CA2201332A1 - Flow cytometer jet monitor system - Google Patents

Flow cytometer jet monitor system

Info

Publication number
CA2201332A1
CA2201332A1 CA002201332A CA2201332A CA2201332A1 CA 2201332 A1 CA2201332 A1 CA 2201332A1 CA 002201332 A CA002201332 A CA 002201332A CA 2201332 A CA2201332 A CA 2201332A CA 2201332 A1 CA2201332 A1 CA 2201332A1
Authority
CA
Canada
Prior art keywords
jet
monitor
substance
flow cytometer
wavelength band
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002201332A
Other languages
French (fr)
Other versions
CA2201332C (en
Inventor
Ger Van Den Engh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
Ger Van Den Engh
University Of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ger Van Den Engh, University Of Washington filed Critical Ger Van Den Engh
Publication of CA2201332A1 publication Critical patent/CA2201332A1/en
Application granted granted Critical
Publication of CA2201332C publication Critical patent/CA2201332C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
    • G01N15/149—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
    • G01N2015/1406—Control of droplet point

Abstract

A direct jet monitor (66) illuminates the jet of a flow cytometer in a monitor wavelength band which is substantially separate from the substance wavelength band.
When a laser is used to cause fluorescence of the substance, it may be appropriate to use an infrared source (67) to illuminate the jet and thus optically monitor the conditions within the jet through a CCD camera (68) or the like. This optical monitoring may be provided to some type of controller or feedback system (34) which automatically changes either the horizontal location of the jet, the point at which droplet separation occurs, or some other condition within the jet in order to maintain optimum conditions. The direct jet monitor (66) may be operated simultaneously with the substance property sensing and analysis system so that continuous monitoring may be achieved without interfering with the substance data gathering and may be configured so as to allow the front of the analysis or free fall area (7) to be unobstructed during processing.
CA002201332A 1994-10-14 1995-10-13 Flow cytometer jet monitor system Expired - Lifetime CA2201332C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/323,352 1994-10-14
US08/323,352 US5602039A (en) 1994-10-14 1994-10-14 Flow cytometer jet monitor system
PCT/US1995/013502 WO1996012172A1 (en) 1994-10-14 1995-10-13 Flow cytometer jet monitor system

Publications (2)

Publication Number Publication Date
CA2201332A1 true CA2201332A1 (en) 1996-04-25
CA2201332C CA2201332C (en) 2006-07-04

Family

ID=23258849

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002201332A Expired - Lifetime CA2201332C (en) 1994-10-14 1995-10-13 Flow cytometer jet monitor system

Country Status (8)

Country Link
US (1) US5602039A (en)
EP (1) EP0786079B1 (en)
JP (1) JPH10507525A (en)
AU (1) AU691693B2 (en)
CA (1) CA2201332C (en)
DE (1) DE69530851T2 (en)
ES (1) ES2196086T3 (en)
WO (1) WO1996012172A1 (en)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19549015C1 (en) * 1995-12-28 1997-04-03 Siemens Ag Method of monitoring precise location at which fluid stream breaks up into droplets
CA2279574C (en) 1997-01-31 2007-07-24 The Horticulture & Food Research Institute Of New Zealand Ltd. Optical apparatus
JP2001518624A (en) 1997-09-26 2001-10-16 ユニバーシティ・オブ・ワシントン Simultaneous particle separation and chemical reactions
US6149867A (en) * 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) * 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6746873B1 (en) 1998-02-20 2004-06-08 Xy, Inc. Vibratory system for a sorting flow cytometer
CA2321075C (en) 1998-02-20 2009-10-06 Cytomation, Inc. A vibratory system for a sorting flow cytometer
US6211477B1 (en) 1998-02-26 2001-04-03 Becton Dickinson And Company Electrostatic deceleration system for flow cytometer
US6248590B1 (en) 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
JP4215397B2 (en) * 1998-05-14 2009-01-28 ルミネックス コーポレイション Multiple analyte diagnostic system
PT1917974E (en) 1998-07-30 2011-02-22 Xy Llc Equine system for non-surgical artificial insemination
US6110427A (en) * 1998-08-14 2000-08-29 Becton, Dickinson And Company Flow regulator to maintain controllable volumetric flow rate
US6372506B1 (en) 1999-07-02 2002-04-16 Becton, Dickinson And Company Apparatus and method for verifying drop delay in a flow cytometer
US6813017B1 (en) 1999-10-20 2004-11-02 Becton, Dickinson And Company Apparatus and method employing incoherent light emitting semiconductor devices as particle detection light sources in a flow cytometer
US7024316B1 (en) * 1999-10-21 2006-04-04 Dakocytomation Colorado, Inc. Transiently dynamic flow cytometer analysis system
US7208265B1 (en) * 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US6263745B1 (en) 1999-12-03 2001-07-24 Xy, Inc. Flow cytometer nozzle and flow cytometer sample handling methods
BR0110731A (en) 2000-05-09 2004-04-27 Xy Inc High purity x-chromosome and y-chromosome populations
US6809804B1 (en) 2000-05-11 2004-10-26 Becton, Dickinson And Company System and method for providing improved event reading and data processing capabilities in a flow cytometer
US20040031071A1 (en) * 2000-10-05 2004-02-12 Xy, Inc. System of hysteroscopic insemination of mares
AU3768902A (en) 2000-11-29 2002-06-11 Xy Inc System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
KR20020065192A (en) * 2001-02-06 2002-08-13 주식회사 디지털 피봇 Method for controlling droplet size and system for controlling the same
US7012689B2 (en) 2001-05-17 2006-03-14 Dako Colorado, Inc. Flow cytometer with active automated optical alignment system
US7345758B2 (en) 2001-05-17 2008-03-18 Cytopeia Apparatus for analyzing and sorting biological particles
US20030211009A1 (en) * 2001-05-18 2003-11-13 Buchanan Kris S. Rapid multi-material sample input system
US6976590B2 (en) 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US7362424B2 (en) * 2002-04-24 2008-04-22 The Institute For Systems Biology Compositions and methods for drop boundary detection and radiation beam alignment
MXPA05000865A (en) * 2002-07-22 2005-04-28 Xy Inc Sperm cell process system.
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
AU2003265362B2 (en) * 2002-08-01 2009-11-05 Xy, Llc. Low pressure sperm cell separation system
AU2003265471B2 (en) * 2002-08-15 2009-08-06 Xy, Llc. High resolution flow cytometer
DE10241545A1 (en) * 2002-09-05 2004-03-25 Gkss-Forschungszentrum Geesthacht Gmbh Device for converting a continuous flow of liquid into a flow of liquid droplets
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US7201875B2 (en) * 2002-09-27 2007-04-10 Becton Dickinson And Company Fixed mounted sorting cuvette with user replaceable nozzle
US6941005B2 (en) * 2002-11-01 2005-09-06 Coulter International Corp. Monitoring and control of droplet sorting
EP1587540B1 (en) 2003-01-09 2021-09-15 MacroGenics, Inc. IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME
DK2308417T3 (en) 2003-03-28 2016-07-04 Inguran Llc Apparatus and methods for obtaining sorted particles
AU2004242121B2 (en) 2003-05-15 2010-06-24 Xy, Llc. Efficient haploid cell sorting for flow cytometer systems
EP2801363B1 (en) 2004-03-29 2018-02-21 Inguran, LLC Process for storing sorted spermatozoa
CA2574499C (en) 2004-07-22 2016-11-29 Monsanto Technology Llc Process for enriching a population of sperm cells
PT1771729E (en) * 2004-07-27 2015-12-31 Beckman Coulter Inc Enhancing flow cytometry discrimination with geometric transformation
AU2006236439B2 (en) 2005-04-15 2012-05-03 Macrogenics, Inc. Covalent diabodies and uses thereof
US7618770B2 (en) * 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
LT2573114T (en) 2005-08-10 2016-10-10 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
WO2007022641A1 (en) 2005-08-25 2007-03-01 Institut National D'optique Flow cytometry analysis across optical fiber
US7324724B2 (en) * 2005-10-21 2008-01-29 Institut National D'optique Optical fiber devices using component insertion
WO2007127936A2 (en) 2006-04-27 2007-11-08 Pikamab, Inc. Methods and compositions for antibody therapy
JP5718637B2 (en) 2007-06-21 2015-05-13 マクロジェニクス，インコーポレーテッド Covalently bonded diabody and its use
CN102046655B (en) 2008-04-02 2016-09-14 宏观基因有限公司 BCR-complex-specific antibody and its using method
MX2010010737A (en) 2008-04-02 2010-12-20 Macrogenics Inc Her2/neu-specific antibodies and methods of using same.
CA2726845C (en) 2008-06-04 2017-09-26 Macrogenics, Inc. Antibodies with altered binding to fcrn and methods of using same
PL2786762T3 (en) 2008-12-19 2019-09-30 Macrogenics, Inc. Covalent diabodies and uses thereof
ES2945686T3 (en) 2009-05-13 2023-07-05 Sartorius Bioanalytical Instr Inc Flow measurement and control for enhanced particle quantification in flow cytometry
JP5446563B2 (en) 2009-08-06 2014-03-19 ソニー株式会社 Fine particle sorting device and flow cytometer using the fine particle sorting device
US8589851B2 (en) * 2009-12-15 2013-11-19 Memoir Systems, Inc. Intelligent memory system compiler
EP2526401A4 (en) 2010-01-18 2015-04-22 Handyem Inc Flow cytometry analysis across optical fiber
ITTO20100651A1 (en) 2010-07-28 2012-01-29 Ist Sperimentale It Lazzaro Spallanza PROCEDURE AND EQUIPMENT FOR THE CHARACTERIZATION AND SEPARATION OF SPERMFERCEE WITH SUSPENDED LEVER MICROMETRIC SENSORS
MX339622B (en) 2010-08-02 2016-06-02 Macrogenics Inc Covalent diabodies and uses thereof.
KR20130096731A (en) 2010-09-08 2013-08-30 할로자임, 아이엔씨 Methods for assessing and identifying or evolving conditionally active therapeutic proteins
MX352929B (en) 2010-11-05 2017-12-13 Zymeworks Inc Stable heterodimeric antibody design with mutations in the fc domain.
JP6145088B2 (en) 2011-05-21 2017-06-07 マクロジェニクス，インコーポレーテッド Deimmunized serum binding domain and its use to extend serum half-life
US20140220621A1 (en) * 2011-08-25 2014-08-07 Sony Corporation Of America Characterization of motion-related error in a stream of moving micro-entities
RU2675319C2 (en) 2011-11-04 2018-12-18 Займворкс Инк. STABLE HETERODIMERIC ANTIBODY DESIGN WITH MUTATIONS IN Fc DOMAIN
JP5601424B2 (en) 2012-03-30 2014-10-08 ソニー株式会社 Microparticle sorting apparatus and fluid stream optimization method in the apparatus
JP5924077B2 (en) 2012-03-30 2016-05-25 ソニー株式会社 Fine particle sorting device and method for determining orbit direction in fine particle sorting device
CN104204766B (en) 2012-03-30 2016-08-31 索尼公司 Microchip type optical measuring device and optical position method of adjustment thereof
AU2013258834B2 (en) 2012-05-10 2017-09-07 Zymeworks Bc Inc. Heteromultimer constructs of immunoglobulin heavy chains with mutations in the Fc domain
DK2898057T3 (en) 2012-09-19 2022-10-10 Inguran Llc FLOW CYTOMETER SYSTEM WITH A CHAMFERED NOZZLE TIP
US11668640B2 (en) 2015-03-06 2023-06-06 Inguran, Llc Nozzle assembly for a flow cytometry system and methods of manufacture
US9404846B2 (en) 2012-09-19 2016-08-02 Inguran, Llc Nozzle assembly for a flow cytometer system and methods of manufacture
WO2014115409A1 (en) 2013-01-28 2014-07-31 ソニー株式会社 Fine particle fractionation device, fine particle fractionation method and program
CA2902842C (en) 2013-03-14 2022-07-26 Cytonome/St, Llc Operatorless particle processing systems and methods
US9952076B2 (en) 2013-04-12 2018-04-24 Becton, Dickinson And Company Automated set-up for cell sorting
EP2989457B1 (en) 2013-04-26 2023-10-04 Becton, Dickinson and Company Methods and systems for the collection of light using total internal reflectance
WO2015056516A1 (en) 2013-10-16 2015-04-23 ソニー株式会社 Particle fractionation device, particle fractionation method, and program
EP3106857B1 (en) 2014-02-13 2020-04-22 Sony Corporation Particle sorting apparatus, particle sorting method, program, and particle sorting system
JP6657625B2 (en) 2014-09-05 2020-03-04 ソニー株式会社 Droplet sorting apparatus, drop sorting method and program
ES2954937T3 (en) 2014-12-04 2023-11-27 Becton Dickinson Co Flow cytometry cell classification systems and methods of using them
CN208443705U (en) 2014-12-10 2019-01-29 贝克顿·迪金森公司 The light collection system and measuring system of optical alignment
US10184879B2 (en) 2015-02-18 2019-01-22 Becton, Dickinson And Company Optical detection systems and methods of using the same
CN107923836B (en) 2015-06-17 2020-12-01 贝克顿·迪金森公司 Optical detector scatter cap assembly with removable scatter bar and method of use thereof
US10078045B2 (en) 2015-10-13 2018-09-18 Omega Biosystems Incorporated Multi-modal fluorescence imaging flow cytometry system
WO2017068822A1 (en) 2015-10-19 2017-04-27 ソニー株式会社 Image processing device, microparticle separation device, and image processing method
WO2017156034A1 (en) 2016-03-10 2017-09-14 Becton, Dickinson And Company Methods of evaluating a cellular sample for her-2/neu expression and compositions for practicing the same
WO2017161247A1 (en) 2016-03-17 2017-09-21 Bd Biosciences Cell sorting using a high throughput fluorescence flow cytometer
KR102501627B1 (en) 2016-04-15 2023-02-21 벡톤 디킨슨 앤드 컴퍼니 Enclosed droplet sorter and methods of using the same
EP3445490B1 (en) 2016-04-22 2022-06-29 Becton, Dickinson and Company High density deposition for array production
US10935485B2 (en) 2016-05-12 2021-03-02 Bd Biosciences Fluorescence imaging flow cytometry with enhanced image resolution
CN109069425B (en) 2016-05-26 2021-07-30 贝克顿·迪金森公司 Method and apparatus for preparing liposomes by centrifugation
EP3513167B1 (en) 2016-09-13 2023-05-24 Becton, Dickinson and Company Flow cytometer with optical equalization
AU2017340136B2 (en) 2016-10-03 2022-02-24 Becton, Dickinson And Company Methods and systems for determining a drop delay of a flow stream in a flow cytometer
ES2950436T3 (en) 2016-12-14 2023-10-10 Becton Dickinson Co Methods and compositions to obtain an assessment of tuberculosis in a subject
US11320437B2 (en) 2017-02-08 2022-05-03 Becton, Dickinson And Company Dried dye reagent devices and methods for making and using the same
KR102608673B1 (en) 2017-02-27 2023-11-30 벡톤 디킨슨 앤드 컴퍼니 Light detection system and method of using the same
JP2021511493A (en) 2018-01-23 2021-05-06 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ Dynamic photodetection suppression system and how to use it
JP2021519841A (en) 2018-03-30 2021-08-12 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ Water-soluble polymer dye with pendant chromophore
CN112136034A (en) 2018-04-27 2020-12-25 贝克顿·迪金森公司 Collection system for flow cytometry sorting samples and methods of use thereof
CN112136033A (en) 2018-04-27 2020-12-25 贝克顿·迪金森公司 Flow cytometer with enclosed droplet sorter with controlled aerosol content and method of using same
US11181464B2 (en) 2018-06-19 2021-11-23 Becton, Dickinson And Company Variable multiplexing switches for detector arrays, systems and methods of use thereof
EP3814748A4 (en) 2018-06-28 2022-03-30 Becton, Dickinson and Company Integrated pre-amplification light detection systems and methods of use thereof
CN112823275A (en) 2018-08-15 2021-05-18 贝克顿·迪金森公司 Flow and vacuum controlled fluid management system for flow particle analyzer
CN112805548A (en) 2018-10-30 2021-05-14 贝克顿·迪金森公司 Particle sorting module with alignment window, system and method of use thereof
AU2019416121A1 (en) 2018-12-28 2021-05-20 Becton, Dickinson And Company Methods for spectrally resolving fluorophores of a sample and systems for same
US11137337B2 (en) 2019-01-21 2021-10-05 Essen Instruments, Inc. Flow cytometry with data analysis for optimized dilution of fluid samples for flow cytometry investigation
WO2020163023A1 (en) 2019-02-08 2020-08-13 Becton, Dickinson And Company Droplet sorting decision modules, systems and methods of use thereof
CN113785187A (en) 2019-03-22 2021-12-10 贝克顿·迪金森公司 Spectral unmixing for fluorescence imaging using radio frequency multiplexed excitation data
US11268890B2 (en) 2019-03-29 2022-03-08 Becton, Dickinson And Company Parameters for use in particle discrimination
EP3969881A4 (en) 2019-05-14 2023-01-25 Becton, Dickinson and Company Phase-calibration for imaging flow cytometry
WO2020243475A1 (en) 2019-05-30 2020-12-03 Becton, Dickinson And Company Phase-correction of radiofrequency-multiplexed signals
EP3997439A4 (en) 2019-07-10 2023-07-19 Becton, Dickinson and Company Reconfigurable integrated circuits for adjusting cell sorting classification
CN114667443A (en) 2019-11-20 2022-06-24 贝克顿·迪金森公司 Optical detection module with adjustable sensitivity
CN115053135A (en) 2019-12-20 2022-09-13 贝克顿·迪金森公司 Method for quantifying extracellular vesicle surface markers and composition for carrying out the method
WO2021154579A1 (en) 2020-01-31 2021-08-05 Becton, Dickinson And Company Methods and systems for adjusting a training gate to accommodate flow cytometer data
US11709116B2 (en) 2020-02-04 2023-07-25 Sartorius Bioanalytical Instruments, Inc. Liquid flourescent dye concentrate for flow cytometry evaluation of virus-size particles and related products and methods
WO2021158400A1 (en) 2020-02-07 2021-08-12 Becton, Dickinson And Company Clustered wavelength division light detection systems and methods of using the same
US11592386B2 (en) 2020-02-26 2023-02-28 Becton, Dickinson And Company Light detection systems having a secondary light scatter detector and methods for using same
JP2023516192A (en) 2020-02-27 2023-04-18 ベクトン・ディキンソン・アンド・カンパニー Method and system for identifying saturating data signals in cell sorting
JP2023518457A (en) 2020-03-17 2023-05-01 ベクトン・ディキンソン・アンド・カンパニー Gain-matched amplifier for photodetection
CN115735111A (en) 2020-04-28 2023-03-03 贝克顿·迪金森公司 Method for index sorting unique phenotypes and system therefor
EP4168801A1 (en) 2020-06-22 2023-04-26 Westfälische Wilhelms-Universität Münster Sperm stratification
CN113376080A (en) * 2021-06-11 2021-09-10 宋卓 Liquid flow device and analytical sorting equipment comprising same
FR3126043A1 (en) * 2021-08-04 2023-02-10 Univers 2020 Flow cytometry installation comprising an optical detection system, in particular for the treatment of cells of the spermatozoon type
US20230053122A1 (en) 2021-08-10 2023-02-16 Becton, Dickinson And Company Clamps for operably coupling an optical component to a mounting block, and methods and systems for using the same
US20230046207A1 (en) 2021-08-10 2023-02-16 Becton, Dickinson And Company Outlet fittings for reducing bubbles at the interface with a flow cell, and flow cytometers and methods using the same

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3299354A (en) * 1962-07-05 1967-01-17 Coulter Electronics Aperture tube structure for particle study apparatus
US3810010A (en) * 1968-11-02 1974-05-07 Telefunken Patent Particle analysis method and apparatus wherein liquid containing particles is sucked into a constricted flow path
US3661460A (en) * 1970-08-28 1972-05-09 Technicon Instr Method and apparatus for optical analysis of the contents of a sheathed stream
US3826364A (en) * 1972-05-22 1974-07-30 Univ Leland Stanford Junior Particle sorting method and apparatus
US3761941A (en) * 1972-10-13 1973-09-25 Mead Corp Phase control for a drop generating and charging system
US4070617A (en) * 1974-05-08 1978-01-24 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Device for controlling the particle flow in an apparatus for measuring the properties of particles suspended in liquid
US3973196A (en) * 1974-05-24 1976-08-03 Coulter Electronics, Inc. Method and apparatus for ejecting a metered amount of particulate sample
US3963606A (en) * 1974-06-03 1976-06-15 Coulter Electronics, Inc. Semi-automatic adjusting delay for an electronic particle separator
US4014611A (en) * 1975-04-30 1977-03-29 Coulter Electronics, Inc. Aperture module for use in particle testing apparatus
US3960449A (en) * 1975-06-05 1976-06-01 The Board Of Trustees Of Leland Stanford Junior University Measurement of angular dependence of scattered light in a flowing stream
US4302166A (en) * 1976-04-22 1981-11-24 Coulter Electronics, Inc. Droplet forming apparatus for use in producing uniform particles
US4162282A (en) * 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
US4230558A (en) * 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4318480A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method and apparatus for positioning the point of droplet formation in the jetting fluid of an electrostatic sorting device
US4318482A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for measuring the velocity of a perturbed jetting fluid in an electrostatic particle sorting system
US4318483A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Automatic relative droplet charging time delay system for an electrostatic particle sorting system using a relatively moveable stream surface sensing system
US4318481A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for automatically setting the correct phase of the charge pulses in an electrostatic flow sorter
US4325483A (en) * 1979-08-20 1982-04-20 Ortho Diagnostics, Inc. Method for detecting and controlling flow rates of the droplet forming stream of an electrostatic particle sorting apparatus
US4317520A (en) * 1979-08-20 1982-03-02 Ortho Diagnostics, Inc. Servo system to control the spatial position of droplet formation of a fluid jet in a cell sorting apparatus
US4487320A (en) * 1980-11-03 1984-12-11 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4691829A (en) * 1980-11-03 1987-09-08 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4395676A (en) * 1980-11-24 1983-07-26 Coulter Electronics, Inc. Focused aperture module
US4361400A (en) * 1980-11-26 1982-11-30 The United States Of America As Represented By The United States Department Of Energy Fluidic assembly for an ultra-high-speed chromosome flow sorter
US4818103A (en) * 1981-05-15 1989-04-04 Ratcom Flow cytometry
US4673288A (en) * 1981-05-15 1987-06-16 Ratcom, Inc. Flow cytometry
US4515274A (en) * 1981-12-02 1985-05-07 Coulter Corporation Particle analyzing and sorting apparatus
SU1056008A1 (en) * 1982-01-25 1983-11-23 Предприятие П/Я Р-6681 Flow-type cytofluorimeter
US4538733A (en) * 1983-10-14 1985-09-03 Becton, Dickinson And Company Particle sorter with neutralized collection wells and method of using same
US4631483A (en) * 1984-02-01 1986-12-23 Coulter Electronics, Inc. Particle analyzing apparatus and method of moving particles in suspension through such apparatus
JPS61139747A (en) * 1984-12-12 1986-06-27 Canon Inc Particle analyser
JPS61159135A (en) * 1984-12-31 1986-07-18 Canon Inc Particle analyzing device
DE3851458T2 (en) * 1987-04-08 1995-02-09 Hitachi Ltd Device with a vaginal flow cell.
JPS63262565A (en) * 1987-04-20 1988-10-28 Hitachi Ltd Flow cell
US4845025A (en) * 1987-11-10 1989-07-04 Coulter Corporation Biological sample mixing apparatus and method
JPH0224535A (en) * 1988-07-12 1990-01-26 Canon Inc Particle analyzing apparatus
JPH0718785B2 (en) * 1988-09-19 1995-03-06 株式会社日立製作所 Flow cell device
US4981580A (en) * 1989-05-01 1991-01-01 Coulter Corporation Coincidence arbitration in a flow cytomery sorting system
JPH0353164A (en) * 1989-07-20 1991-03-07 Canon Inc Sample supply device and sample measuring instrument using the same
US5215376A (en) * 1989-09-08 1993-06-01 Becton, Dickinson And Company Method for causing vortices in a test tube
US5005981A (en) * 1989-09-08 1991-04-09 Becton, Dickinson And Company Apparatus for method for causing vortices in a test tube
US5167926A (en) * 1989-09-13 1992-12-01 Kabushiki Kaisha Tiyoda Seisakusho Apparatus for pretreating cells for flow cytometry
JP3049254B2 (en) * 1990-02-08 2000-06-05 シスメックス株式会社 Optical particle analyzer with two types of light sources
JPH0716392B2 (en) * 1990-06-20 1995-03-01 株式会社ピーシーシーテクノロジー Cell fusion and fused cell sorting system
JPH0710226B2 (en) * 1990-06-20 1995-02-08 株式会社ピーシーシーテクノロジー Protoplast stirring device, cell fusion device and flow cytometer device including the same
US5259593A (en) * 1990-08-30 1993-11-09 University Of Southern California Apparatus for droplet stream manufacturing
JP2874746B2 (en) * 1990-11-22 1999-03-24 シスメックス株式会社 Flow cell mechanism in flow imaging cytometer
JP3121849B2 (en) * 1991-02-27 2001-01-09 シスメックス株式会社 Flow image cytometer
JPH0734012B2 (en) * 1991-02-27 1995-04-12 東亜医用電子株式会社 Flow image cytometer
US5144224A (en) * 1991-04-01 1992-09-01 Larsen Lawrence E Millimeter wave flow cytometer
US5199576A (en) * 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
US5412466A (en) * 1991-07-26 1995-05-02 Toa Medical Electronics Co., Ltd. Apparatus for forming flattened sample flow for analyzing particles
US5370842A (en) * 1991-11-29 1994-12-06 Canon Kabushiki Kaisha Sample measuring device and sample measuring system
US5359907A (en) * 1992-11-12 1994-11-01 Horiba Instruments, Inc. Method and apparatus for dry particle analysis

Also Published As

Publication number Publication date
EP0786079A1 (en) 1997-07-30
CA2201332C (en) 2006-07-04
ES2196086T3 (en) 2003-12-16
AU691693B2 (en) 1998-05-21
AU3962695A (en) 1996-05-06
EP0786079B1 (en) 2003-05-21
US5602039A (en) 1997-02-11
WO1996012172A1 (en) 1996-04-25
DE69530851D1 (en) 2003-06-26
JPH10507525A (en) 1998-07-21
DE69530851T2 (en) 2004-01-22

Similar Documents

Publication Publication Date Title
CA2201332A1 (en) Flow cytometer jet monitor system
SE0201057D0 (en) Apparatus and method for controlling a welding area and arrangement and method for controlling a welding operation
AU1614899A (en) Method and apparatus for illuminating and imaging eyes through eyeglasses using multiple sources of illumination
CA2372376A1 (en) Apparatus and method of monitoring a subject's eyes using two different wavelengths of light
CA2343781A1 (en) Systems and components for enhancing rear vision from a vehicle
ATE173167T1 (en) DEVICE FOR MONITORING AN INTRAVENOUS INFUSION SYSTEM
UA66892C2 (en) Device with a fluorescence detector for determining relevant vegetation parameters
CA2305903A1 (en) Method for monitoring nitrogen status using a multi-sprectral imaging system
CA2066052A1 (en) Flow monitor
AU2808597A (en) Device and method for classification of tissue
HK1041192A1 (en) A system and method for imaging reflectance changes of retina
AU7141494A (en) Monitoring multiple amplification reactions simultaneously and analyzing same
CA2316812A1 (en) Examining diamonds and gemstones
KR910004158B1 (en) Thermal deformation measuring system of ceranics and the like
DE69312480D1 (en) PRESSURE MONITOR
MX9702263A (en) Attenuated total reflectance sensing.
CA2341993A1 (en) Apparatus for monitoring a fluid conduit
SE0000432D0 (en) Apparatus for metal welding
IL111913A (en) Sensor and a method for measuring distances to, and/or physical properties of, a medium
CA2001666A1 (en) Near infrared polyethylene inspection system and method
WO2000060349A3 (en) Skin evaluation apparatus
EP0277792A3 (en) Endoscope imaging systems
JPS5526595A (en) Helmettincorporated rear side monitor
EP0845636A3 (en) A flame monitoring apparatus
EP0777142A3 (en) Adapter for extracting a portion of an image from an optical system or device

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20151013