CA2206102A1 - Comparative fluorescence hybridization to nucleic acid arrays - Google Patents

Comparative fluorescence hybridization to nucleic acid arrays

Info

Publication number
CA2206102A1
CA2206102A1 CA002206102A CA2206102A CA2206102A1 CA 2206102 A1 CA2206102 A1 CA 2206102A1 CA 002206102 A CA002206102 A CA 002206102A CA 2206102 A CA2206102 A CA 2206102A CA 2206102 A1 CA2206102 A1 CA 2206102A1
Authority
CA
Canada
Prior art keywords
nucleic acids
nucleic acid
acid arrays
fluorescence hybridization
comparative fluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002206102A
Other languages
French (fr)
Other versions
CA2206102C (en
Inventor
Daniel Pinkel
Joe W. Gray
Donna Albertson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
University of California
Original Assignee
The Regents Of The University Of California
Daniel Pinkel
Joe W. Gray
Donna Albertson
The Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California, Daniel Pinkel, Joe W. Gray, Donna Albertson, The Medical Research Council filed Critical The Regents Of The University Of California
Publication of CA2206102A1 publication Critical patent/CA2206102A1/en
Application granted granted Critical
Publication of CA2206102C publication Critical patent/CA2206102C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression

Abstract

The present invention provides methods of determining relative copy number of target nucleic acids and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acids immobilized on a solid surface, to which a sample comprising two sets of differentially labeled nucleic acids are hybridized. The hybridization of the labeled nucleic acids to the solid surface is then detected using standard techniques.
CA002206102A 1994-12-09 1995-12-08 Comparative fluorescence hybridization to nucleic acid arrays Expired - Lifetime CA2206102C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/353,018 1994-12-09
US08/353,018 US5830645A (en) 1994-12-09 1994-12-09 Comparative fluorescence hybridization to nucleic acid arrays
PCT/US1995/016155 WO1996017958A1 (en) 1994-12-09 1995-12-08 Comparative fluorescence hybridization to nucleic acid arrays

Publications (2)

Publication Number Publication Date
CA2206102A1 true CA2206102A1 (en) 1996-06-13
CA2206102C CA2206102C (en) 2009-02-03

Family

ID=23387401

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002206102A Expired - Lifetime CA2206102C (en) 1994-12-09 1995-12-08 Comparative fluorescence hybridization to nucleic acid arrays

Country Status (9)

Country Link
US (5) US5830645A (en)
EP (1) EP0800587B1 (en)
JP (1) JP4338783B2 (en)
AT (1) ATE290102T1 (en)
CA (1) CA2206102C (en)
DE (1) DE69534046T2 (en)
DK (1) DK0800587T3 (en)
ES (1) ES2235177T3 (en)
WO (1) WO1996017958A1 (en)

Families Citing this family (354)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721098A (en) * 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
US6416952B1 (en) 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6309822B1 (en) * 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
EP0834576B1 (en) 1990-12-06 2002-01-16 Affymetrix, Inc. (a Delaware Corporation) Detection of nucleic acid sequences
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
WO1993018186A1 (en) 1992-03-04 1993-09-16 The Regents Of The University Of California Comparative genomic hybridization (cgh)
US7534567B2 (en) * 1992-03-04 2009-05-19 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
DE4344726C2 (en) * 1993-12-27 1997-09-25 Deutsches Krebsforsch Method for the detection of unbalanced genetic material of a species or for the detection of gene expression in cells of a species
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US7625697B2 (en) * 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US8236493B2 (en) 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US20030220748A1 (en) * 1994-10-21 2003-11-27 Affymetrix, Inc., A California Corporation Computer-aided techniques for analyzing biological sequences
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US7455964B1 (en) 1996-07-15 2008-11-25 The Hospital For Sick Children Genes from the 20q13 amplicon and their uses
AU7329096A (en) * 1995-11-13 1997-06-05 Institut Pasteur Ultrahigh resolution comparative nucleic acid hybridization to combed dna fibers
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc Nucleic acid analysis techniques
US6881571B1 (en) * 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
FR2755149B1 (en) 1996-10-30 1999-01-15 Pasteur Institut METHOD FOR DIAGNOSING GENETIC DISEASES BY MOLECULAR COMBING AND DIAGNOSTIC KIT
FR2755147B1 (en) * 1996-10-30 1999-01-15 Pasteur Institut METHOD FOR DIAGNOSING GENETIC DISEASES BY MOLECULAR COMBING AND DIAGNOSTIC KIT
GB9622665D0 (en) * 1996-10-31 1997-01-08 Zeneca Ltd Methods
US6277563B1 (en) 1997-01-16 2001-08-21 The Regents Of The University Of California Genetic alterations associated with cancer
US7670767B1 (en) * 1997-01-16 2010-03-02 The Regents Of The University Of California Genetic alterations associated with cancer
NO972006D0 (en) * 1997-04-30 1997-04-30 Forskningsparken I Aas As New method for diagnosis of diseases
US6466923B1 (en) 1997-05-12 2002-10-15 Chroma Graphics, Inc. Method and apparatus for biomathematical pattern recognition
EP0878552A1 (en) * 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molecular detection of chromosome aberrations
US6503711B1 (en) 1997-06-18 2003-01-07 Ulrich J. Krull Nucleic acid biosensor diagnostics
WO1999000520A1 (en) * 1997-06-30 1999-01-07 The Government Of The United States Of America, Reresented By The Secretary Of The Department Of Health And Human Services Spectral cloning-a new technical approach to the cloning and characterization of every chromosomal aberration in cancer samples
US6210878B1 (en) 1997-08-08 2001-04-03 The Regents Of The University Of California Array-based detection of genetic alterations associated with disease
AU9198298A (en) * 1997-08-15 1999-03-08 Affymetrix, Inc. Polymorphism detection utilizing clustering analysis
DE19743301A1 (en) * 1997-09-30 1999-04-01 Metasystems Hard & Software Gm Method for comparing the copy number of nucleic acid sequences
AU753505B2 (en) * 1997-10-30 2002-10-17 Cold Spring Harbor Laboratory Probe arrays and methods of using probe arrays for distinguishing DNA
DE69839525D1 (en) * 1997-11-25 2008-07-03 Oryzon Genomics Sa METHOD FOR PARALLEL FINDING OF INSERTION MUTANES AND REAGENTS TO OBTAIN THIS
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6265163B1 (en) 1998-01-09 2001-07-24 Lynx Therapeutics, Inc. Solid phase selection of differentially expressed genes
AU756357B2 (en) * 1998-01-26 2003-01-09 Genzyme Corporation Methods for identifying therapeutic targets
US6077673A (en) * 1998-03-31 2000-06-20 Clontech Laboratories, Inc. Mouse arrays and kits comprising the same
US6979728B2 (en) * 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules
US6306589B1 (en) 1998-05-27 2001-10-23 Vysis, Inc. Biological assays for analyte detection
EP1090293B2 (en) 1998-06-24 2019-01-23 Illumina, Inc. Decoding of array sensors with microspheres
US7981599B1 (en) 1998-07-31 2011-07-19 Boston Probes, Inc. Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair
FR2783253B1 (en) * 1998-09-16 2002-03-01 Commissariat Energie Atomique METHOD AND KIT FOR DETECTION OF INTRACHROMOSOMAL IMBALANCE IN INTERPHASIC CORES AND APPLICATIONS THEREOF
US6593084B2 (en) * 1998-10-13 2003-07-15 Robert E. Bird Carcinogen assay
AU6074999A (en) 1998-10-14 2000-05-01 Agriculture And Agrifood Canada Hybrid alfalfa ((medicago sativa))
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
US6251601B1 (en) * 1999-02-02 2001-06-26 Vysis, Inc. Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays
US6410231B1 (en) * 1999-02-26 2002-06-25 Incyte Genomics, Inc. SNP detection
US7008768B1 (en) * 1999-02-26 2006-03-07 The United States Of America As Represented By The Department Of Health And Human Services Method for detecting radiation exposure
US6465180B1 (en) * 1999-03-17 2002-10-15 The Regents Of The University Of California Detection of premalignant melanocytes
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6465182B1 (en) * 1999-04-29 2002-10-15 The Regents Of The University Of California Comparative fluorescence hybridization to oligonucleotide microarrays
FR2798673B1 (en) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa METHODS AND COMPOSITIONS FOR DETECTION OF PATHOLOGICAL EVENTS
WO2001020043A1 (en) * 1999-09-17 2001-03-22 Affymetrix, Inc. Method of cluster analysis of gene expression profiles
US7217573B1 (en) * 1999-10-05 2007-05-15 Hitachi, Ltd. Method of inspecting a DNA chip
US6613516B1 (en) 1999-10-30 2003-09-02 Affymetrix, Inc. Preparation of nucleic acid samples
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US7041445B2 (en) 1999-11-15 2006-05-09 Clontech Laboratories, Inc. Long oligonucleotide arrays
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
EP1257668B1 (en) * 2000-02-16 2008-10-29 Illumina, Inc. Parallel genotyping of multiple patient samples
US6921637B2 (en) * 2000-05-04 2005-07-26 The Cbr Institute For Biomedical Research, Inc. Colloid compositions for solid phase biomolecular analytical, preparative and identification systems
EP1158057A1 (en) * 2000-05-18 2001-11-28 Centre National De La Recherche Scientifique Compositions and methods applicable to genetic analyses
EP1158058A1 (en) * 2000-05-19 2001-11-28 Centre National De La Recherche Scientifique Compositions and methods suitable for nucleic acid analyses
US6785614B1 (en) 2000-05-31 2004-08-31 The Regents Of The University Of California End sequence profiling
EP1356088A2 (en) * 2000-06-07 2003-10-29 Baylor College of Medicine Compositions and methods for array-based nucleic acid hybridization
DK1290444T3 (en) 2000-06-14 2010-01-18 Vistagen Inc Toxicity typing using liver stem cells
US6913879B1 (en) * 2000-07-10 2005-07-05 Telechem International Inc. Microarray method of genotyping multiple samples at multiple LOCI
US6965704B2 (en) * 2000-08-22 2005-11-15 Affymetrix, Inc. System, method, and computer software product for grid alignment of multiple scanned images
US7062092B2 (en) 2000-08-22 2006-06-13 Affymetrix, Inc. System, method, and computer software product for gain adjustment in biological microarray scanner
WO2002033068A1 (en) * 2000-10-18 2002-04-25 Canon Kabushiki Kaisha Method of analyzing nucleic acid base sequence
US6858412B2 (en) 2000-10-24 2005-02-22 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA
US20020150887A1 (en) * 2000-11-09 2002-10-17 National Institute Of Advanced Industrial Science And Technology Methods and nucleic acid probes for molecular genetic analysis of polluted environments and environmental samples
US20020137074A1 (en) * 2000-11-21 2002-09-26 Piunno Paul A.E. Selectivity of nucleic acid diagnostic and microarray technologies by control of interfacial nucleic acid film chemistry
US6905816B2 (en) * 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
US20020086294A1 (en) * 2000-12-29 2002-07-04 Ellson Richard N. Device and method for tracking conditions in an assay
SE0101934D0 (en) * 2001-06-01 2001-06-01 Pharmacia Ab New methods
EP1481076A4 (en) 2001-07-12 2005-05-11 Illumina Inc Multiplex nucleic acid reactions
DE60223276T2 (en) * 2001-08-31 2008-08-14 Datascope Investment Corp. Method for blocking nonspecific hybridizations of nucleic acid sequences
US20030082606A1 (en) * 2001-09-04 2003-05-01 Lebo Roger V. Optimizing genome-wide mutation analysis of chromosomes and genes
US7439346B2 (en) 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
JP2005519634A (en) * 2001-10-12 2005-07-07 スペクトラル ジェノミクス、インク． Nucleic acid compositions and arrays and methods using them
US20030124542A1 (en) * 2001-12-28 2003-07-03 Spectral Genomics, Inc. Methods for mapping the chromosomal loci of genes expressed by a cell
US6783944B2 (en) 2002-01-04 2004-08-31 The Regents Of The University Of California Genetic changes in atypical nodular proliferations in congenital melanocytic nevi
US7383134B2 (en) * 2002-01-15 2008-06-03 Piper James R Method and/or system for analyzing biological samples using a computer system
AU2003207611B2 (en) * 2002-01-18 2008-05-08 Syngenta Participations Ag Probe correction for gene expression level detection
US6916621B2 (en) 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
CA2481411C (en) 2002-04-19 2016-06-14 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
US9388459B2 (en) * 2002-06-17 2016-07-12 Affymetrix, Inc. Methods for genotyping
US20070065830A1 (en) * 2002-09-04 2007-03-22 Children's Hospital Medical Center Of Akron, Inc. Cloning multiple control sequences into chromosomes or into artificial centromeres
CA2503905A1 (en) * 2002-09-16 2004-03-25 Plexxikon, Inc. Crystal structure of pim-1 kinase
US7011949B2 (en) * 2002-09-30 2006-03-14 Agilent Technologies, Inc. Methods and compositions for producing labeled probe nucleic acids for use in array based comparative genomic hybridization applications
US6863822B2 (en) * 2002-10-16 2005-03-08 Anthony Pipes Method and apparatus for parallel desalting
US7822555B2 (en) 2002-11-11 2010-10-26 Affymetrix, Inc. Methods for identifying DNA copy number changes
GB0227238D0 (en) * 2002-11-21 2002-12-31 Diagenic As Product and method
CA2511829A1 (en) * 2002-12-04 2004-06-17 Pamgene Bv Method for hybridisation of immobilized genomic dna
US7549817B2 (en) * 2002-12-18 2009-06-23 World Wide Stationery Mfg. Co., Ltd. Ready lock ring binder mechanism
DE03808546T1 (en) * 2002-12-23 2006-01-26 Agilent Technologies, Inc., Palo Alto COMPARATIVE GENOMIC HYBRIDIZATION TESTS USING CHARACTERIZED IMMOBILIZED OLIGONUCLEOTIDES AND COMPOSITIONS FOR IMPLEMENTING THEM
US20040166518A1 (en) * 2003-01-02 2004-08-26 The Regents Of The University Of California Multilabeling mouse FISH assay for detecting structural and numerical chromosomal abnormalities
US20050048573A1 (en) * 2003-02-03 2005-03-03 Plexxikon, Inc. PDE5A crystal structure and uses
US20050170431A1 (en) * 2003-02-28 2005-08-04 Plexxikon, Inc. PYK2 crystal structure and uses
CN104388449A (en) 2003-03-06 2015-03-04 维莱尼姆公司 Amylases, nucleic acids encoding them and methods for making and using them
CA2889013C (en) 2003-03-07 2018-07-17 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
MXPA05010681A (en) 2003-04-04 2005-12-15 Diversa Corp Pectate lyases, nucleic acids encoding them and methods for making and using them.
WO2004097371A2 (en) * 2003-04-25 2004-11-11 Board Of Regents, The University Of Texas System System and method for the detection of analytes
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
RU2390561C2 (en) * 2003-05-23 2010-05-27 Колд Спринг Харбор Лэборетери Virtual sets of fragments of nucleotide sequences
US7211384B2 (en) * 2003-05-28 2007-05-01 Agilent Technologies, Inc. Comparative genomic hybridization assays using immobilized oligonucleotide targets with initially small sample sizes and compositions for practicing the same
CN108486086A (en) 2003-07-02 2018-09-04 维莱尼姆公司 Dextranase, encode they nucleic acid and preparation and use their method
AU2003903417A0 (en) * 2003-07-04 2003-07-17 Genera Biosystems Pty Ltd Multiplex detection
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
WO2005021714A2 (en) 2003-08-11 2005-03-10 Diversa Corporation Laccases, nucleic acids encoding them and methods for making and using them
US20050164300A1 (en) * 2003-09-15 2005-07-28 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
JP2007515947A (en) * 2003-10-30 2007-06-21 タフツ−ニュー イングランド メディカル センター Prenatal diagnosis using acellular fetal DNA in amniotic fluid
US7534875B2 (en) 2003-11-03 2009-05-19 Exagen Diagnostics, Inc. Compositions for glioma classification
PL1696920T3 (en) * 2003-12-19 2015-03-31 Plexxikon Inc Compounds and methods for development of ret modulators
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
WO2005079474A2 (en) * 2004-02-17 2005-09-01 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
US20070031883A1 (en) * 2004-03-04 2007-02-08 Kincaid Robert H Analyzing CGH data to identify aberrations
US8321138B2 (en) * 2005-07-29 2012-11-27 Agilent Technologies, Inc. Method of characterizing quality of hybridized CGH arrays
US20050233339A1 (en) * 2004-04-20 2005-10-20 Barrett Michael T Methods and compositions for determining the relationship between hybridization signal of aCGH probes and target genomic DNA copy number
US20050233338A1 (en) * 2004-04-20 2005-10-20 Barrett Michael T Methods and compositions for assessing chromosome copy number
EP1742627A4 (en) 2004-05-06 2009-08-26 Plexxikon Inc Pde4b inhibitors and uses therefor
EP1766061B1 (en) * 2004-05-20 2013-07-17 Quest Diagnostics Investments Incorporated Single label comparative hybridization
EP2471921A1 (en) 2004-05-28 2012-07-04 Asuragen, Inc. Methods and compositions involving microRNA
JP2008512984A (en) * 2004-05-28 2008-05-01 ダナ−ファーバー キャンサー インスティチュート，インコーポレイテッド Compositions, kits and methods for cancer identification, evaluation, prevention and treatment
GB0412301D0 (en) * 2004-06-02 2004-07-07 Diagenic As Product and method
ES2540728T3 (en) 2004-06-16 2015-07-13 Dsm Ip Assets B.V. Method for enzymatic discoloration of pheophytin
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
WO2006009797A1 (en) * 2004-06-17 2006-01-26 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
US7605168B2 (en) * 2004-09-03 2009-10-20 Plexxikon, Inc. PDE4B inhibitors
US20070099227A1 (en) * 2004-10-12 2007-05-03 Curry Bo U Significance analysis using data smoothing with shaped response functions
US20060078899A1 (en) * 2004-10-12 2006-04-13 Scheffer Alicia F Methods and compositions for reducing label variation in array-based comparative genome hybridization assays
US20060080043A1 (en) * 2004-10-12 2006-04-13 Sampas Nicholas M Comparative genomic hybridization significance analysis using data smoothing with shaped response functions
EP1815021A2 (en) * 2004-11-03 2007-08-08 Almac Diagnostics Limited Transcriptome microarray technology and methods of using the same
EP2302054B1 (en) 2004-11-12 2014-07-16 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
US20060110744A1 (en) 2004-11-23 2006-05-25 Sampas Nicolas M Probe design methods and microarrays for comparative genomic hybridization and location analysis
DE602006018861D1 (en) * 2005-01-27 2011-01-27 Quest Diagnostics Invest Inc FAST COMPARATIVE GENOM HYBRIDIZATION
US7541144B2 (en) * 2005-01-31 2009-06-02 Agilent Technologies, Inc. RNA labeling method
US20060172314A1 (en) * 2005-01-31 2006-08-03 Song Min-Sun Quantification of amplified nucleic acids
EP2333117B1 (en) 2005-02-18 2013-10-16 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Methods for detecting progression of low grade cervical dysplasia
CA2614769A1 (en) 2005-03-10 2006-09-21 Verenium Corporation Lyase enzymes, nucleic acids encoding them and methods for making and using them
BRPI0609140A2 (en) 2005-03-15 2010-02-17 Verenium Corp cellulases, nucleic acids that encode them and methods for their production and use
WO2006119494A2 (en) 2005-05-04 2006-11-09 Exagen Diagnostics, Inc. Acute myelogenous leukemia biomarkers
AU2006272951A1 (en) 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
DK1893612T3 (en) 2005-06-22 2011-11-21 Plexxikon Inc Pyrrole [2,3-B] pyridine derivatives as protein kinase inhibitors
US7544471B2 (en) 2005-07-30 2009-06-09 Agilent Technologies, Inc. Preparing RNA from a wax-embedded tissue specimen
US20070048743A1 (en) * 2005-08-26 2007-03-01 Sampas Nicholas M Methods and compositions for assessing candidate aCGH probe nucleic acids
US20070087355A1 (en) * 2005-10-14 2007-04-19 Barrett Michael T Comparative genomic hybridization assays and compositions for practicing the same
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
US11306351B2 (en) 2005-12-21 2022-04-19 Affymetrix, Inc. Methods for genotyping
BRPI0620420B1 (en) * 2005-12-23 2016-08-09 Perkinelmer Las Inc method to evaluate genomic DNA
US20090104613A1 (en) * 2005-12-23 2009-04-23 Perkinelmer Las, Inc. Methods and compositions relating to multiplexed genomic gain and loss assays
WO2007075910A2 (en) * 2005-12-23 2007-07-05 Perkinelmer Las, Inc. Methods and compositions for detecting enzymatic activity
US7932037B2 (en) * 2007-12-05 2011-04-26 Perkinelmer Health Sciences, Inc. DNA assays using amplicon probes on encoded particles
EP1969337A4 (en) * 2005-12-23 2010-01-27 Perkinelmer Las Inc Multiplex assays using magnetic and non-magnetic particles
US20100009373A1 (en) * 2005-12-23 2010-01-14 Perkinelmer Health Sciences, Inc. Methods and compositions relating to multiplex genomic gain and loss assays
WO2007076726A1 (en) 2006-01-04 2007-07-12 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities
US7932029B1 (en) 2006-01-04 2011-04-26 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities
US20090156431A1 (en) * 2007-12-12 2009-06-18 Si Lok Methods for Nucleic Acid Mapping and Identification of Fine Structural Variations in Nucleic Acids
JP2009523739A (en) 2006-01-20 2009-06-25 ウィメンズ アンド チルドレンズ ヘルス リサーチ インスティテュート インコーポレーティッド Methods for treatment, prevention, and diagnosis of bone lesions
EP2216403A3 (en) 2006-02-02 2010-11-24 Verenium Corporation Esterases and related nucleic acids and methods
NZ595498A (en) 2006-02-10 2013-05-31 Verenium Corp Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
ES2682284T3 (en) 2006-02-14 2018-09-19 Bp Corporation North America Inc. Xylanases, nucleic acids that encode them and methods to make and use them
US20070207489A1 (en) 2006-02-16 2007-09-06 Pestano Gary A Reagents and methods for cancer prognosis and pathological staging
CA2645225A1 (en) 2006-03-07 2007-09-13 Verenium Corporation Aldolases, nucleic acids encoding them and methods for making and using them
EP2316962B1 (en) 2006-03-07 2014-07-09 Cargill, Incorporated Aldolases, nucleic acids encoding them and methods for making and using them
US20070231803A1 (en) * 2006-03-31 2007-10-04 Jensen Mark A Multiplex pcr mixtures and kits containing the same
US20070232556A1 (en) * 2006-03-31 2007-10-04 Montine Thomas J Methods and compositions for the treatment of neurological diseases and disorders
US8058055B2 (en) * 2006-04-07 2011-11-15 Agilent Technologies, Inc. High resolution chromosomal mapping
US20070238106A1 (en) * 2006-04-07 2007-10-11 Agilent Technologies, Inc. Systems and methods of determining alleles and/or copy numbers
US20070238104A1 (en) * 2006-04-07 2007-10-11 Agilent Technologies, Inc. Competitive oligonucleotides
US20070259347A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Methods of increasing the effective probe densities of arrays
US20070259344A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Compound probes and methods of increasing the effective probe densities of arrays
US20070259345A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Target determination using compound probes
US20070259346A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Analysis of arrays
US20080058218A1 (en) * 2006-05-03 2008-03-06 Gordon David B Arrays of compound probes and methods using the same
US8261507B2 (en) * 2006-05-12 2012-09-11 Columbia Insurance Company Flooring profile
EP2444413A1 (en) 2006-08-04 2012-04-25 Verenium Corporation Methods for oil or gas well drilling, washing and/or fracturing
WO2008036765A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
CA2663962A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
EP2617819B1 (en) 2006-09-21 2016-04-27 BASF Enzymes LLC Phytases, nucleic acids encoding them and methods for making and using them
BRPI0716872A2 (en) 2006-09-21 2015-06-16 Verenium Corp Phospholipases, nucleic acids encoding them and methods for their manufacture and use
AU2007324128B2 (en) * 2006-10-10 2013-10-10 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Prostate cancer-specific alterations in ERG gene expression and detection and treatment methods based on those alterations
US20080090236A1 (en) * 2006-10-13 2008-04-17 Yakhini Zohar H Methods and systems for identifying tumor progression in comparative genomic hybridization data
US8618248B2 (en) 2006-10-31 2013-12-31 President And Fellows Of Harvard College Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides
US20080102453A1 (en) * 2006-10-31 2008-05-01 Jayati Ghosh Methods and systems and analysis of CGH data
EP2078197B1 (en) 2006-11-01 2016-03-23 Ventana Medical Systems, Inc. Haptens, hapten conjugates, compositions thereof and method for their preparation and use
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US9201063B2 (en) 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US8305579B2 (en) 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US7662566B2 (en) * 2006-11-22 2010-02-16 Myriad Genetics, Inc. Gene copy number profiling
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
CA2672315A1 (en) 2006-12-14 2008-06-26 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PL3101128T3 (en) 2006-12-21 2019-09-30 Basf Enzymes Llc Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them
PE20081581A1 (en) * 2006-12-21 2008-11-12 Plexxikon Inc PIRROLO [2,3-b] PYRIDINES COMPOUNDS AS KINASE MODULATORS
EP2094701A2 (en) 2006-12-21 2009-09-02 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
NZ610301A (en) 2007-01-30 2015-03-27 Bp Corp North America Inc Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
US20080241829A1 (en) * 2007-04-02 2008-10-02 Milligan Stephen B Methods And Kits For Producing Labeled Target Nucleic Acid For Use In Array Based Hybridization Applications
CA2683559C (en) 2007-04-13 2019-09-24 Dana Farber Cancer Institute, Inc. Methods for treating cancer resistant to erbb therapeutics
CN103555735B (en) 2007-04-27 2016-03-09 加利福尼亚大学董事会 Plant CO 2sensor, encode their nucleic acid and manufacture and their method of use
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
MX2010000617A (en) 2007-07-17 2010-05-17 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor.
US7507539B2 (en) * 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
CA2694281A1 (en) * 2007-08-13 2009-02-19 Almac Diagnostics Limited A 3'-based sequencing approach for microarray manufacture
US20090088330A1 (en) * 2007-09-28 2009-04-02 Leproust Emily M Methods And Kits For Producing Labeled Target Nucleic Acids For Use In Array Based Hybridization Applications
CN110577945A (en) 2007-10-03 2019-12-17 维莱尼姆公司 xylanases, nucleic acids encoding them, and methods for making and using them
MX2010005060A (en) * 2007-11-08 2010-07-05 Univ Washington Dna microarray based identification and mapping of balanced translocation breakpoints.
AU2014203712B2 (en) * 2007-12-05 2016-12-08 Perkinelmer Health Sciences, Inc. Multiplexed genomic gain and loss assays
WO2009079857A1 (en) * 2007-12-24 2009-07-02 Honeywell International Inc. A reactor for the quantitative analysis of nucleic acids
CN104651381A (en) 2008-01-03 2015-05-27 巴斯夫酶有限责任公司 Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
WO2009137369A1 (en) * 2008-05-03 2009-11-12 Tufts Medical Center, Inc. Neonatal salivary genomics
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
WO2010003132A1 (en) 2008-07-02 2010-01-07 Illumina Cambridge Ltd. Using populations of beads for the fabrication of arrays on surfaces
WO2010003316A1 (en) * 2008-07-10 2010-01-14 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
ES2581774T3 (en) 2008-08-29 2016-09-07 Janssen Biotech, Inc. Markers and methods of evaluation and treatment of ulcerative colitis and related disorders using a panel of 20 genes
CN102159726A (en) * 2008-09-05 2011-08-17 生命科技公司 Methods and systems for nucleic acid sequencing validation, calibration and normalization
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
EP2352998A4 (en) 2008-11-07 2011-09-21 Centocor Ortho Biotech Inc Markers and methods for assessing and treating lupus patients susceptible to photoprovocation
ES2661310T3 (en) * 2009-03-09 2018-03-28 Bioatla, Llc Mirac proteins
WO2010114928A2 (en) 2009-04-03 2010-10-07 F.Hoffmann-La Roche Ag Compositions and uses thereof
MX355638B (en) 2009-05-21 2018-03-26 Verenium Corp Phytases, nucleic acids encoding them and methods for making and using them.
AU2010254259A1 (en) 2009-05-29 2012-01-12 Emory University B cell signature associated with tolerance in transplant recipients
AU2010276236B2 (en) 2009-07-21 2014-03-20 Gen-Probe Incorporated Methods and compositions for quantitative detection of nucleic acid sequences over an extended dynamic range
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
CN102630250A (en) 2009-09-25 2012-08-08 基因诊断测试公司 Multiplex (+/-) stranded arrays and assays for detecting chromosomal abnormalities associated with cancer and other diseases
UA109884C2 (en) 2009-10-16 2015-10-26 A POLYPEPTIDE THAT HAS THE ACTIVITY OF THE PHOSPHATIDYLINOSYTOL-SPECIFIC PHOSPHOLIPASE C, NUCLEIC ACID, AND METHOD OF METHOD
UA111708C2 (en) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. METHOD OF OIL REFINING
US20120277112A1 (en) 2009-10-19 2012-11-01 Stichting Het Nederlands Kanker Instituut Predicting response to anti-cancer therapy via array comparative genomic hybridization
WO2011048498A2 (en) 2009-10-19 2011-04-28 Stichting Het Nederlands Kanker Instituut Differentiation between brca2-associated tumours and sporadic tumours via array comparative genomic hybridization
WO2011048495A1 (en) 2009-10-19 2011-04-28 Stichting Het Nederlands Kanker Instituut Predicting benefit of anti-cancer therapy via array comparative genomic hybridization
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
EP2494076B1 (en) 2009-10-26 2017-11-22 Abbott Molecular Inc. Detection of chromosomal abnormalities associated with prognosis of non small cell lung cancer
NZ629615A (en) 2009-11-06 2016-01-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
WO2011083312A1 (en) 2010-01-08 2011-07-14 Oxford Gene Technology (Operations) Ltd Combined cgh & allele-specific hybridisation method
CN102791882A (en) * 2010-01-20 2012-11-21 霍尼韦尔国际公司 Reactor for quantitative analysis of nucleic acids
MX344543B (en) 2010-01-26 2016-12-19 Nat Jewish Health Methods and compositions for risk prediction, diagnosis, prognosis, and treatment of pulmonary disorders.
US9169515B2 (en) * 2010-02-19 2015-10-27 Life Technologies Corporation Methods and systems for nucleic acid sequencing validation, calibration and normalization
WO2011108930A1 (en) 2010-03-04 2011-09-09 Interna Technologies Bv A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS DIAGNOSTIC AND THERAPEUTIC USES IN DISEASES OR CONDITIONS ASSOCIATED WITH EMT
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
US9652585B2 (en) 2010-03-16 2017-05-16 Bluegnome Limited Comparative genomic hybridization array method for preimplantation genetic screening
US20110301051A1 (en) 2010-04-09 2011-12-08 Exagen Diagnostics, Inc. Biomarkers for Ulcerative Colitis and Crohn's Disease
CA2798190A1 (en) 2010-05-10 2011-11-17 Abbott Laboratories Detection of chromosomal abnormalities associated with endometrial cancer
AU2011226767B1 (en) 2010-06-30 2011-11-10 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
US8731847B2 (en) 2010-06-30 2014-05-20 Life Technologies Corporation Array configuration and readout scheme
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
NZ719520A (en) 2010-07-06 2017-07-28 Int Tech Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
EP3034629B1 (en) 2010-09-13 2019-09-04 Clinical Genomics Pty Ltd Diagnosis of cancer by means of methylation marker
US20140018251A1 (en) 2010-09-20 2014-01-16 Stichting Het Nederlands Kanker Instituut Methods for Predicting Response to Anti-Cancer Therapy in Cancer Patients
WO2012051055A2 (en) 2010-10-06 2012-04-19 Bp Corporation North America Inc. Variant cbh i polypeptides
ES2629890T3 (en) 2010-11-17 2017-08-16 Interpace Diagnostics, Llc miRNA as biomarkers to distinguish between benign and malignant thyroid neoplasms
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
JP5941069B2 (en) 2011-02-07 2016-06-29 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． Compounds and methods for kinase regulation and indications therefor
AR085279A1 (en) 2011-02-21 2013-09-18 Plexxikon Inc SOLID FORMS OF {3- [5- (4-CHLORINE-PHENYL) -1H-PIRROLO [2,3-B] PIRIDINA-3-CARBONIL] -2,4-DIFLUOR-PHENIL} -AMIDE OF PROPANE ACID-1- SULFONIC
WO2012158238A2 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
US20140106354A1 (en) 2011-04-18 2014-04-17 Garvan Institute Of Medical Research Method of Diagnosing Cancer
RU2631487C2 (en) 2011-05-17 2017-09-22 Плексксикон Инк. Kinases modulation and indications for its use
WO2012174419A2 (en) 2011-06-17 2012-12-20 Dana-Farber Cancer Institute, Inc. Signatures for predicting the survivability of myelodysplastic syndrome subjects
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
EP2758544B1 (en) 2011-09-23 2017-10-18 Academisch Medisch Centrum Materials and methods for prognosis of progression of barrett's esophagus
WO2013055911A1 (en) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Znf365/zfp365 biomarker predictive of anti-cancer response
WO2013063519A1 (en) 2011-10-26 2013-05-02 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
US20130142728A1 (en) 2011-10-27 2013-06-06 Asuragen, Inc. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
US20130149704A1 (en) 2011-12-10 2013-06-13 Abbott Molecular Inc. Materials and methods for diagnosis of malignant melanoma and prognosis of metastasis of malignant melanoma
EP2798079B1 (en) 2011-12-30 2016-09-07 Abbott Molecular Inc. Materials and methods for diagnosis of bladder cancer and monitoring recurrence thereof
US9469877B2 (en) 2011-12-30 2016-10-18 Abbott Molecular Inc. Materials and methods for diagnosis, prognosis, monitoring of recurrence, and assessment of therapeutic/prophylactic treatment of pancreatobiliary cancer
JP6203752B2 (en) 2011-12-30 2017-09-27 アボツト・モレキユラー・インコーポレイテツド Materials and methods for diagnosis, prediction and evaluation of prostate cancer therapeutic / preventive treatment
WO2013124740A2 (en) 2012-02-23 2013-08-29 Stichting Vu-Vumc BRCA DEFICIENCY PROTEIN AND mRNA SIGNATURES USEFUL IN IDENTIFICATION OF PATIENTS WITH BRCA-DEFICIENT TUMORS AND PREDICTING BENEFIT OF ANTI-CANCER THERAPY IN CANCER PATIENTS
WO2013144202A1 (en) 2012-03-29 2013-10-03 Roche Diagnostics Gmbh Biomarkers for discriminating healthy and/or non-malignant neoplastic colorectal cells from colorectal cancer cells
NZ701527A (en) 2012-05-11 2016-07-29 Clinical Genomics Pty Ltd Diagnostic gene marker panel for colorectal cancer
GB201208726D0 (en) * 2012-05-17 2012-07-04 Oxford Gene Tech Ip Ltd Methods and materials
EP2850212B1 (en) 2012-05-18 2020-01-01 Clinical Genomics Pty. Ltd. A method of screening for colorectal cancer
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
EP2870263A1 (en) 2012-07-03 2015-05-13 InteRNA Technologies B.V. Diagnostic portfolio and its uses
DK2877494T3 (en) 2012-07-23 2020-09-21 La Jolla Inst Allergy & Immunology PTPRS and proteoglycans in autoimmune disease
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
WO2014100626A1 (en) 2012-12-21 2014-06-26 Hutman Diagnostics AG Microarrays
US9266797B2 (en) * 2013-02-12 2016-02-23 Ecolab Usa Inc. Online monitoring of polymerization inhibitors for control of undesirable polymerization
US9267171B2 (en) 2013-02-28 2016-02-23 New York University DNA photolithography with cinnamate crosslinkers
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
CN105209635A (en) 2013-03-14 2015-12-30 雅培分子公司 Cell preparations and cell supports and their use in theranosis
WO2014151551A1 (en) 2013-03-15 2014-09-25 Baylor Research Institute Ulcerative colitis (uc)-associated colorectal neoplasia markers
EP2971132B1 (en) 2013-03-15 2020-05-06 Baylor Research Institute Tissue and blood-based mirna biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
EP2970909A4 (en) 2013-03-15 2017-02-15 The University of Chicago Methods and compositions related to t-cell activity
CN105264366B (en) 2013-03-15 2019-04-16 生命科技公司 Chemical sensor with consistent sensor surface area
EP3004393A4 (en) 2013-05-31 2017-03-08 Si Lok Molecular identity tags and uses thereof in identifying intermolecular ligation products
US10328062B2 (en) 2014-04-04 2019-06-25 Amgen, Inc. Biomarkers and use of MET inhibitor for treatment of cancer
US11624093B2 (en) 2014-04-24 2023-04-11 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
ES2913205T3 (en) 2014-05-13 2022-06-01 Bioatla Inc Conditionally active biological proteins
US9994912B2 (en) 2014-07-03 2018-06-12 Abbott Molecular Inc. Materials and methods for assessing progression of prostate cancer
AU2015308818B2 (en) 2014-08-28 2021-02-25 Bioatla Llc Conditionally active chimeric antigen receptors for modified T-cells
US11111288B2 (en) 2014-08-28 2021-09-07 Bioatla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
JP2017532019A (en) 2014-09-03 2017-11-02 バイオアトラ、エルエルシー Discovery and production of conditionally active biological proteins in the same eukaryotic cell production host
AU2015318823A1 (en) 2014-09-15 2016-03-24 Garvan Institute Of Medical Research Methods for diagnosis, prognosis and monitoring of breast cancer and reagents therefor
AU2015328411C1 (en) 2014-10-06 2022-03-03 Dana-Farber Cancer Institute, Inc. Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
AU2015328163B2 (en) 2014-10-09 2020-10-15 Dana-Farber Cancer Institute, Inc. Multiple-variable IL-2 dose regimen for treating immune disorders
US11094398B2 (en) 2014-10-10 2021-08-17 Life Technologies Corporation Methods for calculating corrected amplicon coverages
US11180761B2 (en) 2014-10-15 2021-11-23 City Of Hope PDGFR RNA aptamers
EP3218482A4 (en) 2014-11-11 2018-05-09 Abbott Molecular Inc. Hybridization probes and methods
CA3225013A1 (en) 2015-02-24 2016-09-01 Bioatla, Llc Conditionally active proteins
CA2976946C (en) 2015-02-24 2023-09-19 City Of Hope Chemically encoded spatially addressed library screening platforms
CA2977532A1 (en) 2015-03-06 2016-09-15 Dana-Farber Cancer Institute, Inc. Pd-l2 biomarkers predictive of pd-1 pathway inhibitor responses in esophagogastric cancers
US10160755B2 (en) 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
JP2018532404A (en) 2015-10-14 2018-11-08 ライフ テクノロジーズ コーポレーション Ribonucleoprotein transfection agent
RU2018123825A (en) 2015-12-07 2020-01-15 Плексксикон Инк. COMPOUNDS AND METHODS FOR MODULATION OF KINASES, AND INDICATIONS FOR THIS
US10519442B2 (en) 2016-02-11 2019-12-31 City Of Hope Twist signaling inhibitor compositions and methods of using the same
US11845938B2 (en) 2016-03-31 2023-12-19 City Of Hope Aptamer compositions and the use thereof
IL308504A (en) 2016-05-13 2024-01-01 Bioatla Llc Anti-ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof
WO2017222834A1 (en) 2016-06-10 2017-12-28 City Of Hope Compositions and methods for mitochondrial genome editing
WO2018013558A1 (en) 2016-07-12 2018-01-18 Life Technologies Corporation Compositions and methods for detecting nucleic acid regions
US11136409B2 (en) 2016-09-20 2021-10-05 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators
TW201815766A (en) 2016-09-22 2018-05-01 美商普雷辛肯公司 Compounds and methods for IDO and TDO modulation, and indications therefor
US11434301B2 (en) 2016-11-11 2022-09-06 The Regents Of The University Of California Anti-CD46 antibodies and methods of use
US10646540B2 (en) 2016-11-18 2020-05-12 City Of Hope Peptide inhibitors of twist
WO2018136202A2 (en) 2016-12-23 2018-07-26 Plexxikon Inc. Compounds and methods for cdk8 modulation and indications therefor
WO2018226685A2 (en) 2017-06-06 2018-12-13 Dana-Farber Cancer Institute, Inc. Methods for sensitizing cancer cells to t cell-mediated killing by modulating molecular pathways
US10428067B2 (en) 2017-06-07 2019-10-01 Plexxikon Inc. Compounds and methods for kinase modulation
JP7382919B2 (en) 2017-08-11 2023-11-17 シティ・オブ・ホープ RNA aptamer for transferrin receptor (TfR)
CN111315890A (en) 2017-09-08 2020-06-19 生命技术公司 Methods and compositions for enhancing homologous recombination
WO2019051237A1 (en) 2017-09-08 2019-03-14 Life Technologies Corporation Methods for improved homologous recombination and compositions thereof
US11497762B2 (en) 2017-11-03 2022-11-15 Interna Technologies B.V. MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
WO2019126037A1 (en) 2017-12-19 2019-06-27 City Of Hope Modified tracrrnas grnas, and uses thereof
WO2019200326A1 (en) 2018-04-13 2019-10-17 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
EP3853250A4 (en) 2018-09-19 2022-06-08 La Jolla Institute for Immunology Ptprs and proteoglycans in rheumatoid arthritis
KR20210151944A (en) 2019-04-12 2021-12-14 더 리전트 오브 더 유니버시티 오브 캘리포니아 Compositions and methods for increasing muscle mass and oxidative metabolism
EP3969591A1 (en) 2019-05-15 2022-03-23 Squadra Lifesciences, Inc Aptamers against glioblastoma
EP3980541A1 (en) 2019-06-04 2022-04-13 Apterna Limited Aptamers against transferrin receptor (tfr)
BR112022004475A2 (en) 2019-09-18 2022-05-31 Novartis Ag nkg2d fusion proteins and uses thereof
CN116419747A (en) 2020-08-07 2023-07-11 福蒂斯治疗公司 CD46 targeting immunoconjugates and methods of use thereof
IL305575A (en) 2021-03-02 2023-10-01 Dana Farber Cancer Inst Inc Methods of treating red blood cell disorders
WO2022261183A2 (en) 2021-06-08 2022-12-15 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating and/or identifying an agent for treating intestinal cancers
WO2023097119A2 (en) 2021-11-29 2023-06-01 Dana-Farber Cancer Institute, Inc. Methods and compositions to modulate riok2
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (en) 1978-04-13 1979-11-09 Pasteur Institut METHOD OF DETECTION AND CHARACTERIZATION OF A NUCLEIC ACID OR OF A SEQUENCE OF THE SAME, AND ENZYMATIC REAGENT FOR THE IMPLEMENTATION OF THIS PROCESS
US4358535A (en) 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4681840A (en) 1984-01-18 1987-07-21 The United States Of America As Represented By The Secretary Of Commerce Deoxyribonucleic acid molecules useful as probes for detecting oncogenes incorporated into chromosomal DNA
US4707440A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US4647529A (en) 1984-06-01 1987-03-03 Rodland Karin D Hybridization method of detecting nucleic acid sequences with probe containing thionucleotide
US4755458A (en) 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US4721669A (en) 1985-01-18 1988-01-26 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents
US4675286A (en) 1985-01-28 1987-06-23 Aspen Diagnostics, Inc. Fetal cell separation and testing
US5851767A (en) 1985-03-04 1998-12-22 The Regents Of The University Of California Detection of prokaryotic organism by DNA hybridization
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4772691A (en) 1985-06-05 1988-09-20 The Medical College Of Wisconsin, Inc. Chemically cleavable nucleotides
US4725536A (en) 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4888278A (en) 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US4770992A (en) 1985-11-27 1988-09-13 Den Engh Gerrit J Van Detection of specific DNA sequences by flow cytometry
US5756696A (en) 1986-01-16 1998-05-26 Regents Of The University Of California Compositions for chromosome-specific staining
US6280929B1 (en) 1986-01-16 2001-08-28 The Regents Of The University Of California Method of detecting genetic translocations identified with chromosomal abnormalities
US5721098A (en) 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
US5447841A (en) * 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
EP0261172A1 (en) 1986-02-21 1988-03-30 Whitehead Institute For Biomedical Research Y-specific dna hybridization probes and uses therefor
US4981783A (en) * 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US5028525A (en) * 1986-11-24 1991-07-02 Regents Of The University Of California Method of preparing and applying single stranded DNA probes to double stranded target DNAs in situ
US5085983A (en) 1988-08-19 1992-02-04 City Of Hope Detection of human tumor progression and drug resistance
US5194300A (en) * 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
US5064948A (en) 1988-02-12 1991-11-12 The United States Of America As Represented By The Department Of Energy Chromosome specific repetitive dna sequences
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
CN1046392A (en) 1988-11-15 1990-10-24 耶鲁大学 By original position suppress hybridization to individual human mid-term and interval the cell chromosome location
US5869237A (en) 1988-11-15 1999-02-09 Yale University Amplification karyotyping
ATE161960T1 (en) 1988-12-06 1998-01-15 Flinders Technologies Pty Ltd ISOLATION OF FETAL CELLS FROM MATERNAL BLOOD TO PERFORM PRENATAL DIAGNOSTICS
CA2046311A1 (en) 1989-02-01 1990-08-02 Tommy Pettersson Coupling device for a motor vehicle
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US6416952B1 (en) 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
AU647741B2 (en) 1989-12-01 1994-03-31 Regents Of The University Of California, The Methods and compositions for chromosome-specific staining
US5173260A (en) * 1990-09-17 1992-12-22 Eastman Kodak Company Beads fused to a test device support
US5491224A (en) 1990-09-20 1996-02-13 Bittner; Michael L. Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture
US5789161A (en) * 1990-09-20 1998-08-04 Amoco Corporation Methods for genome identification using direct label probe composition
EP0834576B1 (en) 1990-12-06 2002-01-16 Affymetrix, Inc. (a Delaware Corporation) Detection of nucleic acid sequences
US5427932A (en) 1991-04-09 1995-06-27 Reagents Of The University Of California Repeat sequence chromosome specific nucleic acid probes and methods of preparing and using
US5976790A (en) 1992-03-04 1999-11-02 The Regents Of The University Of California Comparative Genomic Hybridization (CGH)
WO1993018186A1 (en) * 1992-03-04 1993-09-16 The Regents Of The University Of California Comparative genomic hybridization (cgh)
US5633137A (en) * 1992-12-01 1997-05-27 The University Of South Florida Method for measuring specific gene expression: transcriptional activity per gene dose
US20020048749A1 (en) 1998-04-15 2002-04-25 Robert J. Lipshutz Methods for polymorphism identifcation and profiling
US6027880A (en) 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
EP0666909A4 (en) * 1993-08-12 1998-12-30 Mark W Perlin A system and method for producing maps and cloning genes therefrom.
US5472842A (en) 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
DE69433180T2 (en) 1993-10-26 2004-06-24 Affymetrix, Inc., Santa Clara FIELDS OF NUCLEIC ACID PROBE ON ORGANIC CHIPS
DE4344726C2 (en) 1993-12-27 1997-09-25 Deutsches Krebsforsch Method for the detection of unbalanced genetic material of a species or for the detection of gene expression in cells of a species
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5801021A (en) 1995-10-20 1998-09-01 The Regents Of The University Of California Amplifications of chromosomal region 20q13 as a prognostic indicator in breast cancer
US5837196A (en) 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US6210878B1 (en) 1997-08-08 2001-04-03 The Regents Of The University Of California Array-based detection of genetic alterations associated with disease

Also Published As

Publication number Publication date
JPH11510681A (en) 1999-09-21
EP0800587A1 (en) 1997-10-15
DE69534046D1 (en) 2005-04-07
DK0800587T3 (en) 2005-06-27
US20030008318A1 (en) 2003-01-09
ATE290102T1 (en) 2005-03-15
EP0800587A4 (en) 2001-11-14
ES2235177T3 (en) 2005-07-01
JP4338783B2 (en) 2009-10-07
EP0800587B1 (en) 2005-03-02
WO1996017958A1 (en) 1996-06-13
CA2206102C (en) 2009-02-03
US20070172883A1 (en) 2007-07-26
DE69534046T2 (en) 2006-06-01
US7776536B2 (en) 2010-08-17
US5830645A (en) 1998-11-03
US6562565B1 (en) 2003-05-13
US20050084898A1 (en) 2005-04-21

Similar Documents

Publication Publication Date Title
CA2206102A1 (en) Comparative fluorescence hybridization to nucleic acid arrays
DE60018052D1 (en) COMPARATIVE FLUORESCENCE HYBRIDIZATION ON OLIGONUCLEOTIDE MICROARRAYS
CA2262618A1 (en) Novel boronic acid-containing nucleic acids and their use as diagnostic agents
CA2310077A1 (en) De novo or "universal" sequencing array
US5849483A (en) High throughput screening method for sequences or genetic alterations in nucleic acids
CA2153944A1 (en) Method for the sensitive detection of nucleic acids
CA2172248A1 (en) Self-sustained sequence replication electrochemiluminescent nucleic acid assay
WO1993016094A3 (en) Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides
WO2001036682A3 (en) Long oligonucleotide arrays
CA2254111A1 (en) Artificial mismatch hybridization
CA2189941A1 (en) Fluorescence Polarization Detection of Nucleic Acids
WO2000058516A3 (en) Universal arrays
CA2116215A1 (en) Diagnostic Applications of Double D-Loop Formation
CA2278715A1 (en) Aminooxy-modified oligonucleotides
CA2126391A1 (en) Determination of nucleic acid by pcr, measurement of number of microbial cells, genes, or gene-copies by pcr, and measuring-kit employed for the same
WO1996003529A9 (en) High throughput screening method for sequences or genetic alterations in nucleic acids
CA2217325A1 (en) Nucleic acid detection and amplification by chemical linkage of oligonucleotides
EP0330221A3 (en) End labeled nuceotide probe
AU1248292A (en) Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
EP0341491A3 (en) Molecular diagnosis of alzheimer disease
WO1999067619A3 (en) Compounds and methods for detecting biomolecules
JP2001521765A5 (en)
CA2195971A1 (en) Nucleic acid hybridization assay probes targeted to mycoplasma pneumoniae nucleic acid
AU9355698A (en) Novel nucleoside or nucleotide fluorescent conjugates, preparation method and uses
CA2142156A1 (en) Nucleic Acid Sequences Specific for Mycobacterium Kansasii

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20151208