CA2191478A1 - Process for removing bile salts from a patient and alkylated compositions therefor - Google Patents

Process for removing bile salts from a patient and alkylated compositions therefor

Info

Publication number
CA2191478A1
CA2191478A1 CA002191478A CA2191478A CA2191478A1 CA 2191478 A1 CA2191478 A1 CA 2191478A1 CA 002191478 A CA002191478 A CA 002191478A CA 2191478 A CA2191478 A CA 2191478A CA 2191478 A1 CA2191478 A1 CA 2191478A1
Authority
CA
Canada
Prior art keywords
patient
reaction product
alkylating agent
bile salts
removing bile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002191478A
Other languages
French (fr)
Other versions
CA2191478C (en
Inventor
W. Harry Mandeville, Iii
Stephen Randall Holmes-Farley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valeant International Bermuda
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22980525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2191478(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2191478A1 publication Critical patent/CA2191478A1/en
Application granted granted Critical
Publication of CA2191478C publication Critical patent/CA2191478C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/02—Alkylation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/44—Preparation of metal salts or ammonium salts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/02—Homopolymers or copolymers of vinylamine

Abstract

A method for removing bile salts from a patient that includes administering to the patient a therapeutically effective amount of the reaction product of: a) one or more highly cross-linked polymers characterized by a repeat unit selected from the group consisting essentially of: (1), (2), (3): (NR-CH2 -CH2)n, (4): (NR-CH2CH2-NR-CH2CH2-NR-CH2CHOH-CH2)n and salts and copolymers thereof, where n is an integer and each R, independently, is H or a C1-C8 alkyl group; and b) at least one alkylating agent. The reaction product is characterized in that: (i) at least some of the nitrogen atoms in said repeat units are unreacted with said alkylating agent; (ii) less than 10 mol% of the nitrogen atoms in the repeat units that react with the alkylating agent form quaternary ammonium units; and (iii) the reaction product is non-toxic and stable once ingested.
CA002191478A 1994-06-10 1995-06-05 Process for removing bile salts from a patient and alkylated compositions therefor Expired - Lifetime CA2191478C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25843194A 1994-06-10 1994-06-10
US08/258,431 1994-06-10
PCT/US1995/007181 WO1995034585A1 (en) 1994-06-10 1995-06-05 Process for removing bile salts from a patient and alkylated compositions therefor

Publications (2)

Publication Number Publication Date
CA2191478A1 true CA2191478A1 (en) 1995-12-21
CA2191478C CA2191478C (en) 2007-10-16

Family

ID=22980525

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002191478A Expired - Lifetime CA2191478C (en) 1994-06-10 1995-06-05 Process for removing bile salts from a patient and alkylated compositions therefor

Country Status (21)

Country Link
US (12) US5679717A (en)
EP (2) EP0909768A3 (en)
JP (1) JP3931217B2 (en)
KR (1) KR100271693B1 (en)
CN (1) CN1150217C (en)
AT (1) ATE184027T1 (en)
AU (1) AU698752C (en)
CA (1) CA2191478C (en)
DE (3) DE122004000034I1 (en)
DK (1) DK0764174T3 (en)
ES (1) ES2135743T3 (en)
FR (1) FR04C0021I2 (en)
GR (1) GR3031702T3 (en)
IL (2) IL114073A (en)
LU (1) LU91100I2 (en)
MX (1) MX9606171A (en)
NL (1) NL300159I2 (en)
NZ (1) NZ288076A (en)
RU (1) RU2160742C2 (en)
TW (1) TW474813B (en)
WO (1) WO1995034585A1 (en)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5487888A (en) 1993-05-20 1996-01-30 Geltex, Inc. Iron-binding polymers for oral administration
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
US5925379A (en) * 1997-03-27 1999-07-20 Geltex Pharmaceuticals, Inc. Interpenetrating polymer networks for sequestration of bile acids
US6423754B1 (en) 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
US5985938A (en) * 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6566407B2 (en) 1997-11-05 2003-05-20 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6083497A (en) * 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
US6299868B1 (en) 1999-07-14 2001-10-09 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US7048917B1 (en) 1998-01-09 2006-05-23 Genzyme Corporation Fat-binding polymers
US6264937B1 (en) 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6267952B1 (en) 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
US6294163B1 (en) 1998-10-02 2001-09-25 Geltex Pharmaceuticals, Inc. Polymers containing guanidinium groups as bile acid sequestrants
TW568788B (en) * 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
JP4749649B2 (en) * 1998-10-12 2011-08-17 中外製薬株式会社 Phosphate-binding polymer
DE19850817A1 (en) 1998-11-04 2000-05-11 Basf Ag Modified cationic polymers, processes for their manufacture and their use in papermaking
US6271264B1 (en) 1998-12-01 2001-08-07 Geltex Pharmaceuticals, Inc. Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
WO2000063259A1 (en) 1999-04-16 2000-10-26 Abbott Laboratories Process for producing cross-linked polyallylamine hydrochloride
US6190649B1 (en) 1999-04-23 2001-02-20 Geltex Pharmaceuticals, Inc. Polyether-based bile acid sequestrants
EP1196181A1 (en) * 1999-07-14 2002-04-17 Geltex Pharmaceuticals, Inc. Fat-binding polymers, optionally combined with lipase inhibitors
US6180754B1 (en) 1999-09-03 2001-01-30 The Dow Chemical Company Process for producing cross-linked polyallylamine polymer
US6362266B1 (en) 1999-09-03 2002-03-26 The Dow Chemical Company Process for reducing cohesiveness of polyallylamine polymer gels during drying
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
RU2241462C2 (en) * 2000-07-28 2004-12-10 Ф. Хоффманн-Ля Рош Аг Novel pharmaceutical composition
AU2002232955A1 (en) 2000-11-20 2002-05-27 Dow Global Technologies Inc. In vivo use of water absorbent polymers
US8263112B2 (en) * 2000-11-20 2012-09-11 Sorbent Therapeutics, Inc. In vivo use of water absorbent polymers
CN1273144C (en) 2000-11-28 2006-09-06 三菱制药株式会社 Excretion accelerator for accumulative chlorine compound
AT409630B (en) * 2000-12-13 2002-09-25 Dsm Fine Chem Austria Gmbh ALKYLATION OF N-BZW. CROSSLINKED POLYMERS CONTAINING AMINO OR AMMONIUM GROUPS
US6710162B2 (en) * 2001-02-16 2004-03-23 Genzyme Corporation Method of drying a material having a cohesive phase
WO2002085380A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for treating gout and reducing serum uric acid
WO2002085378A1 (en) * 2001-04-18 2002-10-31 Genzyme Corporation Low salt forms of polyallylamine
EP1923064B1 (en) 2001-04-18 2017-06-28 Genzyme Corporation Use of amine polymer for lowering serum glucose
CA2444046C (en) * 2001-04-18 2011-06-07 Steven K. Burke Use of colesevelam in reducing serum glucose
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
CN1509180A (en) * 2001-04-18 2004-06-30 ԭ���ø� Method for treating syndrome X with aliphatic polyamines
US7049345B2 (en) * 2001-06-29 2006-05-23 Genzyme Corporation Fat-binding polymers
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US6600011B2 (en) 2001-10-09 2003-07-29 Genzyme Corporation Process for purification and drying of polymer hydrogels
AT414237B (en) * 2002-09-03 2006-10-15 Dsm Fine Chem Austria Gmbh Preparation of haloalkyl-ammonium salt, useful as alkylating agent, comprises reacting trimethylamine with dihaloalkane compound in presence of ethyl acetate, cooling the reaction mixture, filtering and drying the reaction mixture
AT411463B (en) 2002-09-03 2004-01-26 Dsm Fine Chem Austria Gmbh High yield production of alkylated nitrogen containing crosslinked polymer gels, e.g. epichlorohydrin crosslinked poly allylamine hydrochloride, comprises washing with methanol, sodium chloride and water
WO2004037274A1 (en) * 2002-10-22 2004-05-06 Genzyme Corporation Amine polymers for promoting bone formation
EP2319843B1 (en) 2003-05-30 2013-04-03 Ranbaxy Laboratories Limited Substituted pyrrole derivatives and their use as HMG-CO inhibitors
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7385012B2 (en) * 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
EP2335709A1 (en) 2004-03-26 2011-06-22 Mitsubishi Tanabe Pharma Corporation Insulin resistance improving agent
US7429394B2 (en) * 2004-03-30 2008-09-30 Relypsa, Inc. Ion binding compositions
US8282960B2 (en) * 2004-03-30 2012-10-09 Relypsa, Inc. Ion binding compositions
US8192758B2 (en) * 2004-03-30 2012-06-05 Relypsa, Inc. Ion binding compositions
US7854924B2 (en) * 2004-03-30 2010-12-21 Relypsa, Inc. Methods and compositions for treatment of ion imbalances
PL1732523T3 (en) * 2004-03-30 2010-08-31 Vifor Pharma Tech Ltd Potassium binding polymers and uses thereof
US7556799B2 (en) * 2004-03-30 2009-07-07 Relypsa, Inc. Ion binding polymers and uses thereof
JP2008510022A (en) * 2004-08-12 2008-04-03 ヴァーサマトリックス・アクティーゼルスカブ Bead-like cross-linked poly (aminoalkylene) matrix and use thereof
JP2008510860A (en) * 2004-08-27 2008-04-10 ヴァーサマトリックス・アクティーゼルスカブ High load functional resin
ATE410461T1 (en) * 2004-08-27 2008-10-15 Novo Nordisk As POLYETHER-POLYMER MATRIX
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
JP4547620B2 (en) * 2004-12-02 2010-09-22 日東紡績株式会社 Method for producing crosslinked allylamine polymers
MY144940A (en) * 2005-01-25 2011-11-30 Avantor Performance Mat Inc Chromatographic media
EP1869090A1 (en) * 2005-03-16 2007-12-26 Council Of Scientific And Industrial Research An improved process for the preparation of crosslinked polyallylamine polymer.
EP1951266A2 (en) 2005-09-02 2008-08-06 Genzyme Corporation Method for removing phosphate and polymer used therefore
AR056499A1 (en) * 2005-09-06 2007-10-10 Serapis Farmaceuticals Ltd COMPOUNDS
NZ566542A (en) 2005-09-15 2011-06-30 Genzyme Corp Sachet formulation for amine polymers
CN101321519A (en) * 2005-09-30 2008-12-10 伊立普萨公司 Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
DE112006002618T5 (en) * 2005-09-30 2008-08-28 Ilypsa Inc., Santa Clara Methods and compositions for selectively removing potassium ions from the mammalian gastrointestinal tract
BRPI0618379A2 (en) 2005-11-08 2011-08-30 Ranbaxy Lab Ltd (3r, 5r) -7- [2- (4-fluorophenyl) -5-isopropyl-3-phenyl-4 - [(4-hydroxymethylphenylamino) carbonyl] -pyrroleic acid 1-yl] -3,5-dihydroxy heptanoic
US20080085259A1 (en) * 2006-05-05 2008-04-10 Huval Chad C Amine condensation polymers as phosphate sequestrants
WO2007145308A1 (en) 2006-06-16 2007-12-21 Mitsubishi Tanabe Pharma Corporation Agent for prevention and/or treatment of glomerulopathy
FR2902799B1 (en) 2006-06-27 2012-10-26 Millipore Corp METHOD AND UNIT FOR PREPARING A SAMPLE FOR THE MICROBIOLOGICAL ANALYSIS OF A LIQUID
WO2008007376A2 (en) * 2006-07-13 2008-01-17 Association For Public Health Services Inoculation loop assembly
AU2007275711A1 (en) * 2006-07-18 2008-01-24 Genzyme Corporation Amine dendrimers
WO2008042222A2 (en) 2006-09-29 2008-04-10 Genzyme Corporation Amide dendrimer compositions
EP2120972A1 (en) 2006-12-14 2009-11-25 Genzyme Corporation Amido-amine polymer compositions
US8163886B2 (en) 2006-12-21 2012-04-24 Emd Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
EP2114376A1 (en) * 2007-02-23 2009-11-11 Genzyme Corporation Amine polymer compositions
WO2008109095A1 (en) * 2007-03-08 2008-09-12 Genzyme Corporation Sulfone polymer compositions
WO2008133954A1 (en) * 2007-04-27 2008-11-06 Genzyme Corporation Amido-amine dendrimer compositions
EP2016947A1 (en) * 2007-07-17 2009-01-21 Chemo Ibérica, S.A. Novel one step process for preparing cross-linked poly(allylamine) polymers
EP2217215A1 (en) * 2007-12-14 2010-08-18 Genzyme Corporation Coated pharmaceutical compositions
PA8807201A1 (en) * 2007-12-14 2009-07-23 Genzyme Corp PHARMACEUTICAL COMPOSITIONS
WO2009151514A1 (en) 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
US20110142952A1 (en) * 2008-06-20 2011-06-16 Harris David J Pharmaceutical Compositions
DE102008030046A1 (en) 2008-06-25 2009-12-31 Ratiopharm Gmbh Preparation of tablets comprising polyallylamine polymer, useful for treating e.g. hyperphosphatemia, comprises mixing polyallylamine polymer and additives, compacting to slug, granulating the slug and compressing the granules into tablets
US20100104527A1 (en) * 2008-08-22 2010-04-29 Relypsa, Inc. Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties
US8337824B2 (en) 2008-08-22 2012-12-25 Relypsa, Inc. Linear polyol stabilized polyfluoroacrylate compositions
MX364398B (en) * 2008-08-22 2019-04-24 Relypsa Inc Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia.
BRPI0918499A2 (en) 2008-09-02 2015-12-01 Usv Ltd cross-linked polymers
WO2010062734A1 (en) * 2008-11-03 2010-06-03 University Of Maryland, Baltimore Blood coagulation inducing polymer hydrogel
US8404784B2 (en) * 2008-12-03 2013-03-26 Navinta Llc Manufacturing process of making polymeric amine salts
EP2370561B1 (en) 2008-12-16 2019-08-07 EMD Millipore Corporation Stirred tank reactor and method
US8673272B2 (en) * 2009-07-27 2014-03-18 Isp Investments Inc. Ultraviolet-absorbing compounds
GB0915449D0 (en) * 2009-09-04 2009-10-07 Univ Robert Gordon Composition
WO2011106542A2 (en) 2010-02-24 2011-09-01 Relypsa, Inc. Crosslinked polyvrnylamine, poly all ylamine, and polyethyleneimine for use as bile acid sequestrants
CN107266681A (en) * 2010-02-24 2017-10-20 瑞立普萨公司 Amine polymer as bile acid sequestrant
ES2754210T3 (en) 2010-05-17 2020-04-16 Emd Millipore Corp Stimulus-sensitive polymers for biomolecule purification
TR201005327A2 (en) 2010-06-30 2012-01-23 Bi̇lgi̇ç Mahmut Synergistic pharmaceutical formulations.
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
PT2637646T (en) 2010-11-08 2016-08-17 Albireo Ab A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder
DK2637668T3 (en) 2010-11-08 2016-08-29 Albireo Ab Ibat inhibitors for the treatment of liver diseases
EA030839B1 (en) 2011-10-28 2018-10-31 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
US20130123433A1 (en) 2011-11-14 2013-05-16 Formosa Laboratories, Inc. Method for preparing poly(allylamine) hydrochloride and derivatives therefrom
WO2014058905A2 (en) 2012-10-08 2014-04-17 Relypsa, Inc. Potassium-binding agents for treating hypertension and hyperkalemia
ES2471340B1 (en) 2012-12-21 2015-08-17 Laboratorios Rubió, S.A. Oral pharmaceutical composition for high dosage drugs
US20160083343A1 (en) * 2013-03-15 2016-03-24 Global Blood Therapeutics, Inc Compounds and uses thereof for the modulation of hemoglobin
CN103446179B (en) * 2013-05-14 2017-03-15 厦门绿洲安源投资管理有限公司 The application of the tree-shaped crosslinking polycation gel of the poly- fullerene of parents of binding chelating agent as phosphate, aliphatic acid and bile acid
PT3578185T (en) 2013-06-05 2020-11-10 Tricida Inc Proton-binding polymers for oral administration
US9475891B2 (en) 2013-09-19 2016-10-25 Navinta, Llc Process for the preparation of colesevelam hydrochloride
WO2015075065A1 (en) 2013-11-20 2015-05-28 Sanovel Ilac Sanayi Ve Ticaret A.S. Tablet formulation of colesevelam
ITMI20132132A1 (en) 2013-12-19 2015-06-20 Chemi Spa PROCESS FOR THE PREPARATION OF COLESEVELAM
JP2017517550A (en) 2014-06-13 2017-06-29 ユナイテッド セラピューティクス コーポレイション Treprostinil preparation
PL3593808T3 (en) * 2014-12-10 2021-06-14 Tricida Inc. Proton-binding polymers for oral administration
EP3261624A1 (en) 2015-02-23 2018-01-03 Amneal Pharmaceuticals Company GmbH Process for granulating sevelamer carbonate
CN108431059B (en) 2015-10-21 2023-10-10 沙特阿拉伯石油公司 Cationic polymers and porous materials
US20190209607A1 (en) 2016-05-06 2019-07-11 Tricida, Inc. Compositions for treating acid-base disorders
CN106008813B (en) * 2016-06-15 2017-11-14 新发药业有限公司 The method that polymerisation in solution prepares colesevelam hydrocholoride
JP7418211B2 (en) 2016-12-14 2024-01-19 エコラブ ユーエスエイ インク Quaternary cationic polymer
CN107232191B (en) * 2017-06-22 2021-05-18 华中师范大学 Perfluorobutyl modified polyethyleneimine macromolecular fluorine-containing surfactant, preparation thereof and application thereof in pesticide slow release
EP3703706A4 (en) 2017-11-03 2022-04-27 Tricida Inc. Compositions for and method of treating acid-base disorders
US11427964B2 (en) 2018-06-12 2022-08-30 Ecolab Usa Inc. Quaternary cationic surfactants and polymers for use as release and coating modifying agents in creping and tissue papers
CN112047854B (en) * 2020-10-20 2021-07-02 中国科学院长春应用化学研究所 Preparation method of N-vinyl alkyl amide

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE580490A (en) * 1958-07-15 1960-01-08 Merck & Co Inc Compositions and methods for lowering the cholesterol content of the blood
US3308020A (en) * 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
US3383281A (en) * 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
US3288770A (en) * 1962-12-14 1966-11-29 Peninsular Chem Res Inc Water soluble quaternary ammonium polymers
BE756035A (en) * 1969-09-12 1971-03-11 Inveresk Res Int POLYMERS BRIDGES
US3803237A (en) * 1969-11-03 1974-04-09 Upjohn Co Reaction products of polyethylenepolyamines and chlorohydrins or epoxy containing compounds
NL7017227A (en) * 1969-12-27 1971-06-29
US3692895A (en) * 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
US3980770A (en) * 1971-06-04 1976-09-14 Pharmacia Aktiebolag Polymerization products containing amino groups useful in serum cholesterol level control
AR206390A1 (en) 1973-02-05 1976-07-23 Rohm & Haas A MATRIX OF RETICULATED POLYMER RESIN AND PROCEDURE FOR ITS PREPARATION
US4217429A (en) * 1973-06-11 1980-08-12 Merck & Co., Inc. Poly-[(methylimino)trimethylene]
US4205064A (en) * 1973-06-11 1980-05-27 Merck & Co., Inc. Bile acid sequestering composition containing poly[{alkyl-(3-ammoniopropyl)imino}-trimethylenedihalides]
US4027009A (en) * 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
CS187563B1 (en) * 1974-02-08 1979-02-28 Petr Strop Method of preparation of the hydrophilic homogeneous or macroporous annexes
CS173201B1 (en) * 1974-02-13 1977-02-28
US4016209A (en) * 1975-04-23 1977-04-05 Merck & Co., Inc. 3-[N'-(3-Halopropyl)-N-'-methylamino]-N,N,N-trimethyl-1-propanaminium halide and acid addition salts thereof
US4101478A (en) * 1976-04-12 1978-07-18 Kostjuchenko Vladimir Mitrofan Synthetic rubber mix
US4071478A (en) * 1976-06-07 1978-01-31 Merck & Co., Inc. Controlled partially cross-linked 3,3-ionenes
FI67483C (en) * 1977-02-17 1985-04-10 Merck & Co Inc PROCEDURE FOR THE FRAMEWORK OF ETHCYCLE ADMINISTRATION OF PHARMACOLOGICAL PRODUCT AGAINST GALLSYRAK COMPLEX BILDANDE ADSORBATE PREPARATION
US4298715A (en) * 1978-03-01 1981-11-03 Monsanto Company Polyamine/epihalohydrin reaction products
JPS5566513A (en) * 1978-11-14 1980-05-20 Ono Pharmaceut Co Ltd Drug for arteriosclerosis comprising high polymer compound as active constituent
IT1106718B (en) * 1978-12-21 1985-11-18 Alfa Farmaceutici Spa PHARMACOLOGICALLY ACTIVE SALONIZED ANIONIC RESIN BASED COMPOSITIONS
DE3272059D1 (en) * 1982-01-18 1986-08-28 Mitsubishi Petrochemical Co Cholesterol lowering drug
JPS6090243A (en) * 1983-10-25 1985-05-21 Nitto Boseki Co Ltd Small spherical crosslinked monoallylamine polymer and its preparation
JPS60106803A (en) * 1983-11-14 1985-06-12 Nitto Boseki Co Ltd Production of allylurea polymer
EP0142962A3 (en) * 1983-11-14 1986-01-15 Nitto Boseki Co., Ltd. Process for producing poly (allylamine) derivatives
US4540760A (en) * 1984-01-11 1985-09-10 Nitto Boseki Co. Ltd. Process for producing polymers of monoallylamine
EP0162388B1 (en) * 1984-05-11 1989-09-13 Bristol-Myers Company Novel bile sequestrant resin and uses
US4759923A (en) * 1987-06-25 1988-07-26 Hercules Incorporated Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
US5300566A (en) * 1988-04-15 1994-04-05 Air Products And Chemicals, Inc. Method for preparing poly(vinyl alcohol)-co-poly(vinylamine) via a two-phase process
DE3901527A1 (en) 1989-01-20 1990-07-26 Hoechst Ag ALKYLATED POLYETHYLENE IMIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND PHARMACEUTICAL PREPARATIONS
US5236701A (en) * 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
GB8928278D0 (en) * 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
GB9011332D0 (en) * 1990-05-21 1990-07-11 Smith Kline French Lab Compounds
IE914179A1 (en) * 1990-12-07 1992-06-17 Ici Plc Nitrogen derivatives
US5055197A (en) * 1991-04-05 1991-10-08 Rohm And Haas Company Process for removing residual monomers and oligemers from amine-containing polymers
US5142019A (en) * 1991-10-03 1992-08-25 Ppg Industries, Inc. Oligomers formed from reaction of acrylamidoglycolate alkyl ethers with β-hydroxyalkylamines
ATE159262T1 (en) * 1992-07-22 1997-11-15 Hoechst Ag POLYVINYLAMINE DERIVATIVES HAVING HYDROPHILIC CENTERS, METHOD FOR THE PRODUCTION THEREOF AND THE USE OF THE COMPOUNDS AS MEDICINAL PRODUCTS, ACTIVE CARRIERS AND FOOD ADDITIVES
ATE146193T1 (en) * 1992-07-22 1996-12-15 Hoechst Ag CROSS-LINKED, NITROGEN-CONTAINING VINYL COPOLYMERS, METHOD FOR THE PRODUCTION THEREOF AND THE USE OF THESE COMPOUNDS
JP3412842B2 (en) * 1992-07-28 2003-06-03 ミヨシ油脂株式会社 Metal collecting agent and method for producing the same
ATE168707T1 (en) * 1992-08-20 1998-08-15 Du Pont CROSS-LINKED POLYMERIC AMMONIUM SALTS
US5451397A (en) * 1992-12-21 1995-09-19 Rohm And Haas Company Bile acid sequestrant
US5607669A (en) 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5703188A (en) 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
EP0706399A4 (en) * 1993-06-02 1998-08-12 Geltex Pharma Inc Compositions and process for removing bile salts
US5624963A (en) 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5667775A (en) * 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5414068A (en) * 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient

Also Published As

Publication number Publication date
LU91100I2 (en) 2004-11-08
US5693675A (en) 1997-12-02
US6225355B1 (en) 2001-05-01
JP3931217B2 (en) 2007-06-13
IL114073A0 (en) 1995-10-31
US20020095002A1 (en) 2002-07-18
US5917007A (en) 1999-06-29
US5981693A (en) 1999-11-09
NL300159I2 (en) 2004-12-01
RU2160742C2 (en) 2000-12-20
US7399821B2 (en) 2008-07-15
ES2135743T3 (en) 1999-11-01
DE122004000034I1 (en) 2005-02-24
DE122004000034I2 (en) 2006-04-27
CN1150435A (en) 1997-05-21
FR04C0021I1 (en) 2007-10-26
EP0909768A2 (en) 1999-04-21
US5679717A (en) 1997-10-21
EP0764174B1 (en) 1999-09-01
US20010044519A1 (en) 2001-11-22
AU698752C (en) 2002-08-08
NL300159I1 (en) 2004-11-01
DK0764174T3 (en) 2000-03-27
US6066678A (en) 2000-05-23
US6784254B2 (en) 2004-08-31
JPH10501842A (en) 1998-02-17
LU91100I9 (en) 2019-01-29
US20090155201A1 (en) 2009-06-18
US7101960B2 (en) 2006-09-05
DE69511861D1 (en) 1999-10-07
DE69511861T2 (en) 2000-02-10
US20040014899A1 (en) 2004-01-22
KR100271693B1 (en) 2000-11-15
EP0909768A3 (en) 2001-01-17
AU698752B2 (en) 1998-11-05
AU2699095A (en) 1996-01-05
TW474813B (en) 2002-02-01
US6433026B2 (en) 2002-08-13
US20050131161A1 (en) 2005-06-16
CA2191478C (en) 2007-10-16
IL114073A (en) 2003-06-24
WO1995034585A1 (en) 1995-12-21
GR3031702T3 (en) 2000-02-29
NZ288076A (en) 1998-08-26
CN1150217C (en) 2004-05-19
IL142419A0 (en) 2002-03-10
FR04C0021I2 (en) 2008-05-16
ATE184027T1 (en) 1999-09-15
MX9606171A (en) 1998-07-31
EP0764174A1 (en) 1997-03-26
US20070155950A1 (en) 2007-07-05

Similar Documents

Publication Publication Date Title
CA2191478A1 (en) Process for removing bile salts from a patient and alkylated compositions therefor
RU96124807A (en) METHOD FOR REMOVAL OF HUMAN ACIDS SALTS FROM HUMAN ORGANISM AND ALKYLED COMPOSITIONS FOR THIS METHOD
MX9606172A (en) Cross-linked polymers for removing bile salts from a patient.
EP0835888A3 (en) Non-crosslinked anion exchange resin and pharmaceutical composition containing same
CA2294036A1 (en) Polyallylamine polymers for treating hypercholesterolemia
CA2103610A1 (en) Polypropylene composition and film thereof
CA2001710A1 (en) Preparation process for bioabsorbable polyester
DE59102512D1 (en) 2'-O-ALKYL NUCLEOTIDES AND POLYMERS CONTAINING SUCH NUCLEOTIDES.
MX9408969A (en) Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles.
ATE184294T1 (en) POLY-3-HYDROXYALKANOATES AND METHOD FOR THE PRODUCTION THEREOF
CA2349620A1 (en) Use of aliphatic polyamines for reducing oxalate
CA2171275A1 (en) Stilbene derivatives and pharmaceutical compositions containing them
MY109669A (en) N,o-sulphated heparosans, process for, preparing them and pharmaceutical compositions containing them
CA2061714A1 (en) Water soluble graft copolymers and methods of use thereof
FR2705673B1 (en) Compositions comprising amino acid derivatives, processes for their preparation and their uses.
EP1493770A3 (en) Ion-exchange polymers
EP0363960A3 (en) Acrylonitrile polymer film and process for preparing same
CA2106695A1 (en) Hyaluronic Acid and Forms to Prevent Arterial Restenosis

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20150605