CA2205906A1 - In-vivo diagnostic process by near infrared radiation - Google Patents

In-vivo diagnostic process by near infrared radiation

Info

Publication number
CA2205906A1
CA2205906A1 CA002205906A CA2205906A CA2205906A1 CA 2205906 A1 CA2205906 A1 CA 2205906A1 CA 002205906 A CA002205906 A CA 002205906A CA 2205906 A CA2205906 A CA 2205906A CA 2205906 A1 CA2205906 A1 CA 2205906A1
Authority
CA
Canada
Prior art keywords
near infrared
infrared radiation
vivo diagnostic
diagnostic process
novel compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002205906A
Other languages
French (fr)
Other versions
CA2205906C (en
Inventor
Kai Licha
Bjorn Riefke
Wolfhard Semmler
Ulrich Speck
Christoph-Stephan Hilger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Kai Licha
Bjorn Riefke
Wolfhard Semmler
Ulrich Speck
Christoph-Stephan Hilger
Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger, Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin filed Critical Kai Licha
Publication of CA2205906A1 publication Critical patent/CA2205906A1/en
Application granted granted Critical
Publication of CA2205906C publication Critical patent/CA2205906C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/105—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a methine or polymethine dye

Abstract

A novel use is provided herein for certain novel compounds for an in vivo diagnostic method based on near infrared radiation. The novel compounds are water-soluble dyes and their biomolecule adducts. Each such dye or adduct has specific photophysical and pharmaco-chemical properties, which make them suitable as a contrast medium for fluorescence and transillumination diagnostics in the NIR range.
CA002205906A 1994-12-07 1995-10-10 In-vivo diagnostic process by near infrared radiation Expired - Fee Related CA2205906C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4445065.6 1994-12-07
DE4445065A DE4445065A1 (en) 1994-12-07 1994-12-07 Methods for in-vivo diagnostics using NIR radiation
PCT/DE1995/001465 WO1996017628A1 (en) 1994-12-07 1995-10-10 In-vivo diagnostic process by near infrared radiation

Publications (2)

Publication Number Publication Date
CA2205906A1 true CA2205906A1 (en) 1996-06-13
CA2205906C CA2205906C (en) 2006-10-03

Family

ID=6536117

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002205906A Expired - Fee Related CA2205906C (en) 1994-12-07 1995-10-10 In-vivo diagnostic process by near infrared radiation

Country Status (18)

Country Link
US (10) US6083485A (en)
EP (2) EP1181940B1 (en)
JP (4) JPH10510250A (en)
KR (2) KR100340290B1 (en)
CN (1) CN1089008C (en)
AT (2) ATE285254T1 (en)
AU (1) AU709152B2 (en)
CA (1) CA2205906C (en)
DE (3) DE4445065A1 (en)
DK (2) DK0796111T3 (en)
ES (2) ES2236131T3 (en)
HU (1) HUT77378A (en)
IL (4) IL141384A (en)
NO (2) NO319741B1 (en)
NZ (1) NZ294568A (en)
PT (2) PT1181940E (en)
WO (1) WO1996017628A1 (en)
ZA (1) ZA959707B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6217848B1 (en) 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications

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* Cited by examiner, † Cited by third party
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