CA2192915A1 - Electrospray and atmospheric pressure chemical ionization mass spectrometer and ion source - Google Patents

Electrospray and atmospheric pressure chemical ionization mass spectrometer and ion source

Info

Publication number
CA2192915A1
CA2192915A1 CA002192915A CA2192915A CA2192915A1 CA 2192915 A1 CA2192915 A1 CA 2192915A1 CA 002192915 A CA002192915 A CA 002192915A CA 2192915 A CA2192915 A CA 2192915A CA 2192915 A1 CA2192915 A1 CA 2192915A1
Authority
CA
Canada
Prior art keywords
electrospray
atmospheric pressure
apci
trajectory
pressure chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002192915A
Other languages
French (fr)
Other versions
CA2192915C (en
Inventor
Stevan Bajic
Roger Giles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10785376&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2192915(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of CA2192915A1 publication Critical patent/CA2192915A1/en
Application granted granted Critical
Publication of CA2192915C publication Critical patent/CA2192915C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/067—Ion lenses, apertures, skimmers

Abstract

The invention comprises Atmospheric Pressure Chemical Ionization (APCI) and electrospray ionization sources for the mass spectrometric analysis of solutions, and associated methods. The apparatus and methods are characterised in that ions generated by APCI or electrospray are directed such that their directions of travel immediately on formation can be resolved into two perpendicular components, one of which is aligned with a linear first trajectory which passes through an entrance orifice, an extraction chamber and into an evacuation port through which the extraction chamber is evacuated.
The direction of travel is such that the component of velocity so aligned is smaller than the component perpendicular to it. Ions leave the chamber along a second trajectory which is inclined at an angle between 30 and 150° to the linear first trajectory and may pass into a mass analyzer. The invention provides improved sensitivity and a lower noise level in comparison with prior apparatus and methods using APCI and electrospray ionization sources.
CA002192915A 1995-12-14 1996-12-13 Electrospray and atmospheric pressure chemical ionization mass spectrometer and ion source Expired - Lifetime CA2192915C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9525507.1 1995-12-14
GBGB9525507.1A GB9525507D0 (en) 1995-12-14 1995-12-14 Electrospray and atmospheric pressure chemical ionization mass spectrometer and ion source

Publications (2)

Publication Number Publication Date
CA2192915A1 true CA2192915A1 (en) 1997-06-15
CA2192915C CA2192915C (en) 2001-11-20

Family

ID=10785376

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002192915A Expired - Lifetime CA2192915C (en) 1995-12-14 1996-12-13 Electrospray and atmospheric pressure chemical ionization mass spectrometer and ion source

Country Status (5)

Country Link
US (1) US5756994A (en)
JP (1) JP3079055B2 (en)
CA (1) CA2192915C (en)
DE (1) DE19652021B4 (en)
GB (2) GB9525507D0 (en)

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Also Published As

Publication number Publication date
JP3079055B2 (en) 2000-08-21
CA2192915C (en) 2001-11-20
JPH09190795A (en) 1997-07-22
DE19652021B4 (en) 2006-12-14
DE19652021A1 (en) 1997-06-19
US5756994A (en) 1998-05-26
GB2308227B (en) 1999-11-24
GB2308227A (en) 1997-06-18
GB2308227B8 (en) 2005-09-05
GB9625995D0 (en) 1997-01-29
GB2308227A8 (en) 2005-09-05
GB9525507D0 (en) 1996-02-14

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