CA2260750A1 - Methods for providing safe local anesthesia - Google Patents

Methods for providing safe local anesthesia

Info

Publication number
CA2260750A1
CA2260750A1 CA002260750A CA2260750A CA2260750A1 CA 2260750 A1 CA2260750 A1 CA 2260750A1 CA 002260750 A CA002260750 A CA 002260750A CA 2260750 A CA2260750 A CA 2260750A CA 2260750 A1 CA2260750 A1 CA 2260750A1
Authority
CA
Canada
Prior art keywords
methods
local anesthesia
patient
providing safe
safe local
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002260750A
Other languages
French (fr)
Other versions
CA2260750C (en
Inventor
Richard S. Sackler
Paul D. Goldenheim
Mark Chasin
Ronald M. Burch
Robert F. Reder
Joseph Tigner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro-Celtique, S.A.
Richard S. Sackler
Paul D. Goldenheim
Mark Chasin
Ronald M. Burch
Robert F. Reder
Joseph Tigner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro-Celtique, S.A., Richard S. Sackler, Paul D. Goldenheim, Mark Chasin, Ronald M. Burch, Robert F. Reder, Joseph Tigner filed Critical Euro-Celtique, S.A.
Publication of CA2260750A1 publication Critical patent/CA2260750A1/en
Application granted granted Critical
Publication of CA2260750C publication Critical patent/CA2260750C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

Methods and formulations for inducing substantially safer local anesthesia in a patient are provided. The methods comprise administering, to a patient in need thereof, a substrate containing a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material to safely obtain a reversible nerve blockade when implanted or injected in a patient.
CA002260750A 1996-06-24 1997-06-24 Methods for providing safe local anesthesia Expired - Fee Related CA2260750C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2031596P 1996-06-24 1996-06-24
US60/020,315 1996-06-24
PCT/US1997/012326 WO1997049391A1 (en) 1996-06-24 1997-06-24 Methods for providing safe local anesthesia

Publications (2)

Publication Number Publication Date
CA2260750A1 true CA2260750A1 (en) 1997-12-31
CA2260750C CA2260750C (en) 2004-11-09

Family

ID=21797932

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002260750A Expired - Fee Related CA2260750C (en) 1996-06-24 1997-06-24 Methods for providing safe local anesthesia

Country Status (6)

Country Link
US (1) US6699908B2 (en)
EP (1) EP0954301A4 (en)
JP (1) JPH11511763A (en)
AU (1) AU733867B2 (en)
CA (1) CA2260750C (en)
WO (1) WO1997049391A1 (en)

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CA2260750C (en) 2004-11-09
AU3728797A (en) 1998-01-14
US20020114835A1 (en) 2002-08-22
US6699908B2 (en) 2004-03-02
EP0954301A4 (en) 2006-03-08
EP0954301A1 (en) 1999-11-10
AU733867B2 (en) 2001-05-31
WO1997049391A1 (en) 1997-12-31
JPH11511763A (en) 1999-10-12

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