CA2265508A1 - Bone morphogenetic protein-16 (bmp-16) compositions - Google Patents
Bone morphogenetic protein-16 (bmp-16) compositionsInfo
- Publication number
- CA2265508A1 CA2265508A1 CA002265508A CA2265508A CA2265508A1 CA 2265508 A1 CA2265508 A1 CA 2265508A1 CA 002265508 A CA002265508 A CA 002265508A CA 2265508 A CA2265508 A CA 2265508A CA 2265508 A1 CA2265508 A1 CA 2265508A1
- Authority
- CA
- Canada
- Prior art keywords
- proteins
- bmp
- compositions
- disorders
- tissues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Purified BMP-16 proteins and processes for producing them are disclosed. DNA
molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/715,202 US5965403A (en) | 1996-09-18 | 1996-09-18 | Nucleic acids encoding bone morphogenic protein-16 (BMP-16) |
US08/715,202 | 1996-09-18 | ||
PCT/US1997/011954 WO1998012322A1 (en) | 1996-09-18 | 1997-07-09 | Bone morphogenetic protein-16 (bmp-16) compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2265508A1 true CA2265508A1 (en) | 1998-03-26 |
CA2265508C CA2265508C (en) | 2003-11-18 |
Family
ID=24873057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002265508A Expired - Fee Related CA2265508C (en) | 1996-09-18 | 1997-07-09 | Bone morphogenetic protein-16 (bmp-16) compositions |
Country Status (9)
Country | Link |
---|---|
US (3) | US5965403A (en) |
EP (1) | EP0941323A1 (en) |
JP (1) | JP2001500737A (en) |
KR (1) | KR20000036012A (en) |
CA (1) | CA2265508C (en) |
FI (1) | FI990596A (en) |
NO (1) | NO991271L (en) |
OA (1) | OA10997A (en) |
WO (1) | WO1998012322A1 (en) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69233022T2 (en) | 1991-11-04 | 2004-02-12 | Genetics Institute, LLC, Cambridge | RECOMBINANT BONE MORPHOGENETIC PROTEIN HETERODIMERS, COMPOSITIONS AND METHODS OF USE |
US8106001B2 (en) * | 1996-08-27 | 2012-01-31 | University Of South Florida | Diagnostic markers of human female infertility |
US5965403A (en) * | 1996-09-18 | 1999-10-12 | Genetics Institute, Inc. | Nucleic acids encoding bone morphogenic protein-16 (BMP-16) |
US7026445B2 (en) * | 1997-02-06 | 2006-04-11 | Genetics Institute, Llc | Human SDF-5 protein and compositions |
CA2299276A1 (en) * | 1997-08-04 | 1999-02-11 | Millennium Biotherapeutics, Inc. | Tango-78, tango-79, and tango-81 nucleic acid molecules and polypeptides |
US6211157B1 (en) | 1998-05-01 | 2001-04-03 | Sulzer Biologics, Inc. | Protein mixtures to induce therapeutic angiogenesis |
US6992066B2 (en) * | 1998-10-16 | 2006-01-31 | Zimmer Orthobiologics, Inc. | Povidone-containing carriers for polypeptide growth factors |
US7087577B2 (en) * | 1998-10-16 | 2006-08-08 | Zimmer Orthobiologies, Inc. | Method of promoting natural bypass |
EP1181041A2 (en) * | 1999-04-30 | 2002-02-27 | Curis, Inc. | Morphogen-induced enhancement of fertility |
WO2001008714A1 (en) * | 1999-07-28 | 2001-02-08 | Regeneration Technologies, Inc. | Cartilage or bone matrix as a nucleic acid delivery vehicle |
CN1331248A (en) * | 2000-06-30 | 2002-01-16 | 上海博德基因开发有限公司 | Polypeptide-human chondral connexin 10.67 and polynucleotide for coding it |
US6482936B1 (en) * | 2001-04-17 | 2002-11-19 | Pe Corporation (Ny) | Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof |
CA2449008A1 (en) * | 2001-06-01 | 2002-12-12 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
US7232802B2 (en) * | 2001-12-21 | 2007-06-19 | Zimmer Orthobiologics, Inc. | Compositions and methods for promoting myocardial and peripheral angiogenesis |
WO2004061423A2 (en) * | 2003-01-06 | 2004-07-22 | Wyeth | Compositions and methods for diagnosing and treating colon cancers |
US20050266409A1 (en) * | 2003-02-04 | 2005-12-01 | Wyeth | Compositions and methods for diagnosing, preventing, and treating cancers |
WO2005001092A2 (en) * | 2003-05-20 | 2005-01-06 | Wyeth | Compositions and methods for diagnosing and treating cancers |
RU2363478C2 (en) | 2003-09-12 | 2009-08-10 | Вайет | Injected calcium phosphate hinges for delivery of osteogene proteins |
DE10361075A1 (en) * | 2003-12-22 | 2005-07-28 | Pac Tech - Packaging Technologies Gmbh | Method and apparatus for drying circuit substrates |
EP1571159A1 (en) * | 2004-03-04 | 2005-09-07 | Bayerische Julius-Maximilians-Universität Würzburg | Mutein of a bone morphogenetic protein and use thereof |
EP1740609A2 (en) * | 2004-04-27 | 2007-01-10 | Research Development Foundation | Antagonism of tgf-beta superfamily receptor signaling |
US20090042780A1 (en) * | 2004-05-20 | 2009-02-12 | Acceleron Pharma Inc | Modified TGF-Beta Superfamily Polypeptides and Related Methods |
CA2567805A1 (en) * | 2004-05-27 | 2005-12-15 | Acceleron Pharma Inc. | Tgf derepressors and uses related thereto |
US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
WO2006081379A1 (en) * | 2005-01-26 | 2006-08-03 | Wyeth | Use of sfrps as markers of bmp activity |
WO2006105359A2 (en) * | 2005-03-30 | 2006-10-05 | Wyeth | Methods for stimulating hair growth by administering bmps |
US20060247790A1 (en) * | 2005-04-30 | 2006-11-02 | Mckay William F | Shaped osteochondral grafts and methods of using same |
NZ571113A (en) | 2005-11-17 | 2012-02-24 | Biomimetic Therapeutics Inc | Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix |
US8147860B2 (en) | 2005-12-06 | 2012-04-03 | Etex Corporation | Porous calcium phosphate bone material |
US7659999B2 (en) * | 2005-12-23 | 2010-02-09 | Xerox Corporation | UIdesign: N-up calculator user interface |
EP2311505B1 (en) | 2006-02-09 | 2013-11-06 | BioMimetic Therapeutics, LLC | Compositions and methods for treating bone |
US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
EP2049145B1 (en) | 2006-06-30 | 2018-03-14 | BioMimetic Therapeutics, LLC | Pdgf-biomatrix compositions and methods for treating rotator cuff injuries |
US8524265B2 (en) | 2006-08-17 | 2013-09-03 | Warsaw Orthopedic, Inc. | Medical implant sheets useful for tissue regeneration |
EP2086598B1 (en) | 2006-11-03 | 2015-05-27 | BioMimetic Therapeutics, LLC | Compositions and methods for arthrodetic procedures |
US20080195476A1 (en) * | 2007-02-09 | 2008-08-14 | Marchese Michael A | Abandonment remarketing system |
ES2422259T3 (en) | 2008-02-07 | 2013-09-10 | Biomimetic Therapeutics Inc | Compositions for distraction osteogenesis |
WO2009152085A1 (en) * | 2008-06-09 | 2009-12-17 | Wyeth | Novel bmp-12-related proteins and methods of their manufacture |
WO2010030714A2 (en) | 2008-09-09 | 2010-03-18 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries |
US8609127B2 (en) | 2009-04-03 | 2013-12-17 | Warsaw Orthopedic, Inc. | Medical implant with bioactive material and method of making the medical implant |
WO2010144696A1 (en) | 2009-06-11 | 2010-12-16 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
EP2538791B1 (en) | 2010-02-22 | 2015-04-08 | BioMimetic Therapeutics, LLC | Platelet-derived growth factor compositions and methods for the treatment of tendinopathies |
US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
US8952131B2 (en) | 2010-08-20 | 2015-02-10 | Wyeth Llc | Designer osteogenic proteins |
US10034945B2 (en) | 2012-07-13 | 2018-07-31 | Trustees Of Tufts College | Silk powder compaction for production of constructs with high mechanical strength and stiffness |
ES2846848T3 (en) | 2015-10-26 | 2021-07-29 | Harvard College | Reduced and oxidized polysaccharides and methods of using them |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5106748A (en) * | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
US5187076A (en) * | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
ZA874681B (en) * | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
US5108922A (en) * | 1986-07-01 | 1992-04-28 | Genetics Institute, Inc. | DNA sequences encoding BMP-1 products |
ATE209251T1 (en) * | 1990-05-16 | 2001-12-15 | Genetics Inst | PROTEINS PRODUCING BONE AND CARTILAGE FORMATION |
US5168050A (en) * | 1990-05-24 | 1992-12-01 | Genentech, Inc. | Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion |
CA2108770C (en) * | 1991-06-25 | 2007-04-03 | John M. Wozney | Bmp-9 compositions |
JP3193050B2 (en) * | 1992-02-12 | 2001-07-30 | ビオファルム ゲゼルシャフト ツア ビオテヒノロ ギッシェン エントヴィックルング フォン ファル マカ ミット ベシュレンクテル ハフツング | DNA sequences encoding novel growth / differentiation factors |
IL106278A0 (en) * | 1992-07-13 | 1993-11-15 | Sumitomo Metal Ind | Bone formation-inducing protein |
CA2153654A1 (en) * | 1993-01-12 | 1994-07-21 | Se-Jin Lee | Growth differentiation factor-5 |
JPH08505771A (en) * | 1993-01-12 | 1996-06-25 | ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | Growth differentiation factor-3 |
CA2157577C (en) * | 1993-03-19 | 2009-11-17 | Se-Jin Lee | Growth differentiation factor-8 |
BR9406715A (en) * | 1993-05-12 | 1996-02-06 | Genetics Inst | DNA molecule isolated host cell vector method to produce a purified bone morphogenetic protein-BMP-11 (BMP-11) polypeptide and chimeric DNA molecule |
CA2161807A1 (en) * | 1993-05-12 | 1994-11-24 | Anthony J. Celeste | Bmp-10 compositions |
CA2124422A1 (en) * | 1993-05-27 | 1994-11-28 | Yukio Fujisawa | Heterodimers of tgf-.beta. superfamily |
EP0804214A4 (en) * | 1993-07-09 | 1998-05-20 | Univ Johns Hopkins Med | Growth differentiation factor-6 |
EP0717633A4 (en) * | 1993-07-09 | 1998-05-20 | Univ Johns Hopkins Med | Growth differentiation factor-7 |
EP0725796A4 (en) * | 1993-10-08 | 1999-12-01 | Univ Johns Hopkins | Growth differentiation factor-10 |
WO1995016035A2 (en) * | 1993-12-07 | 1995-06-15 | Genetics Institute, Inc. | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
US5439904A (en) * | 1993-12-07 | 1995-08-08 | Synphar Laboratories, Inc. | 2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents |
EP1574577A3 (en) * | 1994-07-08 | 2006-06-14 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-11 |
DK0770089T3 (en) * | 1994-07-13 | 2000-10-23 | Univ Johns Hopkins Med | Growth differentiation factor-12 |
US5693779A (en) * | 1994-11-08 | 1997-12-02 | The United States Of America As Represented By The Department Of Health And Human Services | Production and use of anti-dorsalizing morphogenetic protein |
US5965403A (en) * | 1996-09-18 | 1999-10-12 | Genetics Institute, Inc. | Nucleic acids encoding bone morphogenic protein-16 (BMP-16) |
-
1996
- 1996-09-18 US US08/715,202 patent/US5965403A/en not_active Expired - Fee Related
-
1997
- 1997-07-09 JP JP10514651A patent/JP2001500737A/en not_active Ceased
- 1997-07-09 WO PCT/US1997/011954 patent/WO1998012322A1/en active IP Right Grant
- 1997-07-09 EP EP97933347A patent/EP0941323A1/en not_active Ceased
- 1997-07-09 CA CA002265508A patent/CA2265508C/en not_active Expired - Fee Related
- 1997-07-09 KR KR1019997001978A patent/KR20000036012A/en active IP Right Grant
-
1999
- 1999-03-16 NO NO991271A patent/NO991271L/en not_active Application Discontinuation
- 1999-03-17 FI FI990596A patent/FI990596A/en not_active IP Right Cessation
- 1999-03-18 OA OA9900059A patent/OA10997A/en unknown
- 1999-06-09 US US09/328,775 patent/US6331612B1/en not_active Expired - Fee Related
-
2001
- 2001-11-26 US US09/994,177 patent/US6623934B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2001500737A (en) | 2001-01-23 |
US6331612B1 (en) | 2001-12-18 |
WO1998012322A1 (en) | 1998-03-26 |
OA10997A (en) | 2003-03-04 |
CA2265508C (en) | 2003-11-18 |
KR20000036012A (en) | 2000-06-26 |
EP0941323A1 (en) | 1999-09-15 |
US5965403A (en) | 1999-10-12 |
NO991271D0 (en) | 1999-03-16 |
US6623934B2 (en) | 2003-09-23 |
FI990596A (en) | 1999-05-03 |
NO991271L (en) | 1999-03-16 |
FI990596A0 (en) | 1999-03-17 |
US20030158379A1 (en) | 2003-08-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |