CA2265508A1 - Bone morphogenetic protein-16 (bmp-16) compositions - Google Patents

Bone morphogenetic protein-16 (bmp-16) compositions

Info

Publication number
CA2265508A1
CA2265508A1 CA002265508A CA2265508A CA2265508A1 CA 2265508 A1 CA2265508 A1 CA 2265508A1 CA 002265508 A CA002265508 A CA 002265508A CA 2265508 A CA2265508 A CA 2265508A CA 2265508 A1 CA2265508 A1 CA 2265508A1
Authority
CA
Canada
Prior art keywords
proteins
bmp
compositions
disorders
tissues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002265508A
Other languages
French (fr)
Other versions
CA2265508C (en
Inventor
Anthony J. Celeste
Beth L. Murray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute, Inc.
Anthony J. Celeste
Beth L. Murray
Genetics Institute, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute, Inc., Anthony J. Celeste, Beth L. Murray, Genetics Institute, Llc filed Critical Genetics Institute, Inc.
Publication of CA2265508A1 publication Critical patent/CA2265508A1/en
Application granted granted Critical
Publication of CA2265508C publication Critical patent/CA2265508C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/495Transforming growth factor [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Abstract

Purified BMP-16 proteins and processes for producing them are disclosed. DNA
molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
CA002265508A 1996-09-18 1997-07-09 Bone morphogenetic protein-16 (bmp-16) compositions Expired - Fee Related CA2265508C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/715,202 US5965403A (en) 1996-09-18 1996-09-18 Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
US08/715,202 1996-09-18
PCT/US1997/011954 WO1998012322A1 (en) 1996-09-18 1997-07-09 Bone morphogenetic protein-16 (bmp-16) compositions

Publications (2)

Publication Number Publication Date
CA2265508A1 true CA2265508A1 (en) 1998-03-26
CA2265508C CA2265508C (en) 2003-11-18

Family

ID=24873057

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002265508A Expired - Fee Related CA2265508C (en) 1996-09-18 1997-07-09 Bone morphogenetic protein-16 (bmp-16) compositions

Country Status (9)

Country Link
US (3) US5965403A (en)
EP (1) EP0941323A1 (en)
JP (1) JP2001500737A (en)
KR (1) KR20000036012A (en)
CA (1) CA2265508C (en)
FI (1) FI990596A (en)
NO (1) NO991271L (en)
OA (1) OA10997A (en)
WO (1) WO1998012322A1 (en)

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US8106001B2 (en) * 1996-08-27 2012-01-31 University Of South Florida Diagnostic markers of human female infertility
US5965403A (en) * 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
US7026445B2 (en) * 1997-02-06 2006-04-11 Genetics Institute, Llc Human SDF-5 protein and compositions
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US6211157B1 (en) 1998-05-01 2001-04-03 Sulzer Biologics, Inc. Protein mixtures to induce therapeutic angiogenesis
US6992066B2 (en) * 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
US7087577B2 (en) * 1998-10-16 2006-08-08 Zimmer Orthobiologies, Inc. Method of promoting natural bypass
EP1181041A2 (en) * 1999-04-30 2002-02-27 Curis, Inc. Morphogen-induced enhancement of fertility
WO2001008714A1 (en) * 1999-07-28 2001-02-08 Regeneration Technologies, Inc. Cartilage or bone matrix as a nucleic acid delivery vehicle
CN1331248A (en) * 2000-06-30 2002-01-16 上海博德基因开发有限公司 Polypeptide-human chondral connexin 10.67 and polynucleotide for coding it
US6482936B1 (en) * 2001-04-17 2002-11-19 Pe Corporation (Ny) Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
CA2449008A1 (en) * 2001-06-01 2002-12-12 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US7232802B2 (en) * 2001-12-21 2007-06-19 Zimmer Orthobiologics, Inc. Compositions and methods for promoting myocardial and peripheral angiogenesis
WO2004061423A2 (en) * 2003-01-06 2004-07-22 Wyeth Compositions and methods for diagnosing and treating colon cancers
US20050266409A1 (en) * 2003-02-04 2005-12-01 Wyeth Compositions and methods for diagnosing, preventing, and treating cancers
WO2005001092A2 (en) * 2003-05-20 2005-01-06 Wyeth Compositions and methods for diagnosing and treating cancers
RU2363478C2 (en) 2003-09-12 2009-08-10 Вайет Injected calcium phosphate hinges for delivery of osteogene proteins
DE10361075A1 (en) * 2003-12-22 2005-07-28 Pac Tech - Packaging Technologies Gmbh Method and apparatus for drying circuit substrates
EP1571159A1 (en) * 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein of a bone morphogenetic protein and use thereof
EP1740609A2 (en) * 2004-04-27 2007-01-10 Research Development Foundation Antagonism of tgf-beta superfamily receptor signaling
US20090042780A1 (en) * 2004-05-20 2009-02-12 Acceleron Pharma Inc Modified TGF-Beta Superfamily Polypeptides and Related Methods
CA2567805A1 (en) * 2004-05-27 2005-12-15 Acceleron Pharma Inc. Tgf derepressors and uses related thereto
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
WO2006081379A1 (en) * 2005-01-26 2006-08-03 Wyeth Use of sfrps as markers of bmp activity
WO2006105359A2 (en) * 2005-03-30 2006-10-05 Wyeth Methods for stimulating hair growth by administering bmps
US20060247790A1 (en) * 2005-04-30 2006-11-02 Mckay William F Shaped osteochondral grafts and methods of using same
NZ571113A (en) 2005-11-17 2012-02-24 Biomimetic Therapeutics Inc Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US7659999B2 (en) * 2005-12-23 2010-02-09 Xerox Corporation UIdesign: N-up calculator user interface
EP2311505B1 (en) 2006-02-09 2013-11-06 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
EP2049145B1 (en) 2006-06-30 2018-03-14 BioMimetic Therapeutics, LLC Pdgf-biomatrix compositions and methods for treating rotator cuff injuries
US8524265B2 (en) 2006-08-17 2013-09-03 Warsaw Orthopedic, Inc. Medical implant sheets useful for tissue regeneration
EP2086598B1 (en) 2006-11-03 2015-05-27 BioMimetic Therapeutics, LLC Compositions and methods for arthrodetic procedures
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
ES2422259T3 (en) 2008-02-07 2013-09-10 Biomimetic Therapeutics Inc Compositions for distraction osteogenesis
WO2009152085A1 (en) * 2008-06-09 2009-12-17 Wyeth Novel bmp-12-related proteins and methods of their manufacture
WO2010030714A2 (en) 2008-09-09 2010-03-18 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US8609127B2 (en) 2009-04-03 2013-12-17 Warsaw Orthopedic, Inc. Medical implant with bioactive material and method of making the medical implant
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
EP2538791B1 (en) 2010-02-22 2015-04-08 BioMimetic Therapeutics, LLC Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
US8952131B2 (en) 2010-08-20 2015-02-10 Wyeth Llc Designer osteogenic proteins
US10034945B2 (en) 2012-07-13 2018-07-31 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
ES2846848T3 (en) 2015-10-26 2021-07-29 Harvard College Reduced and oxidized polysaccharides and methods of using them

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CA2108770C (en) * 1991-06-25 2007-04-03 John M. Wozney Bmp-9 compositions
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Also Published As

Publication number Publication date
JP2001500737A (en) 2001-01-23
US6331612B1 (en) 2001-12-18
WO1998012322A1 (en) 1998-03-26
OA10997A (en) 2003-03-04
CA2265508C (en) 2003-11-18
KR20000036012A (en) 2000-06-26
EP0941323A1 (en) 1999-09-15
US5965403A (en) 1999-10-12
NO991271D0 (en) 1999-03-16
US6623934B2 (en) 2003-09-23
FI990596A (en) 1999-05-03
NO991271L (en) 1999-03-16
FI990596A0 (en) 1999-03-17
US20030158379A1 (en) 2003-08-21

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