CA2215317A1 - Reduction of adhesions using controlled delivery of active oxygen inhibitors - Google Patents

Reduction of adhesions using controlled delivery of active oxygen inhibitors

Info

Publication number
CA2215317A1
CA2215317A1 CA002215317A CA2215317A CA2215317A1 CA 2215317 A1 CA2215317 A1 CA 2215317A1 CA 002215317 A CA002215317 A CA 002215317A CA 2215317 A CA2215317 A CA 2215317A CA 2215317 A1 CA2215317 A1 CA 2215317A1
Authority
CA
Canada
Prior art keywords
adhesions
active oxygen
reduction
controlled delivery
oxygen inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002215317A
Other languages
French (fr)
Other versions
CA2215317C (en
Inventor
Keith Baker
Arthur J. Coury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Focal, Inc.
Keith Baker
Arthur J. Coury
Genzyme Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Focal, Inc., Keith Baker, Arthur J. Coury, Genzyme Corporation filed Critical Focal, Inc.
Publication of CA2215317A1 publication Critical patent/CA2215317A1/en
Application granted granted Critical
Publication of CA2215317C publication Critical patent/CA2215317C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SOD and other active oxygen inhibitors are directly applied in combination with a barrier material at local sites of tissue injury to prevent or decrease formation of adhesions and undesirable profileration of cells. Preferred barrier materials are polymeric hydrogels providing controlled release of AOI which are directly applied to the afflicted tissue. Examples demonstrate the effects of SOD on pelvic adhesions in the rat when administered by intraperitoneal (IP.) bolus and by localized sustained release from a topically applied hydrogel system.
CA002215317A 1995-03-24 1996-03-20 Reduction of adhesions using controlled delivery of active oxygen inhibitors Expired - Lifetime CA2215317C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41021995A 1995-03-24 1995-03-24
US410.219 1995-03-24
PCT/US1996/003813 WO1996029987A1 (en) 1995-03-24 1996-03-20 Reduction of adhesions using controlled delivery of active oxygen inhibitors

Publications (2)

Publication Number Publication Date
CA2215317A1 true CA2215317A1 (en) 1996-10-03
CA2215317C CA2215317C (en) 2002-07-23

Family

ID=23623783

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002215317A Expired - Lifetime CA2215317C (en) 1995-03-24 1996-03-20 Reduction of adhesions using controlled delivery of active oxygen inhibitors

Country Status (8)

Country Link
US (2) US5785993A (en)
EP (1) EP0814774B1 (en)
JP (1) JP3145409B2 (en)
AT (1) ATE306903T1 (en)
AU (1) AU704222B2 (en)
CA (1) CA2215317C (en)
DE (1) DE69635301T2 (en)
WO (1) WO1996029987A1 (en)

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Also Published As

Publication number Publication date
JPH10508872A (en) 1998-09-02
DE69635301D1 (en) 2006-03-02
WO1996029987A1 (en) 1996-10-03
ATE306903T1 (en) 2005-11-15
JP3145409B2 (en) 2001-03-12
DE69635301T2 (en) 2006-07-20
EP0814774A1 (en) 1998-01-07
CA2215317C (en) 2002-07-23
US5785993A (en) 1998-07-28
EP0814774B1 (en) 2005-10-19
AU704222B2 (en) 1999-04-15
US20010046503A1 (en) 2001-11-29
US6780427B2 (en) 2004-08-24
AU5257596A (en) 1996-10-16

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Effective date: 20160321