CA2258882A1 - Compositions and methods for altering the biodistribution of biological agents - Google Patents
Compositions and methods for altering the biodistribution of biological agentsInfo
- Publication number
- CA2258882A1 CA2258882A1 CA002258882A CA2258882A CA2258882A1 CA 2258882 A1 CA2258882 A1 CA 2258882A1 CA 002258882 A CA002258882 A CA 002258882A CA 2258882 A CA2258882 A CA 2258882A CA 2258882 A1 CA2258882 A1 CA 2258882A1
- Authority
- CA
- Canada
- Prior art keywords
- biodistribution
- methods
- altering
- compositions
- biological agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003124 biologic agent Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Abstract
The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or diagnostic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in improved utility for agents such as oligonucleotides and polynucleotides which are plagued with problems with biodistribution.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/670,999 US5849727A (en) | 1996-06-28 | 1996-06-28 | Compositions and methods for altering the biodistribution of biological agents |
US08/670,999 | 1996-06-28 | ||
PCT/US1997/010766 WO1998000172A2 (en) | 1996-06-28 | 1997-06-20 | Compositions and methods for altering the biodistribution of biological agents |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2258882A1 true CA2258882A1 (en) | 1998-01-08 |
CA2258882C CA2258882C (en) | 2009-03-17 |
Family
ID=24692746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002258882A Expired - Lifetime CA2258882C (en) | 1996-06-28 | 1997-06-20 | Compositions and methods for altering the biodistribution of biological agents |
Country Status (7)
Country | Link |
---|---|
US (5) | US5849727A (en) |
EP (1) | EP0938341B1 (en) |
JP (2) | JP4201348B2 (en) |
AT (1) | ATE260677T1 (en) |
CA (1) | CA2258882C (en) |
DE (1) | DE69727958T2 (en) |
WO (1) | WO1998000172A2 (en) |
Families Citing this family (115)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
US6176842B1 (en) * | 1995-03-08 | 2001-01-23 | Ekos Corporation | Ultrasound assembly for use with light activated drugs |
US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
US5648098A (en) * | 1995-10-17 | 1997-07-15 | The Board Of Regents Of The University Of Nebraska | Thrombolytic agents and methods of treatment for thrombosis |
US6245747B1 (en) | 1996-03-12 | 2001-06-12 | The Board Of Regents Of The University Of Nebraska | Targeted site specific antisense oligodeoxynucleotide delivery method |
JP2001507207A (en) | 1996-05-01 | 2001-06-05 | イマアーレクス・フアーマシユーチカル・コーポレーシヨン | Methods for delivering compounds to cells |
US5849727A (en) * | 1996-06-28 | 1998-12-15 | Board Of Regents Of The University Of Nebraska | Compositions and methods for altering the biodistribution of biological agents |
WO1998018495A2 (en) * | 1996-10-28 | 1998-05-07 | Marsden, John, Christopher | Improvements in or relating to diagnostic/therapeutic agents |
US6331289B1 (en) * | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
US6261537B1 (en) * | 1996-10-28 | 2001-07-17 | Nycomed Imaging As | Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors |
BR9712683A (en) | 1996-10-28 | 1999-10-19 | Nyomed Imaging A S | Diagnostic and / or therapeutically active targetable agent, combined formulation, process for preparing and using it, combined formulation, and processes for generating enhanced images of a human or non-human animal body and for in vitro targeting investigation by an agent. |
IL129445A0 (en) * | 1996-10-28 | 2000-02-29 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
ES2264159T3 (en) * | 1996-10-28 | 2006-12-16 | Amersham Health As | IMPROVEMENTS IN / OR RELATED TO DIAGNOSTIC / THERAPEUTIC AGENTS. |
US20070036722A1 (en) * | 1996-10-28 | 2007-02-15 | Pal Rongved | Separation processes |
WO1998018498A2 (en) * | 1996-10-28 | 1998-05-07 | Marsden, John, Christopher | Improvements in or relating to diagnostic/therapeutic agents |
US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
US6582392B1 (en) | 1998-05-01 | 2003-06-24 | Ekos Corporation | Ultrasound assembly for use with a catheter |
US6676626B1 (en) | 1998-05-01 | 2004-01-13 | Ekos Corporation | Ultrasound assembly with increased efficacy |
US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
US20030078227A1 (en) * | 1998-07-02 | 2003-04-24 | Greenleaf James F. | Site-directed transfection with ultrasound and cavitation nuclei |
WO2000002588A1 (en) * | 1998-07-13 | 2000-01-20 | The Board Of Regents Of The University Of Nebraska | Targeted site specific drug delivery compositions and method of use |
KR100649035B1 (en) * | 1998-07-13 | 2006-11-24 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 네브라스카 | Targeted site specific drug delivery compositions and method of use |
US6309355B1 (en) * | 1998-12-22 | 2001-10-30 | The Regents Of The University Of Michigan | Method and assembly for performing ultrasound surgery using cavitation |
US8106098B2 (en) | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
US6822086B1 (en) | 1999-08-09 | 2004-11-23 | The General Hospital Corporation | Drug-carrier complexes and methods of use thereof |
DE60143085D1 (en) * | 2000-05-17 | 2010-10-28 | Univ Nebraska | MORPHOLINO ANTISENSE OLIGOMERS AS ENZYMINHIBITORS FOR IMPROVING THE PHARMACOKINETICS OF AN ACTIVE SUBSTANCE |
JP2002145784A (en) * | 2000-11-10 | 2002-05-22 | Ryuichi Morishita | Biologically active medicament-introducing composition and method for using the same |
DE10119522A1 (en) * | 2001-04-20 | 2002-12-05 | Innovacell Biotechnologie Gmbh | Preparation and application of a suspension composition with an ultrasound contrast medium |
EP1420643B1 (en) * | 2001-07-10 | 2008-04-23 | Sonogene, LLC | Enhancement of transfection of dna into the liver |
CA2464464A1 (en) * | 2001-10-22 | 2003-05-01 | Nucleonics Inc. | Transfection kinetics and structural promoters |
US7897382B2 (en) * | 2001-10-22 | 2011-03-01 | Alnylam Pharmaceuticals, Inc. | Transfection kinetics and structural promoters |
DE60209799T2 (en) | 2001-12-03 | 2007-01-25 | Ekos Corp., Bothell | CATHETER WITH SEVERAL ULTRASOUND EMITTING PARTS |
EP1488813A4 (en) * | 2002-03-22 | 2005-04-06 | Anges Mg Inc | Compositions for delivering biologically active drug and method of using the same |
US8226629B1 (en) | 2002-04-01 | 2012-07-24 | Ekos Corporation | Ultrasonic catheter power control |
US20040180438A1 (en) * | 2002-04-26 | 2004-09-16 | Pachuk Catherine J. | Methods and compositions for silencing genes without inducing toxicity |
US20040126400A1 (en) * | 2002-05-03 | 2004-07-01 | Iversen Patrick L. | Delivery of therapeutic compounds via microparticles or microbubbles |
US20030207907A1 (en) * | 2002-05-03 | 2003-11-06 | Iversen Patrick L. | Delivery of microparticle-conjugated drugs for inhibition of stenosis |
US7754238B2 (en) * | 2002-05-03 | 2010-07-13 | Avi Biopharma, Inc. | Delivery of microparticle-conjugated drugs for inhibition of stenosis |
EP1549352A4 (en) * | 2002-05-06 | 2005-07-27 | Nucleonics Inc | Methods for delivery of nucleic acids |
EP1540004A4 (en) * | 2002-07-31 | 2007-10-03 | Nucleonics Inc | Double stranded rna structures and constructs, and methods for generating and using the same |
US6921371B2 (en) | 2002-10-14 | 2005-07-26 | Ekos Corporation | Ultrasound radiating members for catheter |
EP1629105B1 (en) * | 2003-04-29 | 2010-09-01 | AVI BioPharma, Inc. | Compositions for enhancing transport and antisense efficacy of nucleic acid analog into cells |
US20050222068A1 (en) * | 2003-10-23 | 2005-10-06 | Mourich Dan V | Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells |
US7025726B2 (en) * | 2004-01-22 | 2006-04-11 | The Regents Of The University Of Nebraska | Detection of endothelial dysfunction by ultrasonic imaging |
US20050288246A1 (en) * | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
DE102004057196A1 (en) * | 2004-11-26 | 2006-06-01 | Rösner Research GmbH & Co.KG | Method for producing albumin conjugates with non-steroidal anti-inflammatory drugs (NSAIDs) |
US20060240032A1 (en) * | 2005-03-31 | 2006-10-26 | Hinrichs David J | Immunomodulating compositions and methods for use in the treatment of human autoimmune diseases |
WO2006129080A1 (en) * | 2005-05-31 | 2006-12-07 | The Institute Of Cancer Research: Royal Cancer Hospital | Materials and methods for transducing cells with a viral vector |
US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
US8057408B2 (en) | 2005-09-22 | 2011-11-15 | The Regents Of The University Of Michigan | Pulsed cavitational ultrasound therapy |
US10219815B2 (en) | 2005-09-22 | 2019-03-05 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
EP1968441A2 (en) * | 2005-12-02 | 2008-09-17 | Barnes-Jewish Hospital | Methods to ameliorate and image angioplasty-induced vascular injury |
US8715221B2 (en) | 2006-03-08 | 2014-05-06 | Fresenius Medical Care Holdings, Inc. | Wearable kidney |
US8012118B2 (en) | 2006-03-08 | 2011-09-06 | Fresenius Medical Care Holdings, Inc. | Artificial kidney dialysis system |
KR101419682B1 (en) | 2006-08-24 | 2014-07-17 | 프레제니우스 메디칼 케어 홀딩스 인코퍼레이티드 | Device for removing fluid from blood in a patient |
US10182833B2 (en) | 2007-01-08 | 2019-01-22 | Ekos Corporation | Power parameters for ultrasonic catheter |
US9044568B2 (en) | 2007-06-22 | 2015-06-02 | Ekos Corporation | Method and apparatus for treatment of intracranial hemorrhages |
CA2691673A1 (en) * | 2007-06-29 | 2009-01-08 | Avi Biopharma, Inc. | Tissue specific peptide conjugates and methods |
US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
WO2009043031A2 (en) | 2007-09-27 | 2009-04-02 | Children's Medical Center Corporation | Microbubbles and methods for oxygen delivery |
WO2009117688A2 (en) * | 2008-03-21 | 2009-09-24 | The Board Of Trustees Of The University Of Arkansas | Methods for producing microbubbles |
JP5551709B2 (en) | 2008-11-03 | 2014-07-16 | フレゼニウス メディカル ケア ホールディングス インコーポレイテッド | Portable peritoneal dialysis system |
CA2746508A1 (en) * | 2008-12-17 | 2010-07-15 | Avi Biopharma, Inc. | Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis |
US20110269665A1 (en) | 2009-06-26 | 2011-11-03 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
WO2011022411A2 (en) | 2009-08-17 | 2011-02-24 | Histosonics, Inc. | Disposable acoustic coupling medium container |
US9943708B2 (en) | 2009-08-26 | 2018-04-17 | Histosonics, Inc. | Automated control of micromanipulator arm for histotripsy prostate therapy while imaging via ultrasound transducers in real time |
AU2010289775B2 (en) | 2009-08-26 | 2016-02-04 | Histosonics, Inc. | Devices and methods for using controlled bubble cloud cavitation in fractionating urinary stones |
US10058837B2 (en) | 2009-08-28 | 2018-08-28 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and devices for production of gas-filled microbubbles |
US8539813B2 (en) | 2009-09-22 | 2013-09-24 | The Regents Of The University Of Michigan | Gel phantoms for testing cavitational ultrasound (histotripsy) transducers |
WO2011084694A1 (en) | 2009-12-17 | 2011-07-14 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Stabilized stat3 decoy oligonucleotides and uses therefor |
WO2012065060A2 (en) * | 2010-11-12 | 2012-05-18 | Children's Medical Center Corporation | Gas-filled microbubbles and systems for gas delivery |
US9161948B2 (en) | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
KR20120140290A (en) * | 2011-06-21 | 2012-12-31 | 주식회사 퍼시픽시스템 | Method of manufacturing bubble for accelerating functional material and device or transferring functional material |
US9144694B2 (en) | 2011-08-10 | 2015-09-29 | The Regents Of The University Of Michigan | Lesion generation through bone using histotripsy therapy without aberration correction |
US10357450B2 (en) | 2012-04-06 | 2019-07-23 | Children's Medical Center Corporation | Process for forming microbubbles with high oxygen content and uses thereof |
US9049783B2 (en) | 2012-04-13 | 2015-06-02 | Histosonics, Inc. | Systems and methods for obtaining large creepage isolation on printed circuit boards |
EP2844343B1 (en) | 2012-04-30 | 2018-11-21 | The Regents Of The University Of Michigan | Ultrasound transducer manufacturing using rapid-prototyping method |
WO2014055906A1 (en) | 2012-10-05 | 2014-04-10 | The Regents Of The University Of Michigan | Bubble-induced color doppler feedback during histotripsy |
WO2014117232A1 (en) * | 2013-02-04 | 2014-08-07 | Farret Neto Abdo | Medicinal preparation in the form of a foam for the sustained release of medicinal drugs, and system for producing the medicinal preparation |
US9101745B2 (en) | 2013-03-14 | 2015-08-11 | Sonogene Llc | Sonochemical induction of ABCA1 expression and compositions therefor |
EP2968825A4 (en) | 2013-03-15 | 2016-09-07 | Childrens Medical Center | Gas-filled stabilized particles and methods of use |
AU2014232195A1 (en) * | 2013-03-15 | 2015-10-15 | Doheny Eye Institute | Management of tractional membranes |
US10124126B2 (en) * | 2013-04-18 | 2018-11-13 | The Regents Of The University Of Colorado, A Body Corporate | System and methods for ventilation through a body cavity |
WO2015003142A1 (en) | 2013-07-03 | 2015-01-08 | Histosonics, Inc. | Histotripsy excitation sequences optimized for bubble cloud formation using shock scattering |
WO2015003154A1 (en) | 2013-07-03 | 2015-01-08 | Histosonics, Inc. | Articulating arm limiter for cavitational ultrasound therapy system |
WO2015027164A1 (en) | 2013-08-22 | 2015-02-26 | The Regents Of The University Of Michigan | Histotripsy using very short ultrasound pulses |
US11305013B2 (en) * | 2014-08-26 | 2022-04-19 | Drexel University | Surfactant microbubbles and process for preparing and methods of using the same |
US10052394B2 (en) | 2014-11-21 | 2018-08-21 | General Electric Company | Microbubble tether for diagnostic and therapeutic applications |
RU2704823C2 (en) * | 2015-05-28 | 2019-10-31 | Пасифик Систем Ко., Лтд. | Cavitation nucleus for drug delivery and method for drug delivery using same |
WO2016196897A1 (en) | 2015-06-04 | 2016-12-08 | Sarepta Therapeutics, Inc. | Methods and compounds for treatment of lymphocyte-related diseases and conditions |
WO2016201136A1 (en) | 2015-06-10 | 2016-12-15 | Ekos Corporation | Ultrasound catheter |
WO2016210133A1 (en) | 2015-06-24 | 2016-12-29 | The Regents Of The Universtiy Of Michigan | Histotripsy therapy systems and methods for the treatment of brain tissue |
SG10202012839TA (en) | 2016-12-19 | 2021-01-28 | Sarepta Therapeutics Inc | Exon skipping oligomer conjugates for muscular dystrophy |
US11147890B2 (en) | 2017-02-28 | 2021-10-19 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
CN113286552A (en) | 2018-11-28 | 2021-08-20 | 希斯托索尼克斯公司 | Histotripsy system and method |
CA3169465A1 (en) | 2020-01-28 | 2021-08-05 | The Regents Of The University Of Michigan | Systems and methods for histotripsy immunosensitization |
WO2021155171A1 (en) | 2020-01-29 | 2021-08-05 | Flagship Pioneering Innovations Vi, Llc | Delivery of compositions comprising circular polyribonucleotides |
TW202142689A (en) | 2020-01-29 | 2021-11-16 | 美商旗艦先鋒創新有限責任公司 | Compositions for translation and methods of use thereof |
WO2021155177A1 (en) | 2020-01-29 | 2021-08-05 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising linear polyribonucleotides for protein modulation and uses thereof |
TW202206097A (en) | 2020-05-20 | 2022-02-16 | 美商旗艦先鋒創新有限責任公司 | Coronavirus antigen compositions and their uses |
JP2023526423A (en) | 2020-05-20 | 2023-06-21 | フラッグシップ パイオニアリング イノベーションズ シックス,エルエルシー | Immunogenic compositions and uses thereof |
WO2022051629A1 (en) | 2020-09-03 | 2022-03-10 | Flagship Pioneering Innovations Vi, Llc | Immunogenic compositions and uses thereof |
CA3232635A1 (en) | 2021-09-17 | 2023-03-23 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for producing circular polyribonucleotides |
TW202322826A (en) | 2021-10-18 | 2023-06-16 | 美商旗艦先鋒創新有限責任公司 | Compositions and methods for purifying polyribonucleotides |
WO2023097003A2 (en) | 2021-11-24 | 2023-06-01 | Flagship Pioneering Innovations Vi, Llc | Immunogenic compositions and their uses |
WO2023096990A1 (en) | 2021-11-24 | 2023-06-01 | Flagship Pioneering Innovation Vi, Llc | Coronavirus immunogen compositions and their uses |
WO2023096963A1 (en) | 2021-11-24 | 2023-06-01 | Flagship Pioneering Innovations Vi, Llc | Varicella-zoster virus immunogen compositions and their uses |
WO2023122745A1 (en) | 2021-12-22 | 2023-06-29 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
TW202342064A (en) | 2021-12-23 | 2023-11-01 | 美商旗艦先鋒創新有限責任公司 | Circular polyribonucleotides encoding antifusogenic polypeptides |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4718433A (en) * | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
US4572203A (en) * | 1983-01-27 | 1986-02-25 | Feinstein Steven B | Contact agents for ultrasonic imaging |
US4634586A (en) * | 1984-05-21 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Reagent and method for radioimaging leukocytes |
US5040537A (en) * | 1987-11-24 | 1991-08-20 | Hitachi, Ltd. | Method and apparatus for the measurement and medical treatment using an ultrasonic wave |
US4844882A (en) * | 1987-12-29 | 1989-07-04 | Molecular Biosystems, Inc. | Concentrated stabilized microbubble-type ultrasonic imaging agent |
US5410516A (en) * | 1988-09-01 | 1995-04-25 | Schering Aktiengesellschaft | Ultrasonic processes and circuits for performing them |
US4957656A (en) * | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5733572A (en) * | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
IN172208B (en) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
US5315997A (en) * | 1990-06-19 | 1994-05-31 | Molecular Biosystems, Inc. | Method of magnetic resonance imaging using diamagnetic contrast |
US5310540A (en) * | 1990-10-05 | 1994-05-10 | Sintetica Sa | Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography |
US5107842A (en) * | 1991-02-22 | 1992-04-28 | Molecular Biosystems, Inc. | Method of ultrasound imaging of the gastrointestinal tract |
DE69215722T3 (en) * | 1991-03-22 | 2001-03-08 | Katsuro Tachibana | Amplifiers for ultrasound therapy of diseases and liquid pharmaceutical compositions containing them |
DE69230885T3 (en) * | 1991-09-17 | 2008-01-24 | Ge Healthcare As | GASOUS ULTRASONIC CONTRASTING AGENTS |
US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
US5304325A (en) * | 1991-11-13 | 1994-04-19 | Hemagen/Pfc | Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use |
US5255683A (en) * | 1991-12-30 | 1993-10-26 | Sound Science Limited Partnership | Methods of and systems for examining tissue perfusion using ultrasonic contrast agents |
IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
US5585479A (en) * | 1992-07-24 | 1996-12-17 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human ELAM-I RNA |
US5302372A (en) * | 1992-07-27 | 1994-04-12 | National Science Council | Method to opacify left ventricle in echocardiography |
DE4232755A1 (en) * | 1992-09-26 | 1994-03-31 | Schering Ag | Microparticle preparations made from biodegradable copolymers |
CN1068230C (en) * | 1993-01-25 | 2001-07-11 | 索纳斯药品有限公司 | Phase shift colloids as ultrasound contrast agents |
US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
BR9405798A (en) * | 1993-02-22 | 1995-12-12 | Vivorx Pharmaceuticals Inc | Methods for in vivo release of biological material and useful compositions thereof |
US5362478A (en) * | 1993-03-26 | 1994-11-08 | Vivorx Pharmaceuticals, Inc. | Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell |
US5401493A (en) * | 1993-03-26 | 1995-03-28 | Molecular Biosystems, Inc. | Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same |
US5701899A (en) * | 1993-05-12 | 1997-12-30 | The Board Of Regents Of The University Of Nebraska | Perfluorobutane ultrasound contrast agent and methods for its manufacture and use |
US5567415A (en) * | 1993-05-12 | 1996-10-22 | The Board Of Regents Of The University Of Nebraska | Ultrasound contrast agents and methods for their manufacture and use |
US5695740A (en) * | 1993-05-12 | 1997-12-09 | The Board Of Regents Of The University Of Nebraska | Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide |
KR100218642B1 (en) * | 1993-07-02 | 1999-09-01 | 스티븐 로손 | Method of making microspheres encapsulated from the temperature-denaturated protein |
US5385147A (en) * | 1993-09-22 | 1995-01-31 | Molecular Biosystems, Inc. | Method of ultrasonic imaging of the gastrointestinal tract and upper abdominal organs using an orally administered negative contrast medium |
NO940711D0 (en) * | 1994-03-01 | 1994-03-01 | Nycomed Imaging As | Preparation of gas-filled microcapsules and contrast agents for diagnostic imaging |
US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
US5560364A (en) * | 1995-05-12 | 1996-10-01 | The Board Of Regents Of The University Of Nebraska | Suspended ultra-sound induced microbubble cavitation imaging |
WO1997033474A1 (en) * | 1996-03-12 | 1997-09-18 | Board Of Regents Of The University Of Nebraska | Targeted site specific drug delivery compositions and method of use |
US5849727A (en) * | 1996-06-28 | 1998-12-15 | Board Of Regents Of The University Of Nebraska | Compositions and methods for altering the biodistribution of biological agents |
-
1996
- 1996-06-28 US US08/670,999 patent/US5849727A/en not_active Expired - Lifetime
-
1997
- 1997-06-20 AT AT97932228T patent/ATE260677T1/en not_active IP Right Cessation
- 1997-06-20 DE DE69727958T patent/DE69727958T2/en not_active Expired - Lifetime
- 1997-06-20 WO PCT/US1997/010766 patent/WO1998000172A2/en active IP Right Grant
- 1997-06-20 CA CA002258882A patent/CA2258882C/en not_active Expired - Lifetime
- 1997-06-20 JP JP50420598A patent/JP4201348B2/en not_active Expired - Lifetime
- 1997-06-20 EP EP97932228A patent/EP0938341B1/en not_active Expired - Lifetime
-
1998
- 1998-07-17 US US09/118,168 patent/US6117858A/en not_active Expired - Lifetime
-
2000
- 2000-06-09 US US09/591,380 patent/US6537814B1/en not_active Expired - Lifetime
-
2003
- 2003-01-31 US US10/355,388 patent/US7115583B2/en not_active Expired - Fee Related
- 2003-09-22 US US10/668,448 patent/US7198949B2/en not_active Expired - Fee Related
-
2008
- 2008-07-24 JP JP2008191487A patent/JP2009029810A/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0938341A2 (en) | 1999-09-01 |
CA2258882C (en) | 2009-03-17 |
US7115583B2 (en) | 2006-10-03 |
WO1998000172A2 (en) | 1998-01-08 |
ATE260677T1 (en) | 2004-03-15 |
US6537814B1 (en) | 2003-03-25 |
US5849727A (en) | 1998-12-15 |
US7198949B2 (en) | 2007-04-03 |
US20040013662A1 (en) | 2004-01-22 |
JP2009029810A (en) | 2009-02-12 |
WO1998000172A3 (en) | 1998-05-14 |
DE69727958T2 (en) | 2005-04-07 |
JP4201348B2 (en) | 2008-12-24 |
DE69727958D1 (en) | 2004-04-08 |
US20040057946A1 (en) | 2004-03-25 |
US6117858A (en) | 2000-09-12 |
JP2000515499A (en) | 2000-11-21 |
EP0938341B1 (en) | 2004-03-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2258882A1 (en) | Compositions and methods for altering the biodistribution of biological agents | |
AU2207197A (en) | Targeted site specific drug delivery compositions and method of use | |
CA2182228A1 (en) | Codrugs as a method of controlled drug delivery | |
CA2318128A1 (en) | Oral liquid compositions | |
CA2406650A1 (en) | Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites | |
CA2242035A1 (en) | Compositions useful for transferring therapeutically active substances into a target cell, and their use in gene therapy | |
IL139285A0 (en) | Peg-lhrh analog conjugates, their preparation and use | |
YU73600A (en) | Novel nucleosides having bicyclic sugar moiety | |
UA52594C2 (en) | Cycloalcanopyridine derivatives, mixture of isomers thereof or individual isomers, their salts and n-oxides, methods and intermediate compounds for preparation thereof, a also a pharmaceutical composition | |
CA2257133A1 (en) | Human dnase i hyperactive variants | |
CA2068324A1 (en) | Metal-peptide compositions and methods for stimulating hair growth | |
HUP0204085A3 (en) | New oxabispidine compounds useful in the treatment of cardiac arrhythmias, process for their preparation and pharmaceutical compositions containing them | |
CA2378613A1 (en) | Selective iglur5 receptor antagonists for the treatment of migraine | |
CA2449856A1 (en) | Pharmaceutical and diagnostic compositions containing nanoparticles useful for treating targeted tissues and cells | |
HUP0302538A3 (en) | 3,7-diazabicyclo[3.3.0]oczanes and their use in the treatment of cardiac arrhythmias, process for their preparation and pharmaceutical compositions containing them | |
HUP0401325A3 (en) | Isoxazolopyridinones useful in the treatment of parkinson's disease, process for their preparation and pharmaceutical compositions containing the compounds | |
HUP9802897A3 (en) | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, the use thereof in the treatment of vascular diseases and pharmaceutical composition containing the compound as active ingredient | |
CA2279184A1 (en) | Pharmaceutical compositions containing ibuprofen and domperidone for the treatment of migraine | |
CA2319542A1 (en) | The treatment of sexual dysfunction in certain patient groups | |
FR2757514B1 (en) | NOVEL CAMPTOTHECIN ANALOGS, PREPARATION METHODS, USE THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
WO1999002120A3 (en) | Compositions and methods for reversibly increasing permeability of biomembranes | |
HUP0102522A3 (en) | 3',3'-n-bis-substituted macrolide lhrh antagonists and their use, process for their preparation and pharmaceutical compositions comprising them | |
HUP0102987A3 (en) | Pharmaceutical composition for treating parkinson's disease comprising astrocyte function-improving agent as active ingredient | |
CA2290739A1 (en) | New bpc peptide salts with organo-protective activity, the process for their preparation and their use in therapy | |
FR2702481B1 (en) | New soluble human Fc-gamma III receptors, their preparation process, the pharmaceutical compositions containing them, their application as medicaments and their diagnostic application. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20170620 |