WO1994025022A1
(en)
|
1993-04-23 |
1994-11-10 |
Abbott Laboratories |
Rapamycin conjugates and antibodies
|
US7279561B1
(en)
|
1993-04-23 |
2007-10-09 |
Wyeth |
Anti-rapamycin monoclonal antibodies
|
US6187757B1
(en)
|
1995-06-07 |
2001-02-13 |
Ariad Pharmaceuticals, Inc. |
Regulation of biological events using novel compounds
|
FR2736550B1
(en)
|
1995-07-14 |
1998-07-24 |
Sandoz Sa |
PHARMACEUTICAL COMPOSITION IN THE FORM OF A SOLID DISPERSION COMPRISING A MACROLIDE AND A VEHICLE
|
GB9606452D0
(en)
|
1996-03-27 |
1996-06-05 |
Sandoz Ltd |
Organic compounds
|
EP0937082A2
(en)
*
|
1996-07-12 |
1999-08-25 |
Ariad Pharmaceuticals, Inc. |
Materials and method for treating or preventing pathogenic fungal infection
|
US20050031611A1
(en)
*
|
1998-05-08 |
2005-02-10 |
Beth Israel Deaconess Medical Center |
Transplant tolerance by costimulation blockade and T-cell activation-induced apoptosis
|
GB9826882D0
(en)
|
1998-12-07 |
1999-01-27 |
Novartis Ag |
Organic compounds
|
US8124630B2
(en)
|
1999-01-13 |
2012-02-28 |
Bayer Healthcare Llc |
ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
EP2298311B1
(en)
|
1999-01-13 |
2012-05-09 |
Bayer HealthCare LLC |
w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
|
US6955661B1
(en)
*
|
1999-01-25 |
2005-10-18 |
Atrium Medical Corporation |
Expandable fluoropolymer device for delivery of therapeutic agents and method of making
|
US6331547B1
(en)
|
1999-08-18 |
2001-12-18 |
American Home Products Corporation |
Water soluble SDZ RAD esters
|
AU783158B2
(en)
|
1999-08-24 |
2005-09-29 |
Ariad Pharmaceuticals, Inc. |
28-epirapalogs
|
US7067526B1
(en)
|
1999-08-24 |
2006-06-27 |
Ariad Gene Therapeutics, Inc. |
28-epirapalogs
|
US7807211B2
(en)
|
1999-09-03 |
2010-10-05 |
Advanced Cardiovascular Systems, Inc. |
Thermal treatment of an implantable medical device
|
US6790228B2
(en)
|
1999-12-23 |
2004-09-14 |
Advanced Cardiovascular Systems, Inc. |
Coating for implantable devices and a method of forming the same
|
US20070032853A1
(en)
*
|
2002-03-27 |
2007-02-08 |
Hossainy Syed F |
40-O-(2-hydroxy)ethyl-rapamycin coated stent
|
US6277983B1
(en)
|
2000-09-27 |
2001-08-21 |
American Home Products Corporation |
Regioselective synthesis of rapamycin derivatives
|
US6670355B2
(en)
*
|
2000-06-16 |
2003-12-30 |
Wyeth |
Method of treating cardiovascular disease
|
US6399626B1
(en)
*
|
2000-10-02 |
2002-06-04 |
Wyeth |
Hydroxyesters of 7-desmethylrapamycin
|
US20040018228A1
(en)
*
|
2000-11-06 |
2004-01-29 |
Afmedica, Inc. |
Compositions and methods for reducing scar tissue formation
|
US6534693B2
(en)
|
2000-11-06 |
2003-03-18 |
Afmedica, Inc. |
Surgically implanted devices having reduced scar tissue formation
|
US20040241211A9
(en)
*
|
2000-11-06 |
2004-12-02 |
Fischell Robert E. |
Devices and methods for reducing scar tissue formation
|
US6821731B2
(en)
*
|
2000-11-28 |
2004-11-23 |
Wyeth |
Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis of prostate cancer
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
AU2011226835C1
(en)
*
|
2001-02-19 |
2018-01-04 |
Novartis Ag |
Cancer treatment
|
AU2002250968C1
(en)
*
|
2001-02-19 |
2018-01-04 |
Novartis Ag |
Cancer treatment
|
AU2016206379B2
(en)
*
|
2001-02-19 |
2017-09-14 |
Novartis Ag |
Cancer Treatment
|
AU2005201004A1
(en)
*
|
2001-02-19 |
2005-03-24 |
Novartis Ag |
Cancer treatment
|
EP1404325A2
(en)
*
|
2001-05-29 |
2004-04-07 |
Guilford Pharmaceuticals Inc. |
Method for treating nerve injury caused by surgery
|
EP1285659B1
(en)
*
|
2001-08-13 |
2007-06-27 |
Fondazione Salvatore Maugeri - Clinica del Lavoro e della Riabilitazione |
Use of clarithromycin compositions in the manufacture of a medicament for the treatment of arthritis deformans
|
US20030054042A1
(en)
*
|
2001-09-14 |
2003-03-20 |
Elaine Liversidge |
Stabilization of chemical compounds using nanoparticulate formulations
|
US20030220297A1
(en)
*
|
2002-02-01 |
2003-11-27 |
Berstein David L. |
Phosphorus-containing compounds and uses thereof
|
MXPA04007832A
(en)
|
2002-02-11 |
2005-09-08 |
Bayer Pharmaceuticals Corp |
Aryl ureas with angiogenesis inhibiting activity.
|
EP1340498A1
(en)
*
|
2002-03-01 |
2003-09-03 |
Schering Aktiengesellschaft |
Use of epothilones in the treatment of brain diseases associated with proliferative processes
|
EP1955696B1
(en)
|
2002-05-16 |
2014-05-28 |
Novartis AG |
Use of the EDG receptor binding agent FTY720 in cancer
|
JP4265888B2
(en)
*
|
2002-06-12 |
2009-05-20 |
株式会社リコー |
Image forming apparatus
|
EP1589031B1
(en)
|
2002-07-16 |
2007-08-15 |
Biotica Technology Limited |
Production of polyketides and other natural products
|
NZ538961A
(en)
|
2002-09-24 |
2008-02-29 |
Novartis Ag |
Sphingosine-1-phosphate receptor agonists in the treatment of demyelinating disorders
|
AU2003293529A1
(en)
|
2002-12-16 |
2004-07-29 |
Nitromed, Inc. |
Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
|
ATE457716T1
(en)
|
2002-12-30 |
2010-03-15 |
Angiotech Int Ag |
RELEASE OF ACTIVE INGREDIENTS FROM QUICK-GELLING POLYMER COMPOSITION
|
WO2004089369A2
(en)
*
|
2003-04-11 |
2004-10-21 |
Cambridge University Technical Services Limited |
Methods and means for treating protein conformational disorders
|
US7160867B2
(en)
|
2003-05-16 |
2007-01-09 |
Isotechnika, Inc. |
Rapamycin carbohydrate derivatives
|
ATE366108T1
(en)
|
2003-05-20 |
2007-07-15 |
Bayer Pharmaceuticals Corp |
DIARYL UREAS FOR PDGFR-MEDIATED DISEASES
|
JP4041774B2
(en)
*
|
2003-06-05 |
2008-01-30 |
住友金属工業株式会社 |
Method for producing β-type titanium alloy material
|
JP4351474B2
(en)
*
|
2003-06-05 |
2009-10-28 |
住友金属工業株式会社 |
Golf club head face plate manufacturing method and golf club head
|
US20050118344A1
(en)
|
2003-12-01 |
2005-06-02 |
Pacetti Stephen D. |
Temperature controlled crimping
|
US8021331B2
(en)
*
|
2003-09-15 |
2011-09-20 |
Atrium Medical Corporation |
Method of coating a folded medical device
|
US7659244B2
(en)
|
2003-11-03 |
2010-02-09 |
Quest Pharmatech, Inc. |
Rapamycin peptides conjugates: synthesis and uses thereof
|
US7220755B2
(en)
*
|
2003-11-12 |
2007-05-22 |
Biosensors International Group, Ltd. |
42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
|
GB0327840D0
(en)
*
|
2003-12-01 |
2003-12-31 |
Novartis Ag |
Organic compounds
|
CA2571710A1
(en)
|
2004-06-24 |
2006-11-02 |
Nicholas Valiante |
Small molecule immunopotentiators and assays for their detection
|
GB0417852D0
(en)
|
2004-08-11 |
2004-09-15 |
Biotica Tech Ltd |
Production of polyketides and other natural products
|
US9000040B2
(en)
|
2004-09-28 |
2015-04-07 |
Atrium Medical Corporation |
Cross-linked fatty acid-based biomaterials
|
US8962023B2
(en)
|
2004-09-28 |
2015-02-24 |
Atrium Medical Corporation |
UV cured gel and method of making
|
US9012506B2
(en)
|
2004-09-28 |
2015-04-21 |
Atrium Medical Corporation |
Cross-linked fatty acid-based biomaterials
|
US8021849B2
(en)
*
|
2004-11-05 |
2011-09-20 |
Siemens Healthcare Diagnostics Inc. |
Methods and kits for the determination of sirolimus in a sample
|
WO2006053754A1
(en)
*
|
2004-11-19 |
2006-05-26 |
Novartis Ag |
COMBINATIONS OF ANTI-ATHEROSCLEROTIC PEPTIDES AND AN mTOR INHIBITING AGENT AND THEIR METHODS OF USE
|
US20100047338A1
(en)
|
2008-03-14 |
2010-02-25 |
Angela Brodie |
Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
|
GB0504544D0
(en)
|
2005-03-04 |
2005-04-13 |
Novartis Ag |
Organic compounds
|
GB0504994D0
(en)
|
2005-03-11 |
2005-04-20 |
Biotica Tech Ltd |
Novel compounds
|
EP1896018A2
(en)
|
2005-03-11 |
2008-03-12 |
Biotica Technology Limited |
Medical uses of 39-desmethoxyrapamycin and analogues thereof
|
US7189582B2
(en)
*
|
2005-04-27 |
2007-03-13 |
Dade Behring Inc. |
Compositions and methods for detection of sirolimus
|
CA2608879A1
(en)
*
|
2005-05-31 |
2006-12-07 |
Novartis Ag |
Combination of hmg-coa reductase inhibitors amd mtor inhibitors
|
US20090062909A1
(en)
|
2005-07-15 |
2009-03-05 |
Micell Technologies, Inc. |
Stent with polymer coating containing amorphous rapamycin
|
CA2615452C
(en)
|
2005-07-15 |
2015-03-31 |
Micell Technologies, Inc. |
Polymer coatings containing drug powder of controlled morphology
|
JP2009501765A
(en)
|
2005-07-20 |
2009-01-22 |
ノバルティス アクチエンゲゼルシャフト |
Combination of pyrimidylaminobenzamide and mTOR kinase inhibitor
|
SI2298815T1
(en)
|
2005-07-25 |
2015-08-31 |
Emergent Product Development Seattle, Llc |
B-cell reduction using CD37-specific and CD20-specific binding molecules
|
EP1919954B1
(en)
|
2005-08-30 |
2016-10-19 |
University of Miami |
Immunomodulating tumor necrosis factor receptor 25 (tnfr25) agonists, antagonists and immunotoxins
|
US9427423B2
(en)
|
2009-03-10 |
2016-08-30 |
Atrium Medical Corporation |
Fatty-acid based particles
|
US9278161B2
(en)
|
2005-09-28 |
2016-03-08 |
Atrium Medical Corporation |
Tissue-separating fatty acid adhesion barrier
|
US20070134739A1
(en)
*
|
2005-12-12 |
2007-06-14 |
Gyros Patent Ab |
Microfluidic assays and microfluidic devices
|
GB0601406D0
(en)
*
|
2006-01-24 |
2006-03-08 |
Novartis Ag |
Organic Compounds
|
JP5639743B2
(en)
*
|
2006-02-02 |
2014-12-10 |
ノバルティス アーゲー |
Tuberous sclerosis treatment
|
CA2996768C
(en)
|
2006-04-26 |
2020-12-08 |
Micell Technologies, Inc. |
Coatings containing multiple drugs
|
EP2056821A2
(en)
*
|
2006-08-22 |
2009-05-13 |
Novartis AG |
Rapamycin and its derivatives for the treatment of liver-associated fibrosing disorders
|
US10695327B2
(en)
|
2006-09-13 |
2020-06-30 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
US8088789B2
(en)
*
|
2006-09-13 |
2012-01-03 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
EP2702993B1
(en)
|
2006-09-13 |
2017-12-06 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
CN101522691B
(en)
|
2006-11-27 |
2012-08-22 |
泰尔茂株式会社 |
Process for producing o-alkylated rapamycin derivative, and o-alkylated rapamycin derivative
|
CA2679712C
(en)
|
2007-01-08 |
2016-11-15 |
Micell Technologies, Inc. |
Stents having biodegradable layers
|
US11426494B2
(en)
|
2007-01-08 |
2022-08-30 |
MT Acquisition Holdings LLC |
Stents having biodegradable layers
|
US7938286B2
(en)
*
|
2007-02-13 |
2011-05-10 |
Gateway Plastics, Inc. |
Container system
|
US8921642B2
(en)
|
2008-01-11 |
2014-12-30 |
Massachusetts Eye And Ear Infirmary |
Conditional-stop dimerizable caspase transgenic animals
|
US20090253733A1
(en)
*
|
2008-04-02 |
2009-10-08 |
Biointeractions, Ltd. |
Rapamycin carbonate esters
|
MX340204B
(en)
|
2008-04-11 |
2016-06-30 |
Emergent Product Dev Seattle |
Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof.
|
EP2271294B1
(en)
|
2008-04-17 |
2018-03-28 |
Micell Technologies, Inc. |
Stents having bioabsorbable layers
|
JP2011525189A
(en)
|
2008-06-20 |
2011-09-15 |
ノバルティス アーゲー |
Pediatric composition for treating multiple sclerosis
|
JP2011528275A
(en)
|
2008-07-17 |
2011-11-17 |
ミセル テクノロジーズ,インク. |
Drug delivery medical device
|
EP2352459A4
(en)
*
|
2008-10-03 |
2013-09-25 |
Elixir Medical Corp |
Macrocyclic lactone compounds and methods for their use
|
CN104042612A
(en)
|
2008-11-11 |
2014-09-17 |
得克萨斯大学体系董事会 |
Inhibition Of Mammalian Target Of Rapamycin
|
DE102008060549A1
(en)
|
2008-12-04 |
2010-06-10 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Drug-peptide construct for extracellular accumulation
|
CA2761389A1
(en)
|
2009-02-05 |
2010-08-12 |
Tokai Pharmaceuticals, Inc. |
Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
|
CN102481195B
(en)
|
2009-04-01 |
2015-03-25 |
米歇尔技术公司 |
Drug delivery medical device
|
WO2010121187A2
(en)
|
2009-04-17 |
2010-10-21 |
Micell Techologies, Inc. |
Stents having controlled elution
|
EP2453834A4
(en)
|
2009-07-16 |
2014-04-16 |
Micell Technologies Inc |
Drug delivery medical device
|
CN102770455B
(en)
|
2009-08-03 |
2017-02-08 |
迈阿密大学 |
Method for in vivo expansion of T regulatory cells
|
US20110038910A1
(en)
|
2009-08-11 |
2011-02-17 |
Atrium Medical Corporation |
Anti-infective antimicrobial-containing biomaterials
|
US9283211B1
(en)
|
2009-11-11 |
2016-03-15 |
Rapamycin Holdings, Llc |
Oral rapamycin preparation and use for stomatitis
|
US10391059B2
(en)
|
2009-11-11 |
2019-08-27 |
Rapamycin Holdings, Inc. |
Oral rapamycin nanoparticle preparations and use
|
US11369498B2
(en)
|
2010-02-02 |
2022-06-28 |
MT Acquisition Holdings LLC |
Stent and stent delivery system with improved deliverability
|
EP2558092B1
(en)
|
2010-04-13 |
2018-06-27 |
Novartis AG |
Combination comprising a cyclin dependent kinase 4 or cyclin dependent kinase 6 (cdk4/6) inhibitor and an mtor inhibitor for treating cancer
|
AU2011240001B2
(en)
|
2010-04-16 |
2014-05-08 |
Novartis Ag |
Combination of organic compounds
|
WO2011133655A1
(en)
|
2010-04-22 |
2011-10-27 |
Micell Technologies, Inc. |
Stents and other devices having extracellular matrix coating
|
MX342590B
(en)
|
2010-04-27 |
2016-10-05 |
Roche Glycart Ag |
Combination therapy of an afucosylated cd20 antibody with a mtor inhibitor.
|
WO2012009707A2
(en)
|
2010-07-16 |
2012-01-19 |
Atrium Medical Corporation |
Composition and methods for altering the rate of hydrolysis of cured oil-based materials
|
CA2805631C
(en)
|
2010-07-16 |
2018-07-31 |
Micell Technologies, Inc. |
Drug delivery medical device
|
ES2547916T3
(en)
|
2011-02-18 |
2015-10-09 |
Novartis Pharma Ag |
MTOR / JAK inhibitor combination therapy
|
WO2012149014A1
(en)
|
2011-04-25 |
2012-11-01 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
AR086481A1
(en)
|
2011-04-25 |
2013-12-18 |
Novartis Ag |
COMBINATION OF A FOSFATIDIL-INOSITOL-3 KINASA INHIBITOR (PI3K), AND A mTOR INHIBITOR
|
CA2841360A1
(en)
|
2011-07-15 |
2013-01-24 |
Micell Technologies, Inc. |
Drug delivery medical device
|
US10188772B2
(en)
|
2011-10-18 |
2019-01-29 |
Micell Technologies, Inc. |
Drug delivery medical device
|
EP2589383A1
(en)
|
2011-11-06 |
2013-05-08 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin |
FKBP subtype-specific rapamycin analogue for use in treatment of diseases
|
BR112014011645A2
(en)
|
2011-11-15 |
2017-05-02 |
Novartis Ag |
combination of a phosphoinositide 3-kinase inhibitor and a janus 2-signal transducer and transcriptional pathway activator 5
|
GB201122305D0
(en)
|
2011-12-23 |
2012-02-01 |
Biotica Tech Ltd |
Novel compound
|
US9867880B2
(en)
|
2012-06-13 |
2018-01-16 |
Atrium Medical Corporation |
Cured oil-hydrogel biomaterial compositions for controlled drug delivery
|
WO2013192367A1
(en)
|
2012-06-22 |
2013-12-27 |
Novartis Ag |
Neuroendocrine tumor treatment
|
WO2014006115A1
(en)
|
2012-07-06 |
2014-01-09 |
Novartis Ag |
Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the il-8/cxcr interaction
|
EP2906214A1
(en)
|
2012-10-12 |
2015-08-19 |
The Board of Regents of The University of Texas System |
Use of mtor inhibitors to treat vascular cognitive impairment
|
US9757432B2
(en)
|
2012-11-14 |
2017-09-12 |
Ohio State Innovation Foundation |
Materials and methods useful for treating glioblastorna
|
CA2897826C
(en)
|
2013-01-09 |
2022-09-27 |
Taylor H. Schreiber |
Compositions and methods for the regulation of t regulatory cells using tl1a-ig fusion protein
|
KR20150143476A
(en)
|
2013-03-12 |
2015-12-23 |
미셀 테크놀로지즈, 인코포레이티드 |
Bioabsorbable biomedical implants
|
EP2968281B1
(en)
|
2013-03-13 |
2020-08-05 |
The Board of Regents of The University of Texas System |
Mtor inhibitors for prevention of intestinal polyp growth
|
AU2014236135A1
(en)
|
2013-03-14 |
2015-09-10 |
Thomas Jefferson University |
Androgen receptor down-regulating agents and uses thereof
|
EP2994758B1
(en)
|
2013-05-08 |
2017-12-20 |
Opthea Limited |
Biomarkers for age-related macular degeneration (amd)
|
KR102079613B1
(en)
|
2013-05-15 |
2020-02-20 |
미셀 테크놀로지즈, 인코포레이티드 |
Bioabsorbable biomedical implants
|
CN105283553B
(en)
|
2013-06-11 |
2021-06-25 |
克隆技术实验室有限公司 |
Protein-enriched microvesicles and methods of making and using same
|
MX2015017536A
(en)
*
|
2013-06-20 |
2016-04-26 |
Novartis Ag |
Alkylation with an alkyl fluoroalkyl sulfonate.
|
US9808472B2
(en)
|
2013-08-12 |
2017-11-07 |
Tokai Pharmaceuticals, Inc. |
Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
|
US9580758B2
(en)
|
2013-11-12 |
2017-02-28 |
Luc Montagnier |
System and method for the detection and treatment of infection by a microbial agent associated with HIV infection
|
US20150140036A1
(en)
|
2013-11-13 |
2015-05-21 |
Novartis Institutes For Biomedical Research, Inc. |
Low, immune enhancing, dose mtor inhibitors and uses thereof
|
RU2714902C2
(en)
|
2013-12-19 |
2020-02-20 |
Новартис Аг |
Chimeric human mesotheliogen antigen receptors and use thereof
|
EP3087101A4
(en)
|
2013-12-20 |
2017-12-06 |
Novartis AG |
Regulatable chimeric antigen receptor
|
CN103739616B
(en)
*
|
2013-12-27 |
2015-12-30 |
福建省微生物研究所 |
Containing thiazolyl rapamycin type derivative and application thereof
|
US9700544B2
(en)
|
2013-12-31 |
2017-07-11 |
Neal K Vail |
Oral rapamycin nanoparticle preparations
|
WO2015121795A1
(en)
|
2014-02-11 |
2015-08-20 |
Novartis Ag |
Pharmaceutical combinations comprising a pi3k inhibitor for the treatment of cancer
|
WO2015142675A2
(en)
|
2014-03-15 |
2015-09-24 |
Novartis Ag |
Treatment of cancer using chimeric antigen receptor
|
WO2015142661A1
(en)
|
2014-03-15 |
2015-09-24 |
Novartis Ag |
Regulatable chimeric antigen receptor
|
CA2943609A1
(en)
|
2014-03-27 |
2015-10-01 |
The Brigham And Women's Hospital, Inc. |
Metabolically-activated drug conjugates to overcome resistance in cancer therapy
|
KR102651707B1
(en)
|
2014-04-07 |
2024-03-29 |
노파르티스 아게 |
Treatment of cancer using anti-cd19 chimeric antigen receptor
|
CA2968049A1
(en)
|
2014-04-16 |
2015-10-22 |
Rapamycin Holdings, Llc |
Oral rapamycin preparation and use for stomatitis
|
US10258639B2
(en)
|
2014-05-06 |
2019-04-16 |
Research Development Foundation |
Methods for treating insulin resistance and for sensitizing patients to GLP1 agonist therapy
|
AU2015270925A1
(en)
|
2014-06-02 |
2016-12-22 |
Children's Medical Center Corporation |
Methods and compositions for immunomodulation
|
WO2016014553A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
US9777061B2
(en)
|
2014-07-21 |
2017-10-03 |
Novartis Ag |
Treatment of cancer using a CD33 chimeric antigen receptor
|
WO2016014530A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
US20170209492A1
(en)
|
2014-07-31 |
2017-07-27 |
Novartis Ag |
Subset-optimized chimeric antigen receptor-containing t-cells
|
JP6919118B2
(en)
|
2014-08-14 |
2021-08-18 |
ノバルティス アーゲー |
Treatment of cancer with GFRα-4 chimeric antigen receptor
|
BR112017003104A2
(en)
|
2014-08-19 |
2017-12-05 |
Novartis Ag |
cancer treatment using an anti-cd123 chimeric antigen receptor
|
CA2960992A1
(en)
|
2014-09-11 |
2016-03-17 |
The Regents Of The University Of California |
Mtorc1 inhibitors
|
US10577417B2
(en)
|
2014-09-17 |
2020-03-03 |
Novartis Ag |
Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
|
SG11201702895SA
(en)
|
2014-10-08 |
2017-05-30 |
Novartis Ag |
Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof
|
WO2016066608A1
(en)
|
2014-10-28 |
2016-05-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for treatment of pulmonary cell senescence and peripheral aging
|
WO2016164580A1
(en)
|
2015-04-07 |
2016-10-13 |
Novartis Ag |
Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives
|
EP4234685A3
(en)
|
2015-04-17 |
2023-09-06 |
Novartis AG |
Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
|
EP3286211A1
(en)
|
2015-04-23 |
2018-02-28 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
CA2986359A1
(en)
|
2015-05-20 |
2016-11-24 |
Novartis Ag |
Pharmaceutical combination of everolimus with dactolisib
|
CN109069467B
(en)
|
2015-11-11 |
2022-11-04 |
诺华股份有限公司 |
Use of myostatin antagonists, combinations containing them and uses thereof
|
EP4014967A1
(en)
|
2016-04-29 |
2022-06-22 |
Icahn School of Medicine at Mount Sinai |
Targeting the innate immunesystem to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis
|
WO2018017708A1
(en)
|
2016-07-20 |
2018-01-25 |
University Of Utah Research Foundation |
Cd229 car t cells and methods of use thereof
|
US10525083B2
(en)
|
2016-10-07 |
2020-01-07 |
Novartis Ag |
Nucleic acid molecules encoding chimeric antigen receptors comprising a CD20 binding domain
|
CA3044355A1
(en)
|
2016-11-23 |
2018-05-31 |
Novartis Ag |
Methods of enhancing immune response with everolimus, dactolisib or both
|
WO2018100190A1
(en)
|
2016-12-02 |
2018-06-07 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for diagnosing renal cell carcinoma
|
DK3558955T3
(en)
|
2016-12-22 |
2021-10-25 |
Amgen Inc |
BENZISOTHIAZOLE, ISOTHIAZOLO [3,4-B] PYRIDINE-, QUINAZOLINE-, PHTHALAZINE-, PYRIDO [2,3-D] PYRIDAZINE- AND PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES LIKE KRAS-GANDERHINH -, PANCREAS OR COLOR RECTAL CANCER
|
JP2020507632A
(en)
|
2017-02-10 |
2020-03-12 |
マウント タム セラピューティクス, インコーポレイテッドMount Tam Therapeutics, Inc. |
Rapamycin analog
|
EP3615055A1
(en)
|
2017-04-28 |
2020-03-04 |
Novartis AG |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
US20210154372A1
(en)
|
2017-05-15 |
2021-05-27 |
C.R. Bard, Inc. |
Medical device with drug-eluting coating and intermediate layer
|
JOP20190272A1
(en)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
Kras g12c inhibitors and methods of using the same
|
CN116003405A
(en)
|
2017-09-08 |
2023-04-25 |
美国安进公司 |
Inhibitors of KRAS G12C and methods of use thereof
|
AR112834A1
(en)
*
|
2017-09-26 |
2019-12-18 |
Novartis Ag |
RAPAMYCIN DERIVATIVES
|
US10596165B2
(en)
|
2018-02-12 |
2020-03-24 |
resTORbio, Inc. |
Combination therapies
|
WO2019210153A1
(en)
|
2018-04-27 |
2019-10-31 |
Novartis Ag |
Car t cell therapies with enhanced efficacy
|
US20190336609A1
(en)
|
2018-05-01 |
2019-11-07 |
Revolution Medicines, Inc. |
C40-, C28-, and C-32-Linked Rapamycin Analogs as mTOR Inhibitors
|
CA3098698A1
(en)
|
2018-05-01 |
2019-11-07 |
Revolution Medicines, Inc. |
C26-linked rapamycin analogs as mtor inhibitors
|
US20210396739A1
(en)
|
2018-05-01 |
2021-12-23 |
Novartis Ag |
Biomarkers for evaluating car-t cells to predict clinical outcome
|
MA52496A
(en)
|
2018-05-04 |
2021-03-10 |
Amgen Inc |
KRAS G12C INHIBITORS AND THEIR PROCEDURES FOR USE
|
AU2019262589B2
(en)
|
2018-05-04 |
2022-07-07 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
WO2019217691A1
(en)
|
2018-05-10 |
2019-11-14 |
Amgen Inc. |
Kras g12c inhibitors for the treatment of cancer
|
AU2019278998B2
(en)
|
2018-06-01 |
2023-11-09 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
US20190375749A1
(en)
|
2018-06-11 |
2019-12-12 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
CA3100390A1
(en)
|
2018-06-12 |
2020-03-12 |
Amgen Inc. |
Kras g12c inhibitors encompassing piperazine ring and use thereof in the treatment of cancer
|
AU2019286524A1
(en)
|
2018-06-15 |
2021-01-07 |
Janssen Pharmaceutica Nv |
Rapamycin analogs and uses thereof
|
JP7262581B2
(en)
|
2018-11-14 |
2023-04-21 |
ルトニックス,インコーポレーテッド |
Medical device with drug eluting coating on modified device surface
|
JP2020090482A
(en)
|
2018-11-16 |
2020-06-11 |
アムジエン・インコーポレーテツド |
Improved synthesis of key intermediate of kras g12c inhibitor compound
|
JP7377679B2
(en)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
Combination therapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer
|
EP3883565A1
(en)
|
2018-11-19 |
2021-09-29 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
JP2022513971A
(en)
|
2018-12-20 |
2022-02-09 |
アムジエン・インコーポレーテツド |
Heteroarylamide useful as a KIF18A inhibitor
|
ES2953821T3
(en)
|
2018-12-20 |
2023-11-16 |
Amgen Inc |
KIF18A inhibitors
|
IL283639B1
(en)
|
2018-12-20 |
2024-02-01 |
Amgen Inc |
Kif18a inhibitors
|
JP2022513967A
(en)
|
2018-12-20 |
2022-02-09 |
アムジエン・インコーポレーテツド |
Heteroarylamide useful as a KIF18A inhibitor
|
KR20210146287A
(en)
|
2019-03-01 |
2021-12-03 |
레볼루션 메디슨즈, 인크. |
Bicyclic heteroaryl compounds and uses thereof
|
WO2020180770A1
(en)
|
2019-03-01 |
2020-09-10 |
Revolution Medicines, Inc. |
Bicyclic heterocyclyl compounds and uses thereof
|
CN113939324A
(en)
|
2019-04-08 |
2022-01-14 |
巴德外周血管股份有限公司 |
Medical devices having drug eluting coatings on modified device surfaces
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
MX2021014126A
(en)
|
2019-05-21 |
2022-01-04 |
Amgen Inc |
Solid state forms.
|
JP2021008453A
(en)
|
2019-07-02 |
2021-01-28 |
エフェクター・セラピューティクス,インコーポレーテッド |
Translation inhibitor and use thereof
|
CA3147451A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
EP4007638A1
(en)
|
2019-08-02 |
2022-06-08 |
Amgen Inc. |
Pyridine derivatives as kif18a inhibitors
|
CN114302880A
(en)
|
2019-08-02 |
2022-04-08 |
美国安进公司 |
KIF18A inhibitors
|
CN114401953A
(en)
|
2019-08-02 |
2022-04-26 |
美国安进公司 |
KIF18A inhibitors
|
AU2020369569A1
(en)
|
2019-10-24 |
2022-04-14 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as KRAS G12C and KRAS G12D inhibitors in the treatment of cancer
|
MX2022005053A
(en)
|
2019-10-28 |
2022-05-18 |
Merck Sharp & Dohme Llc |
Small molecule inhibitors of kras g12c mutant.
|
US20230023023A1
(en)
|
2019-10-31 |
2023-01-26 |
Taiho Pharmaceutical Co., Ltd. |
4-aminobut-2-enamide derivatives and salts thereof
|
TW202132314A
(en)
|
2019-11-04 |
2021-09-01 |
美商銳新醫藥公司 |
Ras inhibitors
|
BR112022008565A2
(en)
|
2019-11-04 |
2022-08-09 |
Revolution Medicines Inc |
COMPOUND, PHARMACEUTICAL COMPOSITION, CONJUGATE, METHODS TO TREAT CANCER AND A RAS PROTEIN-RELATED DISORDER
|
WO2021091967A1
(en)
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
WO2021092115A1
(en)
|
2019-11-08 |
2021-05-14 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
US20230192681A1
(en)
|
2019-11-14 |
2023-06-22 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
EP4058432A1
(en)
|
2019-11-14 |
2022-09-21 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
JP2023505100A
(en)
|
2019-11-27 |
2023-02-08 |
レボリューション メディシンズ インコーポレイテッド |
Covalent RAS inhibitors and uses thereof
|
WO2021106231A1
(en)
|
2019-11-29 |
2021-06-03 |
Taiho Pharmaceutical Co., Ltd. |
A compound having inhibitory activity against kras g12d mutation
|
CA3163680A1
(en)
|
2019-12-05 |
2021-06-10 |
David John O'neill |
Rapamycin analogs and uses thereof
|
KR20220124768A
(en)
|
2020-01-07 |
2022-09-14 |
레볼루션 메디슨즈, 인크. |
SHP2 inhibitor administration and cancer treatment method
|
WO2021215544A1
(en)
|
2020-04-24 |
2021-10-28 |
Taiho Pharmaceutical Co., Ltd. |
Kras g12d protein inhibitors
|
US20230181536A1
(en)
|
2020-04-24 |
2023-06-15 |
Taiho Pharmaceutical Co., Ltd. |
Anticancer combination therapy with n-(1-acryloyl-azetidin-3-yl)-2-((1h-indazol-3-yl)amino)methyl)-1h-imidazole-5-carboxamide inhibitor of kras-g12c
|
KR20230031926A
(en)
|
2020-07-15 |
2023-03-07 |
다이호야쿠힌고교 가부시키가이샤 |
Combinations comprising pyrimidine compounds for use in the treatment of tumors
|
KR20230081726A
(en)
|
2020-09-03 |
2023-06-07 |
레볼루션 메디슨즈, 인크. |
Use of SOS1 inhibitors to treat malignancies with SHP2 mutations
|
MX2023003060A
(en)
|
2020-09-15 |
2023-04-05 |
Revolution Medicines Inc |
Indole derivatives as ras inhibitors in the treatment of cancer.
|
AR124449A1
(en)
|
2020-12-22 |
2023-03-29 |
Qilu Regor Therapeutics Inc |
SOS1 INHIBITORS AND USES THEREOF
|
BR112023018950A2
(en)
|
2021-03-19 |
2024-02-27 |
Icahn School Med Mount Sinai |
COMPOUND, NANOBIOLOGICAL AND PHARMACEUTICAL COMPOSITIONS, METHODS FOR TREATING A CELL PROLIFERATION DISORDER, FOR TREATING SEPSIS AND FOR ACTIVATING A NOD2 RECEPTOR, PROCESS FOR MANUFACTURING A NANOBIOLOGICAL COMPOSITION AND KIT
|
AR125782A1
(en)
|
2021-05-05 |
2023-08-16 |
Revolution Medicines Inc |
RAS INHIBITORS
|
US20220396589A1
(en)
|
2021-05-05 |
2022-12-15 |
Revolution Medicines, Inc. |
Ras inhibitors
|
EP4334324A1
(en)
|
2021-05-05 |
2024-03-13 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
EP4347041A1
(en)
|
2021-05-28 |
2024-04-10 |
Taiho Pharmaceutical Co., Ltd. |
Small molecule inhibitors of kras mutated proteins
|
CA3223081A1
(en)
|
2021-07-15 |
2023-01-19 |
Samir Mitragotri |
Compositions and methods relating to cells with adhered particles
|
AR127308A1
(en)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
RAS INHIBITORS
|
WO2023114954A1
(en)
|
2021-12-17 |
2023-06-22 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
WO2023172940A1
(en)
|
2022-03-08 |
2023-09-14 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|