CA2206753A1 - Atomising devices and methods - Google Patents

Atomising devices and methods

Info

Publication number
CA2206753A1
CA2206753A1 CA002206753A CA2206753A CA2206753A1 CA 2206753 A1 CA2206753 A1 CA 2206753A1 CA 002206753 A CA002206753 A CA 002206753A CA 2206753 A CA2206753 A CA 2206753A CA 2206753 A1 CA2206753 A1 CA 2206753A1
Authority
CA
Canada
Prior art keywords
fluid
container
metered quantity
metered
pressurizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002206753A
Other languages
French (fr)
Other versions
CA2206753C (en
Inventor
Terence Edward Weston
Stephen Terence Dunne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Terence Edward Weston
Stephen Terence Dunne
Boehringer Ingelheim International Gmbh
Dmw (Technology) Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909006340A external-priority patent/GB9006340D0/en
Priority claimed from GB909023767A external-priority patent/GB9023767D0/en
Application filed by Terence Edward Weston, Stephen Terence Dunne, Boehringer Ingelheim International Gmbh, Dmw (Technology) Ltd. filed Critical Terence Edward Weston
Publication of CA2206753A1 publication Critical patent/CA2206753A1/en
Application granted granted Critical
Publication of CA2206753C publication Critical patent/CA2206753C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/26—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/26—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets
    • B05B1/262—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets with fixed deflectors
    • B05B1/265—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets with fixed deflectors the liquid or other fluent material being symmetrically deflected about the axis of the nozzle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0041—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure without contact of the fluid remaining in the container with the atmospheric air
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • B05B11/026—Membranes separating the content remaining in the container from the atmospheric air to compensate underpressure inside the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1001—Piston pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1073—Springs
    • B05B11/1074—Springs located outside pump chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
    • B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/40—Filters located upstream of the spraying outlets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B9/00—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour
    • B05B9/03—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material
    • B05B9/04—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible container; with pump
    • B05B9/08—Apparatus to be carried on or by a person, e.g. of knapsack type
    • B05B9/085—Apparatus to be carried on or by a person, e.g. of knapsack type with a liquid pump
    • B05B9/0877—Apparatus to be carried on or by a person, e.g. of knapsack type with a liquid pump the pump being of pressure-accumulation type or being connected to a pressure accumulation chamber
    • B05B9/0883—Apparatus to be carried on or by a person, e.g. of knapsack type with a liquid pump the pump being of pressure-accumulation type or being connected to a pressure accumulation chamber having a discharge device fixed to the container
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • G01F11/025—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
    • B05B1/3405—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl
    • B05B1/341—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet
    • B05B1/3421—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber
    • B05B1/3431—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves
    • B05B1/3436—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves the interface being a plane perpendicular to the outlet axis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nozzles (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Saccharide Compounds (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Disintegrating Or Milling (AREA)
  • Special Spraying Apparatus (AREA)
  • Crushing And Grinding (AREA)
  • Pinball Game Machines (AREA)
  • External Artificial Organs (AREA)
  • Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
  • Massaging Devices (AREA)
  • Lift-Guide Devices, And Elevator Ropes And Cables (AREA)
  • Detergent Compositions (AREA)
  • Colloid Chemistry (AREA)
  • Detail Structures Of Washing Machines And Dryers (AREA)
  • Heat Treatment Of Water, Waste Water Or Sewage (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Surgical Instruments (AREA)

Abstract

A kit for dispensing a metered quantity of fluid as a spray of droplets for inhalation therapy comprises a metered dose inhaler that includes pressurizing means for pressurizing the metered quantity of fluid, and atomizing means for atomizing the pressurized metered quantity of fluid into droplets having a mean size suitable for inhalation into the lungs; and a container. The container holds a supply of the fluid to be dispensed, and is free from propellants and does not maintain the supply of fluid under pressure. The pressurizing means comprises a chamber for receiving the metered quantity of fluid from said container; and a piston for pressurizing the metered quantity of fluid in the chamber. The container is removably coupled to the chamber for use with the metered dose inhaler.
CA002206753A 1990-03-21 1991-03-21 Atomising devices and methods Expired - Lifetime CA2206753C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB909006340A GB9006340D0 (en) 1990-03-21 1990-03-21 Metered dose aerosol delivery system
GB9006340.5 1990-11-01
GB909023767A GB9023767D0 (en) 1990-11-01 1990-11-01 Atomising devices and methods
GB9023767.8 1990-11-01
CA002078683A CA2078683C (en) 1990-03-21 1991-03-21 Atomising devices and methods

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002078683A Division CA2078683C (en) 1990-03-21 1991-03-21 Atomising devices and methods

Publications (2)

Publication Number Publication Date
CA2206753A1 true CA2206753A1 (en) 1991-09-22
CA2206753C CA2206753C (en) 2006-10-17

Family

ID=26296818

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002206753A Expired - Lifetime CA2206753C (en) 1990-03-21 1991-03-21 Atomising devices and methods
CA002078683A Expired - Lifetime CA2078683C (en) 1990-03-21 1991-03-21 Atomising devices and methods

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002078683A Expired - Lifetime CA2078683C (en) 1990-03-21 1991-03-21 Atomising devices and methods

Country Status (37)

Country Link
US (2) US5497944A (en)
EP (2) EP0521061B1 (en)
JP (1) JP2630347B2 (en)
KR (1) KR0139652B1 (en)
CN (2) CN1042203C (en)
AT (2) ATE160947T1 (en)
AU (1) AU650870B2 (en)
BR (1) BR9106249A (en)
CA (2) CA2206753C (en)
CZ (1) CZ283820B6 (en)
DE (2) DE69131966T2 (en)
DK (2) DK0521061T3 (en)
ES (2) ES2109943T3 (en)
FI (1) FI104311B (en)
GB (1) GB2256805B (en)
GR (2) GR3026065T3 (en)
HK (1) HK1005059A1 (en)
HR (1) HRP921357B1 (en)
HU (1) HU216121B (en)
IE (1) IE62626B1 (en)
IL (1) IL97619A (en)
IN (1) IN177383B (en)
MY (1) MY110310A (en)
NO (1) NO303206B1 (en)
NZ (1) NZ237502A (en)
PH (1) PH30833A (en)
PL (1) PL165926B1 (en)
PT (1) PT97098B (en)
RS (1) RS49548B (en)
RU (1) RU2104048C1 (en)
SG (1) SG45171A1 (en)
SI (1) SI9110500B (en)
SK (1) SK280225B6 (en)
TW (1) TW253846B (en)
UA (1) UA27777C2 (en)
WO (1) WO1991014468A1 (en)
YU (1) YU48710B (en)

Families Citing this family (406)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100224A (en) * 1990-12-04 1994-10-21 Dmw Tech Ltd Atomising nozzles
US6540154B1 (en) * 1991-04-24 2003-04-01 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
GB9114080D0 (en) * 1991-06-28 1991-08-14 Weston Terence E Atomising valve
ES2099266T5 (en) * 1991-07-01 2004-01-01 Alexander George Brian O'neil INFUSION DEVICE CONTROLLED BY THE PATIENT.
EP0632734B1 (en) * 1992-03-25 1998-06-10 Tebro S.A. Powder jet dispenser for medicament inhalation therapies
IL107120A (en) * 1992-09-29 1997-09-30 Boehringer Ingelheim Int Atomising nozzle and filter and spray generating device
US6007676A (en) * 1992-09-29 1999-12-28 Boehringer Ingelheim International Gmbh Atomizing nozzle and filter and spray generating device
US7448375B2 (en) * 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US5873358A (en) * 1993-01-29 1999-02-23 Aradigm Corporation Method of maintaining a diabetic patient's blood glucose level in a desired range
US6098620A (en) * 1993-01-29 2000-08-08 Aradigm Corporation Device for aerosolizing narcotics
US5915378A (en) * 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
US5934272A (en) * 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5507277A (en) * 1993-01-29 1996-04-16 Aradigm Corporation Lockout device for controlled release of drug from patient-activateddispenser
US5724957A (en) * 1993-01-29 1998-03-10 Aradigm Corporation Intrapulmonary delivery of narcotics
US5970973A (en) * 1993-01-29 1999-10-26 Aradigm Corporation Method of delivering insulin lispro
US5672581A (en) * 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
US5743250A (en) * 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5558085A (en) * 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US6012450A (en) * 1993-01-29 2000-01-11 Aradigm Corporation Intrapulmonary delivery of hematopoietic drug
US5694919A (en) * 1993-01-29 1997-12-09 Aradigm Corporation Lockout device for controlled release of drug from patient-activated dispenser
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US5819726A (en) * 1993-01-29 1998-10-13 Aradigm Corporation Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
DK48993D0 (en) * 1993-04-30 1993-04-30 Steen Erik Holm NON-TREATMENT FOR WATERABLE LUNG MEDICINE
US5709202A (en) * 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
US5792057A (en) * 1993-05-21 1998-08-11 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
FR2705911B1 (en) * 1993-06-02 1995-08-11 Oreal Piezoelectric nebulization device.
DE69523301T2 (en) * 1994-05-13 2002-07-04 Aradigm Corp A NARCOTIC AEROSOL FORMULATION
DE4428434A1 (en) * 1994-08-11 1996-02-15 Boehringer Ingelheim Kg Sealing cap and method for filling gas-free containers
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US6782886B2 (en) * 1995-04-05 2004-08-31 Aerogen, Inc. Metering pumps for an aerosolizer
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
EP0840630B1 (en) 1995-06-07 2009-05-06 O'NEIL, Christine Patient controlled drug delivery device
AU710177B2 (en) * 1995-06-07 1999-09-16 Alexander George Brian O'neil Patient controlled drug delivery device
SE9503141D0 (en) * 1995-09-12 1995-09-12 Siemens Elema Ab Anesthesia apparatus
DE19536902A1 (en) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Miniature fluid pressure generating device
DE19545226C1 (en) 1995-12-05 1997-06-19 Boehringer Ingelheim Int Locking mechanism for a spring-operated output
US5829436A (en) * 1996-02-05 1998-11-03 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
FR2745551B1 (en) * 1996-02-29 1998-05-07 Kerplas Snc PUSH CAP FOR A PRODUCT DISPENSING BOTTLE, AND CORRESPONDING BOTTLE
DE19615422A1 (en) * 1996-04-19 1997-11-20 Boehringer Ingelheim Kg Two-chamber cartridge for propellant-free MDIs
AUPO418696A0 (en) 1996-12-12 1997-01-16 Resmed Limited A substance delivery apparatus
US20030215396A1 (en) 1999-09-15 2003-11-20 Boehringer Ingelheim Pharma Kg Method for the production of propellant gas-free aerosols from aqueous medicament preparations
DE19653969A1 (en) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg New aqueous pharmaceutical preparation for the production of propellant-free aerosols
US5829435A (en) * 1997-02-24 1998-11-03 Aradigm Corporation Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles
GB9818111D0 (en) 1998-08-19 1998-10-14 Weston Medical Ltd Device for metered fluid delivery
US5810211A (en) * 1997-03-06 1998-09-22 Hayes Products, Llc Pump assembly with sliding plug
US6089414A (en) 1997-03-06 2000-07-18 Hayes Products, Llc Pump assembly with one piece piston
US5918782A (en) * 1997-03-06 1999-07-06 Hayes Products, Llc Pump assembly with sprayer
US5816447A (en) * 1997-03-06 1998-10-06 Hayes Products, Llc Non-aerosol pump spray apparatus
DE19715893C2 (en) * 1997-04-16 1999-04-29 Boehringer Ingelheim Int Device for removing a liquid from a closed container
US20060239930A1 (en) * 1997-08-04 2006-10-26 Herbert Lamche Process for nebulizing aqueous compositions containing highly concentrated insulin
DE19733651A1 (en) * 1997-08-04 1999-02-18 Boehringer Ingelheim Pharma Aqueous aerosol preparations containing biologically active marrow molecules and processes for producing corresponding aerosols
USD418201S (en) * 1997-08-27 1999-12-28 Hayes Products, Llc Bottle, pump and sprayer assembly
USD417618S (en) * 1997-08-28 1999-12-14 Hayes Products, Llc Pump assembly
DE19742439C1 (en) 1997-09-26 1998-10-22 Boehringer Ingelheim Int Fluid micro-filter
US6016800A (en) * 1997-10-24 2000-01-25 Century; Theodore J. Intrapulmonary aerosolizer
GB9724223D0 (en) * 1997-11-18 1998-01-14 Pa Consulting Services Drug delivery device
US6223746B1 (en) * 1998-02-12 2001-05-01 Iep Pharmaceutical Devices Inc. Metered dose inhaler pump
US7963955B2 (en) * 1998-02-27 2011-06-21 Boehringer Ingelheim International Gmbh Container for a medicinal liquid
US7335186B2 (en) 1998-03-13 2008-02-26 Alexander George Brian O'Neil Patient controlled drug delivery device
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
DE19847968A1 (en) 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Separate storage of an active material and a solvent comprises a closure cap and a container, with a chamber attached to the unit.
US6745763B2 (en) * 1998-10-27 2004-06-08 Garth T. Webb Vaporizing device for administering sterile medication
DE19851404A1 (en) 1998-11-07 2000-05-11 Boehringer Ingelheim Int Pressure compensation device for a double tank
WO2000029167A1 (en) 1998-11-16 2000-05-25 Aradigm Corporation Method of fabricating porous membrane with unique pore structure for aerosolized delivery of drugs
US6070575A (en) * 1998-11-16 2000-06-06 Aradigm Corporation Aerosol-forming porous membrane with certain pore structure
US6354516B1 (en) 1999-11-02 2002-03-12 Aradigm Corporation Pore structures for reduced pressure aerosolization
US6322008B1 (en) * 1999-01-11 2001-11-27 Graves Spray Supply, Inc Liquid impingement nozzle with paired openings
DE19940713A1 (en) * 1999-02-23 2001-03-01 Boehringer Ingelheim Int Diffusion resistant cartridge for storing and dosing liquids, especially for producing drug-containing inhalable aerosols, has three-shell structure with collapsible bag, container and rigid housing
DE19921693A1 (en) 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Pharmaceutical composition for treating respiratory disorders, e.g. asthma, comprises combination of anticholinergic and beta-mimetic agents having synergistic bronchospasmolytic activity and reduced side-effects
US6360922B1 (en) 1999-04-27 2002-03-26 Hayes Products, Llc Pump assembly with pressure release capability
US6606992B1 (en) * 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
ES2165768B1 (en) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
AU781452B2 (en) 1999-09-15 2005-05-26 Aradigm Corporation Pore structures for reduced pressure aerosolization
EP1747816A3 (en) * 1999-09-15 2007-02-14 Aradigm Corporation Pore structures for reduced pressure aerosolization
SE9903990D0 (en) * 1999-11-02 1999-11-02 Shl Medical Ab Inhaler with aerosolizing unit
GB0002798D0 (en) * 2000-02-09 2000-03-29 Glaxo Group Ltd Actuator nozzle for metered dose inhaler
US8336545B2 (en) * 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US6948491B2 (en) * 2001-03-20 2005-09-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US7971588B2 (en) * 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US7600511B2 (en) * 2001-11-01 2009-10-13 Novartis Pharma Ag Apparatus and methods for delivery of medicament to a respiratory system
MXPA02010884A (en) * 2000-05-05 2003-03-27 Aerogen Ireland Ltd Apparatus and methods for the delivery of medicaments to the respiratory system.
GB0012356D0 (en) 2000-05-22 2000-07-12 Textron Automotive Company Lim Fluid spray nozzle
US6325248B1 (en) 2000-07-05 2001-12-04 Robert E. Corba Container assembly
US6299024B1 (en) 2000-07-05 2001-10-09 Robert E. Corba Valve assembly for dispensing container
CN1302823C (en) * 2000-10-05 2007-03-07 欧姆龙健康医疗事业株式会社 Liquid atomizer
RS50859B (en) * 2000-10-31 2010-08-31 Boehringer Ingelheim Pharma Gmbh. & Co.Kg. Inhalative solution formulation containing a tiotropium salt
US20020084290A1 (en) * 2000-11-10 2002-07-04 Therics, Inc. Method and apparatus for dispensing small volume of liquid, such as with a weting-resistant nozzle
AU2002216489A1 (en) * 2000-12-11 2002-06-24 Fenton, Colleen Mary An inflation device
DE10062630A1 (en) * 2000-12-15 2002-08-29 Bartels Mikrotechnik Gmbh Beduftungsverfahren
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US6701921B2 (en) 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US6681998B2 (en) 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US20110301569A1 (en) 2001-01-20 2011-12-08 Gordon Wayne Dyer Methods and apparatus for the CVCS
US6550472B2 (en) * 2001-03-16 2003-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids using flow directors
US6732944B2 (en) * 2001-05-02 2004-05-11 Aerogen, Inc. Base isolated nebulizing device and methods
GB0111336D0 (en) * 2001-05-10 2001-07-04 Innovata Biomed Ltd Device
DE10125564A1 (en) 2001-05-25 2002-11-28 Transmit Technologietransfer Inhalation mask for horses is made of a flexible, preferably transparent material, and incorporates inhalation/exhalation air channels, an inhalate source and exhalation air filters
FR2826344B1 (en) * 2001-06-22 2003-09-05 Oreal DEVICE FOR SPRAYING A PRODUCT, PARTICULARLY IN THE FORM OF A SAMPLE DOSE
DE10131178A1 (en) 2001-06-29 2003-01-16 Boehringer Ingelheim Pharma Nebulizer for applying liquids to the eyes
DE10136555A1 (en) 2001-07-27 2003-02-13 Boehringer Ingelheim Int Method for determining the size distribution of particles in an aerosol, especially particles of a medicament involves mixing of a carrier medium with the medicament to produce an appropriately conditioned aerosol
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
JP4795637B2 (en) * 2001-09-28 2011-10-19 カーブ テクノロジー，インコーポレイティド Nose nebulizer
DE10154237A1 (en) * 2001-11-07 2003-05-15 Steag Microparts Gmbh Manual sputterer, to spray liquid droplets on to a surface, has a spring acting on a piston with a manual release, to spray a portion of the stored liquid with a controlled droplet size
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US6804458B2 (en) 2001-12-06 2004-10-12 Chrysalis Technologies Incorporated Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
US20030178022A1 (en) * 2001-12-21 2003-09-25 Chiesi Farmaceutici S.P.A. Pressurized metered dose inhaler (PMDI) actuators and medicinal aerosol solution formulation products comprising therse actuators
DE10163500A1 (en) * 2001-12-21 2002-12-19 Wella Ag Sprayable hair gel giving good setting and gloss comprises a combination of a hair-setting polymer and a polymeric (meth)acrylamidoalkyl sulfonic acid-based gel-former
US7677467B2 (en) * 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
US20050205089A1 (en) * 2002-01-07 2005-09-22 Aerogen, Inc. Methods and devices for aerosolizing medicament
WO2003057291A1 (en) * 2002-01-07 2003-07-17 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
WO2003059424A1 (en) 2002-01-15 2003-07-24 Aerogen, Inc. Methods and systems for operating an aerosol generator
US6868851B2 (en) * 2002-01-31 2005-03-22 Instrumentarium Corp. Liquid reservoir for nebulizer
US6953133B2 (en) * 2002-04-02 2005-10-11 Hayes Products, Inc. Pump assembly with continuous tube
DE10216036A1 (en) 2002-04-11 2003-10-23 Boehringer Ingelheim Pharma Aerosol formulation for inhalation containing a tiotropium salt
DE10216429A1 (en) 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Synergistic medicaments for treating inflammatory or obstructive respiratory tract diseases, containing quaternized scopine ester anticholinergic agent and steroid, e.g. budesonide
US8122881B2 (en) * 2002-05-09 2012-02-28 Kurve Technology, Inc. Particle dispersion device for nasal delivery
US6915962B2 (en) * 2002-05-20 2005-07-12 Aerogen, Inc. Apparatus for providing aerosol for medical treatment and methods
US20070044792A1 (en) * 2005-08-30 2007-03-01 Aerogen, Inc. Aerosol generators with enhanced corrosion resistance
DE20221948U1 (en) 2002-06-08 2009-09-24 Boehringer Ingelheim International Gmbh Nebulizer with reminder for the therapy regiment
EP1534282B1 (en) 2002-07-09 2006-12-27 Boehringer Ingelheim Pharma GmbH & Co.KG Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
DE10230751A1 (en) 2002-07-09 2004-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug compositions based on new anticholinergics and EGFR kinase inhibitors
GB0217866D0 (en) * 2002-08-01 2002-09-11 Steag Microparts Gmbh Low dose spray pump
GB2391862C (en) * 2002-08-13 2007-01-11 Shield Medicare Ltd Spray dispenser assembly and vessel therefor
US20040166065A1 (en) 2002-08-14 2004-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosol formulation for inhalation comprising an anticholinergic
CN1674887A (en) * 2002-08-14 2005-09-28 贝林格尔英格海姆法玛两合公司 Aerosol formulation for inhalation comprising an anticholinergic
US7699052B2 (en) 2002-09-05 2010-04-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Apparatus for the dispensing of liquids, container cartridge suitable for this, and system comprising the apparatus for the dispensing of liquids, and the container cartridge
DE10243255A1 (en) 2002-09-17 2004-03-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Leak testing for pharmaceutical package, e.g. blister pack, involves exposing it to test gas, opening the package and analyzing for the gas
US20040055595A1 (en) * 2002-09-19 2004-03-25 Noymer Peter D. Aerosol drug delivery system employing formulation pre-heating
SE0202800D0 (en) * 2002-09-23 2002-09-23 Pharmacia Ab Dispensing apparatus and method for liquid products, particularly medicinal products
EP1567217A2 (en) * 2002-10-30 2005-08-31 Nektar Therapeutics Increased dosage metered dose inhaler
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US7037535B2 (en) * 2002-11-19 2006-05-02 Kimberly-Clark Worldwide, Inc. Method and composition for neutralizing house dust mite feces
US7621266B2 (en) 2003-01-14 2009-11-24 Boehringer Ingelheim International Gmbh Nozzle-system for a dispenser for fluids consisting of a nozzle and a nozzle-holder and/or screw cap
DE10300983A1 (en) 2003-01-14 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Jet system for an inhaler, to deliver a mist of fluid droplets, has inner surfaces with micro- or nano-structures on the surfaces in contact with the aerosol flow to reduce precipitation
GB0300939D0 (en) * 2003-01-16 2003-02-12 Unilever Plc Method of creating a cosmetic spray
US7883031B2 (en) 2003-05-20 2011-02-08 James F. Collins, Jr. Ophthalmic drug delivery system
PL1644129T3 (en) 2003-07-16 2007-04-30 Boehringer Ingelheim Pharma A process for producing microfluidic arrangements from a plate-shaped composite structure
US8616195B2 (en) * 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US20050017089A1 (en) * 2003-07-21 2005-01-27 Marc Rohrschneider Finger operated spray pump
KR20060052911A (en) 2003-07-29 2006-05-19 베링거 인겔하임 인터내셔날 게엠베하 Medicaments for inhalation comprising betamimetics and an anticholinergic
JP5144070B2 (en) * 2003-09-05 2013-02-13 カーブ テクノロジー，インコーポレイティド Integrated nebulizer and particle dispersion chamber for nasal delivery of drugs into the deep nasal cavity and sinuses
WO2005023334A2 (en) * 2003-09-05 2005-03-17 Kurve Technology, Inc. Nasal adapter for the base of the nose
US7427004B2 (en) * 2003-10-20 2008-09-23 Meadwestvaco Calmar, Inc. Hand held pressurized sprayer
DE102004001451A1 (en) 2004-01-08 2005-08-11 Boehringer Ingelheim International Gmbh Device for holding a fluidic component
DE102004009434A1 (en) 2004-02-24 2005-12-15 Boehringer Ingelheim International Gmbh atomizer
WO2005079997A1 (en) 2004-02-24 2005-09-01 Boehringer Ingelheim International Gmbh Atomiser
DE102004009436A1 (en) 2004-02-24 2005-10-13 Boehringer Ingelheim International Gmbh atomizer
DE102004009435A1 (en) 2004-02-24 2005-12-08 Boehringer Ingelheim International Gmbh atomizer
DE102004011381A1 (en) * 2004-03-05 2005-09-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Cartridge with a gas-driven aerosol preparation incorporates a valve or a valve system provided with at least two outer channels oriented to one another at a specified angle
DE102004012093A1 (en) * 2004-03-05 2005-09-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder inhaler with Merkanaldüse
BE1015973A3 (en) * 2004-04-09 2005-12-06 Oultremont Aurian D Liquid freshener spraying device for refreshing user during extreme heat, has spritzer fixed, by screw thread, on flexible bag having freshener, where bag has suspension unit which, using twine, permits to suspend it around user`s neck
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
CA2561403C (en) * 2004-04-20 2015-12-01 Aerogen, Inc. Aerosol delivery apparatus for pressure assisted breathing
US7267121B2 (en) * 2004-04-20 2007-09-11 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US7290541B2 (en) * 2004-04-20 2007-11-06 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
EP2422786B1 (en) 2004-04-22 2014-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG New medicine combinations for treating respiratory diseases
US20050272726A1 (en) * 2004-04-22 2005-12-08 Boehringer Ingelheim International Gmbh Novel medicaments for the treatment of respiratory diseases
HUE026152T2 (en) 2004-04-23 2016-05-30 Philip Morris Products Sa Aerosol generators and methods for producing aerosols
DE102004021789A1 (en) * 2004-05-03 2006-04-27 Boehringer Ingelheim International Gmbh Atomizers for dispensing liquids for medical purposes
US7723306B2 (en) 2004-05-10 2010-05-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation
US7727962B2 (en) 2004-05-10 2010-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder comprising new compositions of oligosaccharides and methods for their preparation
US7611709B2 (en) 2004-05-10 2009-11-03 Boehringer Ingelheim Pharma Gmbh And Co. Kg 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives
US20050255050A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Powder formulations for inhalation, comprising enantiomerically pure beta agonists
US20050256115A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Aerosol formulation for the inhalation of beta-agonists
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
ES2257152B1 (en) 2004-05-31 2007-07-01 Laboratorios Almirall S.A. COMBINATIONS THAT INCLUDE ANTIMUSCARINIC AGENTS AND BETA-ADRENERGIC AGONISTS.
PL1905451T3 (en) 2004-05-31 2010-05-31 Almirall Sa Combinations comprising antimuscarinic agents and corticosteroids
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
US7299950B2 (en) * 2004-09-03 2007-11-27 Rieke Corporation Dispensing apparatus
US7152813B2 (en) * 2004-09-13 2006-12-26 Ding Hwa Co., Ltd. Cap with a suction type spray head
WO2006037636A2 (en) * 2004-10-06 2006-04-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing powder
JP2008515606A (en) * 2004-10-12 2008-05-15 アラダイム コーポレーション Apparatus and method for generating an aerosol from a liquid formulation and ensuring its sterility
PT2522365T (en) 2004-11-24 2017-02-08 Meda Pharmaceuticals Inc Compositions comprising azelastine and methods of use thereof
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
US8758816B2 (en) * 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
JP4715254B2 (en) * 2005-03-18 2011-07-06 オムロンヘルスケア株式会社 Inhaler
CN100366347C (en) * 2005-04-15 2008-02-06 池龙岩 Full automatic sprayer
EP1893273B1 (en) 2005-05-18 2014-06-25 Nektar Therapeutics Adapter for use with aerosolization device for endobronchial therapy
ES2265276B1 (en) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. DERIVATIVES OF 4- (2-AMINO-1-HYDROXYETHYL) Phenol as agonists of the BETA2 ADRENERGIC RECEIVER.
DE102005024439A1 (en) 2005-05-24 2006-12-07 Boehringer Ingelheim International Gmbh atomizer
EA012656B1 (en) * 2005-05-25 2009-12-30 Аэроджен, Инк. Vibration systems and use thereof
TWI366460B (en) 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
JP2008543806A (en) * 2005-06-17 2008-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング MRPIV inhibitors for the treatment of respiratory diseases
DE102005029746B4 (en) * 2005-06-24 2017-10-26 Boehringer Ingelheim International Gmbh atomizer
DE102005063657B3 (en) 2005-06-24 2022-11-03 Boehringer Ingelheim International Gmbh atomizers and containers
JP2008544784A (en) 2005-06-29 2008-12-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Method and apparatus for atomizing a liquid
DE102005030733A1 (en) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient
DE102005035715A1 (en) 2005-07-27 2007-02-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for checking the permeability rate of a closed container
PL1917253T3 (en) * 2005-08-15 2015-06-30 Boehringer Ingelheim Int Method for producing betamimetics
MX2008002090A (en) 2005-08-24 2008-04-19 Boehringer Ingelheim Int Atomiser comprising a counter and an end of operation lock.
US20070086957A1 (en) 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
DE102005052898A1 (en) * 2005-11-03 2007-05-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method and device for dosing medicaments
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
EP1792660A1 (en) 2005-12-02 2007-06-06 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device
JP4731304B2 (en) * 2005-12-14 2011-07-20 Ｈｏｙａ株式会社 Endoscope liquid applicator
JP4774290B2 (en) * 2005-12-19 2011-09-14 Ｈｏｙａ株式会社 Endoscope liquid sprayer
JP4674541B2 (en) * 2005-12-22 2011-04-20 パナソニック電工株式会社 Electrostatic atomization device and food storage equipped with electrostatic atomization device
US7958887B2 (en) 2006-03-10 2011-06-14 Aradigm Corporation Nozzle pore configuration for intrapulmonary delivery of aerosolized formulations
TWM297751U (en) * 2006-03-21 2006-09-21 Taidoc Technology Corp Liquid nebulizer
DE102006016901A1 (en) * 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Mouthpiece for an inhaler
DE102006016904A1 (en) * 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg inhaler
DE102006022002A1 (en) * 2006-05-10 2007-11-15 Boehringer Ingelheim International Gmbh Atomizers and methods for atomizing fluid
EP2026785A1 (en) 2006-05-19 2009-02-25 Boehringer Ingelheim International GmbH Propellant-free inhalation aerosol formulation containing ipratropium bromide and salbutamol sulfate
DE102006025871A1 (en) * 2006-06-02 2007-12-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg atomizer
US8061350B2 (en) * 2006-06-02 2011-11-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process and device for dosing pharmaceutical agents
US20090324510A1 (en) 2006-08-07 2009-12-31 Boehringer Ingelheim International Gmbh Drug combinations for the treatment of respiratory tract diseases
UY30550A1 (en) 2006-08-22 2008-03-31 Boehringer Ingelheim Int NEW BETA-AGANISTAS ENANTIOMÉRICAMENTE PUROS, PROCEDURES FOR ITS PREPARATION AND ITS USE AS MEDICATIONS
WO2008028092A2 (en) 2006-08-30 2008-03-06 Kurve Technology, Inc. Aerosol generating and delivery device
NL1033149C2 (en) * 2006-12-29 2008-07-01 Afa Polytek Bv Dosing device consisting of a holder with a neck and a dosing head connected thereto by a snap coupling.
ES2306595B1 (en) 2007-02-09 2009-09-11 Laboratorios Almirall S.A. NAPADISYLATE SALT OF 5- (2 - ((6- (2,2-DIFLUORO-2-PHENYLETOXI) HEXIL) AMINO) -1-HYDROXYETHYL) -8-HYDROXYCHINOLIN-2 (1H) -ONE AS ADRENERGIC RECEIVER AGONIST BETA2 .
CN101636232A (en) * 2007-02-28 2010-01-27 艾博特呼吸有限责任公司 Atomization system based on nozzle
ES2320955B1 (en) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. NEW DERIVATIVES OF 3 - ((1,2,4) TRIAZOLO (4,3-A) PIRIDIN-7-IL) BENZAMIDA.
DE102007020578A1 (en) 2007-05-02 2008-11-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aqueous aerosol preparations containing therapeutically active microorganisms or parts of microorganisms and processes for producing corresponding aerosols
DE102007023012A1 (en) 2007-05-15 2008-11-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Atomizer and filter
TW200911311A (en) 2007-06-15 2009-03-16 Boehringer Ingelheim Int Inhaler
EP2044967A1 (en) * 2007-10-01 2009-04-08 Boehringer Ingelheim Pharma GmbH & Co. KG Atomiser
ES2320961B1 (en) 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. DERIVATIVES OF 4- (2-AMINO-1-HYDROXYETHYL) PHENOL AS BETA2 ADRENERGIC RECEIVER AGONISTS.
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
GB0800709D0 (en) * 2008-01-16 2008-02-20 Dunne Stephen T Double jet impinging nozzle
US9364841B2 (en) * 2008-02-19 2016-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Cartridge system
EP2093219A1 (en) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Crystalline enantiomer free salt form of a betamimetic and its use as medicine
EP2096105A1 (en) 2008-02-28 2009-09-02 Laboratorios Almirall, S.A. Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor
US20090218412A1 (en) * 2008-02-29 2009-09-03 Sge Analytical Science Pty Ltd. Non-contact dispensing of liquid droplets
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
ES2459198T3 (en) 2008-04-20 2014-05-08 D2 Bioscience Group Ltd Use of deuterium oxide as an elastase inhibitor
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
EP2135632A1 (en) 2008-06-20 2009-12-23 Boehringer Ingelheim International Gmbh Inhalator
EP2350118B1 (en) 2008-09-19 2016-03-30 Nektar Therapeutics Carbohydrate-based drug delivery polymers and conjugates thereof
US7984567B2 (en) * 2008-10-07 2011-07-26 Christ Bill Bertakis Apparatus for cleaning simulated hair articles
DE202008015493U1 (en) 2008-11-21 2009-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg folding
EP2189224A1 (en) 2008-11-22 2010-05-26 Grundfos Management A/S Jet
UY32297A (en) 2008-12-22 2010-05-31 Almirall Sa MESILATE SALT OF 5- (2 - {[6- (2,2-DIFLUORO-2-PHENYLITOXI) HEXIL] AMINO} -1-HYDROXYETHYL) -8-HYDROXYCHINOLIN-2 (1H) -ONA AS A RECEIVER AGONIST B (BETA ) 2 ACRENERGIC
EP2393492A1 (en) 2009-02-09 2011-12-14 Boehringer Ingelheim International GmbH New pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
EP2221055A1 (en) 2009-02-18 2010-08-25 Almirall, S.A. 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one for the treatment of lung function
EP2221297A1 (en) 2009-02-18 2010-08-25 Almirall, S.A. 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one and its use in the treatment of pulmonary diseases
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
EP2236227B1 (en) 2009-03-30 2013-12-18 Boehringer Ingelheim International GmbH Forming tool with a rotatable base body
EP2236224B1 (en) 2009-03-30 2013-03-06 Boehringer Ingelheim International GmbH Forming tool with a rotatable basis body for forming an inhalator cartridge and use of such a tool
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
WO2010124795A1 (en) 2009-04-28 2010-11-04 Boehringer Ingelheim International Gmbh Inhalation device
EP3508239B1 (en) 2009-05-18 2020-12-23 Boehringer Ingelheim International GmbH Adapter, inhalant apparatus and atomizer
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
CN107412212B (en) 2009-05-29 2021-01-22 珍珠治疗公司 Pulmonary delivery of long-acting muscarinic antagonists and long-acting beta2Compositions of adrenergic receptor agonists and related methods and systems
RU2452585C2 (en) * 2009-06-03 2012-06-10 Макнейл Аб Pocket distributor
KR101792696B1 (en) * 2009-06-18 2017-11-02 알레간 인코포레이티드 Safe desmopressin administration
WO2011005645A1 (en) 2009-07-06 2011-01-13 Boehringer Ingelheim International Gmbh Polymorph of [4,6-bis(dimethylamino)-2-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)pyrimidin-5-yl]
JP2012532729A (en) * 2009-07-16 2012-12-20 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Single motion control mechanism for pressurized gas oral cleaning device
CA2768379C (en) * 2009-07-17 2017-10-10 David Mark Blakey Negatively biased sealed nebulizers systems and methods
EP2322176A1 (en) 2009-11-11 2011-05-18 Almirall, S.A. New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
KR20120101399A (en) 2009-11-24 2012-09-13 베링거 인겔하임 인터내셔날 게엠베하 Process for preparing a polymorph of the choline salt of a pyrimidin-5-yl acetic acid derivative
JP2013512239A (en) 2009-11-24 2013-04-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel salt forms of pyrimidin-5-ylacetic acid derivatives
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
WO2011064163A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
UA107097C2 (en) 2009-11-25 2014-11-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх Dispenser
US8464742B2 (en) * 2010-02-11 2013-06-18 Honeywell International Inc. Injection or other system with anti-thermal lockdown mechanism and related method
US8974771B2 (en) * 2010-03-09 2015-03-10 Penn-Century, Inc. Apparatus and method for aerosol delivery to the lungs or other locations of the body
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
WO2011154295A2 (en) 2010-06-08 2011-12-15 Boehringer Ingelheim International Gmbh Medical device having a counter having a preset counting range, device having counter variation
EP2585151B1 (en) 2010-06-24 2018-04-04 Boehringer Ingelheim International GmbH Nebulizer
AU2011278924B2 (en) 2010-07-15 2015-06-18 Eyenovia, Inc. Ophthalmic drug delivery
EA201390121A8 (en) 2010-07-15 2014-02-28 Коринтиан Офтэлмик, Инк. METHOD AND SYSTEM FOR PERFORMING REMOTE TREATMENT AND CONTROL
KR101545413B1 (en) 2010-07-15 2015-08-18 아이노비아 인코포레이티드 Drop generating device
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
US9283333B2 (en) 2010-07-16 2016-03-15 Boehringer Ingelheim International Gmbh Filter system for use in medical devices
BR112013005283A2 (en) * 2010-09-06 2019-09-24 Chiesi Farm Spa metered dose inhaler actuator, metered dose inhaler actuator and use of an actuator
EP2441755A1 (en) 2010-09-30 2012-04-18 Almirall, S.A. Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
EP2463289A1 (en) 2010-11-26 2012-06-13 Almirall, S.A. Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
AU2012223160B2 (en) 2011-03-03 2016-08-18 Impel Pharmaceuticals Inc. Nasal drug delivery device
GB2489216B (en) * 2011-03-16 2013-08-07 Consort Medical Plc Fluid delivery device
WO2012130757A1 (en) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medical device comprising a container
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
EP2518071A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Imidazopyridine derivatives as PI3K inhibitors
EP2518070A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Pyrrolotriazinone derivatives as PI3K inhibitors
CA2834171C (en) 2011-05-13 2019-07-30 Unilever Plc Spraying device
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
EP2526945A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. New CRTH2 Antagonists
EP2527344A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases
CA3010658C (en) 2011-06-06 2020-12-01 Trudell Medical International Oscillating positive expiratory pressure device
EP2548863A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists.
EP2548876A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists
EP2554544A1 (en) 2011-08-01 2013-02-06 Almirall, S.A. Pyridin-2(1h)-one derivatives as jak inhibitors
WO2013017393A1 (en) * 2011-08-03 2013-02-07 Unilever N.V. Spraying device
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
WO2013064690A1 (en) * 2011-11-04 2013-05-10 Chv Pharma Gmbh & Co. Kg Inhaler and method for producing an aerosol
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2592077A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
WO2013090459A1 (en) 2011-12-12 2013-06-20 Corinthian Ophthalmic, Inc. Ejector mechanism, ejector device, and methods of use
US8816305B2 (en) 2011-12-20 2014-08-26 Asml Netherlands B.V. Filter for material supply apparatus
US8771799B2 (en) 2011-12-27 2014-07-08 JM Harwood LLC Liquid delivery system
JP6335798B2 (en) * 2012-02-28 2018-05-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング New propellant-containing tiotropium formulation
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
US9220852B2 (en) 2012-04-10 2015-12-29 Boehringer Ingelheim Microparts Gmbh Method for producing trench-like depressions in the surface of a wafer
WO2013152894A1 (en) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Atomiser with coding means
US9562523B2 (en) 2012-10-01 2017-02-07 JM Harwood LLC Wobble drive mechanism
WO2014060431A1 (en) 2012-10-16 2014-04-24 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
EP2738172A1 (en) 2012-11-28 2014-06-04 Almirall, S.A. New bicyclic compounds as crac channel modulators
US9517315B2 (en) 2012-11-30 2016-12-13 Trudell Medical International Oscillating positive expiratory pressure device
CN102963603A (en) * 2012-12-08 2013-03-13 胡成佐 Packaging box
SG11201504452WA (en) 2012-12-18 2015-07-30 Almirall Sa New cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activity
TW201446767A (en) 2013-02-15 2014-12-16 Almirall Sa Pyrrolotriazine derivatives as PI3K inhibitors
RU2696582C2 (en) 2013-03-15 2019-08-05 Перл Терапьютикс, Инк. Methods and systems for conditioning disperse crystalline materials
EP2848615A1 (en) 2013-07-03 2015-03-18 Almirall, S.A. New pyrazole derivatives as CRAC channel modulators
ES2836977T3 (en) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizer
WO2015018904A1 (en) 2013-08-09 2015-02-12 Boehringer Ingelheim International Gmbh Nebulizer
FI20135903L (en) 2013-09-09 2015-03-10 Beneq Oy Device and method for producing aerosol and focusing lot
US10292424B2 (en) * 2013-10-31 2019-05-21 Rai Strategic Holdings, Inc. Aerosol delivery device including a pressure-based aerosol delivery mechanism
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
DE202014103984U1 (en) * 2014-03-10 2015-06-12 Rpc Bramlage Gmbh donor
KR102492824B1 (en) 2014-05-07 2023-01-30 베링거 인겔하임 인터내셔날 게엠베하 Nebulizer, indicator device and container
WO2015169430A1 (en) 2014-05-07 2015-11-12 Boehringer Ingelheim International Gmbh Nebulizer
GB201408561D0 (en) * 2014-05-14 2014-06-25 The Technology Partnership Plc Aerosolisation engine for liquid drug delivery
US11273271B2 (en) * 2014-07-01 2022-03-15 Aerami Therapeutics, Inc. Aerosolization system with flow restrictor and feedback device
GB201413181D0 (en) 2014-07-25 2014-09-10 Dunne Consultancy Services Ltd Inhaler cartridge system
US10300228B2 (en) * 2014-08-26 2019-05-28 Innovosciences, Llc Thermal modulation of an inhalable medicament
US10737042B2 (en) 2014-08-26 2020-08-11 Michael Edward Breede Thermal modulation of an inhalable medicament
US9743999B2 (en) * 2014-08-29 2017-08-29 Piero A. Policicchio Dental prophylaxis device and air appliance
EP3061501A1 (en) 2015-02-27 2016-08-31 Rottapharm Ltd. Composition for the treatment of acne
JP6480598B2 (en) 2015-04-02 2019-03-13 ヒル−ロム サービシーズ プライヴェート リミテッド Respirator manifold
IL238387B (en) * 2015-04-20 2019-01-31 Paz Ilan Medication dispenser depilling mechanism
WO2016170009A1 (en) 2015-04-21 2016-10-27 Almirall, S.A. Amino-substituted heterocyclic derivatives as sodium channel inhibitors
WO2016180975A1 (en) * 2015-05-14 2016-11-17 Medical Graphics Italia S.R.L. Kit for performing a bronchial challenge test with methacholine and device containing methacholine
CN108310560A (en) * 2015-05-16 2018-07-24 苏州汉方医药有限公司 A kind of medicine box for treating sex hypofunction that medicine instrument is combined into
EP3103498B2 (en) * 2015-06-12 2023-06-14 AP Pharma Systems Atomizadores e Dispensadores Ltda Spray dispenser for nasal drugs
WO2016202800A1 (en) 2015-06-16 2016-12-22 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
EP3117825A1 (en) 2015-07-16 2017-01-18 Rottapharm S.p.A. Oral formulation comprising berberine and morus alba extract
MX2018001321A (en) 2015-07-30 2018-08-15 Trudell Medical Int Combined respiratory muscle training and oscillating positive expiratory pressure device.
DE102016105998A1 (en) * 2015-09-23 2017-03-23 Rpc Bramlage Gmbh Dispensers for liquid to pasty masses
WO2017060386A1 (en) 2015-10-09 2017-04-13 Boehringer Ingelheim International Gmbh Method for coating microstructured components
RU2636522C1 (en) * 2016-06-09 2017-11-23 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Method and device for producing fine aerosols with prevention of atomizer clogging
CN106215291A (en) * 2016-08-17 2016-12-14 岑溪市东正动力科技开发有限公司 A kind of medical vaporizer
CN106390252B (en) * 2016-08-30 2019-07-30 苏州涵轩信息科技有限公司 A kind of medicinal liquid atomizer
CN115355347A (en) 2016-09-15 2022-11-18 索芙特海尔公司 Valve, in particular for a device for administering a liquid drug, and corresponding device for administering a liquid drug
WO2018059390A1 (en) * 2016-09-29 2018-04-05 广东东阳光药业有限公司 Pharmaceutical composition
DK3519024T3 (en) * 2016-09-30 2021-07-05 Softhale Nv Atomizer, in particular inhaler, for atomizing a liquid drug substance into an aerosol and a similar method
CN110582316B (en) 2017-04-28 2023-12-26 索芙特海尔公司 Inhalation device and method
JP7227163B2 (en) 2017-06-10 2023-02-21 アイノビア，インコーポレイティド Methods and apparatus for handling and delivering fluids to the eye
CN110869134B (en) * 2017-06-22 2023-12-22 索芙特海尔公司 Inhalation device, reservoir and delivery method for pirfenidone aerosols
WO2018234527A1 (en) 2017-06-22 2018-12-27 Softhale Nv Aerosol delivery of pirfenidone
WO2018234524A1 (en) 2017-06-22 2018-12-27 Softhale Nv Multiliquid-nozzle
CA3067134A1 (en) * 2017-06-22 2018-12-27 Softhale Nv Inhalation device with multiliquid-nozzle and method
DK179667B1 (en) * 2017-06-30 2019-03-14 Mbh-International A/S An enema device and a method of refilling said device with an enema
TW201919682A (en) 2017-08-08 2019-06-01 西班牙商阿爾米雷爾有限公司 Novel compounds activating the Nrf2 pathway
DE202017005165U1 (en) * 2017-10-06 2017-10-18 WERRTA GmbH Düsen- und Zerstäubungstechnik nozzle body
EP3697541B1 (en) 2017-10-18 2023-04-26 Softhale NV Seal for an inhalation device
US10617832B2 (en) 2017-11-22 2020-04-14 Southwest Research Institute High precision, low dose atomizer
ES2906600T3 (en) 2017-11-27 2022-04-19 Softhale Nv Mouthpiece fixing device for an inhalation device
CN109894907A (en) * 2017-12-07 2019-06-18 上海铼钠克数控科技股份有限公司 Brake apparatus
EP3723836A4 (en) * 2017-12-11 2021-11-24 Target Point Technologies Ltd. Intranasal administration device
EP3501582B1 (en) * 2017-12-21 2022-04-27 Boehringer Ingelheim International GmbH Nebulizer and cartridge
CN111491682B (en) * 2017-12-22 2024-02-13 索芙特海尔公司 Flexible pump chamber
EP3727533B1 (en) 2017-12-22 2022-11-16 Softhale NV Blocking device
CA3093176A1 (en) 2018-03-21 2019-09-26 Softhale Nv Spray nozzle for an inhalation device
CN110388467A (en) * 2018-04-20 2019-10-29 梅特勒-托利多(常州)测量技术有限公司 Imbibition handle control valve
EP3563894B1 (en) * 2018-05-04 2021-12-22 Boehringer Ingelheim International GmbH Nebulizer and container
WO2019229042A1 (en) 2018-05-30 2019-12-05 Softhale Nv Inhalation device with a pumping unit
CN108499769B (en) * 2018-06-12 2023-05-19 湖南科道尔生物科技有限公司 High atomizer with automatic hydrojet of time delay
CN108704779A (en) * 2018-06-20 2018-10-26 浙江普莱得电器有限公司 A kind of spray gun
GB201810546D0 (en) * 2018-06-27 2018-08-15 Ttp Plc Droplet Dispenser
DK3823763T3 (en) 2018-07-16 2023-11-27 Invox Belgium Nv IMPROVED INHALATION DEVICE
CN112533656A (en) * 2018-08-10 2021-03-19 索芙特海尔公司 High pressure suction device
CN111345948A (en) * 2018-09-30 2020-06-30 潘爱平 Can breathe wheelchair of dosing
BR112021008861A2 (en) * 2018-11-09 2021-08-31 Softhale Nv RESERVOIR FOR AN INHALATION DEVICE
EP3906119A1 (en) * 2019-01-03 2021-11-10 Aptar Radolfzell GmbH Nozzle unit, liquid dispenser comprising such a nozzle unit, and method for producing such nozzle units
CN111450361B (en) * 2019-01-21 2022-02-08 樊启民 Pulmonary heart disease atomizing and breathing treatment device
TW202100194A (en) 2019-04-15 2021-01-01 比利時商索芙特海爾公司 Improved valve
MX2021012723A (en) * 2019-04-18 2022-01-31 Jon Greenfield Positive pressure inhaler for delivery of inhalable medication and methods for use.
FR3095968B1 (en) 2019-05-14 2021-10-01 Aptar France Sas Fluid dispenser device
CN110141744B (en) * 2019-06-30 2021-03-23 河南省斯科赛斯科技发展有限公司 Airflow atomizer
CN110627149B (en) * 2019-08-23 2021-12-07 江苏星鑫分离设备制造有限公司 Landfill leachate back-spraying treatment equipment capable of treating tail gas
CN110786345A (en) * 2019-11-13 2020-02-14 申璐璐 Natural plant antibacterial agent
US20210283145A1 (en) 2020-03-13 2021-09-16 Softhale Nv Method for the treatment of viral infections
WO2021185912A1 (en) 2020-03-19 2021-09-23 Softhale Nv Method for the treatment nlrp3-associated diseases
CN111299007B (en) * 2020-03-20 2021-06-25 浙江宝龙工贸有限公司 A paint spraying apparatus that spraying is even for timber production
CA3168027A1 (en) 2020-03-31 2021-10-07 Jurgen Rawert Aerosol delivery of at least two liquid compositions
JP2023519523A (en) 2020-03-31 2023-05-11 ソフトハレ エヌヴイ inhaler system
CN111544715B (en) * 2020-04-02 2022-08-19 佛山市澳斯卡医疗器械有限公司 Bottled atomizer
US20210308047A1 (en) 2020-04-03 2021-10-07 Softhale Nv Methods of treatment using niclosamide
EP4132484A1 (en) 2020-04-10 2023-02-15 Galenus G.H. AG Composition comprising resveratrol
CN111532591A (en) * 2020-04-29 2020-08-14 丁亚宁 Disinfection spray bottle for respiratory medicine and using method thereof
EP4153346A1 (en) * 2020-05-20 2023-03-29 Victaulic Company Emitter and system for discharge of a decontaminating liquid-gas stream
US11013688B1 (en) 2020-05-28 2021-05-25 Softhale Nv Methods of treatment of viral diseases
RU2745231C9 (en) * 2020-06-08 2021-04-27 Акционерное общество "Столетика" Spray inhaler with preparation and storage functions
US20230248924A1 (en) 2020-06-26 2023-08-10 Softhale Nv Inverted nozzle fixture and method
CN113171895B (en) * 2021-04-20 2022-12-13 广州腾龙健康实业股份有限公司 Multi-directional nozzle
EP4109066A1 (en) 2021-06-25 2022-12-28 Harro Höfliger Verpackungsmaschinen GmbH Device for leakage testing of a pump assembly for high pressure spray applicators
TW202317217A (en) 2021-07-20 2023-05-01 比利時商索芙特海爾公司 Inhalation device system with a counting and blocking assembly
DE202021002812U1 (en) 2021-08-31 2021-09-15 Harro Höfliger Verpackungsmaschinen GmbH Device for testing high-pressure check valves attached to capillaries, in particular for use in spray applicators
CN114392454A (en) * 2022-02-09 2022-04-26 商丘市中心医院 Controllable atomizer of local anesthesia for clinical anesthesia
WO2024023231A1 (en) 2022-07-29 2024-02-01 Softhale Nv Microfluidic devices and methods of producing
CN115068755B (en) * 2022-08-24 2023-06-06 中国人民解放军总医院第六医学中心 Atomizing device for department of respiration

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US460458A (en) * 1891-09-29 Edward t
US334110A (en) * 1886-01-12 Edwaed j
US1035261A (en) * 1912-02-16 1912-08-13 Hermann Strumpf Atomizer.
US1116536A (en) * 1913-10-06 1914-11-10 Charles Ballreich Lawn-sprinkler.
US1276245A (en) * 1916-11-03 1918-08-20 Gilmour Sharp Spraying-nozzle.
US1838873A (en) * 1930-02-27 1931-12-29 Lewis L Scott Atomizer
GB405458A (en) * 1933-05-18 1934-02-08 Harry Krantz An improved device for disinfecting the mouthpieces of telephones
US2024339A (en) * 1933-11-11 1935-12-17 James W Connell Water spraying device
US2052869A (en) * 1934-10-08 1936-09-01 Coanda Henri Device for deflecting a stream of elastic fluid projected into an elastic fluid
US2187779A (en) * 1936-07-22 1940-01-23 Gardner Mfg Company Atomizing nozzle
US2432791A (en) * 1945-12-12 1947-12-16 Osses Jacob Defense weapon
US2673123A (en) * 1949-10-14 1954-03-23 Atlantic Plastics Inc Spray cap
US2676845A (en) * 1949-11-04 1954-04-27 Gen Closure Corp Atomizing closure device for liquid receptacles
US2786656A (en) * 1954-06-23 1957-03-26 Ernest R Corneil Impact spraying of slurries
FR1072399A (en) * 1961-01-07 1954-09-13 Intra-dermal injector
NL296493A (en) * 1962-08-14
US3187748A (en) * 1963-04-29 1965-06-08 Merck And Company Inc Inhalation-actuated aerosol device
US3330277A (en) * 1964-08-17 1967-07-11 Scherer Corp R P Multidose hypodermic injector
US3317002A (en) * 1965-02-08 1967-05-02 Walker Mfg Co Fluid distributing system
GB1131918A (en) * 1965-05-06 1968-10-30 Murray Budd Burgess Jet injector
DE1475174A1 (en) * 1965-09-20 1969-01-16 Afa Corp Liquid spray device
US3421662A (en) * 1967-03-07 1969-01-14 Ralph W Hanson Dispersal device
US3396874A (en) * 1967-05-15 1968-08-13 Afa Corp Positive action dispensing valve
DE1803541A1 (en) * 1968-10-17 1970-04-23 Wild Dr Walter J Method and device for spraying low-viscosity media
GB1239855A (en) * 1969-01-30 1971-07-21 Pye Ltd Improvements in or relating to liquid injectors for medical respirators
US3514017A (en) * 1969-03-03 1970-05-26 Afa Corp Pressure regulating structure for piston pump
US3575322A (en) * 1969-03-21 1971-04-20 Union Carbide Corp Metering aerosol actuator with downstroke discharge
US3605738A (en) * 1969-06-20 1971-09-20 Paul J Ciranna Medicinal spray device
US3647143A (en) * 1970-04-06 1972-03-07 Champion Spark Plug Co Atomizer
US3838686A (en) 1971-10-14 1974-10-01 G Szekely Aerosol apparatus for inhalation therapy
BE795375A (en) * 1972-02-14 1973-08-13 Thiokol Chemical Corp ATOMIZER
US3797748A (en) 1972-03-30 1974-03-19 T Nozawa Liquid spraying device
US3818908A (en) * 1972-08-07 1974-06-25 Riker Laboratories Inc Medicament dispenser
US3794247A (en) * 1972-11-22 1974-02-26 Corsette Douglas Frank Spray fitment for squeeze bottles
US3933279A (en) * 1972-11-28 1976-01-20 Ciba-Geigy Corporation Aerosol dispenser for fluid products comprising a piston pump assembly for generating compressed air
US3831861A (en) * 1973-03-23 1974-08-27 Par Way Mfg Co Liquid spray head for producing rectangular spray patterns
US3878973A (en) * 1973-10-31 1975-04-22 Ciba Geigy Corp Metered dose dispenser
CH588896A5 (en) * 1973-10-31 1977-06-15 Ciba Geigy Ag
US3921857A (en) * 1973-11-29 1975-11-25 Ciba Geigy Corp Non-spitting liquid dispensing device
US3923202A (en) * 1973-11-29 1975-12-02 Ciba Geigy Corp Non-spitting liquid dispensing device with pressurized product supply
AT343788B (en) * 1973-11-30 1978-06-12 Thomae Gmbh Dr K LOCKING DEVICE FOR PUMP METERING VALVES
US4017007A (en) * 1973-12-26 1977-04-12 Ciba-Geigy Corporation Single dose air pressure operated dispenser
CA1008825A (en) * 1974-03-28 1977-04-19 William E. Warren Pump assembly for an atomizing piston pump
US3893628A (en) * 1974-04-08 1975-07-08 Alsons Corp Spray head
JPS5824183B2 (en) * 1974-05-17 1983-05-19 コンドウ ヒロシ Chikuatsufunmusouchi
US3921916A (en) * 1974-12-31 1975-11-25 Ibm Nozzles formed in monocrystalline silicon
US4007855A (en) * 1975-03-24 1977-02-15 Joseph M. Magrath Liquid dispenser of the metering type
CA1099674A (en) * 1975-12-05 1981-04-21 Gerald A. Rooney Manually operated liquid dispensing device
IT1069354B (en) * 1976-03-05 1985-03-25 Zanasi Nigris Spa IMPROVEMENTS IN VOLUME DOSING UNITS
US4167941A (en) * 1976-10-05 1979-09-18 James D. Pauls, Ltd. (Limited Partnership) Mechanically operated dispensing device for increasing discharge pressure and dispensing time
US4174055A (en) * 1977-04-20 1979-11-13 James D. Pauls & J. Claybrook Lewis & Associates, Ltd. Non-aerosol pressure dispenser
US4179070A (en) * 1977-05-09 1979-12-18 Tetsuya Tada Sprayer
US4174056A (en) * 1977-05-10 1979-11-13 Ciba-Geigy Corporation Pump type dispenser with continuous flow feature
US4079865A (en) * 1977-06-30 1978-03-21 John H. Oltman Non-pulsating, non-throttling, vented pumping system for continuously dispensing product
US4183449A (en) 1978-01-09 1980-01-15 The Afa Corporation Manually operated miniature atomizer
US4245788A (en) * 1978-03-20 1981-01-20 Wright Hershel E Dispensing device for fluid material
US4271875A (en) * 1978-09-21 1981-06-09 Philip Meshberg Dispenser adapted for fast pressure filling
DE2854841C2 (en) * 1978-12-19 1981-03-26 Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart Liquid atomizer, preferably inhalation device
US4345718A (en) 1979-04-23 1982-08-24 William Horvath Manually actuated trigger sprayer
CA1156695A (en) * 1979-10-10 1983-11-08 Macmillan Bloedel Limited Self protecting spray nozzle
US4602726A (en) * 1979-12-31 1986-07-29 George Goda Dispensing device
US4402432A (en) * 1980-02-13 1983-09-06 Corsette Douglas Frank Leak-proof dispensing pump
DE3007512C2 (en) 1980-02-28 1982-04-29 Fa. Hermann Heye, 3063 Obernkirchen Device for applying a lubricating or separating liquid to a glass molding machine part
EP0045419B1 (en) * 1980-08-04 1984-10-17 FISONS plc Inhalation device for administering medicaments
GB2109690B (en) * 1981-02-12 1985-02-20 Robert Charles Turner Dose metering plunger devices for use with syringes
US4412632A (en) * 1981-05-28 1983-11-01 Berger Richard F Self-cleaning valve
SE438261B (en) * 1981-07-08 1985-04-15 Draco Ab USE IN A DOSHALATOR OF A PERFORED MEMBRANE
SU992070A1 (en) * 1981-09-28 1983-01-30 Тартуский Ордена Трудового Красного Знамени Государственный Университет Inhalator
US4441634A (en) * 1982-01-13 1984-04-10 Philip Meshberg Dispenser adapted for fast pressure filling
FR2521036A1 (en) * 1982-02-05 1983-08-12 Valois Sa DEVICE FOR PROJECTING PRECISE DOSES OF AEROSOL
FR2524348A1 (en) * 1982-03-30 1983-10-07 Ramis Michel Vaporising pump made with plastics parts - has spray orifice which closes automatically after vapourisation under plastics spring action
EP0105964A1 (en) * 1982-10-18 1984-04-25 Fischer, Jürgen L. Process for continuous separation of polluting matter from a carrier fluid
US4771769A (en) * 1982-12-20 1988-09-20 Schering Corporation Hand held metered spray dispenser
DE3303419A1 (en) * 1983-02-02 1984-08-02 W. Schlafhorst & Co, 4050 Mönchengladbach METHOD AND DEVICE FOR DOSING AND INJECTING SMALL LIQUID AMOUNTS INTO THE SPLICE AIR OF A COMPRESSED GAS THREAD SPLICING DEVICE
JPS59222251A (en) * 1983-05-31 1984-12-13 Matsushita Electric Works Ltd Motor type extruder for viscous material
DE3339180C2 (en) 1983-10-28 1993-10-14 Pfeiffer Erich Gmbh & Co Kg Discharge device for media
US4648393A (en) * 1984-11-02 1987-03-10 Ackrad Laboratories, Inc. Breath activated medication spray
DE8621135U1 (en) * 1985-09-02 1987-01-29 Callahan, George Edgar, Prof.
US4705034A (en) * 1985-10-02 1987-11-10 Perkins Warren E Method and means for dispensing respirating gases by effecting a known displacement
CA1323004C (en) * 1985-10-15 1993-10-12 Yuji Higo Process for injecting a minute volume of a solution and an apparatus therefor
US4693675A (en) * 1986-01-16 1987-09-15 The Pharmasol Corporation Non-throttling discharge pump
US4738398A (en) * 1986-07-29 1988-04-19 Corsette Douglas Frank Sprayer having induced air assist
US4819834A (en) * 1986-09-09 1989-04-11 Minnesota Mining And Manufacturing Company Apparatus and methods for delivering a predetermined amount of a pressurized fluid
GB8629982D0 (en) * 1986-12-16 1987-01-28 English Glass Co Ltd Dispenser pump
EP0293442A1 (en) * 1986-12-17 1988-12-07 Microvol Limited Pressurised metering dispenser
DE3704210A1 (en) * 1987-02-11 1988-08-25 Friedhelm Schneider DOSING GUN FOR LIQUIDS AND PASTE
JPS63232866A (en) * 1987-03-20 1988-09-28 Tokyo Electron Ltd Spray nozzle
US4896832A (en) * 1987-09-07 1990-01-30 Bespak Plc Dispensing apparatus for metered quantities of pressurised fluid
US4892232A (en) * 1988-07-25 1990-01-09 Martin James H Unit dose dispenser
US4828184A (en) * 1988-08-12 1989-05-09 Ford Motor Company Silicon micromachined compound nozzle
FR2641202B1 (en) * 1989-01-03 1991-03-15 Poizot Francis FOAM PRODUCTION DEVICE
DK0401060T3 (en) * 1989-05-31 1993-10-25 Conceptair Anstalt Process and electrical, electronic and mechanical device for distributing, dosing or diffusing liquid or gaseous flavoring agents, drugs and other liquid or viscous products
US5031839A (en) * 1989-09-13 1991-07-16 Dowelanco Volume controllable applicator
US5056511A (en) * 1989-12-14 1991-10-15 Juergen L. Fischer Method and apparatus for compressing, atomizing, and spraying liquid substances
GB2243880B (en) * 1990-05-01 1994-03-16 Bespak Plc Dispensing device
US5088649A (en) * 1990-07-12 1992-02-18 Par-Way Group Pump sprayable dispensing system for vegetable oil based pan coatings

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