CA2258603A1 - Method and apparatus for performing automated analysis - Google Patents

Method and apparatus for performing automated analysis

Info

Publication number
CA2258603A1
CA2258603A1 CA002258603A CA2258603A CA2258603A1 CA 2258603 A1 CA2258603 A1 CA 2258603A1 CA 002258603 A CA002258603 A CA 002258603A CA 2258603 A CA2258603 A CA 2258603A CA 2258603 A1 CA2258603 A1 CA 2258603A1
Authority
CA
Canada
Prior art keywords
whole blood
blood sample
aliquot
sample
tests
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002258603A
Other languages
French (fr)
Other versions
CA2258603C (en
Inventor
James E. Gill
Vernon L. Chupp
Luc Van Hove
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
James E. Gill
Vernon L. Chupp
Luc Van Hove
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories, James E. Gill, Vernon L. Chupp, Luc Van Hove filed Critical Abbott Laboratories
Publication of CA2258603A1 publication Critical patent/CA2258603A1/en
Application granted granted Critical
Publication of CA2258603C publication Critical patent/CA2258603C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
    • B01F25/3132—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
    • B01F25/3132—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices
    • B01F25/31324—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices arranged concentrically
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/0092—Scheduling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14—Suction devices, e.g. pumps; Ejector devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G01N2015/011—
    • G01N2015/014—
    • G01N2015/018—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
    • G01N2015/1413—Hydrodynamic focussing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00524—Mixing by agitating sample carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1032—Dilution or aliquotting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

Provided are automated methods for distinguishing and differentiating cells in a whole blood sample. In one of the methods, a whole blood sample is provided. One or more tests to be performed on the whole blood sample is selected. The tests to be performed on the whole blood sample are correlated. A volume of the whole blood sample is aspirated into an automated instrument system which automatically performs conventional hematology analysis and fluorescent cytometry analysis on the whole blood sample. A first aliquot of the whole blood sample is dispensed into at least one sample receiving vessel. The first aliquot of the whole blood sample is mixed with a fluorescent reagent. The first aliquot of the whole blood sample mixed with fluorescent reagent is diluted and transported through a flow transducer system. The flow transducer system detects multi-angle light scatter and fluorescence from the first aliquot of the whole blood sample mixed with fluorescent reagent and counts and differentiates platelets or platelet clumps or both in the sample. Detecting and differentiation data for the one or more tests performed on the whole blood sample are stored.
Results of the one or more tests performed on the whole blood sample are reported in a quantitative manner if so requested. The instrument system automatically performs all method steps without physically separating cells from the whole blood sample or an aliquot of the sample and results of a conventional hematology analysis may be utilized in at least reporting of results of the fluorescent cytometry testing.
CA002258603A 1996-07-17 1997-06-26 Method and apparatus for performing automated analysis Expired - Lifetime CA2258603C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/682,334 US5891734A (en) 1994-08-01 1996-07-17 Method for performing automated analysis
US08/682,334 1996-07-17
PCT/US1997/011105 WO1998002727A1 (en) 1996-07-17 1997-06-26 Method and apparatus for performing automated analysis

Publications (2)

Publication Number Publication Date
CA2258603A1 true CA2258603A1 (en) 1998-01-22
CA2258603C CA2258603C (en) 2006-01-03

Family

ID=24739238

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002258603A Expired - Lifetime CA2258603C (en) 1996-07-17 1997-06-26 Method and apparatus for performing automated analysis

Country Status (5)

Country Link
US (1) US5891734A (en)
EP (1) EP0912885A1 (en)
JP (1) JP3701977B2 (en)
CA (1) CA2258603C (en)
WO (1) WO1998002727A1 (en)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509192B1 (en) * 1992-02-24 2003-01-21 Coulter International Corp. Quality control method
CA2279574C (en) * 1997-01-31 2007-07-24 The Horticulture & Food Research Institute Of New Zealand Ltd. Optical apparatus
US6149867A (en) * 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
NZ509434A (en) 1998-07-30 2004-03-26 Univ Colorado State Res Found Equine system for non-surgical artificial insemination
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
CA2408939C (en) * 2000-05-09 2011-11-08 Xy, Inc. High purity x-chromosome bearing and y-chromosome bearing populations of spermatozoa
CN1633259A (en) * 2000-06-12 2005-06-29 Xy公司 Integrated herd management system utilizing isolated populations of X-chromosome bearing and Y-chromosome bearing spermatozoa
WO2002043486A1 (en) 2000-11-29 2002-06-06 Xy, Inc. System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US10173008B2 (en) 2002-01-29 2019-01-08 Baxter International Inc. System and method for communicating with a dialysis machine through a network
US8775196B2 (en) 2002-01-29 2014-07-08 Baxter International Inc. System and method for notification and escalation of medical data
AR035231A1 (en) * 2002-03-11 2004-05-05 Ypf S A A TEAM TO ANALYZE THE GROWTH OF MICROORGANISMS AND PROCEDURE TO QUANTIFY THE CONCENTRATION OF MICROORGANISMS
EP2500076B1 (en) * 2002-04-26 2017-11-01 Abbott Laboratories Structure and method for handling magnetic particles in biological assays
US8234128B2 (en) 2002-04-30 2012-07-31 Baxter International, Inc. System and method for verifying medical device operational parameters
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
MXPA05001100A (en) 2002-08-01 2005-04-28 Xy Inc Low pressure sperm cell separation system.
MXPA05001654A (en) 2002-08-15 2005-10-18 Xy Inc High resolution flow cytometer.
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US20040088189A1 (en) * 2002-11-06 2004-05-06 Veome Edmond A. System and method for monitoring , reporting, managing and administering the treatment of a blood component
MX347048B (en) 2003-03-28 2017-04-07 Inguran Llc * Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm.
ES2541121T3 (en) 2003-05-15 2015-07-16 Xy, Llc Efficient classification of haploid cells by flow cytometry systems
CA2561661C (en) 2004-03-29 2015-11-24 Monsanto Technology Llc Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
WO2006085897A2 (en) * 2004-05-13 2006-08-17 Advanced Animal Diagnostics Microfluidic device and leucocyte antigen mediated microfluidic assay
US7390662B2 (en) * 2005-11-09 2008-06-24 Beckman Coulter, Inc. Method and apparatus for performing platelet measurement
AR049732A1 (en) 2004-07-22 2006-08-30 Monsanto Co PROCESS TO ENRICH A Sperm Cell Population
ES2445148T3 (en) * 2004-09-01 2014-02-28 Maine Standards Company Llc Novel stable lipid patterns
US7888125B2 (en) 2005-05-09 2011-02-15 Theranos, Inc. Calibration of fluidic devices
US20070025879A1 (en) * 2005-07-27 2007-02-01 Dakocytomation Denmark A/S Method and apparatus for syringe-based sample introduction within a flow cytometer
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US7618770B2 (en) * 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
US7482165B2 (en) 2005-08-24 2009-01-27 Beckman Coulter, Inc. Method of preventing white blood cell interferences to red blood cell measurements of a blood sample
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
WO2008024778A1 (en) * 2006-08-21 2008-02-28 Anp Technologies, Inc. Automated self-contained liquid handling and detection system device
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
US20090051372A1 (en) * 2006-10-30 2009-02-26 Palaniappan Sethu 3D fluid confined sample stream coulter flow cytometry
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
CN101236150B (en) * 2007-02-02 2012-09-05 深圳迈瑞生物医疗电子股份有限公司 Stream type cell technique instrument opto-electronic sensor and its irradiation unit
WO2009014737A1 (en) * 2007-07-25 2009-01-29 Abbott Laboratories Magnetic mixer
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
SG10201606120XA (en) 2007-10-02 2016-09-29 Theranos Inc Modular Point-Of-Care Devices And Uses Thereof
US20090129990A1 (en) * 2007-11-16 2009-05-21 Abbott Laboratories Rack for sample containers for clinical analyzer
US7678331B2 (en) 2007-12-20 2010-03-16 Abbott Laboratories Inc. Automatic loading of sample tubes for clinical analyzer
CA2718992C (en) 2008-03-21 2013-04-30 Abbott Point Of Care, Inc. Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells
CA2718995C (en) 2008-03-21 2014-08-19 Abbott Point Of Care, Inc. Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells
US7929121B2 (en) 2008-03-21 2011-04-19 Abbott Point Of Care, Inc. Method and apparatus for detecting and counting platelets individually and in aggregate clumps
WO2009117678A1 (en) 2008-03-21 2009-09-24 Abbott Point Of Care, Inc. Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample
CA2719020C (en) 2008-03-21 2014-07-08 Abbott Point Of Care, Inc. Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching
EP2274613B1 (en) 2008-04-02 2014-06-04 Abbott Point Of Care, Inc. Method for serologic agglutination assays performed in a thin film fluid sample
EP2269033B1 (en) 2008-04-09 2016-09-21 Abbott Point Of Care, Inc. Method for measuring the area of a sample disposed within an analysis chamber
US7897907B1 (en) 2008-04-24 2011-03-01 The United States Of America As Represented By The Secretary Of The Navy System and method for increasing signal-to-noise ratio in optical-based sensor systems
PL2283356T3 (en) 2008-05-06 2015-03-31 Colgate Palmolive Co Method of measuring effects of components on cell reactive oxygen species production
US8057679B2 (en) 2008-07-09 2011-11-15 Baxter International Inc. Dialysis system having trending and alert generation
US10089443B2 (en) 2012-05-15 2018-10-02 Baxter International Inc. Home medical device systems and methods for therapy prescription and tracking, servicing and inventory
US7940105B2 (en) * 2008-08-08 2011-05-10 Beckman Coulter, Inc. High-resolution parametric signal restoration
US8554579B2 (en) 2008-10-13 2013-10-08 Fht, Inc. Management, reporting and benchmarking of medication preparation
US9464978B2 (en) 2009-03-04 2016-10-11 Beckman Coulter, Inc. Cross-instrument method and system for cell population discrimination
US8753290B2 (en) * 2009-03-27 2014-06-17 Intellectual Inspiration, Llc Fluid transfer system and method
FR2945126B1 (en) * 2009-04-29 2019-11-01 Commissariat A L'energie Atomique METHOD AND APPARATUS FOR COUNTING THROMBOCYTES
CN105825049A (en) 2009-10-19 2016-08-03 提拉诺斯公司 Integrated health data capture and analysis system
EP2519820B1 (en) 2009-12-31 2013-11-06 Abbott Point Of Care, Inc. Method and apparatus for determining mean cell volume of red blood cells
WO2011116305A1 (en) 2010-03-18 2011-09-22 Abbott Point Of Care, Inc. Method and apparatus for optically determining at least one hemoglobin related parameter of a whole blood sample
CN101825534B (en) * 2010-04-19 2012-08-15 河北省电力研究院 Oscillation device for mixing oil samples
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
WO2011146632A1 (en) 2010-05-18 2011-11-24 Gene Security Network Inc. Methods for non-invasive prenatal ploidy calling
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
WO2011159708A1 (en) * 2010-06-14 2011-12-22 Accuri Cytometers, Inc. System and method for creating a flow cytometer network
ES2897531T3 (en) 2010-10-25 2022-03-01 Accuri Cytometers Inc Systems and user interface for collecting a data set in a flow cytometer
CN106248582B (en) 2011-01-21 2020-10-20 拉布拉多诊断有限责任公司 System and method for maximizing sample usage
US8339586B2 (en) 2011-04-15 2012-12-25 Constitution Medical, Inc. Measuring volume and constituents of cells
US9103759B2 (en) 2011-05-04 2015-08-11 Abbott Laboratories Nucleated red blood cell analysis system and method
EP3650831A1 (en) 2011-05-04 2020-05-13 Abbott Laboratories Basophil analysis system and method
US9091624B2 (en) 2011-05-04 2015-07-28 Abbott Laboratories White blood cell analysis system and method
US9891149B2 (en) * 2011-08-08 2018-02-13 Thermo Fisher Scientific Oy Method and apparatus for automated analysis
FI20115785A0 (en) 2011-08-08 2011-08-08 Thermo Fisher Scientific Oy Method and apparatus for automatic analysis
EP2607899B1 (en) * 2011-12-21 2016-08-10 Beckman Coulter, Inc. Method for labeling intracellular and extracellular targets of leukocytes
CN104520691B (en) 2012-06-14 2018-02-06 生物辐射实验室股份有限公司 Flow rate balance, the sheath delivery system being dynamically adapted for flow cytometry
EP2864849B1 (en) * 2012-06-22 2020-09-02 Bio-Rad Laboratories, Inc. Fluid mixing and rinsing system for a flow cytometer
KR20150048816A (en) 2012-08-31 2015-05-07 백스터 코포레이션 잉글우드 Medication requisition fulfillment system and method
KR101974258B1 (en) 2012-10-26 2019-04-30 백스터 코포레이션 잉글우드 Improved image acquisition for medical dose preparation system
US9375079B2 (en) 2012-10-26 2016-06-28 Baxter Corporation Englewood Work station for medical dose preparation system
EP2939000A1 (en) 2012-12-31 2015-11-04 Beckman Coulter, Inc. Immature platelet enumeration systems and methods
BR112015010498B1 (en) * 2012-12-31 2020-09-29 Beckman Coulter, Inc HEMATOLOGY SYSTEM FOR DETERMINING A PLATELET COUNT ON A BIOLOGICAL SAMPLE, AND AUTOMATED METHOD FOR DETERMINING A PLATELET COUNT ON A BIOLOGICAL SAMPLE
CN113789372A (en) * 2013-08-08 2021-12-14 伊鲁米那股份有限公司 Fluidic system for reagent delivery to a flow cell
JP6116502B2 (en) * 2014-02-28 2017-04-19 シスメックス株式会社 Sample analyzer and sample analysis method
CN113774132A (en) 2014-04-21 2021-12-10 纳特拉公司 Detection of mutations and ploidy in chromosomal segments
JP2017525032A (en) 2014-06-30 2017-08-31 バクスター・コーポレーション・イングルウッドＢａｘｔｅｒ Ｃｏｒｐｏｒａｔｉｏｎ Ｅｎｇｌｅｗｏｏｄ Managed medical information exchange
US9766105B2 (en) * 2014-07-02 2017-09-19 Cnh Industrial America Llc Device and method for detecting blockages in an agricultural sprayer
US11575673B2 (en) 2014-09-30 2023-02-07 Baxter Corporation Englewood Central user management in a distributed healthcare information management system
US11107574B2 (en) 2014-09-30 2021-08-31 Baxter Corporation Englewood Management of medication preparation with formulary management
US11478789B2 (en) 2014-11-26 2022-10-25 Medica Corporation Automated microscopic cell analysis
US20170328924A1 (en) 2014-11-26 2017-11-16 Ronald Jones Automated microscopic cell analysis
US10625259B1 (en) 2014-11-26 2020-04-21 Medica Corporation Automated microscopic cell analysis
WO2016090091A1 (en) 2014-12-05 2016-06-09 Baxter Corporation Englewood Dose preparation data analytics
SG11201707114XA (en) 2015-03-03 2017-09-28 Baxter Corp Englewood Pharmacy workflow management with integrated alerts
JP6542557B2 (en) * 2015-03-27 2019-07-10 シスメックス株式会社 Blood measurement apparatus and control method of blood measurement apparatus
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
WO2016207206A1 (en) 2015-06-25 2016-12-29 Gambro Lundia Ab Medical device system and method having a distributed database
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
DE102016120726A1 (en) * 2016-10-28 2018-05-03 Als Automated Lab Solutions Gmbh Apparatus and method for treating biological cell-containing samples, in particular blood or cell samples
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
KR102476516B1 (en) 2016-12-21 2022-12-09 감브로 룬디아 아베 A medical device system that includes an information technology infrastructure with secure cluster domains supporting external domains.
GB201704747D0 (en) 2017-01-05 2017-05-10 Illumina Inc Reagent mixing system and methods
CN108303363B (en) * 2017-01-12 2023-08-22 长春市布拉泽医疗科技有限公司 Blood cell analysis method and blood cell analyzer using same
US11725227B2 (en) * 2017-08-01 2023-08-15 Essenlix Corporation Devices and methods for examining drug effects on microorganisms
CN111033256B (en) * 2017-09-05 2022-07-12 深圳迈瑞生物医疗电子股份有限公司 Alarming method of platelet aggregation sample, blood cell analyzer and storage medium
US11047845B1 (en) 2017-11-15 2021-06-29 Medica Corporation Control material and methods for cell analyzers
CN111656161B (en) * 2018-04-28 2024-02-20 深圳迈瑞生物医疗电子股份有限公司 Sample analyzer abnormality alarming method, system and storage medium
CN110609139B (en) * 2018-06-14 2023-06-30 深圳市理邦精密仪器股份有限公司 Antigen concentration excess detection method, device and storage medium
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
EP3830576A2 (en) * 2018-07-27 2021-06-09 Vaxess Technologies, Inc. Polymer-based biospecimen collection devices and uses thereof
WO2020133285A1 (en) * 2018-12-28 2020-07-02 深圳迈瑞生物医疗电子股份有限公司 Blood cell parameter correction method, blood sample detector and storage medium
WO2021097610A1 (en) * 2019-11-18 2021-05-27 深圳迈瑞生物医疗电子股份有限公司 Sample analyzer and sample analysis method
CN114556086A (en) * 2020-05-19 2022-05-27 生命科技股份有限公司 Nozzle sealing and unclogging station for flow cytometer

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770349A (en) * 1969-03-17 1973-11-06 Sanchez G Legorreta Method and apparatus for automatically classifying complex, microscopic particles such as human cells
US3586859A (en) * 1970-02-16 1971-06-22 Irwin J Katz Fluorescent cell viability counter
US4054151A (en) * 1974-05-20 1977-10-18 Buchler Instruments, Division Of Searle Diagnostics Inc. Concentrating vortex shaker
US4053229A (en) * 1976-01-13 1977-10-11 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration 2°/90° Laboratory scattering photometer
US4577964A (en) * 1978-09-06 1986-03-25 Ortho Diagnostics, Inc. Apparatus and method for detecting platelets in whole blood
US4325910A (en) * 1979-07-11 1982-04-20 Technicraft, Inc. Automated multiple-purpose chemical-analysis apparatus
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
US4265538A (en) * 1979-10-18 1981-05-05 Leeds & Northrup Company Optical sample cell for analysis of particles in liquid suspension
US4463708A (en) * 1980-05-27 1984-08-07 Gerry Martin E Fuel and water homogenizer
US4520110A (en) * 1981-10-06 1985-05-28 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor
DE3220879A1 (en) * 1982-06-03 1983-12-08 Gebr. Liebisch, 4800 Bielefeld Test tube shaker for mixing and whirling up analysis fluids
US4542104A (en) * 1983-04-06 1985-09-17 The Board Of Trustees Of The Leland Stanford Jr. Univ. Phycobiliprotein fluorescent conjugates
US4599307A (en) * 1983-07-18 1986-07-08 Becton, Dickinson And Company Method for elimination of selected cell populations in analytic cytology
US4710021A (en) * 1983-10-14 1987-12-01 Sequoia-Turner Corporation Particulate matter analyzing apparatus and method
US5188935A (en) * 1984-05-31 1993-02-23 Coulter Electronics, Inc. Reagent system and method for identification, enumeration and examination of classes and subclasses of blood leukocytes
US4751179A (en) * 1984-05-31 1988-06-14 Coulter Electronics, Inc. Method and reagents for differential determination of four populations of leukocytes in blood
US4661913A (en) * 1984-09-11 1987-04-28 Becton, Dickinson And Company Apparatus and method for the detection and classification of articles using flow cytometry techniques
US5380663A (en) * 1984-12-24 1995-01-10 Caribbean Microparticles Corporation Automated system for performance analysis and fluorescence quantitation of samples
US5073497A (en) * 1989-06-30 1991-12-17 Caribbean Microparticles Corporation Microbead reference standard and method of adjusting a flow cytometer to obtain reproducible results using the microbeads
JPS61153546A (en) * 1984-12-26 1986-07-12 Canon Inc Particle analyzer
US4727020A (en) * 1985-02-25 1988-02-23 Becton, Dickinson And Company Method for analysis of subpopulations of blood cells
JPS61274268A (en) * 1985-05-30 1986-12-04 Toshiba Corp Automatic chemical analyzer
US4707251A (en) * 1985-06-20 1987-11-17 Golden Aluminum Company Container scanning and accounting device
US4989977A (en) * 1985-07-29 1991-02-05 Becton, Dickinson And Company Flow cytometry apparatus with improved light beam adjustment
US4978624A (en) * 1985-09-06 1990-12-18 Technicon Instruments Corporation Reagent for the determination of a differential white blood cell count
US4941809A (en) * 1986-02-13 1990-07-17 Pinkerton Harry E Valveless positive displacement metering pump
NL8601000A (en) * 1986-04-21 1987-11-16 Jan Greve T H Twente Afdeling THE USE OF POLARIZED LIGHT IN FLOW CYTOMETRY.
US4745285A (en) * 1986-08-21 1988-05-17 Becton Dickinson And Company Multi-color fluorescence analysis with single wavelength excitation
GB2198674B (en) * 1986-12-17 1990-01-31 Metal Box Plc Resistance welding apparatus
US5260192A (en) * 1987-03-13 1993-11-09 Coulter Corporation Method and apparatus for screening cells or formed bodies with populations expressing selected characteristics utilizing at least one sensing parameter
US5223398A (en) * 1987-03-13 1993-06-29 Coulter Corporation Method for screening cells or formed bodies for enumeration of populations expressing selected characteristics
US5238812A (en) * 1987-03-13 1993-08-24 Coulter Corporation Method and apparatus for rapid mixing of small volumes for enhancing biological reactions
EP0299419B1 (en) * 1987-07-14 1993-10-20 Kabushiki Kaisha Kyoto Daiichi Kagaku Automatic measurement method of glycohemoglobin
JPS6435345A (en) * 1987-07-31 1989-02-06 Canon Kk Particle analyzing device
US4987086A (en) * 1987-11-30 1991-01-22 Becton, Dickinson And Company Method for analysis of subpopulations of cells
US5385822A (en) * 1988-05-02 1995-01-31 Zynaxis, Inc. Methods for detection and quantification of cell subsets within subpopulations of a mixed cell population
US5047321A (en) * 1988-06-15 1991-09-10 Becton Dickinson & Co. Method for analysis of cellular components of a fluid
US5408307A (en) * 1988-07-11 1995-04-18 Omron Tateisi Electronics Co. Cell analyzer
JPH0663945B2 (en) * 1988-08-26 1994-08-22 株式会社日立製作所 Stirrer
US4848917A (en) * 1988-08-26 1989-07-18 E. I. Du Pont De Nemours And Company Automatic vortex mixer
JPH0718785B2 (en) * 1988-09-19 1995-03-06 株式会社日立製作所 Flow cell device
BE1002614A6 (en) * 1988-11-24 1991-04-09 Labotics Bv Met Beperkte Aansp METHOD AND APPARATUS FOR diluting compositions.
US5032381A (en) * 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US5038911A (en) * 1989-02-16 1991-08-13 Rapistan Corporation Controlled spacing induction from plural lines
US5015157A (en) * 1990-01-10 1991-05-14 Dennis Pinkerton Pump with multi-port discharge
JP3049254B2 (en) * 1990-02-08 2000-06-05 シスメックス株式会社 Optical particle analyzer with two types of light sources
JPH0738839Y2 (en) * 1990-05-15 1995-09-06 オムロン株式会社 Flow particle analyzer
US5044889A (en) * 1990-05-16 1991-09-03 Dennis Pinkerton Phase adjustable metering pump, and method of adjusting the flow rate thereof
US5204884A (en) * 1991-03-18 1993-04-20 University Of Rochester System for high-speed measurement and sorting of particles
US5191967A (en) * 1990-10-30 1993-03-09 Rapistan Corp. Conveyor system having non-singulating accumulation conveyor
US5208762A (en) * 1990-12-06 1993-05-04 Baxter International Inc. Automated prescription vial filling system
JP3213334B2 (en) * 1991-05-14 2001-10-02 シスメックス株式会社 Urine cell analyzer
JP3067849B2 (en) * 1991-07-29 2000-07-24 シスメックス株式会社 Sample preparation method for leukocyte classification and counting
JP3048260B2 (en) * 1991-07-29 2000-06-05 シスメックス株式会社 Sample preparation method for leukocyte classification and counting
US5315094A (en) * 1991-09-23 1994-05-24 R. R. Donnelley & Sons Co. Automated receiving station for inventorying stock items
US5360739A (en) * 1991-12-05 1994-11-01 Miles Inc. Methods for the identification and characterization of reticulocytes in whole blood
JP3232145B2 (en) * 1991-12-27 2001-11-26 シスメックス株式会社 Reticulocyte measurement method
CA2087086A1 (en) * 1992-01-22 1993-07-23 Leon Wmm Terstappen Multidimensional cell differential analysis
EP0626067A4 (en) * 1992-02-07 1997-06-25 Abbott Lab Method for accurately enumerating and sensitively qualifying heterogeneous cell populations in cytolytic processing conditions.
AU665413B2 (en) * 1992-02-24 1996-01-04 Coulter International Corporation Hematology control composition for leukocyte analogs; and methods for their preparation and use
US5244633A (en) * 1992-05-22 1993-09-14 Eastman Kodak Company Analyzer incubator with plural independently driven rings supporting cuvettes
US5324025A (en) * 1992-09-18 1994-06-28 Chadwick Charles M Physical delay buffer for paper items
US5371585A (en) * 1992-11-10 1994-12-06 Pacific Scientific Company Particle detecting instrument with sapphire detecting cell defining a rectangular flow path
GR940100272A (en) * 1993-06-08 1995-11-29 Ortho Diagnostic Systems Inc Three-colour flow cytometry with automatic gating function.
US5692220A (en) * 1993-09-02 1997-11-25 Coulter Corporation Decision support system and method for diagnosis consultation in laboratory hematopathology
DE69532045T2 (en) * 1994-08-01 2004-07-08 Abbott Laboratories, Abbott Park Method and device for preparing a liquid
US5623415A (en) * 1995-02-16 1997-04-22 Smithkline Beecham Corporation Automated sampling and testing of biological materials

Also Published As

Publication number Publication date
JP2002503333A (en) 2002-01-29
JP3701977B2 (en) 2005-10-05
WO1998002727A1 (en) 1998-01-22
EP0912885A1 (en) 1999-05-06
CA2258603C (en) 2006-01-03
US5891734A (en) 1999-04-06

Similar Documents

Publication Publication Date Title
CA2258603A1 (en) Method and apparatus for performing automated analysis
CA2321691C (en) Method for performing blood cell counts
EP2267443B1 (en) Determination of white blood cell differential and reticulocyte counts
US5559037A (en) Method for rapid and simultaneous analysis of nucleated red blood cells
JP4433611B2 (en) Identification method for nucleated red blood cells
US20100054575A1 (en) Analysis method for 5-differential complete blood cell based on visual image
JP3098273B2 (en) Urine cell analyzer
US6391263B1 (en) Automated analyzing system and method therefor
JPH05322885A (en) Instrument for analyzing cell in urine
EP1033573B1 (en) Automated analyzing system and method thereof
JP4087560B2 (en) How to identify erythroblasts
Dimech et al. Evaluation of an automated urinalysis system for testing urine chemistry, microscopy and culture
US6329167B1 (en) Method of testing adequacy of cells in a specimen
US5045474A (en) Semi-automatic process for white cell differential count
JPH04151541A (en) Cell analyzing apparatus
Kelliher et al. Novel use of the BD FACS™ SPA to automate custom monoclonal antibody panel preparations for immunophenotyping

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170627