CA2253238A1 - Novel agouti-related gene - Google Patents

Novel agouti-related gene

Info

Publication number
CA2253238A1
CA2253238A1 CA002253238A CA2253238A CA2253238A1 CA 2253238 A1 CA2253238 A1 CA 2253238A1 CA 002253238 A CA002253238 A CA 002253238A CA 2253238 A CA2253238 A CA 2253238A CA 2253238 A1 CA2253238 A1 CA 2253238A1
Authority
CA
Canada
Prior art keywords
novel
agouti
art
related gene
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002253238A
Other languages
French (fr)
Other versions
CA2253238C (en
Inventor
Kevin Lee Stark
Roland Luethy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc.
Kevin Lee Stark
Roland Luethy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc., Kevin Lee Stark, Roland Luethy filed Critical Amgen Inc.
Publication of CA2253238A1 publication Critical patent/CA2253238A1/en
Application granted granted Critical
Publication of CA2253238C publication Critical patent/CA2253238C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Disclosed is a novel gene termed ART which is expressed primarily in selected regions of the brain, as well as adrenal and lung tissues. Polypeptides encoded by ART are also disclosed, as are methods for preparing ART DNA and amino acid sequences.
CA002253238A 1996-05-10 1997-04-22 Novel agouti-related gene Expired - Fee Related CA2253238C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1750596P 1996-05-10 1996-05-10
US60/017,505 1996-05-10
US08/757,541 US5766877A (en) 1996-05-10 1996-11-27 Genes encoding art, an agouti-related transcript
US08/757,541 1996-11-27
PCT/US1997/006853 WO1997043412A1 (en) 1996-05-10 1997-04-22 Novel agouti-related gene

Publications (2)

Publication Number Publication Date
CA2253238A1 true CA2253238A1 (en) 1997-11-20
CA2253238C CA2253238C (en) 2008-08-12

Family

ID=26689965

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002253238A Expired - Fee Related CA2253238C (en) 1996-05-10 1997-04-22 Novel agouti-related gene

Country Status (12)

Country Link
US (5) US5766877A (en)
EP (1) EP0917571B1 (en)
JP (1) JP4219404B2 (en)
AT (1) ATE283917T1 (en)
AU (1) AU2681497A (en)
CA (1) CA2253238C (en)
DE (1) DE69731834T2 (en)
DK (1) DK0917571T3 (en)
ES (1) ES2234015T3 (en)
PT (1) PT917571E (en)
SI (1) SI0917571T1 (en)
WO (1) WO1997043412A1 (en)

Families Citing this family (33)

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Publication number Priority date Publication date Assignee Title
US6310034B1 (en) 1993-05-21 2001-10-30 Ut-Battelle, Llc Agouti polypeptide compositions
US5843652A (en) * 1993-05-21 1998-12-01 Lockheed Martin Energy Systems, Inc. Isolation and characterization of Agouti: a diabetes/obesity related gene
WO2002064091A2 (en) * 2001-02-13 2002-08-22 Palatin Technologies, Inc. Melanocortin metallopeptides for treatment of sexual dysfunction
US5766877A (en) * 1996-05-10 1998-06-16 Amgen Inc. Genes encoding art, an agouti-related transcript
AU5243798A (en) * 1996-11-06 1998-05-29 Children's Medical Center Corporation Transgenic animal expressing a syndecan in the regions of hypothalamus
DE69838104T2 (en) * 1997-12-16 2008-04-10 Merck & Co., Inc. C-TERMINAL REGION OF AGOUTI-RELATED TRANSCRIPT PROTEIN (ART)
US6878520B1 (en) * 1997-12-16 2005-04-12 Merck & Co., Inc. C-terminal region of agouti-related transcript (ART) protein
WO1999050295A2 (en) * 1998-03-30 1999-10-07 Gryphon Sciences Agouti-related protein analogs and methods of use
US6689873B1 (en) 1998-04-29 2004-02-10 Merck & Co., Inc. Nucleic acid encoding rat agouti related protein
AU6022799A (en) * 1998-09-03 2000-03-27 Millennium Pharmaceuticals, Inc. Mc4-r as target for the identification of compounds used to treat drug addiction
US6716810B1 (en) * 1998-12-09 2004-04-06 Eleanor Roosevelt Institute Composition and method for regulation of body weight and associated conditions
US6603058B1 (en) 1998-12-09 2003-08-05 Oklahoma Medical Research Foundation Non-human animal model for obesity and uses thereof
US6303749B1 (en) 1999-01-29 2001-10-16 Amgen Inc. Agouti and agouti-related peptide analogs
US20030064921A1 (en) * 1999-10-27 2003-04-03 The Regents Of The University Of California Methods and compounds for modulating melanocortin receptor ligand binding and activity
EP1125579A3 (en) 2000-01-18 2003-01-02 Pfizer Products Inc. Uses of agrp-melanocortin receptor binding modulating compounds
MXPA02011836A (en) * 2000-05-31 2003-05-14 Du Pont Catalysts for olefin polymerization.
US7456183B2 (en) 2001-04-09 2008-11-25 Novartis Vaccines And Diagnostics, Inc. Guanidino compounds
US20030207814A1 (en) * 2002-02-04 2003-11-06 Chiron Corporation Novel guanidinyl derivatives
US20030195187A1 (en) * 2002-02-04 2003-10-16 Chiron Corporation Guanidino compounds
US20050124652A1 (en) * 2002-02-04 2005-06-09 Rustum Boyce Guanidino compounds
WO2003072056A2 (en) * 2002-02-25 2003-09-04 Chiron Corporation Intranasal administration of mc4-r agonists
WO2003099818A1 (en) * 2002-05-23 2003-12-04 Chiron Corporation Substituted quinazolinone compounds
JP2006506968A (en) * 2002-07-03 2006-03-02 メルク　エンド　カムパニー　インコーポレーテッド Agouti-related protein-deficient cells, non-human transgenic animals, and methods for selecting compounds that modulate energy metabolism
KR20060018217A (en) * 2003-05-23 2006-02-28 카이론 코포레이션 Guanidino-substituted quinazolinone compounds as mc4-r agonists
JP2007501622A (en) * 2003-08-13 2007-02-01 サンド・アクチエンゲゼルシヤフト Methods for purifying recombinant polypeptides
KR20060105785A (en) * 2003-11-19 2006-10-11 카이론 코포레이션 Quinazolinone compounds with reduced bioaccumulation
US6974187B2 (en) * 2004-01-28 2005-12-13 Tachi-S Co., Ltd. Vehicle seat structure
MXPA06012130A (en) * 2004-04-20 2007-01-31 Transtech Pharma Inc Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators.
US7910101B2 (en) 2004-10-25 2011-03-22 Centocor, Inc. Melanocortin receptor binding mimetibodies, compositions, methods and uses
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
US7833927B2 (en) * 2005-08-31 2010-11-16 Rohm And Haas Company Single site palladium catalyst complexes
JP2012501334A (en) * 2008-08-29 2012-01-19 トランス テック ファーマ，インコーポレイテッド Substituted aminothiazole derivatives, pharmaceutical compositions, and methods of use
WO2012100342A1 (en) 2011-01-27 2012-08-02 Université de Montréal Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4263428A (en) * 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
DE3169595D1 (en) * 1980-11-10 1985-05-02 Gersonde Klaus Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3374837D1 (en) * 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
US4615885A (en) * 1983-11-01 1986-10-07 Terumo Kabushiki Kaisha Pharmaceutical composition containing urokinase
EP0154316B1 (en) * 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Chemically modified lymphokine and production thereof
DE68925966T2 (en) * 1988-12-22 1996-08-29 Kirin Amgen Inc CHEMICALLY MODIFIED GRANULOCYTE COLONY EXCITING FACTOR
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5766877A (en) * 1996-05-10 1998-06-16 Amgen Inc. Genes encoding art, an agouti-related transcript

Also Published As

Publication number Publication date
SI0917571T1 (en) 2005-06-30
EP0917571B1 (en) 2004-12-01
US6060589A (en) 2000-05-09
US6203995B1 (en) 2001-03-20
ES2234015T3 (en) 2005-06-16
DE69731834T2 (en) 2005-12-15
US5766877A (en) 1998-06-16
CA2253238C (en) 2008-08-12
DK0917571T3 (en) 2005-03-14
DE69731834D1 (en) 2005-01-05
JP4219404B2 (en) 2009-02-04
US7122520B2 (en) 2006-10-17
JP2001517931A (en) 2001-10-09
US20030082737A1 (en) 2003-05-01
US20010007752A1 (en) 2001-07-12
AU2681497A (en) 1997-12-05
EP0917571A1 (en) 1999-05-26
PT917571E (en) 2005-04-29
WO1997043412A1 (en) 1997-11-20
ATE283917T1 (en) 2004-12-15

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