CA2201756A1 - Self-quenching fluorescence probe and method - Google Patents

Self-quenching fluorescence probe and method

Info

Publication number
CA2201756A1
CA2201756A1 CA002201756A CA2201756A CA2201756A1 CA 2201756 A1 CA2201756 A1 CA 2201756A1 CA 002201756 A CA002201756 A CA 002201756A CA 2201756 A CA2201756 A CA 2201756A CA 2201756 A1 CA2201756 A1 CA 2201756A1
Authority
CA
Canada
Prior art keywords
probe
reporter molecule
molecule
hybridized
fluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002201756A
Other languages
French (fr)
Other versions
CA2201756C (en
Inventor
Kenneth J. Livak
Susan J.A. Flood
Jeffrey Marmaro
Khairuzzaman Mullah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Kenneth J. Livak
Susan J.A. Flood
Jeffrey Marmaro
Khairuzzaman Mullah
Perkin-Elmer Corporation
Pe Corporation (Ny)
Applera Corporation
Applied Biosystems Inc.
Applied Biosystems, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23333909&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2201756(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kenneth J. Livak, Susan J.A. Flood, Jeffrey Marmaro, Khairuzzaman Mullah, Perkin-Elmer Corporation, Pe Corporation (Ny), Applera Corporation, Applied Biosystems Inc., Applied Biosystems, Llc filed Critical Kenneth J. Livak
Publication of CA2201756A1 publication Critical patent/CA2201756A1/en
Application granted granted Critical
Publication of CA2201756C publication Critical patent/CA2201756C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

Abstract

An oligonucleotide probe is provided which includes a fluorescent reporter molecule and a quencher molecule capable of quenching the fluorescence of the reporter molecule. The oligonucleotide probe is constructed such that the probe exists in at least one single-stranded conformation when unhybridized where the quencher molecule is near enough to the reporter molecule to quench the fluorescence of the reporter molecule. The oligonucleotide probe also exists in at least one conformation when hybridized to a target polynucloetide where the quencher molecule is not positioned close enough to the reporter molecule to quench the fluorescence of the reporter molecule. By adopting these hybridized and unhybridized conformations, the reporter molecule and quencher molecule on the probe exhibit different fluorescence signal intensities when the probe is hybridized and unhybridized. As a result, it is possible to determine whether the probe is hybridized or unhybridized based on a change in the fluorescence intensity of the reporter molecule, the quencher molecule, or a combination thereof. In addition, because the probe can be designed such that the quencher molecule quenches the reporter molecule when the probe is not hybridized, the probe can be designed such that the reporter molecule exhibits limited fluorescence until the probe is either hybridized or digested.

designed such that the reporter molecule exhibits limited fluorescence until the probe is either hybridized or digested.
CA002201756A 1994-11-16 1995-11-15 Self-quenching fluorescence probe and method Expired - Fee Related CA2201756C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/340,558 1994-11-16
US08/340,558 US5538848A (en) 1994-11-16 1994-11-16 Method for detecting nucleic acid amplification using self-quenching fluorescence probe
PCT/US1995/014882 WO1996015270A1 (en) 1994-11-16 1995-11-15 Self-quenching fluorescence probe and method

Publications (2)

Publication Number Publication Date
CA2201756A1 true CA2201756A1 (en) 1996-05-23
CA2201756C CA2201756C (en) 2005-02-08

Family

ID=23333909

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002201756A Expired - Fee Related CA2201756C (en) 1994-11-16 1995-11-15 Self-quenching fluorescence probe and method

Country Status (7)

Country Link
US (5) US5538848A (en)
EP (2) EP0792374B1 (en)
JP (3) JP4131749B2 (en)
AT (1) ATE198775T1 (en)
CA (1) CA2201756C (en)
DE (1) DE69519940T2 (en)
WO (1) WO1996015270A1 (en)

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