CA2248260A1 - Vascular catheter-based system for heating tissue - Google Patents

Vascular catheter-based system for heating tissue

Info

Publication number
CA2248260A1
CA2248260A1 CA002248260A CA2248260A CA2248260A1 CA 2248260 A1 CA2248260 A1 CA 2248260A1 CA 002248260 A CA002248260 A CA 002248260A CA 2248260 A CA2248260 A CA 2248260A CA 2248260 A1 CA2248260 A1 CA 2248260A1
Authority
CA
Canada
Prior art keywords
vein
catheter
heating
further characterized
shrinkage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002248260A
Other languages
French (fr)
Other versions
CA2248260C (en
Inventor
Michael D. Laufer
Brian E. Farley
Grace Y. Schulz
Arthur W. Zikorus
Mark P. Parker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covidien LP
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/610,911 external-priority patent/US6036687A/en
Priority claimed from US08/720,209 external-priority patent/US6139527A/en
Priority claimed from US08/717,994 external-priority patent/US6033397A/en
Application filed by Individual filed Critical Individual
Publication of CA2248260A1 publication Critical patent/CA2248260A1/en
Application granted granted Critical
Publication of CA2248260C publication Critical patent/CA2248260C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00008—Vein tendon strippers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22097—Valve removal in veins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00029—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids open
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A61B2018/00083—Electrical conductivity low, i.e. electrically insulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00107—Coatings on the energy applicator
    • A61B2018/00154—Coatings on the energy applicator containing and delivering drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/00267—Expandable means emitting energy, e.g. by elements carried thereon having a basket shaped structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00273—Anchoring means for temporary attachment of a device to tissue
    • A61B2018/00279—Anchoring means for temporary attachment of a device to tissue deployable
    • A61B2018/00285—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00404—Blood vessels other than those in or around the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00482—Digestive system
    • A61B2018/00488—Esophagus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00702—Power or energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00744—Fluid flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00755—Resistance or impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A61B2018/00797—Temperature measured by multiple temperature sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A61B2018/00821—Temperature measured by a thermocouple
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00875—Resistance or impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B2018/1246—Generators therefor characterised by the output polarity
    • A61B2018/1253—Generators therefor characterised by the output polarity monopolar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B2018/1246—Generators therefor characterised by the output polarity
    • A61B2018/126—Generators therefor characterised by the output polarity bipolar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1465—Deformable electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1497—Electrodes covering only part of the probe circumference

Abstract

A catheter (10) delivers at least one electrode (12) within a vein for a minimally invasive procedure using RF energy. The catheter (10) is introduced into a patient and positioned within the section of the vein to be treated. The electrode (12) radiates high frequency energy towards the vein, and the surrounding venous tissue becomes heated and begins to shrink. A bowable member (32) can be controlled to limit the amount of shrinkage of the vein to the diameter defined by the member (32). The electrode (12) remains active until there has been sufficient shrinkage of the vein. The extent of shrinkage of the vein may be detected by fluoroscopy. After treating one section of the vein, the catheter (10) and the electrode (12) can be repositioned intraluminally within the vein to treat different sections of the vein until all desired venous sections and valves are repaired and rendered functionally competent.

Claims (35)

1. An apparatus for applying energy to cause shrinkage of a vein, the apparatus being characterized by:
a catheter (10) having a working end and an outer diameter, the outer diameter of the catheter is less than the inner diameter of the vein;
a heating device (12) capable of heating a venous treatment area to cause shrinkage of the vein, the heating device is located at the working end of the catheter;
and means (32) for controlling shrinkage of the vein so that the vein remains patent for venous function.
2. The apparatus of claim 1, further characterized in that the controlling means includes a bowable member (32) capable of moving the heating device outwards from the catheter.
3. The apparatus of claim 2, further characterized in that the bowable member (32) has sufficient structural strength to prevent shrinkage beyond an effective diameter defined by the bowable member, the effective diameter being greater than the outer diameter of the catheter.
4. The apparatus of claim 2, further characterized in that the bowable member is conductive, and the bowable member further includes an insulating film (35) covering the surface of the conductive bowable member except for an uncovered portion that contacts the vein wall when the bowable member is moved outwardly from the catheter, wherein the heating device includes the uncovered portion of the bowable conductive member.
5. The apparatus of claim 4, further characterized in that the catheter includesa movable outer sleeve (36), and the bowable member includes a first end and a second end, the first end being connected to the working end of the catheter, the second end being connected to the movable outer sleeve so that the exposed portion of the bowable member can be moved into apposition with the vein by manipulating the outer sleeve.
6. The apparatus of any of the preceding claims, further comprising a balloon (40) located between the bowable member and the catheter, wherein the bowable member is capable of moving the heating device into apposition with the vein wall, the balloon is inflatable to a selected diameter, and the bowable member is capable of allowing the shrinkage of the vein caused by the heating device to push the bowable member toward the inflated balloon, and the inflated balloon is capable of preventing further shrinkage of the vein beyond the diameter defined by the inflated balloon.
7. The apparatus of any of the preceding claims, further comprising a balloon (40) located between the extendable member and the catheter, wherein theballoon engages and forces the extendable member radially outward when the balloon is inflated.
8. The apparatus of any of the preceding claims, further characterized in that the heating device is part of the controlling means.
9. The apparatus of any of the preceding claims, further characterized in that the heating device includes at least one electrode.
10. The apparatus of claim 9, further characterized in that the at least one electrode further includes a plurality of longitudinal electrodes arranged along the circumference of the catheter at the working end so as to provide omnidirectional heating along a section of the catheter; wherein the vein is shrunk circumferentially and axial shrinking is reduced.
11. The apparatus of claim 10, further characterized in that each of the longitudinal electrodes has a polarity opposite to the polarity of immediately adjacent longitudinal electrodes.
12. The apparatus of claim 10, further characterized in that there are an even number of the longitudinal electrodes arranged on the catheter so as to provide effective pairs of longitudinal electrodes.
13. The catheter of claim 10, further characterized in that there are an even number of electrodes arranged circumferentially on the catheter so as to provide effective pairs of electrodes, wherein each of the electrodes has a polarity opposite to the polarity of the immediately adjacent electrodes.
14. The catheter of claim 10, further characterized in that there are an even number of electrodes arranged circumferentially on the catheter so as to provide effective pairs of electrodes, wherein a first electrode has a first polarity, a second electrode adjacent to the first electrode has a second polarity opposite to the first polarity, and a third electrode adjacent to the first electrode has the same polarity as the first polarity, wherein there are an even number of arranged on the catheter so as to provide effective pairs of electrodes to apply energy in a directional manner.
15. The apparatus of any of the preceding claims, further characterized in that the controlling means includes a positioning device (40) to bring the heating device into apposition with the venous treatment area of the vein.
16. The apparatus of any of the preceding claims, further characterized in that the catheter further includes an asymmetrical balloon (40) located on one side of the catheter at the working end, and the heating device being on the side opposite the side having the asymmetrical balloon.
17. The apparatus of any of the preceding claims, further characterized in that the catheter further includes a lumen (27) and a stiff jacket (25) surrounding the catheter except at the working end of the catheter, and a deflection wire (29) having a stiff bend which deflects the working end of thecatheter into apposition with the vein when the deflection wire is pushed through the lumen toward the working end of the catheter.
18. The apparatus of claim 17, further characterized in that the lumen (27) is sealed at the distal end to prevent the deflection wire from exiting the lumen.
19. The apparatus of any of the preceding claims, further characterized in that the controlling means includes an inflatable balloon (40) located at the working end of the catheter, and the balloon being configured to occlude the vein when inflated.
20. The apparatus of any of the preceding claims, further comprising a sensor (60) located at the working end of the catheter, further characterized in that the controlling means includes a microprocessor receiving a signal from the sensor representing a condition at the treatment area, the microprocessor controlling the heating device in order to control the spread of the heating effect in the venous tissue in response to the signal from the sensor.
21. The apparatus of any of the preceding claims, further characterized in that the controlling means further comprises a microprocessor capable of selecting a frequency for the heating device in order to control the spread of the heating effect in the venous tissue.
22. The apparatus of any of the preceding claims, further characterized in that the catheter further includes a lumen for injecting fluid into the vein.
23. The apparatus of any of the preceding claims, further characterized in that the catheter further includes a guide wire lumen, wherein the guide wire lumen is insulated for preventing electrical coupling between the guide wire and the electrode.
24. The apparatus of any of the preceding claims, further characterized in that the extendable member further includes a balloon inflatable with a conductive inflation medium, the balloon being formed on the working end of the catheter, wherein the at least one electrode causes the inflation medium to become heated so as to conductively transfer heat to the vein wall in apposition with the inflation medium and causeshrinkage of the vein.
25. A method of applying energy to cause shrinkage of a vein, the method comprising the steps of:

introducing a catheter having a working end and means for heating located at the working end, to a treatment site in a vein;
positioning the means for heating at the treatment site in the vein;
applying energy from the means for heating to heat the treatment site and cause shrinkage of the vein;
terminating the application of energy from the means for heating after sufficient shrinkage of the vein so that the vein remains patent for venous function.
26. The method of claim 25, wherein the step of positioning the means for heating at the treatment site further includes the step of placing the means for heating adjacent the venous valves at the treatment site to restore venous valve competency.
27. The method of claim 25, wherein the step of positioning the means for heating further includes the step of arranging the means for heating for achieving circumferential shrinkage of the vein and minimizing axial shortening.
28. The method of claim 25, wherein the step of positioning the means for heating further includes the step of moving the means for heating into apposition with the vein wall at the treatment site.
29. The method of claim 25, wherein the step of positioning further includes the step of increasing an effective diameter of the catheter to place the means for heating into apposition with the vein wall; and the step of applying energy further includes the step of reducing the effective diameter of the catheter in a controlled manner so as to maintain apposition with the vein wall as the vein wall shrinks, until a diameter for the vein is achieved for restoring venous function.
30. The method of claim 25, further comprising the step of limiting the shrinkage of the vein to a diameter defined by the heating means.
31. The method of claim 30, further comprising the step of moving the heating means radially outward from the catheter with a bowable member so as to place the heating means in apposition with the vein.
32. The method of claim 31, wherein the step of applying energy further includes the step of controlling the energy from the means for heating so as to control the depth of heating at the treatment site of the vein.
33. The method of claim 25, further comprising the step of determining the extent of shrinkage of the vein.
34. The method of claim 25, further comprising the step of determining the extent of shrinkage of the vein using fluoroscopy.
35. The method of claim 25, further comprising the step of determining the extent of shrinkage of the vein using ultrasound.
CA2248260A 1996-03-05 1997-03-04 Vascular catheter-based system for heating tissue Expired - Fee Related CA2248260C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US08/610,911 1996-03-05
US08/610,911 US6036687A (en) 1996-03-05 1996-03-05 Method and apparatus for treating venous insufficiency
US08/717,994 1996-09-26
US08/720,209 US6139527A (en) 1996-03-05 1996-09-26 Method and apparatus for treating hemorrhoids
US08/717,994 US6033397A (en) 1996-03-05 1996-09-26 Method and apparatus for treating esophageal varices
US08/720,209 1996-09-26
US08/811,820 US6033398A (en) 1996-03-05 1997-03-04 Method and apparatus for treating venous insufficiency using directionally applied energy
PCT/US1997/003637 WO1997032532A1 (en) 1996-03-05 1997-03-04 Vascular catheter-based system for heating tissue
US09/483,969 US6981972B1 (en) 1996-03-05 2000-01-18 Apparatus for treating venous insufficiency using directionally applied energy

Publications (2)

Publication Number Publication Date
CA2248260A1 true CA2248260A1 (en) 1997-09-12
CA2248260C CA2248260C (en) 2010-11-16

Family

ID=46203076

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2248260A Expired - Fee Related CA2248260C (en) 1996-03-05 1997-03-04 Vascular catheter-based system for heating tissue

Country Status (6)

Country Link
US (3) US6033398A (en)
EP (1) EP0921765B1 (en)
JP (1) JP4060887B2 (en)
AU (1) AU733465B2 (en)
CA (1) CA2248260C (en)
WO (1) WO1997032532A1 (en)

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CA2248260C (en) 2010-11-16
AU733465B2 (en) 2001-05-17
AU2073497A (en) 1997-09-22
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JP4060887B2 (en) 2008-03-12
US6033398A (en) 2000-03-07
WO1997032532A1 (en) 1997-09-12
US6981972B1 (en) 2006-01-03
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US20060069417A1 (en) 2006-03-30
EP0921765B1 (en) 2007-05-02

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