CA2249375A1 - Propofol microdroplet formulations - Google Patents

Propofol microdroplet formulations

Info

Publication number
CA2249375A1
CA2249375A1 CA002249375A CA2249375A CA2249375A1 CA 2249375 A1 CA2249375 A1 CA 2249375A1 CA 002249375 A CA002249375 A CA 002249375A CA 2249375 A CA2249375 A CA 2249375A CA 2249375 A1 CA2249375 A1 CA 2249375A1
Authority
CA
Canada
Prior art keywords
formulations
propofol
microdroplet formulations
propofol microdroplet
bacteriostatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002249375A
Other languages
French (fr)
Other versions
CA2249375C (en
Inventor
Duncan H. Haynes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Triangle Pharmaceuticals Ltd
Original Assignee
Research Triangle Pharmaceuticals Ltd.
Duncan H. Haynes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24469788&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2249375(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Research Triangle Pharmaceuticals Ltd., Duncan H. Haynes filed Critical Research Triangle Pharmaceuticals Ltd.
Publication of CA2249375A1 publication Critical patent/CA2249375A1/en
Application granted granted Critical
Publication of CA2249375C publication Critical patent/CA2249375C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Motorcycle And Bicycle Frame (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Formulations of phospholipid-coated microdroplets of propofol devoid of fats and triglycerides provide chronic sedation over extended periods of time without fat overload. Being free of nutrients that support bacterial growth, these microdroplet formulations are bacteriostatic and bactericidal (e.g. self-sterilizing) and thus have extended shelf life.
CA002249375A 1996-03-19 1997-03-17 Propofol microdroplet formulations Expired - Fee Related CA2249375C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/616,511 US5637625A (en) 1996-03-19 1996-03-19 Propofol microdroplet formulations
US08/616,511 1996-03-19
PCT/US1997/004168 WO1997034588A1 (en) 1996-03-19 1997-03-17 Propofol microdroplet formulations

Publications (2)

Publication Number Publication Date
CA2249375A1 true CA2249375A1 (en) 1997-09-25
CA2249375C CA2249375C (en) 2002-06-18

Family

ID=24469788

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002249375A Expired - Fee Related CA2249375C (en) 1996-03-19 1997-03-17 Propofol microdroplet formulations

Country Status (19)

Country Link
US (1) US5637625A (en)
EP (1) EP0796616B1 (en)
JP (1) JP2000507244A (en)
KR (1) KR100484516B1 (en)
CN (1) CN1124845C (en)
AT (1) ATE182074T1 (en)
AU (1) AU719756B2 (en)
BR (1) BR9708099B8 (en)
CA (1) CA2249375C (en)
DE (1) DE69700317T2 (en)
DK (1) DK0796616T3 (en)
ES (1) ES2135969T3 (en)
FI (1) FI982009A (en)
GR (1) GR3031414T3 (en)
HU (1) HU225046B1 (en)
NO (1) NO324498B1 (en)
NZ (1) NZ331669A (en)
RU (1) RU2186564C2 (en)
WO (1) WO1997034588A1 (en)

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US6465016B2 (en) * 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
CH692322A5 (en) * 1997-05-26 2002-05-15 Westy Ag clear injectable formulation of propofol.
CN100462066C (en) * 1997-06-27 2009-02-18 美国生物科学有限公司 Novel formulations of pharmacological agents, method for preparation thereof and method for use thereof
US6638621B2 (en) * 2000-08-16 2003-10-28 Lyotropic Therapeutics, Inc. Coated particles, methods of making and using
AR015516A1 (en) 1998-02-10 2001-05-02 Gensia Sicor Inc STERILE PHARMACEUTICAL COMPOSITION FOR PARENTERAL ADMINISTRATION AND USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT
CN1289091C (en) * 1998-02-11 2006-12-13 Rtp药品公司 Method and composition for treatment of inflammatory conditions
US6254853B1 (en) * 1998-05-08 2001-07-03 Vyrex Corporation Water soluble pro-drugs of propofol
DK1079808T3 (en) 1998-05-29 2004-06-07 Skyepharma Canada Inc Compositions with thermally protected microparticles and process for final vapor sterilization thereof
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
AU759641B2 (en) * 1998-08-19 2003-04-17 Skyepharma Canada Inc. Injectable aqueous dispersions of propofol
US6150423A (en) * 1998-10-15 2000-11-21 Phoenix Scientific, Inc. Propofol-based anesthetic and method of making same
US6140374A (en) * 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition
EP1133281A1 (en) 1998-11-20 2001-09-19 RTP Pharma Inc. Dispersible phospholipid stabilized microparticles
PT1143962E (en) * 1999-01-28 2005-03-31 Kurani Shashikant Prabhudas PARENTERIC SOLUTION OF PROPOFOL (2,6-DI-ISOPROPYLPHENOL) AND 2,5-DI-O-METHYL-1,4, 3,6-DI-ANHYDRO-D-GLUCITOL, AS A DISSOLVENT
US6177477B1 (en) * 1999-03-24 2001-01-23 American Home Products Corporation Propofol formulation containing TRIS
US6100302A (en) * 1999-04-05 2000-08-08 Baxter International Inc. Propofol formulation with enhanced microbial characteristics
GB2350297A (en) * 1999-05-27 2000-11-29 Abbott Lab Injectable halogenated anesthetic formulation in emulsion form
KR100801588B1 (en) * 1999-09-21 2008-02-05 스키에파마 캐나다 인코포레이티드 Surface Modified Particulate Compositions of Biological Active Substances
US6071933A (en) * 1999-12-03 2000-06-06 Diversified Medical Innovations, Inc. Homogeneous remifentanil-propofol blend for patient controlled anesthesia and process for its use
GB2359747B (en) 2000-02-29 2002-04-24 Maelor Pharmaceuticals Ltd Anaesthetic formulations
JP5102423B2 (en) 2000-04-20 2012-12-19 オバン・エナジー・リミテッド Improved treatment of water-insoluble drug particles
AU6689601A (en) 2000-06-16 2002-01-02 Rtp Pharma Inc Improved injectable dispersions of propofol
US6623765B1 (en) 2000-08-01 2003-09-23 University Of Florida, Research Foundation, Incorporated Microemulsion and micelle systems for solubilizing drugs
EP1313451B1 (en) 2000-08-31 2009-03-11 Jagotec AG Milled particles
CA2423336C (en) * 2000-09-20 2011-03-08 Rtp Pharma Inc. Stabilised fibrate microparticles
US8586094B2 (en) 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
DE60127457T2 (en) * 2001-02-22 2007-11-29 Jagotec Ag FIBRATE STATIN COMBINES WITH REDUCED EFFECT ON THE FOOD RECEIPT
CA2451432A1 (en) 2001-06-23 2003-01-03 Lyotropic Therapeutics, Inc. Particles with improved solubilization capacity
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
CA2461349C (en) * 2001-09-26 2011-11-29 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
WO2003026632A2 (en) 2001-09-26 2003-04-03 Theravance, Inc. Substituted phenol compounds useful for anesthesia and sedation
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
BR0215303A (en) * 2001-12-28 2005-04-05 Guilford Pharm Inc Water-based pharmaceutical formulations of water-soluble propofol prodrugs
JP4842514B2 (en) * 2002-03-20 2011-12-21 エラン ファーマ インターナショナル，リミティド Nanoparticle composition of angiogenesis inhibitor
US20080220075A1 (en) * 2002-03-20 2008-09-11 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
IL164217A0 (en) * 2002-04-08 2005-12-18 Guilford Pharm Inc Pharmaceutical compositions containing water-soluble propofol and methods of administering same
US20040220283A1 (en) * 2002-07-29 2004-11-04 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
US7550155B2 (en) * 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
WO2004010941A2 (en) * 2002-07-29 2004-02-05 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
JP2006504771A (en) * 2002-10-29 2006-02-09 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド Propofol with cysteine
CA2508441A1 (en) * 2002-12-06 2004-06-24 Otsuka Pharmaceutical Factory, Inc. Propofol-containing fat emulsions
US20040225022A1 (en) * 2003-05-09 2004-11-11 Desai Neil P. Propofol formulation containing reduced oil and surfactants
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
US7182948B2 (en) * 2003-08-04 2007-02-27 Ko Manufacturing, Inc. Topical veterinary compositions and methods for the treatment and prevention of infection
NZ548195A (en) * 2004-01-14 2011-01-28 Gilead Sciences Inc Lipid-based dispersions useful for drug delivery
US7125954B2 (en) 2005-01-27 2006-10-24 General Electric Company Method for producing polyether polymers
US20060280786A1 (en) * 2005-06-14 2006-12-14 Rabinow Barrett E Pharmaceutical formulations for minimizing drug-drug interactions
EP3527202A1 (en) * 2005-08-31 2019-08-21 Abraxis BioScience, LLC Compositions and methods for preparation of poorly water soluble drugs with increased stability
US7771751B2 (en) * 2005-08-31 2010-08-10 Abraxis Bioscience, Llc Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
WO2007059515A2 (en) * 2005-11-15 2007-05-24 Baxter International, Inc. Compositions of lipoxygenase inhibitors
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
RU2535001C1 (en) * 2013-07-11 2014-12-10 Общество с ограниченной ответственностью "ВИК-здоровье животных" Microcolloidal solution of propofol for anaesthesia
US20160346219A1 (en) 2015-06-01 2016-12-01 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
TW201705941A (en) * 2015-06-01 2017-02-16 奧托德里克有限公司 Phospholipid-coated therapeutic agent nanoparticlesn and related methods
WO2017218630A2 (en) * 2016-06-15 2017-12-21 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
US20230054162A1 (en) * 2019-12-20 2023-02-23 Fresenius Kabi Austria Gmbh Methods for producing oil-in-water emulsions
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US4798846A (en) * 1974-03-28 1989-01-17 Imperial Chemical Industries Plc Pharmaceutical compositions
GB1472793A (en) * 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
US4725442A (en) * 1983-06-17 1988-02-16 Haynes Duncan H Microdroplets of water-insoluble drugs and injectable formulations containing same
US4622219A (en) * 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
DE4132677C2 (en) * 1991-10-01 1995-08-24 Braun Melsungen Ag Liposomes containing volatile inhalation anesthetics, their preparation and use
GB9405593D0 (en) * 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
US5496537A (en) * 1995-03-23 1996-03-05 Henry; Richard A. Propofol hydrofluorocarbon propellant formulations

Also Published As

Publication number Publication date
WO1997034588A1 (en) 1997-09-25
BR9708099B1 (en) 2010-02-23
DK0796616T3 (en) 1999-11-29
ATE182074T1 (en) 1999-07-15
KR100484516B1 (en) 2005-09-02
AU719756B2 (en) 2000-05-18
DE69700317D1 (en) 1999-08-19
CN1124845C (en) 2003-10-22
US5637625A (en) 1997-06-10
JP2000507244A (en) 2000-06-13
HUP9902553A3 (en) 2001-04-28
HUP9902553A2 (en) 2000-10-28
GR3031414T3 (en) 2000-01-31
BR9708099A (en) 2000-01-04
NO324498B1 (en) 2007-10-29
AU2329297A (en) 1997-10-10
NO984370D0 (en) 1998-09-18
EP0796616A1 (en) 1997-09-24
KR20000064762A (en) 2000-11-06
NO984370L (en) 1998-09-18
HU225046B1 (en) 2006-05-29
NZ331669A (en) 2000-01-28
EP0796616B1 (en) 1999-07-14
FI982009A0 (en) 1998-09-17
CA2249375C (en) 2002-06-18
RU2186564C2 (en) 2002-08-10
DE69700317T2 (en) 1999-12-02
BR9708099B8 (en) 2014-04-29
ES2135969T3 (en) 1999-11-01
CN1218398A (en) 1999-06-02
FI982009A (en) 1998-09-17

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20170317