CA2230819A1 - Medicament comprising hgf gene - Google Patents

Medicament comprising hgf gene

Info

Publication number
CA2230819A1
CA2230819A1 CA002230819A CA2230819A CA2230819A1 CA 2230819 A1 CA2230819 A1 CA 2230819A1 CA 002230819 A CA002230819 A CA 002230819A CA 2230819 A CA2230819 A CA 2230819A CA 2230819 A1 CA2230819 A1 CA 2230819A1
Authority
CA
Canada
Prior art keywords
medicament
hgf gene
hgf
present
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002230819A
Other languages
French (fr)
Other versions
CA2230819C (en
Inventor
Ryuichi Morishita
Toshio Ogihara
Toshikazu Nakamura
Tetsuya Tomita
Takahiro Ochi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anges Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2230819A1 publication Critical patent/CA2230819A1/en
Application granted granted Critical
Publication of CA2230819C publication Critical patent/CA2230819C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The present invention relates to a medicament comprising a HGF gene. The medicament of the present invention may be topically applied to the target organs so that the effects can be selectively exhibited, resulting in minimizing the side effects of HGF.
CA002230819A 1995-08-29 1996-08-22 Medicament comprising hgf gene Expired - Lifetime CA2230819C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP24547595 1995-08-29
JP7/245475 1995-08-29
JP8/58467 1996-02-20
JP5846796 1996-02-20
PCT/JP1996/002359 WO1997007824A1 (en) 1995-08-29 1996-08-22 Medicine comprising hgf gene

Publications (2)

Publication Number Publication Date
CA2230819A1 true CA2230819A1 (en) 1997-03-06
CA2230819C CA2230819C (en) 2009-04-14

Family

ID=26399523

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002230819A Expired - Lifetime CA2230819C (en) 1995-08-29 1996-08-22 Medicament comprising hgf gene

Country Status (13)

Country Link
US (4) US6248722B1 (en)
EP (1) EP0847757B1 (en)
JP (1) JP3431633B2 (en)
KR (2) KR100765687B1 (en)
CN (1) CN100478033C (en)
AT (1) ATE292476T1 (en)
AU (1) AU6754496A (en)
CA (1) CA2230819C (en)
DE (1) DE69634567T2 (en)
ES (1) ES2240999T3 (en)
NZ (1) NZ315769A (en)
PT (1) PT847757E (en)
WO (1) WO1997007824A1 (en)

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KR100765687B1 (en) * 1995-08-29 2007-10-11 안제스에무지 가부시키가이샤 Medicine comprising hgf gene
US6775574B1 (en) * 1997-11-07 2004-08-10 Medtronic, Inc. Method and system for myocardial infarction repair
JP2002507584A (en) * 1998-03-26 2002-03-12 ロング アイランド ジューイッシュ メディカル センター Use of scattering factors to enhance angiogenesis
US6576618B1 (en) * 1999-06-22 2003-06-10 Research Development Foundation Methods to enhance wound healing and enhanced wound coverage material
CN1194762C (en) 1999-09-21 2005-03-30 安增生摩祺株式会社 Gene therapy for cerebrovasclar disorders
CN101085363A (en) * 1999-10-08 2007-12-12 安增子摩祺株式会社 Application of liver cell growth factor gene
AU778826B2 (en) * 1999-10-29 2004-12-23 Anges Mg, Inc. Gene therapy for diabetic ischemic disease
AU2001260696B2 (en) * 2000-06-02 2005-04-14 Hiroshi Okamoto Agents for proliferating pancreatic beta-cells of the islets of langerhans, agents for suppressing apoptosis of said cells, and screening of candidate compounds for these agents
AU2001284576A1 (en) 2000-08-28 2002-03-13 Fariba Nayeri The synergetic effects of hgf and antibacterial treatment
AU9418501A (en) * 2000-10-04 2002-04-15 Kyowa Hakko Kogyo Kk Method of coating fine particle with lipid film
CA2446946A1 (en) * 2001-05-09 2002-11-14 Anges Mg, Inc. Gene transfer of angiogenic factor for skin disease
CN1596130A (en) * 2001-11-28 2005-03-16 安琪士多摩奇株式会社 Genetic remedies for neurodegenerative diseases
KR100562824B1 (en) * 2002-03-20 2006-03-23 주식회사 바이로메드 Hybrid hepatocyte growth factor gene which has a high expression efficiency and expresses two heterotypes of hepatocyte growth factor
AU2003268741B2 (en) * 2002-10-02 2009-06-11 Anges Mg, Inc. Drug for auditory dysfunction
US8029780B2 (en) * 2003-04-08 2011-10-04 Yeda Research And Development Co. Ltd. Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same
US20050026830A1 (en) * 2003-05-14 2005-02-03 Yasushi Kawaguchi Compositions and methods for treating fibrosis
CA2541603A1 (en) * 2003-10-14 2005-04-21 Kringle Pharma Inc. Agent for improving mental disorders
KR101222254B1 (en) * 2004-07-26 2013-01-16 제넨테크, 인크. Methods and compositions for mudulating hepatocyte growth factor activation
WO2006046766A1 (en) * 2004-10-29 2006-05-04 Anges Mg, Inc. Gene therapy for treatment of cardiac failure
US20110230407A1 (en) * 2005-03-14 2011-09-22 Alexander Yuzhakov Hepatocyte growth factor pathway activators in demyelinating diseases and central nervous system trauma
ES2561155T3 (en) 2005-07-28 2016-02-24 Anges Mg, Inc. Lymphangiogenesis promoter
JP2009517343A (en) * 2005-11-14 2009-04-30 エンタープライズ パートナーズ ベンチャー キャピタル Stem cell factor therapy for tissue damage
US20090202606A1 (en) * 2008-01-25 2009-08-13 Viromed Co., Ltd. Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor
ES2556711T3 (en) * 2008-04-09 2016-01-19 Viromed Co., Ltd. Lyophilized DNA formulations for increased expression of plasmid DNA
JP5775452B2 (en) 2008-07-10 2015-09-09 アンジオン バイオメディカ コーポレイション Compositions and methods of small molecule modulators of hepatocyte growth factor (dispersion factor) activity
CN102573924A (en) 2009-08-31 2012-07-11 福田惠一 Drug composition for angiogenesis therapy
SG11201602452SA (en) 2013-10-22 2016-05-30 Viromed Co Ltd Composition for preventing or treating amyotrophic lateral sclerosis using two or more isoforms of hepatocyte growth factor
KR101567954B1 (en) 2013-11-25 2015-11-11 인하대학교 산학협력단 Composition for preventing or treating erectile dysfunction comprising HGF protein or gene therefor and use thereof
AU2019305221A1 (en) 2018-07-19 2021-02-18 Helixmith Co., Ltd. Lyophilized pharmaceutical compositions for naked DNA gene therapy
KR20220004083A (en) 2019-04-11 2022-01-11 앤지온 바이오메디카 코포레이션 Solid form of (E)-3-[2-(2-thienyl)vinyl]-1H-pyrazole

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US3560394A (en) * 1964-04-09 1971-02-02 Dow Corning Extracoordinate silicon complexes containing a cyclic anhydride of a polycarboxylic organic acid
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US3679630A (en) * 1970-12-11 1972-07-25 Dow Chemical Co Curable compositions comprising a polyepoxide,a polyisocyanato silane and a catalyst therefor
US4171420A (en) * 1974-06-21 1979-10-16 The Dow Chemical Company Latent catalysts for promoting reaction of epoxides with phenols and/or carboxylic acids
EP0452457B1 (en) 1989-11-03 1997-08-20 Vanderbilt University Method of in vivo delivery of functioning foreign genes
DE69133492T2 (en) * 1990-06-11 2006-08-10 Nakamura, Toshikazu Recombinant human hepatocyte growth factor and method for its production
DE4018818C2 (en) * 1990-06-12 1994-03-24 J Dr Med Reinhardt Rackets, in particular tennis or squash rackets
KR950000091B1 (en) * 1990-06-20 1995-01-09 후지쓰 가부시끼가이샤 Reticle having phase shifter and manufacturing method thereof and correcting method
CA2091700C (en) 1990-09-14 2002-11-19 Jeffrey S. Rubin A non-mitogenic competitive hgf antagonist
JP3200609B2 (en) 1990-12-28 2001-08-20 敏一 中村 Epithelial cell growth promoter
CA2055811A1 (en) 1991-01-11 1992-07-12 Ross R. Muth Sterilization of growth factors
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US5756122A (en) * 1995-06-07 1998-05-26 Georgetown University Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells
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US6121246A (en) * 1995-10-20 2000-09-19 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating ischemic tissue
KR100567618B1 (en) * 1997-12-03 2006-05-25 스미또모 베이크라이트 가부시키가이샤 Latent catalyst, thermosetting resin composition comprising the catalyst, epoxy resin molding material comprising the catalyst, and semiconductor device
CN1194762C (en) * 1999-09-21 2005-03-30 安增生摩祺株式会社 Gene therapy for cerebrovasclar disorders
CN101085363A (en) * 1999-10-08 2007-12-12 安增子摩祺株式会社 Application of liver cell growth factor gene
WO2001042479A2 (en) * 1999-12-08 2001-06-14 Genoptera, Llc Insecticide targets and methods of use

Also Published As

Publication number Publication date
US6248722B1 (en) 2001-06-19
US7285540B2 (en) 2007-10-23
EP0847757B1 (en) 2005-04-06
CA2230819C (en) 2009-04-14
DE69634567T2 (en) 2006-02-16
KR19990044279A (en) 1999-06-25
KR100765687B1 (en) 2007-10-11
EP0847757A4 (en) 2000-04-12
EP0847757A1 (en) 1998-06-17
US20040220126A1 (en) 2004-11-04
KR20040097246A (en) 2004-11-17
NZ315769A (en) 1999-05-28
JP3431633B2 (en) 2003-07-28
CN100478033C (en) 2009-04-15
AU6754496A (en) 1997-03-19
US20040105882A1 (en) 2004-06-03
PT847757E (en) 2005-06-30
CN1198675A (en) 1998-11-11
US20090004260A1 (en) 2009-01-01
ES2240999T3 (en) 2005-10-16
KR100725199B1 (en) 2007-08-16
ATE292476T1 (en) 2005-04-15
WO1997007824A1 (en) 1997-03-06
DE69634567D1 (en) 2005-05-12

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20160822