CA2237946A1 - Method and apparatus for maldi analysis - Google Patents

Method and apparatus for maldi analysis

Info

Publication number
CA2237946A1
CA2237946A1 CA002237946A CA2237946A CA2237946A1 CA 2237946 A1 CA2237946 A1 CA 2237946A1 CA 002237946 A CA002237946 A CA 002237946A CA 2237946 A CA2237946 A CA 2237946A CA 2237946 A1 CA2237946 A1 CA 2237946A1
Authority
CA
Canada
Prior art keywords
specimen
matrix
plume
compartment
baffle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002237946A
Other languages
French (fr)
Other versions
CA2237946C (en
Inventor
Franz Hillenkamp
Dirk Reuter
Scott Higgins
David M. Lough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sequenom Inc
Original Assignee
Sequenom, Inc.
Franz Hillenkamp
Dirk Reuter
Scott Higgins
David M. Lough
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequenom, Inc., Franz Hillenkamp, Dirk Reuter, Scott Higgins, David M. Lough filed Critical Sequenom, Inc.
Publication of CA2237946A1 publication Critical patent/CA2237946A1/en
Application granted granted Critical
Publication of CA2237946C publication Critical patent/CA2237946C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409—Sample holders or containers
    • H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpening the spectral peaks. In one embodiment the light is delivered to a matrix or sample holder having a cover, baffle or compartment. The baffle or compartment impedes or contains a plume of desorbed material and the analyte undergoes collisions to lower its mean velocity and directionality. Thus "thermalized", the analyte ions are passed to a mass analysis instrument. In a preferred embodiment, an optical fiber butts up against a thin transparent plate on which the specimen resides, with the matrix side in a vacuum acceleration chamber. A mechanical stage moves the specimen in both the x- and y-directions to select a point on the specimen which is to receive the radiation. The use of a fiber optic illuminator allows the entire stage assembly to be subsumed essentially within the dimensions of a conventional stage.
CA002237946A 1996-09-19 1997-09-19 Method and apparatus for maldi analysis Expired - Fee Related CA2237946C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/710,565 1996-09-19
US08/710,565 US5777324A (en) 1996-09-19 1996-09-19 Method and apparatus for maldi analysis
PCT/US1997/016115 WO1998012734A1 (en) 1996-09-19 1997-09-19 Method and apparatus for maldi analysis

Publications (2)

Publication Number Publication Date
CA2237946A1 true CA2237946A1 (en) 1998-03-26
CA2237946C CA2237946C (en) 2003-06-17

Family

ID=24854565

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002237946A Expired - Fee Related CA2237946C (en) 1996-09-19 1997-09-19 Method and apparatus for maldi analysis

Country Status (8)

Country Link
US (4) US5777324A (en)
EP (2) EP0868740B1 (en)
JP (1) JP3601834B2 (en)
AT (1) ATE231284T1 (en)
AU (1) AU724884B2 (en)
CA (1) CA2237946C (en)
DE (1) DE69718438T2 (en)
WO (1) WO1998012734A1 (en)

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