2013-04-30 2020-04-08 Univ Leuven Kath Cell therapy for myelodysplastic syndromes
WO2014185358A1 (en) 2013-05-14 2014-11-20 国立大学法人京都大学 Efficient myocardial cell induction method
US9758763B2 (en) 2013-05-29 2017-09-12 The Regents Of The University Of California Methods and compositions for somatic cell proliferation and viability
CN113648323A (en) 2013-06-05 2021-11-16 再生疗法有限公司 Compositions and methods for induced tissue regeneration in mammalian species
US10119122B2 (en) 2013-06-10 2018-11-06 Academisch Ziekenhuis Leiden Differentiation and expansion of endothelial cells from pluripotent stem cells and the in vitro formation of vasculature like structures
WO2014200905A2 (en) 2013-06-10 2014-12-18 President And Fellows Of Harvard College Early developmental genomic assay for characterizing pluripotent stem cell utility and safety
DK3008168T3 (en) 2013-06-11 2020-05-04 Harvard College SC-CELLS AND COMPOSITIONS AND PROCEDURE FOR CREATING THEREOF
EP3020803B1 (en) 2013-06-11 2020-03-11 Kyoto University Method for producing renal precursor cells
JP6493881B2 (en) 2013-06-12 2019-04-03 国立大学法人京都大学 Method for selecting induced pluripotent stem cells and method for inducing differentiation into blood cells
US9624471B2 (en) 2013-06-12 2017-04-18 University Of Washington Through Its Center For Commercialization Methods for maturing cardiomyocytes and uses thereof
CA2913478C (en) 2013-06-28 2021-08-24 Otsuka Pharmaceutical Factory, Inc. Trehalose- and dextran-containing solution for transplanting mammalian cells
EP3031905A4 (en) 2013-08-07 2017-04-26 Kyoto University Method for producing pancreatic hormone-producing cell
KR102473199B1 (en) 2013-08-16 2022-12-01 예일 유니버시티 Epithelial cell differentiation of human mesenchymal stromal cells
EP3569699A1 (en) 2013-09-04 2019-11-20 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
CA2923592A1 (en) 2013-09-05 2015-03-12 Kyoto University Method for inducing dopamine-producing neural precursor cells from pluripotent stem cells
SG11201601922PA (en) 2013-09-13 2016-04-28 Univ Health Network Methods and compositions for generating epicardium cells
CN105960453A (en) 2013-10-01 2016-09-21 卡迪马干细胞有限公司 Directed differentiation of astrocytes from human pluripotent stem cells for use in drug screening and the treatment of amyotrophic lateral sclerosis (ALS)
US10100283B2 (en) 2013-11-01 2018-10-16 Kyoto University Efficient chondrocyte induction method
WO2015069736A1 (en) 2013-11-08 2015-05-14 The Mclean Hospital Corporation METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS
US9932607B2 (en) 2013-11-15 2018-04-03 The Board Of Trustees Of The Leland Stanford Junior University Site-specific integration of transgenes into human cells
WO2015073918A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
WO2015071474A2 (en) 2013-11-18 2015-05-21 Crispr Therapeutics Ag Crispr-cas system materials and methods
WO2015087231A1 (en) 2013-12-11 2015-06-18 Pfizer Limited Method for producing retinal pigment epithelial cells
WO2015089277A1 (en) 2013-12-12 2015-06-18 The Regents Of The University Of California Methods and compositions for modifying a single stranded target nucleic acid
EP2896688A1 (en) 2014-01-20 2015-07-22 Centre National de la Recherche Scientifique (CNRS) A method of producing beta pancreatic cells from progenitor cells through the use of hydrogen peroxide
EP3096713B1 (en) 2014-01-23 2022-09-21 President and Fellows of Harvard College Engineered polymeric valves, tubular structures and sheets
EP3099801B1 (en) 2014-01-31 2020-03-18 Factor Bioscience Inc. Synthetic rna for use in the treatment of dystrophic epidermolysis bullosa
WO2015119642A1 (en) 2014-02-10 2015-08-13 The Johns Hopkins University Low oxygen tension enhances endothelial fate of human pluripotent stem cells
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
KR102460549B1 (en) 2014-03-04 2022-10-28 페이트 세러퓨틱스, 인코포레이티드 Improved reprogramming methods and cell culture platforms
US11066649B2 (en) 2014-03-19 2021-07-20 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for inducing human cholangiocyte differentiation
KR102443578B1 (en) 2014-03-19 2022-09-16 브이셀 세라퓨틱스 인코포레이티드 Methods relating to pluripotent cells
WO2015140005A1 (en) 2014-03-19 2015-09-24 Ifom Fondazione Istituto Firc Di Oncologia Molecolare Method of generation of pluripotent cells
ES2837840T3 (en) 2014-03-20 2021-07-01 Ares Trading Sa Quantitative measurement of developmental kinetics of human morula and blastocyst morphology
WO2015143342A1 (en) 2014-03-21 2015-09-24 Cellular Dynamics International, Inc. Production of midbrain dopaminergic neurons and methods for the use thereof
WO2015164228A1 (en) 2014-04-21 2015-10-29 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
EP3954759A1 (en) 2014-05-16 2022-02-16 Janssen Biotech, Inc. Use of small molecules to enhance mafa expression in pancreatic endocrine cells
WO2015186128A1 (en) 2014-06-02 2015-12-10 Kadimastem Ltd. Methods of inducing myelination and maturation of oligodendrocytes
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
WO2016010002A1 (en) 2014-07-14 2016-01-21 中外製薬株式会社 Method for identifying epitope of protein
US11920164B2 (en) 2014-07-30 2024-03-05 Yeda Research And Development Co. Ltd. Media for culturing naive human pluripotent stem cells
US20180363070A9 (en) 2014-08-12 2018-12-20 Univ Wayne State Systems and methods to detect stem cell stress and uses thereof
US10596200B2 (en) 2014-08-22 2020-03-24 Procella Therapeutics Ab Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells
WO2016029122A1 (en) 2014-08-22 2016-02-25 Chien Kenneth R Use of jagged 1/frizzled 4 as a cell surface marker for isolating human cardiac ventricular progenitor cells
EP3188763B1 (en) 2014-09-02 2020-05-13 The Regents of The University of California Methods and compositions for rna-directed target dna modification
EP3842514A1 (en) 2014-09-12 2021-06-30 Whitehead Institute for Biomedical Research Cells expressing apolipoprotein e and uses thereof
JP6841753B2 (en) 2014-09-15 2021-03-10 ザ チルドレンズ メディカル センター コーポレーション Methods and compositions for increasing somatic cell nuclear transfer (SCNT) efficiency by removing histone H3-lysine trimethylation
US9371516B2 (en) 2014-09-19 2016-06-21 Regenerative Medical Solutions, Inc. Compositions and methods for differentiating stem cells into cell populations comprising beta-like cells
JP6581655B2 (en) 2014-10-14 2019-09-25 フジフィルム セルラー ダイナミクス,インコーポレイテッド Generation of pluripotent stem cell-derived keratinocytes and maintenance of keratinocyte culture
CN107148275A (en) 2014-10-20 2017-09-08 神经干细胞公司 The NSC of the stabilization of exogenous polynucleotide comprising encoding growth hormone and its application method
DK3211071T3 (en) 2014-10-24 2021-07-26 Sumitomo Dainippon Pharma Co Ltd MANUFACTURING PROCEDURE FOR RETINAL TISSUE
EP3220945A2 (en) 2014-11-17 2017-09-27 Yeda Research and Development Co., Ltd. Methods of treating diseases related to mitochondrial function
AU2015353853B2 (en) 2014-11-25 2020-10-15 President And Fellows Of Harvard College Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
US20160215268A1 (en) 2014-12-19 2016-07-28 Janssen Biotech, Inc. Suspension Culturing of Pluripotent Stem Cells
WO2016103269A1 (en) 2014-12-23 2016-06-30 Ramot At Tel-Aviv University Ltd. Populations of neural progenitor cells and methods of producing and using same
IL305070A (en) 2014-12-30 2023-10-01 Cell Cure Neurosciences Ltd Rpe cell populations and methods of generating same
CA2972580A1 (en) 2014-12-30 2016-07-07 Cell Cure Neurosciences Ltd. Assessing retinal pigment epithelial cell populations
WO2016118824A1 (en) 2015-01-22 2016-07-28 Regenerative Medical Solutions, Inc. Markers for differentiation of stem cells into differentiated cell populations
CA2976376A1 (en) 2015-02-13 2016-08-18 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
WO2016131137A1 (en) 2015-02-17 2016-08-25 University Health Network Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes
EP3059307B2 (en) 2015-02-20 2022-05-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of a laminin for differentiating pluripotent cells into hepatocyte lineage cells
EP3266864A4 (en) 2015-03-06 2018-08-29 Kyoto University Method for inducing differentiation of alveolar epithelial cells
US10772917B2 (en) 2015-03-11 2020-09-15 Ccs Ventures Limited Pancreatic endocrine progenitor cell therapies for the treatment of obesity and type 2 diabetes (T2D)
WO2016185457A1 (en) 2015-05-19 2016-11-24 Yeda Research And Development Co. Ltd. Methods of promoting lymphangiogenesis
WO2017014165A1 (en) 2015-07-17 2017-01-26 国立大学法人京都大学 Method for inducing vascular endothelial cells
ES2865024T3 (en) 2015-07-29 2021-10-14 Hadasit Med Res Service Large-scale production of retinal pigment epithelium cells
ES2932823T3 (en) 2015-08-05 2023-01-26 Cell Cure Neurosciences Ltd Preparation of retinal pigment epithelium cells
CN108138145A (en) 2015-08-05 2018-06-08 细胞治疗神经科学有限公司 For treating the preparation of the photoreceptor of retinal disease
US11312940B2 (en) 2015-08-31 2022-04-26 University Of Louisville Research Foundation, Inc. Progenitor cells and methods for preparing and using the same
WO2017043605A1 (en) 2015-09-08 2017-03-16 大日本住友製薬株式会社 Method for producing retinal pigment epithelial cells
DK3347456T3 (en) 2015-09-08 2024-02-19 Us Health PROCEDURE FOR REPRODUCIBLE DIFFERENTIATION OF CLINICAL-GRADE RETINAL PIGMENT EPITHELIAL CELLS
DK3347457T3 (en) 2015-09-08 2022-01-17 Fujifilm Cellular Dynamics Inc MACS-based purification of stem cell-derived retinal pigment epithelium
CA2998096C (en) 2015-09-11 2024-01-30 Astellas Pharma Inc. Method for producing renal progenitor cells
WO2017064546A1 (en) 2015-09-24 2017-04-20 Crispr Therapeutics Ag Novel family of rna-programmable endonucleases and their uses in genome editing and other applications
KR20180055918A (en) 2015-10-16 2018-05-25 페이트 세러퓨틱스, 인코포레이티드 Platform for the induction and maintenance of ground-state versatility
WO2017070145A1 (en) 2015-10-19 2017-04-27 Cellular Dynamics International, Inc. Production of virus-receptive pluripotent stem cell (psc)-derived hepatocytes
JP6976939B2 (en) 2015-10-20 2021-12-08 フジフィルム セルラー ダイナミクス,インコーポレイテッド Creation of multilineage hematopoietic progenitor cells by genetic programming
WO2017072763A1 (en) 2015-10-26 2017-05-04 Cell Cure Neurosciences Ltd. Preparation of retinal pigment epithelium cells
WO2017075389A1 (en) 2015-10-30 2017-05-04 The Regents Of The Universtiy Of California Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells
IL259470B (en) 2015-11-18 2022-08-01 Univ Georgia Neural cell extracellular vessicles
EP3387112A4 (en) 2015-12-07 2019-08-21 BioTime, Inc. Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells
EP3397753B1 (en) 2015-12-30 2021-10-27 FUJIFILM Cellular Dynamics, Inc. Microtissue formation using stem cell-derived human hepatocytes
WO2017172086A1 (en) 2016-02-19 2017-10-05 Leung Chuen Yan Genetic markers for engraftment of human cardiac ventricular progenitor cells
US11674952B2 (en) 2016-02-24 2023-06-13 The Rockefeller University Embryonic cell-based therapeutic candidate screening systems, models for Huntington's Disease and uses thereof
EP3423568A4 (en) 2016-03-04 2019-11-13 University Of Louisville Research Foundation, Inc. Methods and compositions for ex vivo expansion of very small embryonic-like stem cells (vsels)
WO2017153982A1 (en) 2016-03-06 2017-09-14 Yeda Research And Development Co. Ltd. Method for modulating myelination
US11534466B2 (en) 2016-03-09 2022-12-27 Aal Scientifics, Inc. Pancreatic stem cells and uses thereof
CA3019357A1 (en) 2016-04-04 2017-10-12 Biotime, Inc. Pluripotent stem cell-derived 3d retinal tissue and uses thereof
MA45479A (en) 2016-04-14 2019-02-20 Janssen Biotech Inc DIFFERENTIATION OF PLURIPOTENT STEM CELLS IN ENDODERMAL CELLS OF MIDDLE INTESTINE
CN109072198B (en) 2016-04-22 2022-08-26 国立大学法人京都大学 Preparation method of dopamine-producing neural progenitor cells
WO2017202814A1 (en) 2016-05-24 2017-11-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of neuropathological disorders characterized by a loss of cortical neurons
AU2017270234B2 (en) 2016-05-25 2023-11-23 Assistance Publique-Hôpitaux De Paris (Aphp) Methods and compositions for treating cancers
US20200325449A1 (en) 2016-06-02 2020-10-15 The Cleveland Clinic Foundation Complement inhibition for improving cell viability
WO2017216771A2 (en) 2016-06-17 2017-12-21 Genesis Technologies Limited Crispr-cas system, materials and methods
MA45502A (en) 2016-06-21 2019-04-24 Janssen Biotech Inc GENERATION OF FUNCTIONAL BETA CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS WITH GLUCOSE-DEPENDENT MITOCHONDRIAL RESPIRATION AND TWO-PHASE INSULIN SECRETION RESPONSE
AU2017290805B2 (en) 2016-07-01 2023-11-16 Research Development Foundation Elimination of proliferating cells from stem cell-derived grafts
EP3478824A1 (en) 2016-07-01 2019-05-08 Centre National de la Recherche Scientifique - CNRS Amplifying beta cell differentiation with small molecules bet (bromodomain and extraterminal family of bromodomain-containing proteins) inhibitors
EP3500664B1 (en) 2016-08-16 2021-09-22 FUJIFILM Cellular Dynamics, Inc. Methods for differentiating pluripotent cells
CA3033788A1 (en) 2016-08-17 2018-02-22 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
AU2017340634B2 (en) 2016-10-05 2022-06-02 FUJIFILM Cellular Dynamics, Inc. Generating mature lineages from induced pluripotent stem cells with MECP2 disruption
CN110167349A (en) 2016-11-02 2019-08-23 Aal科学有限公司 Non- mesenchyma people Lung stem cells and the method that they are used to treat respiratory disorder
WO2018084228A1 (en) 2016-11-04 2018-05-11 国立大学法人東京大学 Solution for cryopreservation of animal cells or animal tissues, cryopreserved product, and cryopreservation method
WO2018089011A1 (en) 2016-11-10 2018-05-17 Viacyte, Inc Pdx1 pancreatic endoderm cells in cell delivery devices and methods thereof
CA3044509A1 (en) 2016-11-25 2018-05-31 Riken Cell population for transplantation and method for producing same
US10508263B2 (en) 2016-11-29 2019-12-17 Procella Therapeutics Ab Methods for isolating human cardiac ventricular progenitor cells
CN110072992A (en) 2016-12-14 2019-07-30 株式会社大塚制药工场 Mammalian cell freezen protective liquid
US10828330B2 (en) 2017-02-22 2020-11-10 IO Bioscience, Inc. Nucleic acid constructs comprising gene editing multi-sites and uses thereof
JP7007686B2 (en) 2017-03-08 2022-01-25 大日本住友製薬株式会社 Manufacturing method of retinal pigment epithelial cells
CN110913874A (en) 2017-03-16 2020-03-24 谱系细胞疗法公司 Method for measuring the efficacy of a retinal disease therapy
US20200131473A1 (en) 2017-03-20 2020-04-30 Ifom Fondazione Istituto Firc Di Oncologia Molecolare Method of generating 2 cell-like stem cells
EP4083063A3 (en) 2017-04-18 2023-01-04 FUJIFILM Cellular Dynamics, Inc. Antigen-specific immune effector cells
US20210130849A1 (en) 2017-04-20 2021-05-06 Oregon Health & Science University Human gene correction
KR102422175B1 (en) 2017-06-19 2022-07-18 고에키 자이단 호징 고베 이료 산교 도시 스이신 기코 Method for predicting differentiation capacity of pluripotent stem cells and reagents therefor
KR20200029479A (en) 2017-07-20 2020-03-18 고쿠리쓰 겐큐 가이하쓰 호징 리가가쿠 겐큐소 Methods of preservation of nerve tissue
EP3656852A4 (en) 2017-07-20 2021-04-21 Riken Method for maturation of retinal tissue containing continuous epithelium
JP2020530839A (en) 2017-07-31 2020-10-29 バイオタイム インコーポレイテッド Compositions and Methods for Recovering or Preventing Visual Loss Caused by Disease or Traumatic Injury
DK3487988T3 (en) 2017-08-23 2020-02-03 Procella Therapeutics Ab USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE COLLECTOR FOR INSULATING HUMAN HEART VENTRICULAR STEM CELLS
CA3074426A1 (en) 2017-09-08 2019-03-14 Sumitomo Dainippon Pharma Co., Ltd. Cell aggregate including retinal tissue and production method therefor
JP7360583B2 (en) 2017-09-14 2023-10-13 国立研究開発法人理化学研究所 Method for manufacturing retinal tissue
CA3075883A1 (en) 2017-09-14 2019-03-21 Riken Method for amplifying cone photoreceptors or rod photoreceptors using dorsalization signal transmitter or ventralization signal transmitter
MA50578A (en) 2017-11-09 2021-09-15 Vertex Pharma CRISPR / CAS SYSTEMS FOR THE TREATMENT OF DMD
JP7271539B2 (en) 2017-11-14 2023-05-11 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Regulatory T cells genetically modified for the lymphotoxin alpha gene and uses thereof
WO2019103125A1 (en) 2017-11-24 2019-05-31 住友化学株式会社 Production method for cell mass including neural cells/tissue and non-neural epithelial tissue, and cell mass from same
CN111670043A (en) 2017-11-24 2020-09-15 国家医疗保健研究所 Methods and compositions for treating cancer
CN111386336A (en) 2017-11-24 2020-07-07 住友化学株式会社 Method for producing cell mass containing pituitary tissue and cell mass
CA3084825A1 (en) 2017-12-14 2019-06-20 Crispr Therapeutics Ag Novel rna-programmable endonuclease systems and their use in genome editing and other applications
EP4000568A1 (en) 2017-12-29 2022-05-25 Cell Cure Neurosciences Ltd. Retinal pigment epithelium cell compositions
JP7414530B2 (en) 2018-02-19 2024-01-16 住友ファーマ株式会社 Cell aggregates, mixtures of cell aggregates, and methods for producing them
EP3768834A1 (en) 2018-03-19 2021-01-27 CRISPR Therapeutics AG Novel rna-programmable endonuclease systems and uses thereof
US11401264B2 (en) 2018-03-30 2022-08-02 Orizuru Therapeutics, Inc. Heterocyclic compound
WO2019189554A1 (en) 2018-03-30 2019-10-03 国立大学法人京都大学 Cardiomyocyte maturation promoter
CA3097428A1 (en) 2018-04-20 2019-10-24 FUJIFILM Cellular Dynamics, Inc. Method for differentiation of ocular cells and use thereof
EP3788138A1 (en) 2018-05-02 2021-03-10 Novartis AG Regulators of human pluripotent stem cells and uses thereof
EP3572512A1 (en) 2018-05-24 2019-11-27 B.R.A.I.N. Ag A method for engineering a protein
EP3813861A4 (en) 2018-06-27 2022-08-10 Juvena Therapeutics, Inc. Heparin-associated polypeptides and uses thereof
JP7285015B2 (en) 2018-07-19 2023-06-01 国立大学法人京都大学 Lamellar cartilage derived from pluripotent stem cells and method for producing the same
EP3828262A4 (en) 2018-07-23 2022-03-30 Kyoto University Novel renal progenitor cell marker and method for concentrating renal progenitor cells using same
CN112703011A (en) 2018-08-06 2021-04-23 国家医疗保健研究所 Methods and compositions for treating cancer
CA3108275A1 (en) 2018-08-10 2020-02-13 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
EP3842527A4 (en) 2018-08-24 2022-05-18 Sumitomo Chemical Company Limited Cell aggregation including olfactory neuron or precursor cell thereof, and method for producing same
CA3112902A1 (en) 2018-09-28 2020-04-02 Otsuka Pharmaceutical Factory, Inc. Mammal cell preserving solution containing acarbose or stachyose
WO2020090903A1 (en) 2018-10-31 2020-05-07 国立大学法人京都大学 Method for producing pluripotent stem cell having released differentiation resistance to mesendoderm
WO2020100481A1 (en) 2018-11-15 2020-05-22 Jsr株式会社 Method for producing brain organoids
SG11202104401RA (en) 2018-11-19 2021-05-28 The United States Of America As Represented By The Secretary Biodegradable tissue replacement implant and its use
US20210380950A1 (en) 2018-11-28 2021-12-09 Milica Radisic Methods for tissue generation
CN113207297A (en) 2018-12-20 2021-08-03 住友化学株式会社 Cell population comprising embryo-type erythroblasts, method for producing same, cell culture composition, and method for testing compound
EP3900787A4 (en) 2018-12-21 2022-02-23 Kyoto University Lubricin-localized cartilage-like tissue, method for producing same and composition comprising same for treating articular cartilage damage
EP3903789A4 (en) 2018-12-28 2022-10-05 Riken Therapeutic drug for disease accompanied by disorders in retinal system cells or retinal tissue
EP3914698A1 (en) 2019-01-23 2021-12-01 Yeda Research and Development Co. Ltd Culture media for pluripotent stem cells
EP3923718A1 (en) 2019-02-13 2021-12-22 TiGenix, S.A.U. Cryopreservation of stem cells
SG11202108114YA (en) 2019-02-27 2021-08-30 Tigenix S A U Improved stem cell populations for allogeneic therapy
GB2595606B (en) 2019-03-07 2022-09-21 Univ California CRISPR-Cas effector polypeptides and methods of use thereof
WO2020209959A1 (en) 2019-03-08 2020-10-15 Crispr Therapeutics Ag Nucleobase-editing fusion protein systems, compositions, and uses thereof
AU2020239225A1 (en) 2019-03-12 2021-09-30 Bayer Healthcare Llc Novel high fidelity RNA-programmable endonuclease systems and uses thereof
CA3132804A1 (en) 2019-03-13 2020-09-17 Sumitomo Dainippon Pharma Co., Ltd. Method for evaluating quality of transplant neural retina, and transplant neural retina sheet
EP3950953A4 (en) 2019-03-29 2023-04-19 Public University Corporation Yokohama City University Screening method and toxicity evaluation method
EP3957366A4 (en) 2019-04-26 2023-01-04 Riken Composite including neural retina, retinal pigment epithelial cells, and hydrogel, and method for producing same
TW202106870A (en) 2019-04-26 2021-02-16 日商大塚製藥工場股份有限公司 Trehalose-containing liquid for mammalian cell preservation
US20210047649A1 (en) 2019-05-08 2021-02-18 Vertex Pharmaceuticals Incorporated Crispr/cas all-in-two vector systems for treatment of dmd
KR20220007879A (en) 2019-05-09 2022-01-19 후지필름 셀룰러 다이내믹스, 인코포레이티드 How to generate hepatocytes
JP2022533591A (en) 2019-05-14 2022-07-25 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Regulatory T cells targeted by lymphotoxin alpha blockers and their uses
EP3973049A1 (en) 2019-05-22 2022-03-30 Hadasit Medical Research Services and Development Ltd. Methods of culturing human pluripotent cells
EP3754014A1 (en) 2019-06-21 2020-12-23 Centre d'Etude des Cellules Souches (CECS) Automated method for preparing retinal pigment epithelium cells
EP3990624A1 (en) 2019-06-25 2022-05-04 Vertex Pharmaceuticals Incorporated Enhanced differentiation of beta cells
JP7385244B2 (en) 2019-06-27 2023-11-22 国立大学法人 東京大学 Method for isolating pancreatic progenitor cells
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
WO2021030424A1 (en) 2019-08-13 2021-02-18 Semma Therapeutics, Inc. Pancreatic differentiation
WO2021045217A1 (en) 2019-09-06 2021-03-11 学校法人慶應義塾 Method for producing cell aggregate including glial progenitor cells
US20240083973A1 (en) 2019-10-09 2024-03-14 Ecole Normale Supérieure de Lyon T cells modified to express mutated cxcr4 or partially deleted and uses thereof
CN115003156A (en) 2019-11-20 2022-09-02 住友制药株式会社 Method for freezing cell aggregates
WO2021100829A1 (en) 2019-11-20 2021-05-27 大日本住友製薬株式会社 Method for freezing neural cells
WO2021106832A1 (en) 2019-11-25 2021-06-03 国立大学法人京都大学 T-cell master cell bank
JP2023504013A (en) 2019-11-29 2023-02-01 ノヴァディップ バイオサイエンシズ Biomaterials for prevention and treatment of tissue damage
CN114929243A (en) 2019-11-29 2022-08-19 诺瓦迪普生物科学股份公司 Pharmaceutical composition based on miRNA and use thereof for preventing and treating tissue pathologies
US20230030814A1 (en) 2019-12-12 2023-02-02 National University Corporation Chiba University Freeze-Dried Preparations Comprising Megakaryocytes and Platelets
EP3875581A1 (en) 2020-03-02 2021-09-08 Centre d'Etude des Cellules Souches (CECS) Automated method for preparing keratinocytes
EP3875580A1 (en) 2020-03-02 2021-09-08 Centre d'Etude des Cellules Souches (CECS) Methods for preparing keratinocytes
BR112022018101A2 (en) 2020-03-13 2022-11-22 Goliver Therapeutics LIVER STEM-TYPE CELLS FOR TREATMENT AND/OR PREVENTION OF FULLMINANT LIVER DISORDERS
US20230136878A1 (en) 2020-03-19 2023-05-04 Orizuru Therapeutics, Inc. Cardiomyocyte purification method
EP4123016A1 (en) 2020-03-19 2023-01-25 Orizuru Therapeutics, Inc. Method for purifying cardiomyocytes
EP4132479A1 (en) 2020-04-07 2023-02-15 Ramot at Tel-Aviv University Ltd. Cannabidiol-containing compositions and uses thereof
EP4157865A1 (en) 2020-05-29 2023-04-05 FUJIFILM Cellular Dynamics, Inc. Bilayer of retinal pigmented epithelium and photoreceptors and use thereof
JP2023528377A (en) 2020-05-29 2023-07-04 フジフィルム セルラー ダイナミクス,インコーポレイテッド Double cell aggregates of retinal pigment epithelium and photoreceptors and methods of use thereof
WO2021250058A2 (en) 2020-06-12 2021-12-16 Bayer Aktiengesellschaft CRISPR-Cas12a DIRECTED RANDOM MUTAGENESIS AGENTS AND METHODS
EP4180516A4 (en) 2020-07-13 2024-01-17 Univ Kyoto Skeletal muscle precursor cells and method for purifying same, composition for treating myogenic diseases, and method for producing cell group containing skeletal muscle precursor cells
US20230310614A1 (en) 2020-09-11 2023-10-05 Sumitomo Pharma Co., Ltd. Medium for Tissue for Transplantation
WO2022054925A1 (en) 2020-09-11 2022-03-17 国立研究開発法人理化学研究所 Complex containing neural retina-containing cell aggregates and matrix, and method for manufacturing same
US20230332109A1 (en) 2020-09-24 2023-10-19 Institute Of Zoology, Chinese Academy Of Sciences Activated pluripotent stem cell, and preparation method therefor and use thereof
WO2022079322A1 (en) 2020-10-16 2022-04-21 Fundació Centre De Regulació Genòmica Therapy for degenerative disease and tissue damage
EP4005577A1 (en) 2020-11-26 2022-06-01 Novadip Biosciences Cellular and/or extracellular extracts for preventing and/or treating cancer and/or inflammation
CN112538458A (en) 2020-11-26 2021-03-23 北京赛尔湃腾科技咨询合伙企业(有限合伙) Method for reprogramming cells
WO2022138101A1 (en) 2020-12-23 2022-06-30 三井化学株式会社 Culture member and use thereof
EP4306634A1 (en) 2021-03-09 2024-01-17 Riken Method for producing hypoimmunogenic retinal pigment epithelial cells
WO2022207889A1 (en) 2021-04-01 2022-10-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Liver organoid manufacturing methods, liver organoids obtained with the same, and uses thereof
CA3213988A1 (en) 2021-04-07 2022-10-13 Christopher MCMAHON Dopaminergic precursor cells and methods of use
CA3216537A1 (en) 2021-04-11 2022-10-20 President And Fellows Of Harvard College Cardiomyocytes and compositions and methods for producing the same
CN117242173A (en) 2021-05-03 2023-12-15 安斯泰来再生医药协会 Method for producing mature corneal endothelial cells
CA3217861A1 (en) 2021-05-07 2022-11-10 Astellas Institute For Regenerative Medicine Methods of generating mature hepatocytes
WO2022251477A1 (en) 2021-05-28 2022-12-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Biodegradable tissue scaffold with secondary matrix to host weakly adherent cells
WO2022251499A1 (en) 2021-05-28 2022-12-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods to generate macular, central and peripheral retinal pigment epithelial cells
WO2022258511A1 (en) 2021-06-07 2022-12-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for generating highly functional hepatocytes by differentiating hepatoblasts
TW202303145A (en) 2021-06-09 2023-01-16 美商譜系細胞治療公司 Methods and compositions for treating retinal diseases and conditions
EP4101928A1 (en) 2021-06-11 2022-12-14 Bayer AG Type v rna programmable endonuclease systems
CA3222950A1 (en) 2021-06-11 2022-12-15 Bayer Aktiengesellschaft Type v rna programmable endonuclease systems
JPWO2022265086A1 (en) 2021-06-17 2022-12-22
IL310156A (en) 2021-07-28 2024-03-01 Lineage Cell Therapeutics Inc Expansion of retinal pigment epithelium cells
EP4144841A1 (en) 2021-09-07 2023-03-08 Bayer AG Novel small rna programmable endonuclease systems with impoved pam specificity and uses thereof
US20230078230A1 (en) 2021-09-13 2023-03-16 FUJIFILM Cellular Dynamics, Inc. Methods for the production of committed cardiac progenitor cells
WO2023049826A1 (en) 2021-09-23 2023-03-30 President And Fellows Of Harvard College Genetically encoded voltage indicators and uses thereof
US20230226116A1 (en) 2021-10-20 2023-07-20 University Of Rochester Method for rejuvenating glial progenitor cells and rejuvenated glial progenitor cells per se
WO2023069987A1 (en) 2021-10-20 2023-04-27 University Of Rochester Rejuvenation treatment of age-related white matter loss cross reference to related application
WO2023070019A1 (en) 2021-10-21 2023-04-27 Vertex Pharmaceuticals Incorporated Hypoimmune cells
WO2023077140A2 (en) 2021-11-01 2023-05-04 Vertex Pharmaceuticals Incorporated Stem cell derived pancreatic islet differentiation
WO2023095149A1 (en) 2021-11-29 2023-06-01 Ramot At Tel-Aviv University Ltd. Methods and compositions for treating spinal cord injury
WO2023118068A1 (en) 2021-12-23 2023-06-29 Bayer Aktiengesellschaft Novel small type v rna programmable endonuclease systems
WO2023167986A1 (en) 2022-03-02 2023-09-07 Lineage Cell Therapeutics, Inc. Methods and compositions for treating hearing loss
WO2023178239A1 (en) 2022-03-16 2023-09-21 The Children's Medical Center Corporation Hpsc-derived articular chondrocyte compositions, systems and methods of use thereof
US20230330264A1 (en) 2022-04-15 2023-10-19 Smartcella Solutions Ab COMPOSITIONS AND METHODS FOR EXOSOME-MEDIATED DELIVERY OF mRNA AGENTS
WO2023211857A1 (en) 2022-04-25 2023-11-02 Lineage Cell Therapeutics, Inc. Methods and compositions for treating vision loss
WO2023215455A1 (en) 2022-05-05 2023-11-09 University Of Rochester Dual macroglial-microglial approach towards therapeutic cell replacement in neurodegenerative and neuropsychiatric disease
WO2023230391A1 (en) 2022-05-26 2023-11-30 Tender Food, Inc. Plant-based shredded meat products, and methods of producing the same
WO2023237587A1 (en) 2022-06-10 2023-12-14 Bayer Aktiengesellschaft Novel small type v rna programmable endonuclease systems

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060078A (en) * 1960-12-02 1962-10-23 Burlington Industries Inc Bonding of polyethylene terephthalate fibers to certain rubbers
BE637575A (en) * 1962-09-21 1900-01-01
WO1990001541A1 (en) 1988-08-04 1990-02-22 Amrad Corporation Limited In vitro propagation of embryonic stem cells
US20030032178A1 (en) * 1988-08-04 2003-02-13 Williams Robert Lindsay In vitro propagation of embryonic stem cells
JP2750464B2 (en) * 1990-01-30 1998-05-13 日本ゼオン株式会社 Method for producing fiber-rubber composite
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5340740A (en) 1992-05-15 1994-08-23 North Carolina State University Method of producing an avian embryonic stem cell culture and the avian embryonic stem cell culture produced by the process
US5589376A (en) 1992-07-27 1996-12-31 California Institute Of Technology Mammalian neural crest stem cells
WO1994003585A1 (en) * 1992-08-04 1994-02-17 Commonwealth Scientific And Industrial Research Organisation A method for maintaining embryonic stem cells and avian factor useful for same
US5453357A (en) * 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5690926A (en) * 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US5591625A (en) * 1993-11-24 1997-01-07 Case Western Reserve University Transduced mesenchymal stem cells
US5449620A (en) * 1994-01-25 1995-09-12 Thomas Jefferson University Apparatus and method for culturing embryonic stem cells
US5541081A (en) * 1994-03-22 1996-07-30 President And Fellows Of Harvard College Process for assessing oocyte and embryo quality
JP3496292B2 (en) * 1994-09-30 2004-02-09 日本ゼオン株式会社 Composites of nitrile group-containing highly saturated copolymer rubber and fiber
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5654099A (en) * 1996-02-21 1997-08-05 Dayco Products, Inc. Method of improving adhesion between alkylated chlorosulfonated polyethylene (ACSM) or chlorosulfonated polyethylene (CSM), and resorcinol formaldehyde latex (RFL) treated polyester cord
CA2417356A1 (en) * 2000-08-01 2002-02-07 Yissum Research Development Company Directed differentiation of embryonic cells
US20070077654A1 (en) * 2004-11-01 2007-04-05 Thomson James A Platelets from stem cells

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7413902B2 (en) 1997-10-23 2008-08-19 Geron Corporation Feeder-free culture method for embryonic stem cells or primate primordial stem cells
US8637311B2 (en) 1998-10-23 2014-01-28 Asterias Biotherapeutics, Inc. Human embryonic stem cells genetically modified to contain a nucleic acid and cultured with fibroblast growth factor
US10059939B2 (en) 1998-10-23 2018-08-28 Asterias Biotherapeutics, Inc. Screening methods for human embryonic stem cells

Also Published As

Publication number Publication date
EP0770125A4 (en) 1998-01-14
US20150056698A1 (en) 2015-02-26
US5843780A (en) 1998-12-01
EP1640448A3 (en) 2006-04-26
US20090011503A1 (en) 2009-01-08
EP1640448A2 (en) 2006-03-29
WO1996022362A1 (en) 1996-07-25
US20030008392A1 (en) 2003-01-09
US7029913B2 (en) 2006-04-18
US20050164381A1 (en) 2005-07-28
US20060040383A1 (en) 2006-02-23
EP0770125A1 (en) 1997-05-02
US8273569B2 (en) 2012-09-25
US20110256623A1 (en) 2011-10-20
AU4758496A (en) 1996-08-07
US7582479B2 (en) 2009-09-01
US7781216B2 (en) 2010-08-24
CA2190528C (en) 2010-04-27
US20120328582A1 (en) 2012-12-27
US20010024825A1 (en) 2001-09-27
US20050158854A1 (en) 2005-07-21
US6200806B1 (en) 2001-03-13

Similar Documents

Publication Publication Date Title
CA2190528A1 (en) Primate embryonic stem cells
Suemori et al. Efficient establishment of human embryonic stem cell lines and long-term maintenance with stable karyotype by enzymatic bulk passage
Reubinoff et al. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro
Suemori et al. Establishment of embryonic stem cell lines from cynomolgus monkey blastocysts produced by IVF or ICSI
US6875607B1 (en) Embryonic stem cells
Baharvand et al. Neural differentiation from human embryonic stem cells in a defined adherent culture condition
Strelchenko et al. Morula-derived human embryonic stem cells
RU2007146777A (en) OBTAINING A LINE OF HUMAN EMBRYONIC STEM CELLS USING MAMMAL CELLS
RU2012144428A (en) PARTENOGENETIC ACTIVATION OF HUMAN OOCYTES TO OBTAIN HUMAN EMBRYONAL STEM CELLS
EP0363125A3 (en) Proliferated pancreatic endocrine cell product and process
Suemori et al. Establishment of the Embryo‐derived Stem (ES) Cell Lines from Mouse Blastocysts: Effects of the Feeder Cell Layer.
Pera Human pluripotent stem cells: a progress report
US5532156A (en) Hepatocyte cell line derived from the epiblast of pig blastocysts
Draper et al. Embryonic stem cells: advances toward potential therapeutic use
González et al. Establishment of mouse embryonic stem cells from isolated blastomeres and whole embryos using three derivation methods
WO2006036164A1 (en) Morula derived embryonic stem cells
Tian et al. Factors derived from mouse embryonic stem cells promote self-renewal of goat embryonic stem-like cells
Oshima et al. Murine embryonal carcinoma hybrids: decreased ability to spontaneously differentiate as a dominant trait
JP4317337B2 (en) Cell line passage enzyme solution and method for culturing and proliferating primate embryonic stem cells using the same
AU2003264611B2 (en) Embryonic stem cells
Tan et al. Derivation of embryonic stem cell line from frozen human embryos and neural differentiation
Amit et al. Human embryonic stem cells
Zhou et al. Establishment and maintenance of three Chinese human embryonic stem cell lines
Seshagiri et al. Reproductive Immunology SK Gupta (Ed) Copyright© 1999 Narosa Publishing House, New Delhi, India

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20160119