CA2201887A1 - Patched genes and their use - Google Patents
Patched genes and their useInfo
- Publication number
- CA2201887A1 CA2201887A1 CA002201887A CA2201887A CA2201887A1 CA 2201887 A1 CA2201887 A1 CA 2201887A1 CA 002201887 A CA002201887 A CA 002201887A CA 2201887 A CA2201887 A CA 2201887A CA 2201887 A1 CA2201887 A1 CA 2201887A1
- Authority
- CA
- Canada
- Prior art keywords
- patched
- genes
- gene
- ligands
- isolation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Abstract
Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched, isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31974594A | 1994-10-07 | 1994-10-07 | |
US08/319,745 | 1994-10-07 | ||
PCT/US1995/013233 WO1996011260A1 (en) | 1994-10-07 | 1995-10-06 | Patched genes and their use |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2201887A1 true CA2201887A1 (en) | 1996-04-18 |
CA2201887C CA2201887C (en) | 2009-04-14 |
Family
ID=23243482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002201887A Expired - Lifetime CA2201887C (en) | 1994-10-07 | 1995-10-06 | Patched genes and their use |
Country Status (10)
Country | Link |
---|---|
US (6) | US5837538A (en) |
EP (2) | EP0804548B1 (en) |
JP (1) | JP3776454B2 (en) |
AT (1) | ATE299529T1 (en) |
AU (1) | AU4001195A (en) |
CA (1) | CA2201887C (en) |
DE (1) | DE69534310T2 (en) |
DK (1) | DK0804548T3 (en) |
ES (1) | ES2245454T3 (en) |
WO (1) | WO1996011260A1 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030186357A1 (en) * | 1993-12-30 | 2003-10-02 | Philip W. Ingham | Vertebrate embryonic pattern-inducing proteins, and uses related thereto |
US7060450B1 (en) * | 1993-12-30 | 2006-06-13 | President And Fellows Of Harvard College | Screening assays for agonists and antagonists of the hedgehog signaling pathway |
AU752969B2 (en) * | 1994-10-07 | 2002-10-03 | Board Of Trustees Of The Leland Stanford Junior University | Patched genes and their use |
US6027882A (en) * | 1994-10-07 | 2000-02-22 | The Regents Of The University Of California | Patched genes and their use for diagnostics |
US6429354B1 (en) | 1994-10-07 | 2002-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | Patched genes and uses related thereto |
AU4001195A (en) * | 1994-10-07 | 1996-05-02 | Board Of Trustees Of The Leland Stanford Junior University | Patched genes and their use |
WO1997043414A2 (en) * | 1996-05-17 | 1997-11-20 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | A basal cell carcinoma tumor suppressor gene |
JP2002504805A (en) * | 1996-05-17 | 2002-02-12 | アメリカ合衆国 | Basal cell carcinoma tumor suppressor gene |
US6552181B1 (en) | 1996-05-17 | 2003-04-22 | The United States Of America As Represented By The Department Of Health And Human Services | Basal cell carcinoma tumor supressor gene |
IL128999A0 (en) | 1996-09-20 | 2000-02-17 | Harvard College | Hedgehog interacting proteins and uses related thereto |
US6713065B2 (en) * | 1997-02-10 | 2004-03-30 | President And Fellows Of Harvard College | Methods of using hedgehog proteins to modulate hematopoiesis and vascular growth |
AU6164098A (en) * | 1997-02-14 | 1998-09-08 | Incyte Pharmaceuticals, Inc. | Novel human mago nashi protein |
US6051400A (en) * | 1997-05-23 | 2000-04-18 | Smithkline Beecham Plc | Patched-2 polypeptides and polynucleotides |
AU8173098A (en) | 1997-06-27 | 1999-01-19 | Ontogeny, Inc. | Neuroprotective methods and reagents |
US7144997B2 (en) * | 1997-07-24 | 2006-12-05 | Curis, Inc. | Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto |
US7361336B1 (en) | 1997-09-18 | 2008-04-22 | Ivan Bergstein | Methods of cancer therapy targeted against a cancer stem line |
US6639051B2 (en) | 1997-10-20 | 2003-10-28 | Curis, Inc. | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
EP1037982A1 (en) | 1997-12-08 | 2000-09-27 | Ontogeny, Inc. | Human patched genes and proteins, and uses related thereto |
US6709838B1 (en) | 1998-04-15 | 2004-03-23 | Genentech, Inc. | Nucleic acid encoding patched-2 |
US6348575B1 (en) | 1998-04-15 | 2002-02-19 | Genentech, Inc. | Patched-2 |
EP1100872A1 (en) * | 1998-07-24 | 2001-05-23 | Carnegie Institution Of Washington | Method for maintenance and propagation of germline stem cells using members of the tgf-beta family of growth factors |
EP1109569A2 (en) * | 1998-09-11 | 2001-06-27 | President And Fellows Of Harvard College | Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
WO2000018428A2 (en) * | 1998-09-11 | 2000-04-06 | Biogen, Inc. | Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor |
US6884770B1 (en) | 1998-11-06 | 2005-04-26 | Curis, Inc. | Methods and compositions for treating or preventing peripheral neuropathies |
US7498304B2 (en) * | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
CA2425356C (en) * | 2000-10-13 | 2015-10-06 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
US7708998B2 (en) * | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
US20030044409A1 (en) * | 2001-05-01 | 2003-03-06 | Carson Dennis A. | Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens |
US7682607B2 (en) * | 2001-05-01 | 2010-03-23 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
WO2005061002A2 (en) * | 2003-12-19 | 2005-07-07 | Curis, Inc. | Composition and methods for modulating cns activity |
DK1730280T3 (en) * | 2004-03-26 | 2019-02-04 | Curis Inc | RNA interference modulators for hedgehog signaling and applications thereof |
US7999940B2 (en) | 2006-06-30 | 2011-08-16 | Asml Netherlands B.V. | Apparatus for angular-resolved spectroscopic lithography characterization |
ES2528166T3 (en) * | 2006-11-15 | 2015-02-04 | Eli Lilly And Company | Methods and compositions to treat the flu |
JP6109077B2 (en) * | 2011-01-18 | 2017-04-05 | アメリカ合衆国 | Methods for amplification and detection of prions |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US66A (en) * | 1836-10-20 | Machinery for forming webs of cloth of wool | ||
US5023180A (en) | 1986-06-17 | 1991-06-11 | Lubrizol Genetics, Inc. | Bradyrhizobium japonicum nodulation regulatory protein and gene |
US5789543A (en) * | 1993-12-30 | 1998-08-04 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins and uses related thereto |
US6610656B1 (en) | 1993-12-30 | 2003-08-26 | President And Fellows Of Harvard College | Method of promoting chondrocyte differentiation with hedgehog related polypeptides |
US5750367A (en) * | 1993-11-08 | 1998-05-12 | Baylor College Of Medicine | Human and mouse very low density lipoprotein receptors and methods for use of such receptors |
US6165747A (en) | 1993-12-30 | 2000-12-26 | President & Fellows Of Harvard College | Nucleic acids encoding hedgehog proteins |
US6884775B1 (en) | 1993-12-30 | 2005-04-26 | President And Fellows Of Harvard College | Methods and compositions for regulating skeletogenic formation |
US20030186357A1 (en) | 1993-12-30 | 2003-10-02 | Philip W. Ingham | Vertebrate embryonic pattern-inducing proteins, and uses related thereto |
US6384192B1 (en) | 1993-12-30 | 2002-05-07 | President & Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins |
US7060450B1 (en) | 1993-12-30 | 2006-06-13 | President And Fellows Of Harvard College | Screening assays for agonists and antagonists of the hedgehog signaling pathway |
US6261786B1 (en) | 1993-12-30 | 2001-07-17 | Imperial Cancer Res. Technology | Screening assays for hedgehog agonists and antagonists |
US6001968A (en) | 1994-08-17 | 1999-12-14 | The Rockefeller University | OB polypeptides, modified forms and compositions |
US6946257B1 (en) | 1994-10-07 | 2005-09-20 | Regents Of The University Of California | Patched genes and uses related thereto |
AU4001195A (en) * | 1994-10-07 | 1996-05-02 | Board Of Trustees Of The Leland Stanford Junior University | Patched genes and their use |
US6027882A (en) | 1994-10-07 | 2000-02-22 | The Regents Of The University Of California | Patched genes and their use for diagnostics |
US6429354B1 (en) | 1994-10-07 | 2002-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | Patched genes and uses related thereto |
-
1995
- 1995-10-06 AU AU40011/95A patent/AU4001195A/en not_active Abandoned
- 1995-10-06 EP EP95938749A patent/EP0804548B1/en not_active Expired - Lifetime
- 1995-10-06 AT AT95938749T patent/ATE299529T1/en active
- 1995-10-06 JP JP51272396A patent/JP3776454B2/en not_active Expired - Lifetime
- 1995-10-06 DE DE69534310T patent/DE69534310T2/en not_active Expired - Lifetime
- 1995-10-06 ES ES95938749T patent/ES2245454T3/en not_active Expired - Lifetime
- 1995-10-06 CA CA002201887A patent/CA2201887C/en not_active Expired - Lifetime
- 1995-10-06 DK DK95938749T patent/DK0804548T3/en active
- 1995-10-06 WO PCT/US1995/013233 patent/WO1996011260A1/en active IP Right Grant
- 1995-10-06 EP EP05014986A patent/EP1616942A3/en not_active Withdrawn
- 1995-10-06 US US08/540,406 patent/US5837538A/en not_active Expired - Lifetime
-
1997
- 1997-10-20 US US08/954,701 patent/US6610507B2/en not_active Expired - Fee Related
- 1997-10-20 US US08/954,668 patent/US6172200B1/en not_active Expired - Lifetime
-
2001
- 2001-01-03 US US09/754,032 patent/US6921646B2/en not_active Expired - Fee Related
-
2007
- 2007-08-20 US US11/894,801 patent/US7659371B2/en not_active Expired - Fee Related
-
2010
- 2010-01-11 US US12/685,274 patent/US8178298B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6172200B1 (en) | 2001-01-09 |
ATE299529T1 (en) | 2005-07-15 |
WO1996011260A1 (en) | 1996-04-18 |
EP0804548A1 (en) | 1997-11-05 |
US6921646B2 (en) | 2005-07-26 |
US6610507B2 (en) | 2003-08-26 |
US20030148388A1 (en) | 2003-08-07 |
EP1616942A3 (en) | 2006-11-22 |
US20080300167A1 (en) | 2008-12-04 |
EP0804548A4 (en) | 1999-07-21 |
ES2245454T3 (en) | 2006-01-01 |
US20100221724A1 (en) | 2010-09-02 |
DK0804548T3 (en) | 2005-11-07 |
US8178298B2 (en) | 2012-05-15 |
JP3776454B2 (en) | 2006-05-17 |
JPH10507349A (en) | 1998-07-21 |
AU4001195A (en) | 1996-05-02 |
US5837538A (en) | 1998-11-17 |
EP0804548B1 (en) | 2005-07-13 |
US7659371B2 (en) | 2010-02-09 |
DE69534310T2 (en) | 2006-04-27 |
EP1616942A2 (en) | 2006-01-18 |
US20030032085A1 (en) | 2003-02-13 |
CA2201887C (en) | 2009-04-14 |
DE69534310D1 (en) | 2005-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDC | Discontinued application reinstated | ||
MKEX | Expiry |
Effective date: 20151006 |