CA2195318A1 - Iron-containing nanoparticles with double coating and their use in diagnosis and therapy - Google Patents

Iron-containing nanoparticles with double coating and their use in diagnosis and therapy

Info

Publication number
CA2195318A1
CA2195318A1 CA002195318A CA2195318A CA2195318A1 CA 2195318 A1 CA2195318 A1 CA 2195318A1 CA 002195318 A CA002195318 A CA 002195318A CA 2195318 A CA2195318 A CA 2195318A CA 2195318 A1 CA2195318 A1 CA 2195318A1
Authority
CA
Canada
Prior art keywords
iron
diagnosis
therapy
polymer
containing nanoparticles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002195318A
Other languages
French (fr)
Other versions
CA2195318C (en
Inventor
Mayk Kresse
Detlev Pfefferer
Rudiger Lawaczek
Susanne Wagner
Wolfgang Ebert
Volker Elste
Wolfhard Semmler
Matthias Taupitz
Josef Gaida
Anja Herrmann
Monika Jukl
Udo Swiderski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Mayk Kresse
Detlev Pfefferer
Rudiger Lawaczek
Susanne Wagner
Wolfgang Ebert
Volker Elste
Wolfhard Semmler
Matthias Taupitz
Josef Gaida
Anja Herrmann
Monika Jukl
Udo Swiderski
Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayk Kresse, Detlev Pfefferer, Rudiger Lawaczek, Susanne Wagner, Wolfgang Ebert, Volker Elste, Wolfhard Semmler, Matthias Taupitz, Josef Gaida, Anja Herrmann, Monika Jukl, Udo Swiderski, Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin filed Critical Mayk Kresse
Publication of CA2195318A1 publication Critical patent/CA2195318A1/en
Application granted granted Critical
Publication of CA2195318C publication Critical patent/CA2195318C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1863—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1866—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle the nanoparticle having a (super)(para)magnetic core coated or functionalised with a peptide, e.g. protein, polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/12—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar
    • G01N2400/14—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar alpha-D-Glucans, i.e. having alpha 1,n (n=3,4,6) linkages between saccharide units, e.g. pullulan
    • G01N2400/22—Dextran
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/30—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form

Abstract

A nanoparticle compound is provided herein for use in diagnosis and therapy. The nanoparticle compound is an iron-containing core comprising iron material, namely magnetite or maghemite. A synthesis polymer coats the iron-containing core, the synthesis polymer being a dextran or a derivative of dextran. A targeting polymer is non-covalently bonded to, and envelopes, the synthesis polymer to form a second coating. In this way, the targeting polymer is not exposed to synthesis conditions.
CA002195318A 1994-08-04 1995-07-10 Iron-containing nanoparticles with double coating and their use in diagnosis and therapy Expired - Fee Related CA2195318C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4428851A DE4428851C2 (en) 1994-08-04 1994-08-04 Nanoparticles containing iron, their production and application in diagnostics and therapy
DEP4428851.4 1994-08-04
PCT/DE1995/000924 WO1996004017A1 (en) 1994-08-04 1995-07-10 Iron-containing nanoparticles with double coating and their use in diagnosis and therapy

Publications (2)

Publication Number Publication Date
CA2195318A1 true CA2195318A1 (en) 1996-02-15
CA2195318C CA2195318C (en) 2002-11-12

Family

ID=6525704

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002195318A Expired - Fee Related CA2195318C (en) 1994-08-04 1995-07-10 Iron-containing nanoparticles with double coating and their use in diagnosis and therapy

Country Status (13)

Country Link
US (3) US6048515A (en)
EP (1) EP0773796A1 (en)
JP (1) JPH10503496A (en)
KR (1) KR100278513B1 (en)
CN (1) CN1103604C (en)
AU (1) AU703042B2 (en)
CA (1) CA2195318C (en)
DE (1) DE4428851C2 (en)
HU (1) HUT77993A (en)
IL (1) IL114713A (en)
NO (1) NO314785B1 (en)
WO (1) WO1996004017A1 (en)
ZA (1) ZA956005B (en)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4428851C2 (en) * 1994-08-04 2000-05-04 Diagnostikforschung Inst Nanoparticles containing iron, their production and application in diagnostics and therapy
US5855868A (en) * 1996-04-01 1999-01-05 Nycomed Imaging As Method of T1 -weighted resonance imaging of RES organs
JP2000516131A (en) * 1996-08-05 2000-12-05 シエーリング アクチエンゲゼルシヤフト Method and apparatus for separating a magnetic material from a drug composition, its starting material or intermediate product, and a drug manufactured using this device
FR2753902B1 (en) * 1996-09-27 1999-04-02 Ioualalen Karim NEW TYPE OF BIODEGRADABLE ION MATRIX OF MODULATED INTERNAL POLARITY WITH GRAFT POLYMER
DE19652374A1 (en) * 1996-12-04 1998-06-10 Schering Ag Use of endothelin conjugates in therapy, new endothelin conjugates, agents containing them, and processes for their preparation
ATE250895T1 (en) * 1997-02-26 2003-10-15 Zeiss Carl Meditec Ag MARKER FOR DETERMINING ITS POSITION IN A CAVITY WITHIN THE ORGANISM OF A LIVING BEING
US6306166B1 (en) * 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
EP2360271A1 (en) * 1998-06-24 2011-08-24 Illumina, Inc. Decoding of array sensors with microspheres
US6470220B1 (en) * 1999-03-29 2002-10-22 The Regents Of The University Of California Diagnosis and treatment of cancers using in vivo magnetic domains
US7871597B2 (en) 1999-04-09 2011-01-18 Amag Pharmaceuticals, Inc. Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
WO2001037721A2 (en) * 1999-11-22 2001-05-31 The Research Foundation Of State University Of New York Magnetic nanoparticles for selective therapy
US6530944B2 (en) 2000-02-08 2003-03-11 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
US7179660B1 (en) 2000-03-06 2007-02-20 Dade Behring Marburg Gmbh Carriers coated with polysaccharides, their preparation and use
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
CA2406650C (en) * 2000-05-03 2009-07-21 Mbt Munich Biotechnology Ag Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
AU2001275078A1 (en) * 2000-06-01 2001-12-11 The Board Of Regents For Oklahoma State University Bioconjugates of nanoparticles as radiopharmaceuticals
US20050013775A1 (en) * 2000-06-01 2005-01-20 Kotov Nicholas A. Bioconjugates of nanoparticles as radiopharmaceuticals
US6690962B2 (en) * 2000-09-15 2004-02-10 Institut fur Diagnostikforshung GmbH Process for graphic visualization and diagnosis of thrombi by means of nuclear spin tomography with use of particulate contrast media
US8088358B2 (en) 2001-03-08 2012-01-03 Centrum Fur Angewandte Nanotechnologie (Can) Gmbh Paramagnetic nanoparticle
US7081489B2 (en) * 2001-08-09 2006-07-25 Florida State University Research Foundation Polymeric encapsulation of nanoparticles
DE10154016B4 (en) * 2001-10-26 2004-02-12 Berlin Heart Ag Magnetic fluid and process for its manufacture
EP1482956A1 (en) * 2002-02-01 2004-12-08 Vanderbilt University Targeted drug delivery methods
US20030185757A1 (en) * 2002-03-27 2003-10-02 Mayk Kresse Iron-containing nanoparticles with double coating and their use in diagnosis and therapy
US20030190475A1 (en) * 2002-04-09 2003-10-09 Everett Carpenter Magnetic nanoparticles having passivated metallic cores
US6962685B2 (en) * 2002-04-17 2005-11-08 International Business Machines Corporation Synthesis of magnetite nanoparticles and the process of forming Fe-based nanomaterials
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
AU2003259846A1 (en) * 2002-08-16 2004-03-03 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
US20040058457A1 (en) * 2002-08-29 2004-03-25 Xueying Huang Functionalized nanoparticles
US20050064508A1 (en) * 2003-09-22 2005-03-24 Semzyme Peptide mediated synthesis of metallic and magnetic materials
US6989196B2 (en) * 2002-10-02 2006-01-24 Florida State University Research Foundation Microencapsulation of magnetic material using heat stabilization
WO2004083902A2 (en) * 2002-10-25 2004-09-30 Georgia Tech Research Corporation Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
GB0227738D0 (en) * 2002-11-28 2003-01-08 Univ Liverpool Nanoparticle conjugates and method of production thereof
AU2003900335A0 (en) * 2003-01-22 2003-02-13 Sirtex Medical Limited Microparticles for selectively targeted hyperthermia
DE10331439B3 (en) * 2003-07-10 2005-02-03 Micromod Partikeltechnologie Gmbh Magnetic nanoparticles with improved magnetic properties
US7235228B2 (en) * 2003-04-15 2007-06-26 The United States Of America As Represented By The Secretary Of The Navy Fluorescent-magnetic nanoparticles with core-shell structure
US20070003975A1 (en) * 2003-05-02 2007-01-04 Canon Kabushiki Kaisha Structured construct and producing method therefor
KR100936269B1 (en) * 2003-06-07 2010-01-12 연세대학교 산학협력단 A ferrimagnetic-polymer particle and a process for the preparation thereof
US8651113B2 (en) * 2003-06-18 2014-02-18 Swr&D Inc. Magnetically responsive nanoparticle therapeutic constructs and methods of making and using
US7723311B2 (en) * 2003-06-18 2010-05-25 Nanobiomagnetics, Inc. Delivery of bioactive substances to target cells
US7344491B1 (en) 2003-11-26 2008-03-18 Nanobiomagnetics, Inc. Method and apparatus for improving hearing
WO2005002643A2 (en) * 2003-06-24 2005-01-13 Johns Hopkins University Method and products for delivering biological molecules to cells using multicomponent nanostructures
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
GB0316912D0 (en) 2003-07-18 2003-08-20 Oxford Instr Superconductivity Therapeutic treatment
US20050031544A1 (en) * 2003-08-07 2005-02-10 Njemanze Philip Chidi Receptor mediated nanoscale copolymer assemblies for diagnostic imaging and therapeutic management of hyperlipidemia and infectious diseases
WO2005019470A2 (en) * 2003-08-11 2005-03-03 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
DE10354361A1 (en) * 2003-11-20 2005-06-23 Eberhard-Karls-Universität Tübingen Device for insertion into body tissue for examination by nuclear spin resonance tomography, e.g. medical implant/instrument, has diamagnetic material provided at least occasionally to compensate for paramagnetic material magnetic properties
WO2005060610A2 (en) * 2003-12-11 2005-07-07 The Trustees Of Columbia University In The City Ofnew York Nano-sized particles, processes of making, compositions and uses thereof
US7795041B2 (en) * 2004-02-11 2010-09-14 Massachusetts Institute Of Technology Multi-polymer-coated magnetic nanoclusters
US8562505B2 (en) 2004-02-20 2013-10-22 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US9028829B2 (en) * 2004-02-20 2015-05-12 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US7846201B2 (en) * 2004-02-20 2010-12-07 The Children's Hospital Of Philadelphia Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex
DE102004010387A1 (en) * 2004-03-03 2005-09-22 Siemens Ag Contrast agent for X-ray computed tomography
JP2005296942A (en) * 2004-03-15 2005-10-27 Hitachi Maxell Ltd Magnetic composite particle and method for producing it
WO2005087367A1 (en) * 2004-03-15 2005-09-22 Hitachi Maxell, Ltd. Magnetic composite particle and process for producing the same
US7842281B2 (en) * 2004-05-10 2010-11-30 The Florida State University Research Foundation Magnetic particle composition for therapeutic hyperthermia
DE102004052533A1 (en) * 2004-10-15 2006-05-04 Mykhaylyk, Olga, Dr. Particles for use in diagnosis and therapy, especially for binding therapeutic agent for treating e.g. tumors and bacterial, rheumatic, neurologic and thrombotic diseases, have nanocrystalline magnetic core and envelope enclosing core
EP1805318B1 (en) 2004-10-27 2014-09-03 Cepheid Closed-system multi-stage nucleic acid amplification reactions
US7939267B2 (en) * 2004-11-04 2011-05-10 Laboratory Corporation Of America Holdings Detection of activation of endothelial cells as surrogate marker for angiogenesis
US20060140867A1 (en) * 2004-12-28 2006-06-29 Helfer Jeffrey L Coated stent assembly and coating materials
DE102005016873A1 (en) 2005-04-12 2006-10-19 Magforce Nanotechnologies Ag New nano-particle useful for production of composition to treatment and/or prophylaxis of proliferative illnesses, cancer and bacterial infections, where nano-particle is bonded therapeutic substance
WO2006113668A1 (en) * 2005-04-15 2006-10-26 University Of South Florida A method of transdermal drug delivery using hyaluronic acid nanoparticles
EP1721603A1 (en) * 2005-05-11 2006-11-15 Albert-Ludwigs-Universität Freiburg Nanoparticles for bioconjugation
WO2006125452A1 (en) * 2005-05-23 2006-11-30 Universite De Geneve Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant
US20060281104A1 (en) * 2005-06-13 2006-12-14 Macevicz Stephen C Leuco dye particles and uses thereof
KR100806669B1 (en) * 2005-06-23 2008-02-26 김정환 Nanoparticle-Biological Material Complex
WO2007002732A1 (en) * 2005-06-28 2007-01-04 Joslin Diabetes Center, Inc. Methods of imaging inflammation in pancreatic islets
US20070009436A1 (en) * 2005-07-08 2007-01-11 Rondinone Adam J Radionuclide nanoparticles encased by inorganic shell having vector biomolecules attached thereto
ATE522151T1 (en) * 2005-07-15 2011-09-15 Unilever Nv IRON REINFORCED FOOD AND ADDITIVE
CZ301067B6 (en) * 2006-02-24 2009-10-29 Ústav makromolekulární chemie AV CR Iron oxide-based superparamagnetic nanoparticles with modified surface, process of their preparation and use
CA2650021A1 (en) * 2006-04-21 2007-11-01 The Children's Hospital Of Philadelphia Magnetic gradient targeting and sequestering of therapeutic formulations and therapeutic systems thereof
JP5282031B2 (en) * 2006-05-15 2013-09-04 ドミトリィ ビー カーポティン Magnetic fine particles containing organic matter
KR100827292B1 (en) * 2006-05-30 2008-05-07 애니젠 주식회사 Nanoparticles Coated with Silicon-Containing Polymers and Their Use as Contrast Agents
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
US20080014285A1 (en) * 2006-07-13 2008-01-17 Di Mauro Thomas M Method of treating neurodegenerative brain disease with a composite comprising superparamagnetic nanoparticles and a therapeutic compound
US20090297626A1 (en) * 2006-11-03 2009-12-03 The Trustees Of Columbia University In The City Of New York Methods for preparing metal oxides
US8501159B2 (en) * 2006-12-18 2013-08-06 Colorobbia Italia S.P.A. Magnetic nanoparticles for the application in hyperthermia, preparation thereof and use in constructs having a pharmacological application
DE112008000881A5 (en) 2007-01-21 2010-01-21 Hemoteq Ag Medical device for the treatment of occlusions of body passages and for the prevention of imminent reocclusions
KR100809402B1 (en) * 2007-01-29 2008-03-05 김정환 Nanoparticle mark, diagnosis kit using the same and diagnosis method using the same
US20080255460A1 (en) * 2007-04-13 2008-10-16 Ethicon Endo-Surgery, Inc. Nanoparticle tissue based identification and illumination
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
EP2182924A1 (en) * 2007-07-26 2010-05-12 Nanoscan Imaging, Llc Methods for imaging using improved nanoparticulate contrast agents
EP2022508A1 (en) * 2007-08-07 2009-02-11 Charité-Universitätsmedizin Berlin Production of targeted MRI probes by biocompatible coupling of macromolecules with charged nanoparticles
KR101169029B1 (en) * 2007-09-06 2012-07-27 애니젠 주식회사 Multi-Functional Complex for Imaging and Drug Delivery
EP2211910B1 (en) * 2007-11-07 2017-11-01 University Of Houston Ultrasmall superparamagnetic iron oxide nanoparticles and uses thereof
US20090157069A1 (en) * 2007-12-06 2009-06-18 Curtis Tom Systems and methods for thermal treatment of body tissue
DE102008008522A1 (en) 2008-02-11 2009-08-13 Magforce Nanotechnologies Ag Implantable nanoparticle-containing products
JP2009256286A (en) * 2008-04-21 2009-11-05 Fujifilm Corp Polymer particle containing paramagnetic metal compound
US20100018674A1 (en) * 2008-07-22 2010-01-28 Donald John Enzinna Reservoir with moveable partition for quick recovery
WO2010102065A1 (en) 2009-03-05 2010-09-10 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives
US20120107229A1 (en) * 2009-04-15 2012-05-03 Xuefei Huang Novel nano-probes for molecular imaging and targeted therapy of diseases
US20100297745A1 (en) * 2009-05-19 2010-11-25 Nanyang Technological University Flow-through method of functionalizing inner surfaces of a microfluidic device
ES2550634T3 (en) 2009-07-10 2015-11-11 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
US10080821B2 (en) * 2009-07-17 2018-09-25 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US20110054236A1 (en) * 2009-08-25 2011-03-03 The Regents Of The University Of Michigan Compositions and methods for targeting tumors
ES2600229T3 (en) * 2009-11-12 2017-02-07 Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH Biocompatible magnetic nanoparticles for the treatment of glioblastomas
DE102009058769A1 (en) 2009-12-16 2011-06-22 MagForce Nanotechnologies AG, 10589 Temperature-dependent activation of catalytic nucleic acids for controlled drug release
US20110160645A1 (en) * 2009-12-31 2011-06-30 Boston Scientific Scimed, Inc. Cryo Activated Drug Delivery and Cutting Balloons
KR101057484B1 (en) * 2010-03-19 2011-08-17 강원대학교산학협력단 Oral imaging agent for imaging in small intestine
EP2611476B1 (en) 2010-09-02 2016-08-10 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US8815294B2 (en) 2010-09-03 2014-08-26 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives and a carrier material
US9744235B2 (en) 2010-10-19 2017-08-29 The Board Of Regents Of The University Of Oklahoma Treatment of cardiovascular disorders with targeted nanoparticles
US10398668B2 (en) 2010-10-19 2019-09-03 The Board Of Regents Of The University Of Oklahoma Glutamate treatment of cardiovascular disorders
US8740872B2 (en) 2010-10-19 2014-06-03 The Board Of Regents Of The University Of Oklahoma Magnetically-targeted treatment for cardiac disorders
KR101297815B1 (en) 2010-11-18 2013-09-03 충남대학교산학협력단 Optical Imaging Probe for Mapping Sentinel Lymp Node Containing Complex of Poly Gamma Glutamic Acid and Optical Imaging Dye
US8197471B1 (en) * 2011-02-14 2012-06-12 Samuel Harry Tersigni Core-excited nanoparticles and methods of their use in the diagnosis and treatment of disease
WO2012110835A2 (en) 2011-02-15 2012-08-23 Semmelweis Egyetem Prussian blue based nanoparticle as multimodal imaging contrast material
KR101398214B1 (en) * 2011-04-06 2014-05-23 주식회사 바이오리더스 Sensitive MRI Contrast Nano Agents Based Ionic Complex Containing Anionic and Cationic Polymer and Preparing Method Thereof
US9084727B2 (en) 2011-05-10 2015-07-21 Bend Research, Inc. Methods and compositions for maintaining active agents in intra-articular spaces
WO2013022458A1 (en) 2011-08-05 2013-02-14 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US9433699B2 (en) 2011-11-21 2016-09-06 Innotherapy Inc. Hydrogel comprising catechol group-coupled chitosan or polyamine and poloxamer comprising thiol group coupled to end thereof, preparation method thereof, and hemostat using same
EP2647389A1 (en) 2012-04-04 2013-10-09 Charité - Universitätsmedizin Berlin Magnetic nanoparticle dispersion, its preparation and diagnostic and therapeutic use
US8873041B1 (en) 2013-01-29 2014-10-28 Bayspec, Inc. Raman spectroscopy using multiple excitation wavelengths
WO2014132107A1 (en) * 2013-02-27 2014-09-04 Empire Technology Development Llc Preparation and use of magnetic polymer nanocomposites
EP2823858A1 (en) * 2013-07-12 2015-01-14 Brossel, Rémy System generating a constraint field, and medical device implementing the same
US20150064107A1 (en) * 2013-09-04 2015-03-05 King's College London Imaging agent
DE102014106603A1 (en) 2014-05-12 2015-11-12 Verein zur Förderung von Innovationen durch Forschung, Entwicklung und Technologietransfer e.V. (Verein INNOVENT e.V.) Method and apparatus for depleting circulating tumor cells from a cell suspension
US20170342383A1 (en) 2016-05-27 2017-11-30 Corning Incorporated Lithium disilicate glass-ceramic compositions and methods thereof
US10059621B2 (en) * 2016-05-27 2018-08-28 Corning Incorporated Magnetizable glass ceramic composition and methods thereof
WO2019108556A1 (en) 2017-11-28 2019-06-06 Corning Incorporated Bioactive glass compositions and dentin hypersensitivity remediation
EP3717427A1 (en) 2017-11-28 2020-10-07 Corning Incorporated High liquidus viscosity bioactive glass
EP3717426A1 (en) 2017-11-28 2020-10-07 Corning Incorporated Chemically strengthened bioactive glass-ceramics
WO2020174476A1 (en) * 2019-02-28 2020-09-03 Hadasit Medical Research Services And Development Ltd. Targeted magnetic vehicles and method of using the same
CN111330023B (en) * 2020-03-23 2023-01-31 中国科学院宁波材料技术与工程研究所慈溪生物医学工程研究所 Magnetic nano composite material and preparation method and application thereof
DE102020116859A1 (en) 2020-06-26 2021-12-30 Pharma Development Holding Gmbh Liposomes
CN112402389A (en) * 2020-11-24 2021-02-26 常州欧法玛制药技术有限公司 Zolpidem double-layer osmotic pump controlled release tablet and preparation method thereof
CN112870387B (en) * 2021-02-26 2023-08-29 中山大学孙逸仙纪念医院 Magnetic nano-drug carrier and preparation method and application thereof
WO2023245000A2 (en) * 2022-06-13 2023-12-21 Russell Van De Casteele Methods for processing, enrichment, delivery, formulation, uptake and testing for supplements and pharmaceuticals

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5913521B2 (en) * 1975-06-19 1984-03-30 メイトウサンギヨウ カブシキガイシヤ Method for producing magnetic iron oxide/dextran complex
US4247406A (en) * 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
US4323056A (en) * 1980-05-19 1982-04-06 Corning Glass Works Radio frequency induced hyperthermia for tumor therapy
EP0093757A1 (en) * 1981-11-12 1983-11-16 Ulf SCHRÖDER Intravascularly administrable, magnetically responsive nanosphere or nanoparticle, a process for the production thereof, and the use thereof
SE8201972L (en) * 1982-03-29 1983-09-30 Gambro Lundia Ab MAGNETIC PORTABLE CRYSTALLIZED CARBOHYDRATED SPHERES OR PARTICLES TO BE USED TOGETHER WITH BIODOUS PREPARING MATERIALS
US4731239A (en) * 1983-01-10 1988-03-15 Gordon Robert T Method for enhancing NMR imaging; and diagnostic use
US4735796A (en) * 1983-12-08 1988-04-05 Gordon Robert T Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
JPS59195161A (en) * 1983-04-21 1984-11-06 Fujirebio Inc Magnetic particle and its production
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US5720939A (en) * 1985-08-15 1998-02-24 Nycomed Imaging As Method of contrast enhanced magnetic resonance imaging using magnetically responsive-particles
US4788281A (en) * 1984-01-04 1988-11-29 Tosoni Anthony L Dextran hexonic acid derivative, ferric hydroxide complex and method manufacture thereof
GB8408127D0 (en) * 1984-03-29 1984-05-10 Nyegaard & Co As Contrast agents
JPS60260463A (en) * 1984-06-01 1985-12-23 松下電器産業株式会社 Manufacture of high density oxide sintered body
SE454885B (en) * 1984-10-19 1988-06-06 Exploaterings Ab Tbf POLYMER COATED PARTICLES WITH IMMOBILIZED METAL ZONES IN ITS SURFACE PROCEDURES FOR PRODUCING THEREOF
EP0184899B1 (en) * 1984-11-01 1990-04-18 Nycomed As Paramagnetic contrast agents for use in "in vivo" diagnostic methods using nmr, and their preparation
JPH07100666B2 (en) * 1986-04-07 1995-11-01 フランスワ ディエトラン Contrast agent for density tomography
US5679323A (en) * 1986-07-03 1997-10-21 Advanced Magnetics, Inc. Hepatocyte-specific receptor-mediated endocytosis-type compositions
US4827945A (en) * 1986-07-03 1989-05-09 Advanced Magnetics, Incorporated Biologically degradable superparamagnetic materials for use in clinical applications
US4770183A (en) * 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
US5352432A (en) * 1986-07-03 1994-10-04 Advanced Magnetics, Inc. Hepatocyte specific composition and their use as diagnostic imaging agents
US5262176A (en) * 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
DE3709851A1 (en) * 1987-03-24 1988-10-06 Silica Gel Gmbh Adsorptions Te NMR DIAGNOSTIC LIQUID COMPOSITIONS
DE3729697A1 (en) * 1987-09-04 1989-03-23 Siemens Ag Process for producing pressable granular material (granulate) for the manufacture of oxide ceramic products, in particular manganese-zinc ferrites
US5395688A (en) * 1987-10-26 1995-03-07 Baxter Diagnostics Inc. Magnetically responsive fluorescent polymer particles
WO1990001295A1 (en) * 1988-08-04 1990-02-22 Advanced Magnetics, Incorporated Receptor mediated endocytosis type mri contrast agents
JPH0678247B2 (en) * 1988-10-04 1994-10-05 大塚製薬株式会社 Iron-containing preparation for NMR contrast
US5612019A (en) * 1988-12-19 1997-03-18 Gordon, Deceased; David Diagnosis and treatment of HIV viral infection using magnetic metal transferrin particles
US5393525A (en) * 1989-07-21 1995-02-28 Nycomed Imaging As Contrast medium comprising superparamagnetic or ferromagnetic particles capable of increasing viscosity after administration
JP2726520B2 (en) * 1989-10-20 1998-03-11 名糖産業株式会社 Organic magnetic composite
US5389377A (en) * 1989-12-22 1995-02-14 Molecular Bioquest, Inc. Solid care therapeutic compositions and methods for making same
US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
IL98744A0 (en) * 1990-07-06 1992-07-15 Gen Hospital Corp Method of studying biological tissue using monocrystalline particles
CA2078679C (en) * 1991-01-19 2006-12-05 Kyoji Kito Magnetic metal oxide ultrafine particles-containing composition
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
DE4117782C2 (en) * 1991-05-28 1997-07-17 Diagnostikforschung Inst Nanocrystalline magnetic iron oxide particles, processes for their production and diagnostic and / or therapeutic agents
US5424419A (en) * 1991-06-11 1995-06-13 Meito Sangyo Kabushiki Kaisha Oxidized complex comprising water-soluble carboxypolysaccharide and magnetic iron oxide
JP3189154B2 (en) * 1991-07-18 2001-07-16 東ソー株式会社 Method for producing carrier for immunoassay
JPH08500700A (en) * 1992-06-08 1996-01-23 バイオクエスト インコーポレイテッド Manufacture of controlled particle size inorganic particles for use as inorganic liposomes for separations, magnetic molecular switches, and medical applications
EP0656368B2 (en) * 1992-08-05 2003-06-04 Meito Sangyo Kabushiki Kaisha Small-diameter composite composed of water-soluble carboxypolysaccharide and magnetic iron oxide
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
US5349957A (en) * 1992-12-02 1994-09-27 Sterling Winthrop Inc. Preparation and magnetic properties of very small magnetite-dextran particles
DE4301871A1 (en) * 1993-01-13 1994-07-14 Diagnostikforschung Inst New means of diagnosing vascular diseases
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
EP0634174A1 (en) * 1993-07-13 1995-01-18 Takeda Chemical Industries, Ltd. Antianemic composition for veterinary use
US5411730A (en) * 1993-07-20 1995-05-02 Research Corporation Technologies, Inc. Magnetic microparticles
DE4428851C2 (en) * 1994-08-04 2000-05-04 Diagnostikforschung Inst Nanoparticles containing iron, their production and application in diagnostics and therapy

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