CA2218483A1 - Microspheres with fluorescent spherical zones - Google Patents

Microspheres with fluorescent spherical zones

Info

Publication number
CA2218483A1
CA2218483A1 CA002218483A CA2218483A CA2218483A1 CA 2218483 A1 CA2218483 A1 CA 2218483A1 CA 002218483 A CA002218483 A CA 002218483A CA 2218483 A CA2218483 A CA 2218483A CA 2218483 A1 CA2218483 A1 CA 2218483A1
Authority
CA
Canada
Prior art keywords
microspheres
fluorescent
novel
labeled
distinct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002218483A
Other languages
French (fr)
Other versions
CA2218483C (en
Inventor
Yu-Zhong Zhang
Courtenay R. Kemper
Richard P. Haugland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Probes Inc
Original Assignee
Molecular Probes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Probes Inc filed Critical Molecular Probes Inc
Publication of CA2218483A1 publication Critical patent/CA2218483A1/en
Application granted granted Critical
Publication of CA2218483C publication Critical patent/CA2218483C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1012—Calibrating particle analysers; References therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Abstract

The invention describes novel fluorescent microspheres that are labeled so as to possess at least one fluorescent spherical zone, such that following excitation of the part icle at an appropriate wavelength, an equatorial cross-section displays a distinct fluorescent ring tha t is concentric with and within said microsphere. The invention also describes the method of preparing th e novel microspheres, the method of calibrating microscopy instrumentation using the nov el microspheres, the method of using the novel microspheres as distinct labels for combinatorial analysis and the use of the labeled microspheres as tagging agents and tracers.
CA002218483A 1996-10-28 1997-10-16 Microspheres with fluorescent spherical zones Expired - Lifetime CA2218483C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/740,184 US5786219A (en) 1996-10-28 1996-10-28 Microspheres with fluorescent spherical zones
US08/740,184 1996-10-28

Publications (2)

Publication Number Publication Date
CA2218483A1 true CA2218483A1 (en) 1998-04-28
CA2218483C CA2218483C (en) 2001-12-18

Family

ID=24975407

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002218483A Expired - Lifetime CA2218483C (en) 1996-10-28 1997-10-16 Microspheres with fluorescent spherical zones

Country Status (3)

Country Link
US (1) US5786219A (en)
CA (1) CA2218483C (en)
GB (1) GB2318580B (en)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005960A (en) * 1994-04-14 1999-12-21 Moore; Lewis J. Anti-counterfeiting system
ES2288760T3 (en) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. ELECTROCINETIC ASSEMBLY CONTROLLED BY LIGHT OF PARTICLES NEXT TO SURFACES.
US5941572A (en) * 1997-09-12 1999-08-24 Nocopi Technologies, Inc. Method for authenticating a textile product and a thread and a woven label usable therewith
CA2306501C (en) * 1997-10-14 2011-03-29 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
AU2464299A (en) * 1998-01-22 1999-08-09 Luminex Corporation Microparticles with multiple fluorescent signals
US7079241B2 (en) 2000-04-06 2006-07-18 Invitrogen Corp. Spatial positioning of spectrally labeled beads
US6576155B1 (en) * 1998-11-10 2003-06-10 Biocrystal, Ltd. Fluorescent ink compositions comprising functionalized fluorescent nanocrystals
WO2000028598A1 (en) 1998-11-10 2000-05-18 Biocrystal Limited Methods for identification and verification
AU4710800A (en) * 1999-05-12 2000-11-21 Axys Pharmaceuticals, Inc. Methods of software driven flow sorting for reiterative synthesis cycles
DE19925402C2 (en) * 1999-06-02 2001-12-20 Molecular Machines & Ind Gmbh Screening of target-ligand interactions
DE19933104A1 (en) * 1999-07-15 2001-01-18 Ingo Klimant Phosphorescent micro- and nanoparticles as reference standards and phosphorescence markers
DE60040603D1 (en) * 1999-08-17 2008-12-04 Luminex Corp METHOD FOR ANALYZING A MULTIPLE OF SAMPLES OF VARIOUS ORIGIN ON AN ANALYTE
US6287870B1 (en) * 1999-08-20 2001-09-11 Robert A. Levine Method and assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sample
US7098042B2 (en) * 1999-09-02 2006-08-29 Btf Pty Ltd. Internal quality control
US7192778B2 (en) * 1999-10-06 2007-03-20 Natan Michael J Surface enhanced spectroscopy-active composite nanoparticles
US6361079B1 (en) 1999-10-25 2002-03-26 Wayne Trademark Manufacturing Company Labels for detecting counterfeit products
US6864631B1 (en) * 2000-01-12 2005-03-08 Imaging Systems Technology Gas discharge display device
WO2001071318A1 (en) * 2000-03-21 2001-09-27 The Board Of Trustees Of The University Of Illinois Colorimetric artificial nose having an array of dyes and method for artificial olfaction
US6368558B1 (en) * 2000-03-21 2002-04-09 The Board Of Trustees Of The University Of Illinois Colorimetric artificial nose having an array of dyes and method for artificial olfaction
DE60117556T2 (en) 2000-06-21 2006-11-02 Bioarray Solutions Ltd. MULTI-ANALYTIC MOLECULAR ANALYSIS THROUGH THE USE OF APPLICATION SPECIFIC RAPID PARTICLE ARRAYS
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU2001276867A1 (en) * 2000-07-11 2002-01-21 Sri International Encoding methods using up-converting phosphors for high-throughput screening of catalysts
DE10042023C2 (en) * 2000-08-08 2003-04-10 Biognostic Ag Capsules that encapsulate solid particles of signal-generating substances and their use in bioassays for the detection of target molecules in a sample
US6723108B1 (en) * 2000-09-18 2004-04-20 Cordis Neurovascular, Inc Foam matrix embolization device
US6905881B2 (en) * 2000-11-30 2005-06-14 Paul Sammak Microbead-based test plates and test methods for fluorescence imaging systems
US6861263B2 (en) * 2001-01-26 2005-03-01 Surromed, Inc. Surface-enhanced spectroscopy-active sandwich nanoparticles
CA2445960A1 (en) * 2001-02-21 2002-12-19 Amnis Corporation Method and apparatus for labeling and analyzing cellular components
JP2002251091A (en) * 2001-02-27 2002-09-06 Konica Corp Image fixing device and image forming device
US20020164271A1 (en) * 2001-05-02 2002-11-07 Ho Winston Z. Wavelength-coded bead for bioassay and signature recogniton
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
EP1412413B1 (en) * 2001-06-29 2011-08-10 Nanomics Biosystems Pty, Ltd. Synthesis and use of organosilica particles
US8148171B2 (en) 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US20050164261A1 (en) * 2001-10-09 2005-07-28 Chandler Don J. Multiplexed analysis of clinical specimens apparatus and methods
ES2661167T3 (en) * 2001-10-15 2018-03-27 Bioarray Solutions Ltd. Multiplexed analysis of polymorphic loci by simultaneous consultation and enzyme-mediated detection
US20080138800A1 (en) * 2001-10-15 2008-06-12 Alice Xiang Li Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
AU2002362013B2 (en) 2001-11-21 2008-04-24 Applied Biosystems, Llc. Digital assay
US7335153B2 (en) 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
US6792019B2 (en) * 2002-02-28 2004-09-14 Texas Instruments Incorporated Driver with tail currents in discrete subranges
US7491491B2 (en) * 2002-03-12 2009-02-17 Polytechnic Institute Of New York University Detecting and/or measuring a substance based on a resonance shift of photons orbiting within a microsphere
US20030236205A1 (en) * 2002-06-21 2003-12-25 Zhang David Y. Hybridization signal amplification method (HSAM) nanostructures for diagnostic and therapeutic uses
US7312040B2 (en) * 2002-09-20 2007-12-25 Agilent Technologies, Inc. Microcapsule biosensors and methods of using the same
EP1545762A2 (en) * 2002-09-27 2005-06-29 Carlsberg A/S Spatially encoded polymer matrix
AU2003284319A1 (en) * 2002-10-22 2004-05-13 Polytechnic University Enhancing the sensitivity of a microsphere sensor
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US20040196465A1 (en) * 2002-12-12 2004-10-07 Stephen Arnold Using a change in one or more properties of light in one or more microspheres for sensing chemicals such as explosives and poison gases
US7326573B2 (en) * 2003-01-10 2008-02-05 Beckman Coulter, Inc. Assay procedures and apparatus
US20040238744A1 (en) * 2003-01-15 2004-12-02 Stephen Arnold Perturbation approach to resonance shift of whispering gallery modes in a dielectric microsphere as a probe of a surrounding medium
US7255895B2 (en) * 2003-01-21 2007-08-14 Bioarray Solutions, Ltd. Method for controlling solute loading of polymer microparticles
US6964747B2 (en) * 2003-01-21 2005-11-15 Bioarray Solutions, Ltd. Production of dyed polymer microparticles
WO2004072613A2 (en) * 2003-02-07 2004-08-26 Board Of Regents, The University Of Texas System Multi-shell microspheres with integrated chomatographic and detection layers for use in array sensors
US20060237665A1 (en) * 2003-03-10 2006-10-26 Barney William S Bioaerosol discrimination
US7060992B1 (en) 2003-03-10 2006-06-13 Tiax Llc System and method for bioaerosol discrimination by time-resolved fluorescence
WO2004106890A2 (en) * 2003-05-22 2004-12-09 Ciphergen Biosystems, Inc. Trace incorporation of fluorescent monomer facilitating quality control of polymerization reactions
US20060131517A1 (en) * 2003-06-26 2006-06-22 Ross Gary A Security markers for controlling operation of an item
US7378675B2 (en) * 2003-06-26 2008-05-27 Ncr Corporation Security markers for indicating condition of an item
US20060180792A1 (en) * 2003-06-26 2006-08-17 Prime Technology Llc Security marker having overt and covert security features
US7256398B2 (en) * 2003-06-26 2007-08-14 Prime Technology Llc Security markers for determining composition of a medium
US20060118738A1 (en) * 2003-06-26 2006-06-08 Ncr Corporation Security markers for ascertaining navigational information
US20060219961A1 (en) * 2003-06-26 2006-10-05 Ross Gary A Security markers for controlling access to a secure area
US7501646B2 (en) * 2003-06-26 2009-03-10 Ncr Corporation Security markers for reducing receipt fraud
US7488954B2 (en) * 2003-06-26 2009-02-10 Ncr Corporation Security markers for marking a person or property
US7800088B2 (en) * 2003-06-26 2010-09-21 Ncr Corporation Security markers for identifying a source of a substance
GB0314883D0 (en) * 2003-06-26 2003-07-30 Ncr Int Inc Security labelling
US20060118739A1 (en) * 2003-06-26 2006-06-08 Ncr Corporation Security markers for marking pharmaceuticals
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US8501098B1 (en) * 2003-09-18 2013-08-06 The Research Foundation Of State University Of New York Temporally addressable detection array
AU2004276761B2 (en) 2003-09-22 2009-12-24 Bioarray Solutions, Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
AU2004286252A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
EP1699553A2 (en) * 2003-12-22 2006-09-13 VersaMatrix A/S Apparatus and methods for analysis and sorting of particles such as polymer beads
EP1701784A1 (en) * 2003-12-22 2006-09-20 VersaMatrix A/S Identification of encoded beads
US7939249B2 (en) * 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US7323696B2 (en) 2004-01-09 2008-01-29 Applera Corporation Phosphor particle coded beads
US7486815B2 (en) * 2004-02-20 2009-02-03 Microsoft Corporation Method and apparatus for scene learning and three-dimensional tracking using stereo video cameras
US7247375B2 (en) * 2004-04-30 2007-07-24 Kimberly-Clark Worldwide, Inc. Polymeric matrices for the encapsulation of phosphorescent molecules for analytical applications
US7407816B2 (en) 2004-05-07 2008-08-05 Gentius, Inc Isoelectric particles and uses thereof
US7238301B2 (en) * 2004-06-29 2007-07-03 Kimberly-Clark Worldwide, Inc. Cross-linked encapsulated phosphorescent molecules
US20060024815A1 (en) * 2004-07-30 2006-02-02 Allman Steve L High sensitivity array-based detection system
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US20060045814A1 (en) * 2004-09-01 2006-03-02 Zhang Yu-Zhong Microplates containing microsphere fluorescence standards, microsphere standards, and methods for their use
US7901632B2 (en) * 2004-11-16 2011-03-08 Chi Yung Fu Ultrasensitive olfactory system fabrication with doped aerogels
US8209267B2 (en) * 2004-12-08 2012-06-26 Lockheed Martin Corporation Automatic revenue protection and adjustment of postal indicia products
US7937332B2 (en) * 2004-12-08 2011-05-03 Lockheed Martin Corporation Automatic verification of postal indicia products
US8005764B2 (en) 2004-12-08 2011-08-23 Lockheed Martin Corporation Automatic verification of postal indicia products
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2008054341A2 (en) * 2005-06-20 2008-05-08 The Research Foundation Of State University Of New York Method of bioimaging using nanocrystals of fluorescent dyes
US7427025B2 (en) * 2005-07-08 2008-09-23 Lockheed Marlin Corp. Automated postal voting system and method
NO20053373D0 (en) * 2005-07-11 2005-07-11 Rikshospitalet Radiumhospitale Multicolored Particles.
US7618792B2 (en) * 2006-01-06 2009-11-17 Bioarray Solutions Ltd. Multiplexed detection of anti-red cell alloantibodies
CA2571904A1 (en) * 2006-02-15 2007-08-15 Fio Corporation System and method of detecting pathogens
US20080019921A1 (en) * 2006-06-30 2008-01-24 Invitrogen Corporation Uniform fluorescent microsphere with hydrophobic surfaces
US20080129037A1 (en) * 2006-12-01 2008-06-05 Prime Technology Llc Tagging items with a security feature
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
JP5208430B2 (en) * 2007-01-31 2013-06-12 オリンパス株式会社 Fluorescence observation device for living tissue
CA2682826C (en) 2007-04-02 2013-08-13 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
JP2010530912A (en) 2007-06-22 2010-09-16 フィオ コーポレイション Manufacturing system and method for polymer microbeads doped with quantum dots
JP5507454B2 (en) * 2007-07-09 2014-05-28 フィオ コーポレイション System and method for improved fluorescence detection of target molecules in a test sample
KR101832658B1 (en) * 2007-07-23 2018-02-26 피오 코포레이션 A method and system for collating, storing, analyzing and enabling access to collected and analyzed data associated with biological and environmental test subjects
US20090029347A1 (en) * 2007-07-27 2009-01-29 Thornthwaite Jerry T Method for Identifying Multiple Analytes Using Flow Cytometry
JP5628037B2 (en) * 2007-10-12 2014-11-19 フィオ コーポレイション Flow focusing method and system for forming concentrated microbeads, and microbeads formed in the system
US9734442B2 (en) * 2007-10-31 2017-08-15 Ncr Corporation LumID barcode format
CN103364381B (en) * 2007-12-17 2016-04-06 生命技术公司 For detecting the method for the defect in inorganic-coated polymer surfaces
US20130020507A1 (en) 2010-06-17 2013-01-24 Life Technologies Corporation Methods for Detecting Defects in Inorganic-Coated Polymer Surfaces
BRPI0915514A2 (en) 2008-06-25 2016-01-26 Fio Corp biohazard warning infrastructure system and method, biohazard warning device and a method for alerting a user
CN102065929B (en) * 2008-06-26 2013-11-06 凯希特许有限公司 System for stimulation of cartilage formation using reduced pressure treatment
US8085980B2 (en) * 2008-08-13 2011-12-27 Lockheed Martin Corporation Mail piece identification using bin independent attributes
RU2515209C2 (en) 2008-08-29 2014-05-10 Эф-Ай-Оу Корпорейшн Disposable portable diagnostic instrument and appropriate system and method to investigate biological and natural samples
US20100100233A1 (en) * 2008-10-22 2010-04-22 Lockheed Martin Corporation Universal intelligent postal identification code
US8415161B2 (en) 2008-11-13 2013-04-09 Becton, Dickinson And Company Instrument setup system for a fluorescence analyzer
KR20110107357A (en) * 2008-12-30 2011-09-30 케이씨아이 라이센싱 인코포레이티드 Reduced pressure augmentation of microfracture procedures for cartilage repair
CN104374932A (en) 2009-01-13 2015-02-25 Fio公司 A handheld diagnostic test device used with an electronic device and a test cartridge in a rapid diagnostic test
JP5458301B2 (en) * 2009-02-10 2014-04-02 三菱化学株式会社 Dibenzopyromethene boron chelate compound and method for producing the same, solar cell using the same, photopolymerizable composition, optical storage medium, light emitting element, optical filter, and fluorescent dye for medical diagnosis
US8642111B2 (en) * 2009-05-19 2014-02-04 Polytechnic Institute Of New York University Functionalizing a sensing ribbon on a whispering gallery mode microresonator using light force to fabricate a whispering gallery mode sensor
GB2475226A (en) * 2009-11-03 2011-05-18 Genetic Analysis As Universal Prokaryote 16S ribosome PCR primer pair
US20120065092A1 (en) 2010-09-14 2012-03-15 Wai Hobert Fusion analyte cytometric bead assay, and systems and kits for performing the same
CA2816014A1 (en) 2010-11-03 2012-05-10 Reametrix Inc. Method and device for fluorescent measurement of samples
GB201021397D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Diagnosis of Crohn's disease
GB201021399D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Oligonucleotide probe set and methods of microbiota profiling
GB201102693D0 (en) 2011-02-16 2011-03-30 Genetic Analysis As Method for identifying neonates at risk for necrotizing enterocolitis
CN102286213A (en) * 2011-05-12 2011-12-21 河南大学 Near-infrared aza-BODIPY dye as well as preparation method and application thereof
US8785177B2 (en) 2011-11-04 2014-07-22 The Board Of Trustees Of The University Of Illinois, A Body Corporate And Politic Of The State Of Illinois Methods for nano-mechanoporation
US9604871B2 (en) 2012-11-08 2017-03-28 Corning Incorporated Durable glass ceramic cover glass for electronic devices
US11542080B2 (en) * 2013-05-07 2023-01-03 BBB Holding Company Track and trace packaging and systems
WO2015157246A2 (en) * 2014-04-07 2015-10-15 Massachusetts Institute Of Technology Use of microparticle additives to simultaneously enable artifact-free image registration, auto-focusing, and chromatic aberration correction in microscopy
WO2016179286A1 (en) 2015-05-05 2016-11-10 Massachusetts Institute Of Technology Substrate pre-scanning for high throughput microscopy
WO2017007431A1 (en) * 2015-07-09 2017-01-12 National University Of Singapore Microsphere for generating a photonic nanojet
JP2019503203A (en) 2016-01-29 2019-02-07 アカオジェン インコーポレイテッド Screening methods for identifying antibodies that bind to cell surface epitopes
CN105859973B (en) * 2016-05-18 2018-07-06 苏州知益微球科技有限公司 A kind of monodisperse fluorescent microsphere preparation method
JP6717979B2 (en) * 2016-12-19 2020-07-08 富士フイルム株式会社 Light emitting resin composition for wavelength conversion, method for producing the same, wavelength conversion member and light emitting device
WO2018140827A1 (en) 2017-01-27 2018-08-02 Achaogen, Inc. Reporter microorganisms and uses thereof
US11262298B2 (en) * 2018-08-30 2022-03-01 Caterpillar Inc. System and method for determining fluid origin
CN112694873B (en) * 2019-10-23 2022-11-01 中国石油化工股份有限公司 Traceable polymer microsphere emulsion and application thereof
CN110961071B (en) * 2019-12-20 2022-05-27 湖北海汇化工科技有限公司 Wastewater treatment agent, preparation method and application thereof, and wastewater treatment method
CN115353875B (en) * 2022-10-20 2023-01-03 苏州纳微生命科技有限公司 Fluorescent coding microsphere, preparation method and application thereof, and diagnostic kit

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4326008A (en) * 1976-08-27 1982-04-20 California Institute Of Technology Protein specific fluorescent microspheres for labelling a protein
US4413070A (en) * 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
US4609689A (en) * 1984-04-27 1986-09-02 Becton, Dickinson And Company Method of preparing fluorescently labeled microbeads
US4774189A (en) * 1984-12-24 1988-09-27 Flow Cytometry Standards Corp. Fluorescent calibration microbeads simulating stained cells
US4767205A (en) * 1986-01-28 1988-08-30 Flow Cytometry Standards Corporation Composition and method for hidden identification
US4774339A (en) * 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US4916711A (en) * 1988-09-29 1990-04-10 Boyer Joseph H Lasing compositions and methods for using the same
US5136005A (en) * 1989-10-13 1992-08-04 The United States Of America As Represented By The United States Department Of Energy Composition and method of preparation of solid state dye laser rods
US5326692B1 (en) * 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5274113A (en) * 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5433896A (en) * 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5189029A (en) * 1990-04-23 1993-02-23 Bo-Dekk Ventures, Ltd. Indacene compounds and methods for using the same
US5446157A (en) * 1990-04-23 1995-08-29 Morgan; Lee R. Boron difluoride compounds useful in photodynamic therapy and production of laser light
US5286803A (en) * 1990-11-26 1994-02-15 The United States Of America As Represented By The Secretary Of The Navy Coumarin dyes and side-chain coumarin dye-substituted polymers which exhibit nonlinear optical properties
US5248782A (en) * 1990-12-18 1993-09-28 Molecular Probes, Inc. Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes
US5338854A (en) * 1991-02-13 1994-08-16 Molecular Probes, Inc. Fluorescent fatty acids derived from dipyrrometheneboron difluoride dyes
US5187288A (en) * 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis

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GB2318580A (en) 1998-04-29
GB9722158D0 (en) 1997-12-17
GB2318580B (en) 1999-01-06
US5786219A (en) 1998-07-28

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