CA2212537A1 - Therapeutic inhibitor of vascular smooth muscle cells - Google Patents
Therapeutic inhibitor of vascular smooth muscle cellsInfo
- Publication number
- CA2212537A1 CA2212537A1 CA002212537A CA2212537A CA2212537A1 CA 2212537 A1 CA2212537 A1 CA 2212537A1 CA 002212537 A CA002212537 A CA 002212537A CA 2212537 A CA2212537 A CA 2212537A CA 2212537 A1 CA2212537 A1 CA 2212537A1
- Authority
- CA
- Canada
- Prior art keywords
- smooth muscle
- vascular smooth
- vascular
- muscle cells
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilatation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002559392A CA2559392A1 (en) | 1995-02-15 | 1996-02-15 | Therapeutic inhibitor of vascular smooth muscle cells |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/389,712 US6515009B1 (en) | 1991-09-27 | 1995-02-15 | Therapeutic inhibitor of vascular smooth muscle cells |
US08/389,712 | 1995-02-15 | ||
PCT/US1996/002125 WO1996025176A1 (en) | 1995-02-15 | 1996-02-15 | Therapeutic inhibitor of vascular smooth muscle cells |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002559392A Division CA2559392A1 (en) | 1995-02-15 | 1996-02-15 | Therapeutic inhibitor of vascular smooth muscle cells |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2212537A1 true CA2212537A1 (en) | 1996-08-22 |
CA2212537C CA2212537C (en) | 2006-12-19 |
Family
ID=23539404
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002559392A Abandoned CA2559392A1 (en) | 1995-02-15 | 1996-02-15 | Therapeutic inhibitor of vascular smooth muscle cells |
CA002212537A Expired - Fee Related CA2212537C (en) | 1995-02-15 | 1996-02-15 | Therapeutic inhibitor of vascular smooth muscle cells |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002559392A Abandoned CA2559392A1 (en) | 1995-02-15 | 1996-02-15 | Therapeutic inhibitor of vascular smooth muscle cells |
Country Status (9)
Country | Link |
---|---|
US (7) | US6515009B1 (en) |
EP (3) | EP1669091A3 (en) |
JP (2) | JPH11500635A (en) |
AT (2) | ATE265233T1 (en) |
AU (1) | AU4985196A (en) |
CA (2) | CA2559392A1 (en) |
DE (2) | DE69635968T2 (en) |
ES (1) | ES2217306T3 (en) |
WO (1) | WO1996025176A1 (en) |
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1995
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- 1995-10-23 US US08/546,794 patent/US6171609B1/en not_active Expired - Lifetime
-
1996
- 1996-02-15 AT AT96906490T patent/ATE265233T1/en not_active IP Right Cessation
- 1996-02-15 AT AT04000646T patent/ATE321573T1/en not_active IP Right Cessation
- 1996-02-15 DE DE69635968T patent/DE69635968T2/en not_active Revoked
- 1996-02-15 AU AU49851/96A patent/AU4985196A/en not_active Abandoned
- 1996-02-15 JP JP8525163A patent/JPH11500635A/en active Pending
- 1996-02-15 EP EP06006402A patent/EP1669091A3/en not_active Withdrawn
- 1996-02-15 ES ES96906490T patent/ES2217306T3/en not_active Expired - Lifetime
- 1996-02-15 CA CA002559392A patent/CA2559392A1/en not_active Abandoned
- 1996-02-15 DE DE69632310T patent/DE69632310T2/en not_active Expired - Lifetime
- 1996-02-15 EP EP96906490A patent/EP0809515B1/en not_active Revoked
- 1996-02-15 WO PCT/US1996/002125 patent/WO1996025176A1/en active IP Right Grant
- 1996-02-15 CA CA002212537A patent/CA2212537C/en not_active Expired - Fee Related
- 1996-02-15 EP EP04000646A patent/EP1407786B1/en not_active Revoked
-
2001
- 2001-07-20 US US09/910,387 patent/US6599928B2/en not_active Expired - Fee Related
-
2006
- 2006-09-27 JP JP2006263350A patent/JP2007075623A/en active Pending
-
2007
- 2007-01-04 US US11/650,059 patent/US8158670B2/en not_active Expired - Lifetime
- 2007-02-27 US US11/679,650 patent/US8097642B2/en not_active Expired - Fee Related
-
2011
- 2011-08-15 US US13/209,956 patent/US20110300221A1/en not_active Abandoned
-
2012
- 2012-04-13 US US13/446,760 patent/US20120195951A1/en not_active Abandoned
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EP1407786A1 (en) | 2004-04-14 |
EP0809515A1 (en) | 1997-12-03 |
DE69635968D1 (en) | 2006-05-18 |
US6171609B1 (en) | 2001-01-09 |
CA2212537C (en) | 2006-12-19 |
US20120195951A1 (en) | 2012-08-02 |
US8097642B2 (en) | 2012-01-17 |
DE69632310T2 (en) | 2004-09-09 |
US6599928B2 (en) | 2003-07-29 |
EP1669091A3 (en) | 2009-06-17 |
DE69632310D1 (en) | 2004-06-03 |
US8158670B2 (en) | 2012-04-17 |
AU4985196A (en) | 1996-09-04 |
EP1669091A2 (en) | 2006-06-14 |
US20020040064A1 (en) | 2002-04-04 |
US20110300221A1 (en) | 2011-12-08 |
WO1996025176A1 (en) | 1996-08-22 |
ATE321573T1 (en) | 2006-04-15 |
DE69635968T2 (en) | 2007-01-25 |
US6515009B1 (en) | 2003-02-04 |
JP2007075623A (en) | 2007-03-29 |
ES2217306T3 (en) | 2004-11-01 |
EP1407786B1 (en) | 2006-03-29 |
JPH11500635A (en) | 1999-01-19 |
ATE265233T1 (en) | 2004-05-15 |
US20070134314A1 (en) | 2007-06-14 |
EP0809515B1 (en) | 2004-04-28 |
CA2559392A1 (en) | 1996-08-22 |
US20070148207A1 (en) | 2007-06-28 |
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