CA2245461A1 - Detection of conditions or diseases associated with an altered level of telomerase activity - Google Patents

Detection of conditions or diseases associated with an altered level of telomerase activity

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Publication number
CA2245461A1
CA2245461A1 CA002245461A CA2245461A CA2245461A1 CA 2245461 A1 CA2245461 A1 CA 2245461A1 CA 002245461 A CA002245461 A CA 002245461A CA 2245461 A CA2245461 A CA 2245461A CA 2245461 A1 CA2245461 A1 CA 2245461A1
Authority
CA
Canada
Prior art keywords
telomerase activity
detection
conditions
diseases associated
altered level
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002245461A
Other languages
French (fr)
Other versions
CA2245461C (en
Inventor
Michael D. West
Jerry Shay
Woodring Wright
Elizabeth H. Blackburn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of Texas System
Original Assignee
Board Of Regents, The University Of Texas System
Michael D. West
Jerry Shay
Woodring Wright
Elizabeth H. Blackburn
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Board Of Regents, The University Of Texas System, Michael D. West, Jerry Shay, Woodring Wright, Elizabeth H. Blackburn, The Regents Of The University Of California filed Critical Board Of Regents, The University Of Texas System
Publication of CA2245461A1 publication Critical patent/CA2245461A1/en
Application granted granted Critical
Publication of CA2245461C publication Critical patent/CA2245461C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/115831—Condition or time responsive

Abstract

Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
CA002245461A 1992-05-13 1993-05-13 Detection of conditions or diseases associated with an altered level of telomerase activity Expired - Lifetime CA2245461C (en)

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EP0642591A1 (en) 1995-03-15
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US5707795A (en) 1998-01-13
CA2245462C (en) 2002-06-25
US20040198659A1 (en) 2004-10-07
US6368789B1 (en) 2002-04-09
JP2005198659A (en) 2005-07-28
US20070010476A1 (en) 2007-01-11
US20020127634A1 (en) 2002-09-12
AU8949598A (en) 1999-01-07
AU688262B2 (en) 1998-03-12
US5695932A (en) 1997-12-09
US5489508A (en) 1996-02-06
CA2245462A1 (en) 1993-11-25
JPH08501079A (en) 1996-02-06
JPH11127874A (en) 1999-05-18
CA2135648A1 (en) 1993-11-25
US20030175766A1 (en) 2003-09-18
CA2245461C (en) 2001-06-26
CA2135648C (en) 2002-06-25
US5840495A (en) 1998-11-24
JP2000116388A (en) 2000-04-25
JP2002101898A (en) 2002-04-09
WO1993023572A1 (en) 1993-11-25
US5686245A (en) 1997-11-11
EP0642591A4 (en) 1995-05-31
US6194206B1 (en) 2001-02-27
US20060172960A1 (en) 2006-08-03

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